Details for: THEM6

Gene ID: 51337

Symbol: THEM6

Ensembl ID: ENSG00000130193

Description: thioesterase superfamily member 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 73.3870
    Cell Significance Index: -11.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.9808
    Cell Significance Index: -12.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.0210
    Cell Significance Index: -11.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.3279
    Cell Significance Index: -11.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.6857
    Cell Significance Index: -13.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7035
    Cell Significance Index: -12.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.4465
    Cell Significance Index: -13.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8342
    Cell Significance Index: 147.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7120
    Cell Significance Index: 15.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3575
    Cell Significance Index: 158.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1583
    Cell Significance Index: 69.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9912
    Cell Significance Index: 178.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9774
    Cell Significance Index: 106.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9602
    Cell Significance Index: 867.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7739
    Cell Significance Index: 125.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7031
    Cell Significance Index: 86.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6695
    Cell Significance Index: 66.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4802
    Cell Significance Index: 33.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4787
    Cell Significance Index: 21.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3747
    Cell Significance Index: 17.4700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3596
    Cell Significance Index: 4.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3426
    Cell Significance Index: 9.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3274
    Cell Significance Index: 178.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3111
    Cell Significance Index: 22.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3093
    Cell Significance Index: 6.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3041
    Cell Significance Index: 60.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3024
    Cell Significance Index: 57.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2955
    Cell Significance Index: 59.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1880
    Cell Significance Index: 6.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1880
    Cell Significance Index: 11.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1596
    Cell Significance Index: 3.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1392
    Cell Significance Index: 61.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1352
    Cell Significance Index: 6.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1312
    Cell Significance Index: 90.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1181
    Cell Significance Index: 15.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1168
    Cell Significance Index: 6.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1124
    Cell Significance Index: 12.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1013
    Cell Significance Index: 3.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0963
    Cell Significance Index: 16.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0920
    Cell Significance Index: 33.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0714
    Cell Significance Index: 9.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0646
    Cell Significance Index: 0.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0639
    Cell Significance Index: 8.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0594
    Cell Significance Index: 6.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0492
    Cell Significance Index: 1.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0440
    Cell Significance Index: 5.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0400
    Cell Significance Index: 2.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0248
    Cell Significance Index: 0.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0086
    Cell Significance Index: 0.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0033
    Cell Significance Index: 2.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0042
    Cell Significance Index: -3.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0048
    Cell Significance Index: -3.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0084
    Cell Significance Index: -12.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0103
    Cell Significance Index: -5.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0133
    Cell Significance Index: -8.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0161
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0250
    Cell Significance Index: -11.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0300
    Cell Significance Index: -6.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0309
    Cell Significance Index: -0.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0475
    Cell Significance Index: -13.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0510
    Cell Significance Index: -3.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0610
    Cell Significance Index: -8.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0717
    Cell Significance Index: -4.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0851
    Cell Significance Index: -3.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0981
    Cell Significance Index: -7.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0997
    Cell Significance Index: -1.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1019
    Cell Significance Index: -3.8600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1142
    Cell Significance Index: -1.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1208
    Cell Significance Index: -1.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1258
    Cell Significance Index: -13.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1268
    Cell Significance Index: -1.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1406
    Cell Significance Index: -8.6400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1426
    Cell Significance Index: -2.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1494
    Cell Significance Index: -11.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1577
    Cell Significance Index: -4.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1706
    Cell Significance Index: -10.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1747
    Cell Significance Index: -5.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1748
    Cell Significance Index: -9.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1828
    Cell Significance Index: -4.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1879
    Cell Significance Index: -4.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1972
    Cell Significance Index: -3.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2050
    Cell Significance Index: -10.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2054
    Cell Significance Index: -5.4000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2177
    Cell Significance Index: -3.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2199
    Cell Significance Index: -5.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2386
    Cell Significance Index: -7.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2422
    Cell Significance Index: -5.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2663
    Cell Significance Index: -8.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2695
    Cell Significance Index: -9.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2710
    Cell Significance Index: -3.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2716
    Cell Significance Index: -7.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2758
    Cell Significance Index: -2.8600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2778
    Cell Significance Index: -3.0200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2912
    Cell Significance Index: -7.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2918
    Cell Significance Index: -10.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** THEM6 is a gene that belongs to the thioesterase superfamily, which is characterized by the presence of a thioesterase domain. This domain is responsible for the cleavage of thioesters, which are compounds containing a thioester bond. THEM6 is a member of this superfamily and shares similarities with other thioesterases, such as THEM1 and THEM3. THEM6 is a small gene, consisting of only 3 exons, and is highly conserved across species, suggesting its critical role in cellular processes. **Pathways and Functions:** THEM6 is involved in several cellular pathways, including: 1. **Cell signaling:** THEM6 has been shown to interact with other proteins, such as CD4 and CD8, which are involved in T-cell signaling. This interaction suggests that THEM6 plays a role in regulating T-cell activation and function. 2. **Immune response:** THEM6 has been expressed in immune cells, such as mast cells and epithelial cells, which are involved in the innate and adaptive immune responses. This suggests that THEM6 may play a role in regulating immune responses and inflammation. 3. **Cellular differentiation:** THEM6 has been shown to be involved in the differentiation of hematopoietic cells, such as erythroblasts and mast cells. This suggests that THEM6 may play a role in regulating cellular differentiation and development. **Clinical Significance:** THEM6 has been implicated in several diseases, including: 1. **Immunodeficiency disorders:** THEM6 has been shown to be involved in the regulation of immune responses, and mutations in this gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** THEM6 has been expressed in various types of cancer, including leukemia and lymphoma. This suggests that THEM6 may play a role in the development and progression of these diseases. 3. **Inflammatory disorders:** THEM6 has been shown to be involved in the regulation of inflammation, and its dysregulation has been implicated in inflammatory disorders, such as asthma and rheumatoid arthritis. In conclusion, THEM6 is a gene with significant immunological and cellular significance. Its involvement in cell signaling, immune response, and cellular differentiation makes it a critical regulator of various cellular processes. Further research is needed to fully understand the role of THEM6 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 3203620438

Symbol: THEM6_HUMAN

Name: Protein THEM6

UniProtKB Accession Codes:

Q8WUY1 B2RDN6 Q8NBN2 Q9NYI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 208
  • Mass: 23865
  • Checksum: 6F9808DB345194D5
  • Sequence:
    • MLGLLVALLA LGLAVFALLD VWYLVRLPCA VLRARLLQPR VRDLLAEQRF PGRVLPSDLD 
LLLHMNNARY LREADFARVA HLTRCGVLGA LRELRAHTVL AASCARHRRS LRLLEPFEVR 
TRLLGWDDRA FYLEARFVSL RDGFVCALLR FRQHLLGTSP ERVVQHLCQR RVEPPELPAD 
LQHWISYNEA SSQLLRMESG LSDVTKDQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.