Details for: ANXA10

Gene ID: 11199

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ANXA10

Ensembl ID: ENSG00000109511

Description: annexin A10

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • mucous neck cell CL0000651
    CSI 8.35
    rCSI 12.04%
    PRS 98.84
  • foveolar cell of stomach CL0002179
    CSI 7.19
    rCSI 15.3%
    PRS 98.89
  • epithelial cell of lung CL0000082
    CSI 5.44
    rCSI 4.51%
    PRS 99.32
  • pancreatic acinar cell CL0002064
    CSI 5.23
    rCSI 6.96%
    PRS 98.73
  • intestine goblet cell CL0019031
    CSI 4.31
    rCSI 3.83%
    PRS 98.31
  • enteroendocrine cell CL0000164
    CSI 3.62
    rCSI 4.95%
    PRS 97.84
  • goblet cell CL0000160
    CSI 3.45
    rCSI 3.26%
    PRS 98.41
  • hepatocyte CL0000182
    CSI 3.21
    rCSI 5.74%
    PRS 97.7
  • stem cell CL0000034
    CSI 3.1
    rCSI 2.99%
    PRS 98.57
  • colon epithelial cell CL0011108
    CSI 3.07
    rCSI 3.22%
    PRS 98.59
  • M cell of gut CL0000682
    CSI 2.75
    rCSI 2.92%
    PRS 98.88
  • enterocyte CL0000584
    CSI 1.94
    rCSI 3.13%
    PRS 97.65
  • parietal cell CL0000162
    CSI 0.92
    rCSI 7.95%
    PRS 98.13
  • peptic cell CL0000155
    CSI 0.89
    rCSI 8.76%
    PRS 98.61

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ANXA10](/details-gene/11199) (annexin A10) is a protein-coding gene located on chromosome 4q32.3. As a member of the annexin family, it is characterized by its ability to bind to phospholipids in a calcium-dependent manner ([GO:0005544](https://www.ebi.ac.uk/QuickGO/term/GO:0005544)). Expression data indicates that [ANXA10](/details-gene/11199) is a highly significant gene in secretory epithelial cells, particularly within the gastrointestinal tract and pancreas. Its primary function is likely associated with membrane-related processes such as vesicle trafficking and exocytosis, consistent with its high expression in cells like [mucous neck cell](/details-cell/CL0000651) and [pancreatic acinar cell](/details-cell/CL0002064). The gene's evolutionary origins have been linked to genome duplications during early chordate evolution ([Link](https://doi.org/10.1006/geno.1999.5895)). ## Cellular Roles and Expression Landscape The expression profile of [ANXA10](/details-gene/11199) strongly suggests a specialized role in glandular and mucosal epithelial tissues. **Overall**, the gene shows the highest significance in secretory cell types of the stomach, including [mucous neck cell](/details-cell/CL0000651) (CSI: 8.35) and [foveolar cell of stomach](/details-cell/CL0002179) (CSI: 7.19). This pattern extends to other parts of the digestive system, with high significance in [pancreatic acinar cell](/details-cell/CL0002064) (CSI: 5.23), which are responsible for producing digestive enzymes, and various intestinal epithelial cells such as [intestine goblet cell](/details-cell/CL0019031) (CSI: 4.31) and [enteroendocrine cell](/details-cell/CL0000164) (CSI: 3.62). Significant expression is also noted in [epithelial cell of lung](/details-cell/CL0000082) (CSI: 5.44) and [hepatocyte](/details-cell/CL0000182) (CSI: 3.21), reinforcing its association with secretory and metabolic epithelial functions. The presence of [ANXA10](/details-gene/11199) as a significant marker in [stem cell](/details-cell/CL0000034) populations (CSI: 3.10) may indicate a role in the maintenance or differentiation of these specialized epithelial lineages. This consistent, high-level expression across multiple secretory cell types points to [ANXA10](/details-gene/11199) as a key component of the cellular machinery governing secretion and mucosal barrier function. ## Pathways and Molecular Function The functions of [ANXA10](/details-gene/11199) are characteristic of the annexin protein family. Gene Ontology annotations highlight its role in [calcium ion binding](/details-go/GO:0005509) and, consequently, [calcium-dependent phospholipid binding](/details-go/GO:0005544), including a specific affinity for [phosphatidylserine](/details-go/GO:0001786). These activities are fundamental to the protein's involvement in membrane organization and dynamics. Its annotated localization to the [cytoplasm](/details-go/GO:0005737), [nucleus](/details-go/GO:0005634), [plasma membrane](/details-go/GO:0005886), and [vesicle membrane](/details-go/GO:0012506) suggests it is a dynamic protein that can translocate between compartments to participate in various cellular processes. In the context of the highly secretory cells where it is prominently expressed, these molecular functions are consistent with a role in regulating exocytosis, vesicle fusion, and membrane repair, all of which are critical for the physiological function of glandular tissues. ## Research Directions While the primary expression pattern of [ANXA10](/details-gene/11199) is established in healthy tissues, its role in pathology, particularly in diseases affecting the gastrointestinal tract and pancreas like cancer or inflammatory conditions, remains an important area for investigation. The specific enrichment in mucosal and glandular epithelia makes it a compelling gene to study in these contexts. **Proposed Hypotheses:** 1. Given its high significance in secretory cells ([pancreatic acinar cell](/details-cell/CL0002064), [intestine goblet cell](/details-cell/CL0019031)) and its function in calcium-dependent membrane binding, [ANXA10](/details-gene/11199) may be a critical regulator of stimulated exocytosis, controlling the fusion of secretory vesicles with the plasma membrane for the release of digestive enzymes and mucins. 2. Based on its expression in gastrointestinal [stem cell](/details-cell/CL0000034) populations, [ANXA10](/details-gene/11199) may play a role in the differentiation of epithelial lineages or the maintenance of epithelial barrier integrity, with its dysregulation potentially contributing to inflammatory bowel disease or carcinogenesis. **Experimental Approach:** To test the first hypothesis regarding its role in exocytosis, one could utilize an *in vitro* model such as the human pancreatic cell line AsPC-1 or the gastric cell line AGS. [ANXA10](/details-gene/11199) expression could be knocked down using shRNA or knocked out via CRISPR-Cas9. Following stimulation with a secretagogue (e.g., cholecystokinin for pancreatic cells), the supernatant could be collected and analyzed by ELISA or Western blot to quantify the release of specific secretory products (e.g., amylase, MUC5AC). A significant reduction in secretion in the knockdown/knockout cells compared to controls would support a direct role for [ANXA10](/details-gene/11199) in this process. **Therapeutic Potential:** The highly specific expression of [ANXA10](/details-gene/11199) in gastrointestinal and pancreatic epithelial cells makes it an attractive candidate for targeted therapies. If overexpressed in certain malignancies, such as gastric or pancreatic adenocarcinoma, it could serve as a biomarker or a target for antibody-drug conjugates, assuming it has an accessible extracellular domain or is selectively expressed on the surface of cancer cells. Therefore, inhibition of its function could be a potential therapeutic strategy in cancers where it is found to be a driver of proliferation or survival.

Genular Protein ID: 2939575419

Symbol: ANX10_HUMAN

Name: Annexin A10

UniProtKB Accession Codes:

Q9UJ72 Q96IQ5 Q9UJV4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10458909

Title: Novel human and mouse annexin A10 are linked to the genome duplications during early chordate evolution.

PubMed ID: 10458909

DOI: 10.1006/geno.1999.5895

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 324
  • Mass: 37278
  • Checksum: DE17DF81B5D8D047
  • Sequence:
    • MFCGDYVQGT IFPAPNFNPI MDAQMLGGAL QGFDCDKDML INILTQRCNA QRMMIAEAYQ 
SMYGRDLIGD MREQLSDHFK DVMAGLMYPP PLYDAHELWH AMKGVGTDEN CLIEILASRT 
NGEIFQMREA YCLQYSNNLQ EDIYSETSGH FRDTLMNLVQ GTREEGYTDP AMAAQDAMVL 
WEACQQKTGE HKTMLQMILC NKSYQQLRLV FQEFQNISGQ DMVDAINECY DGYFQELLVA 
IVLCVRDKPA YFAYRLYSAI HDFGFHNKTV IRILIARSEI DLLTIRKRYK ERYGKSLFHD 
IRNFASGHYK KALLAICAGD AEDY