Details for: NRGN

Gene ID: 4900

Symbol: NRGN

Ensembl ID: ENSG00000154146

Description: neurogranin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.6010
    Cell Significance Index: -19.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.8331
    Cell Significance Index: -18.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.1348
    Cell Significance Index: -14.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 33.3797
    Cell Significance Index: -17.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6697
    Cell Significance Index: -19.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.4178
    Cell Significance Index: -14.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 6.1370
    Cell Significance Index: 51.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9721
    Cell Significance Index: -19.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 4.0368
    Cell Significance Index: 53.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.4520
    Cell Significance Index: 98.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.8379
    Cell Significance Index: 190.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6934
    Cell Significance Index: 540.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.5400
    Cell Significance Index: 112.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.3209
    Cell Significance Index: 49.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.1511
    Cell Significance Index: 81.4600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 2.0221
    Cell Significance Index: 22.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3360
    Cell Significance Index: 132.1600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8827
    Cell Significance Index: 14.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6844
    Cell Significance Index: 111.3100
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.3083
    Cell Significance Index: 3.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3079
    Cell Significance Index: 16.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2711
    Cell Significance Index: 18.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2487
    Cell Significance Index: 89.2000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2281
    Cell Significance Index: 2.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2260
    Cell Significance Index: 13.5700
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: 0.2078
    Cell Significance Index: 2.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1685
    Cell Significance Index: 92.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1648
    Cell Significance Index: 124.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1285
    Cell Significance Index: 2.2700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1236
    Cell Significance Index: 0.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0659
    Cell Significance Index: 12.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0454
    Cell Significance Index: 5.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0276
    Cell Significance Index: 0.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0184
    Cell Significance Index: 1.1300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0072
    Cell Significance Index: 0.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0035
    Cell Significance Index: 0.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0102
    Cell Significance Index: -19.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0135
    Cell Significance Index: -0.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0155
    Cell Significance Index: -2.7900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0161
    Cell Significance Index: -21.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0231
    Cell Significance Index: -0.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0258
    Cell Significance Index: -16.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0282
    Cell Significance Index: -12.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0295
    Cell Significance Index: -21.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0344
    Cell Significance Index: -0.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0370
    Cell Significance Index: -4.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0399
    Cell Significance Index: -22.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0400
    Cell Significance Index: -18.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0449
    Cell Significance Index: -8.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0487
    Cell Significance Index: -1.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0553
    Cell Significance Index: -1.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0555
    Cell Significance Index: -15.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0630
    Cell Significance Index: -7.7500
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0661
    Cell Significance Index: -0.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0906
    Cell Significance Index: -2.3300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0915
    Cell Significance Index: -1.8100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0960
    Cell Significance Index: -1.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0965
    Cell Significance Index: -13.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1041
    Cell Significance Index: -21.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1097
    Cell Significance Index: -15.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1119
    Cell Significance Index: -11.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1123
    Cell Significance Index: -2.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1134
    Cell Significance Index: -14.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1141
    Cell Significance Index: -1.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1177
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1313
    Cell Significance Index: -22.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1459
    Cell Significance Index: -3.6400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.1482
    Cell Significance Index: -0.8800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1533
    Cell Significance Index: -1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1695
    Cell Significance Index: -4.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1788
    Cell Significance Index: -20.4800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1870
    Cell Significance Index: -19.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1934
    Cell Significance Index: -12.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2090
    Cell Significance Index: -15.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2107
    Cell Significance Index: -16.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2353
    Cell Significance Index: -14.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2407
    Cell Significance Index: -18.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2426
    Cell Significance Index: -7.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2459
    Cell Significance Index: -5.2200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2569
    Cell Significance Index: -1.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2636
    Cell Significance Index: -13.8400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2655
    Cell Significance Index: -9.3000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2671
    Cell Significance Index: -34.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2951
    Cell Significance Index: -13.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2976
    Cell Significance Index: -21.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3122
    Cell Significance Index: -16.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3123
    Cell Significance Index: -6.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3367
    Cell Significance Index: -21.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3377
    Cell Significance Index: -18.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3444
    Cell Significance Index: -8.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3503
    Cell Significance Index: -3.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3594
    Cell Significance Index: -7.8700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3684
    Cell Significance Index: -6.3700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3707
    Cell Significance Index: -8.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3770
    Cell Significance Index: -13.1000
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.3968
    Cell Significance Index: -4.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Neurogranin is a 43-kDa protein that belongs to the granin family of proteins. It is highly expressed in the brain, particularly in the hippocampus and cerebral cortex, where it is involved in the regulation of synaptic transmission. Neurogranin is characterized by its high affinity for calcium ions (Ca2+), which allows it to bind to calmodulin, a calcium-binding protein. This interaction is essential for the regulation of neurogranin's function in LTP. **Pathways and Functions:** Neurogranin is involved in several key signaling pathways, including: 1. **Activation of NMDA receptors and postsynaptic events**: Neurogranin binds to NMDA receptors, which are essential for the induction of LTP. This binding modulates the activity of NMDA receptors, leading to an increase in synaptic strength. 2. **Calmodulin binding**: Neurogranin's high affinity for Ca2+ allows it to bind to calmodulin, which in turn regulates the activity of various downstream targets, including protein kinases and phosphatases. 3. **Long-term potentiation**: Neurogranin is essential for the induction and maintenance of LTP, a process critical for learning and memory. 4. **Nervous system development**: Neurogranin is also involved in the development of the nervous system, particularly in the formation of synapses and the regulation of neuronal excitability. **Signaling Mechanisms:** Neurogranin's signaling mechanisms involve the regulation of various proteins, including: 1. **Protein kinases**: Neurogranin binds to protein kinases, such as CaMKII, which phosphorylate and activate downstream targets. 2. **Phosphatases**: Neurogranin also binds to phosphatases, such as PP2A, which dephosphorylate and inactivate downstream targets. 3. **Adaptors and scaffolds**: Neurogranin interacts with adaptors and scaffolds, such as PSD-95, which regulate the assembly of synaptic complexes. **Clinical Significance:** Dysregulation of neurogranin has been implicated in various neurological and psychiatric disorders, including: 1. **Alzheimer's disease**: Decreased neurogranin expression has been observed in Alzheimer's disease, which is associated with impaired LTP and synaptic plasticity. 2. **Schizophrenia**: Abnormal neurogranin expression has been linked to schizophrenia, a disorder characterized by impaired cognitive function and synaptic dysfunction. 3. **Depression**: Decreased neurogranin expression has been observed in depression, which is associated with impaired LTP and synaptic plasticity. In conclusion, neurogranin is a critical protein involved in the regulation of neuronal excitability and synaptic plasticity. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of neurogranin in maintaining normal brain function. Further research is needed to fully understand the mechanisms of neurogranin and its role in human disease.

Genular Protein ID: 3160830842

Symbol: NEUG_HUMAN

Name: Neurogranin

UniProtKB Accession Codes:

Q92686

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8929222

Title: Cloning cDNA for human neurogranin.

PubMed ID: 8929222

PubMed ID: 9499372

Title: Structure and chromosomal localization of human neurogranin gene.

PubMed ID: 9499372

PubMed ID: 9143500

Title: Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN).

PubMed ID: 9143500

DOI: 10.1006/geno.1997.4622

PubMed ID: 9329454

Title: Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia.

PubMed ID: 9329454

DOI: 10.1097/00005072-199710000-00004

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23828821

Title: Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation.

PubMed ID: 23828821

DOI: 10.1002/pmic.201300064

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 78
  • Mass: 7618
  • Checksum: 0D6ED790A31D5785
  • Sequence:
    • MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE RGRKGPGPGG 
PGGAGVARGG AGGGPSGD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.