Details for: SMPDL3B

Gene ID: 27293

Symbol: SMPDL3B

Ensembl ID: ENSG00000130768

Description: sphingomyelin phosphodiesterase acid like 3B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.5033
    Cell Significance Index: -7.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.7304
    Cell Significance Index: -6.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 13.6657
    Cell Significance Index: -9.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.2695
    Cell Significance Index: -7.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3673
    Cell Significance Index: 107.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2239
    Cell Significance Index: 48.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.9669
    Cell Significance Index: 27.2900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8933
    Cell Significance Index: 28.3700
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.3919
    Cell Significance Index: 10.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2108
    Cell Significance Index: 1093.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1945
    Cell Significance Index: 34.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6986
    Cell Significance Index: 48.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6267
    Cell Significance Index: 73.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5415
    Cell Significance Index: 17.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4513
    Cell Significance Index: 21.0400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4465
    Cell Significance Index: 9.5100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3755
    Cell Significance Index: 5.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3558
    Cell Significance Index: 4.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3284
    Cell Significance Index: 179.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2980
    Cell Significance Index: 15.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2881
    Cell Significance Index: 54.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2630
    Cell Significance Index: 9.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2376
    Cell Significance Index: 5.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2319
    Cell Significance Index: 37.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1912
    Cell Significance Index: 18.9200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1526
    Cell Significance Index: 3.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1247
    Cell Significance Index: 2.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1213
    Cell Significance Index: 20.7100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1089
    Cell Significance Index: 1.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0998
    Cell Significance Index: 19.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0727
    Cell Significance Index: 5.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0668
    Cell Significance Index: 8.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0496
    Cell Significance Index: 8.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0480
    Cell Significance Index: 33.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0219
    Cell Significance Index: 9.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0188
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0082
    Cell Significance Index: 6.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0008
    Cell Significance Index: -1.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0063
    Cell Significance Index: -11.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0066
    Cell Significance Index: -2.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0087
    Cell Significance Index: -13.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0093
    Cell Significance Index: -1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0122
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -10.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0192
    Cell Significance Index: -11.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0223
    Cell Significance Index: -4.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0226
    Cell Significance Index: -10.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0328
    Cell Significance Index: -3.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0358
    Cell Significance Index: -10.3000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0364
    Cell Significance Index: -2.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0378
    Cell Significance Index: -1.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0429
    Cell Significance Index: -6.2400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.0452
    Cell Significance Index: -0.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0490
    Cell Significance Index: -6.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0606
    Cell Significance Index: -12.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0677
    Cell Significance Index: -1.7800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0693
    Cell Significance Index: -1.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0699
    Cell Significance Index: -2.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0728
    Cell Significance Index: -7.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0729
    Cell Significance Index: -3.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0735
    Cell Significance Index: -1.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0739
    Cell Significance Index: -7.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0754
    Cell Significance Index: -4.6200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0863
    Cell Significance Index: -1.3100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0867
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0884
    Cell Significance Index: -2.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0943
    Cell Significance Index: -11.1200
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0950
    Cell Significance Index: -1.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1006
    Cell Significance Index: -4.7300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1057
    Cell Significance Index: -1.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1122
    Cell Significance Index: -3.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1123
    Cell Significance Index: -2.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1183
    Cell Significance Index: -9.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1192
    Cell Significance Index: -9.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1277
    Cell Significance Index: -4.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1327
    Cell Significance Index: -3.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1469
    Cell Significance Index: -9.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1476
    Cell Significance Index: -5.1700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1481
    Cell Significance Index: -1.9400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1484
    Cell Significance Index: -2.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1517
    Cell Significance Index: -7.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1522
    Cell Significance Index: -9.5900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1584
    Cell Significance Index: -1.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1618
    Cell Significance Index: -10.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1672
    Cell Significance Index: -2.5200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1691
    Cell Significance Index: -2.3000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1697
    Cell Significance Index: -4.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1700
    Cell Significance Index: -7.5200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1701
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1727
    Cell Significance Index: -9.6900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1757
    Cell Significance Index: -1.0900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1757
    Cell Significance Index: -0.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1779
    Cell Significance Index: -5.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1873
    Cell Significance Index: -11.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1966
    Cell Significance Index: -1.5700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1986
    Cell Significance Index: -1.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** SMPDL3B is a phosphodiesterase enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine. 2. **Tissue Distribution:** SMPDL3B is widely expressed in various tissues, including cardiac endothelial cells, pancreatic acinar cells, and cerebral cortex GABAergic interneurons. 3. **Cellular Localization:** SMPDL3B is primarily localized to the plasma membrane, where it regulates sphingomyelin catabolism and immune responses. 4. **Protein Structure:** The ASM3B protein has a characteristic structure, consisting of a catalytic domain and a zinc-binding motif. **Pathways and Functions:** 1. **Sphingomyelin Catabolism:** SMPDL3B plays a crucial role in the breakdown of sphingomyelin, which is essential for maintaining cellular homeostasis and regulating cell signaling pathways. 2. **Immune Response:** SMPDL3B is involved in regulating inflammatory responses and negative signaling pathways, such as the toll-like receptor (TLR) pathway. 3. **Extracellular Signaling:** SMPDL3B can interact with extracellular ligands, such as sphingomyelin, to regulate cellular signaling pathways. 4. **Cytoskeleton Organization:** SMPDL3B has been shown to regulate cytoskeleton organization and cell migration, which is essential for immune cell function. **Clinical Significance:** 1. **Inflammatory Diseases:** SMPDL3B has been implicated in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, and multiple sclerosis. 2. **Neurological Disorders:** SMPDL3B has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** SMPDL3B has been shown to play a role in cancer development and progression, particularly in the context of immune evasion. 4. **Regulatory T Cells:** SMPDL3B has been implicated in the regulation of regulatory T cells (Tregs), which are essential for maintaining immune homeostasis. In conclusion, SMPDL3B is a critical regulator of sphingomyelin catabolism and immune response. Its dysregulation has been implicated in various diseases, including inflammatory disorders, neurological disorders, and cancer. Further research is needed to fully elucidate the functional significance of SMPDL3B and its role in human disease.

Genular Protein ID: 2433326873

Symbol: ASM3B_HUMAN

Name: Acid sphingomyelinase-like phosphodiesterase 3b

UniProtKB Accession Codes:

Q92485 B7ZB35 Q5T0Z0 Q96CB7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26095358

Title: The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity.

PubMed ID: 26095358

DOI: 10.1016/j.celrep.2015.05.006

Sequence Information:

  • Length: 455
  • Mass: 50814
  • Checksum: E947E49C3A8449BA
  • Sequence:
    • MRLLAWLIFL ANWGGARAEP GKFWHIADLH LDPDYKVSKD PFQVCPSAGS QPVPDAGPWG 
DYLCDSPWAL INSSIYAMKE IEPEPDFILW TGDDTPHVPD EKLGEAAVLE IVERLTKLIR 
EVFPDTKVYA ALGNHDFHPK NQFPAGSNNI YNQIAELWKP WLSNESIALF KKGAFYCEKL 
PGPSGAGRIV VLNTNLYYTS NALTADMADP GQQFQWLEDV LTDASKAGDM VYIVGHVPPG 
FFEKTQNKAW FREGFNEKYL KVVRKHHRVI AGQFFGHHHT DSFRMLYDDA GVPISAMFIT 
PGVTPWKTTL PGVVNGANNP AIRVFEYDRA TLSLKDMVTY FMNLSQANAQ GTPRWELEYQ 
LTEAYGVPDA SAHSMHTVLD RIAGDQSTLQ RYYVYNSVSY SAGVCDEACS MQHVCAMRQV 
DIDAYTTCLY ASGTTPVPQL PLLLMALLGL CTLVL

Genular Protein ID: 1703841550

Symbol: B4DEC6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEC6

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 249
  • Mass: 27830
  • Checksum: 85B327B8CB0A34FB
  • Sequence:
    • MADPGQQFQW LEDVLTDASK AGDMVYIVGH VPPGFFEKTQ NKAWFREGFN EKYLKVVRKH 
HRVIAGQFFG HHHTDSFRML YDDAGVPISA MFITPGVTPW KTTLPGVVNG ANNPAIRVFE 
YDRATLSLKD MVTYFMNLSQ ANAQGTPRWE LEYQLTEAYG VPDASAHSMH TVLDRIAGDQ 
STLQRYYVYN SVSYSAGVCD EACSMQHVCA MRQVDIDAYT TCLYASGTTP VPQLPLLLMA 
LLGLCTLVL

Genular Protein ID: 4219263086

Symbol: B4DW34_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DW34

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 455
  • Mass: 50786
  • Checksum: FFC3F915BC0059A5
  • Sequence:
    • MRLLAWLIFL ANWGGARAEP GKFWHIADLH LDPDYKVSKD PFQVCPSAGS QPVPDAGPWG 
DYLCDSPWAL INSSIYAMKE IEPEPDFILW TGDDTPHVPD EKLGEAAVLE IVERLTKLIR 
EVFPDTKVYA ALGNHDFHPK NQFPAGSNNI YNQIAELWKP WLSNESIALF KKGAFYCEKL 
PGPSGAGRIV VLNTNLYYTS NALTADMADP GQQFQWLEDV LTDASKAGDM VYIVGHVPPG 
FFEKTQNKAW FREGFNEKYL KVARKHHRVI AGQFFGHHHT DSFRMLYDDA GVPISAMFIT 
PGVTPWKTTL PGVVNGANNP AIRVFEYDRA TLSLKDMVTY FMNLSQANAQ GTPRWELEYQ 
LTEAYGVPDA SAHSMHTVLD RIAGDQSTLQ RYYVYNSVSY SAGVCDEACS MQHVCAMRQV 
DIDAYTTCLY ASGTTPVPQL PLLLMALLGL CTLVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.