Details for: MROH6

Gene ID: 642475

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MROH6

Ensembl ID: ENSG00000204839

Description: maestro heat like repeat family member 6

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • neural progenitor cell CL0011020
    CSI 3.35
    rCSI 14.73%
    PRS 92.66
  • epithelial cell of lung CL0000082
    CSI 3.14
    rCSI 2.61%
    PRS 98.81
  • intestinal epithelial cell CL0002563
    CSI 2.66
    rCSI 2.78%
    PRS 97.24
  • squamous epithelial cell CL0000076
    CSI 2.63
    rCSI 6.24%
    PRS 95.38
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.56
    rCSI 2.46%
    PRS 97.62
  • basal cell of epidermis CL0002187
    CSI 2.07
    rCSI 3.66%
    PRS 81.57
  • promonocyte CL0000559
    CSI 1.77
    rCSI 3.03%
    PRS 98.94
  • melanocyte of skin CL1000458
    CSI 1.61
    rCSI 2.2%
    PRS 82.56

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MROH6](/details-gene/642475) (Maestro Heat Like Repeat Family Member 6) is a protein-coding gene located on human chromosome 8q24.3. Functional annotation is currently limited, with evidence primarily localizing the MROH6 protein to the cytoplasm. Expression data indicates that [MROH6](/details-gene/642475) is a highly significant gene in progenitor and epithelial cell populations. **Overall**, it exhibits its highest cell-type specific significance in [neural progenitor cells](/details-cell/CL0011020), as well as in various epithelial cells of the lung, intestine, and skin, suggesting a potential role in development, tissue homeostasis, and barrier function. The initial characterization of its chromosomal locus was part of the comprehensive sequencing of human chromosome 8 [Link](https://doi.org/10.1038/nature04406). ## Cellular Roles and Expression Landscape The expression profile of [MROH6](/details-gene/642475) points towards a specialized role in progenitor and epithelial lineages. **Overall**, the gene shows the most significant expression enrichment in [neural progenitor cells](/details-cell/CL0011020) (CSI: 3.35), indicating it may function in the maintenance or differentiation of the developing nervous system. Beyond the nervous system, [MROH6](/details-gene/642475) demonstrates a strong and consistent association with diverse epithelial tissues responsible for forming barrier surfaces. This is evident from its high significance in [epithelial cells of the lung](/details-cell/CL0000082) (CSI: 3.14), [intestinal epithelial cells](/details-cell/CL0002563) (CSI: 2.66), [squamous epithelial cells](/details-cell/CL0000076) (CSI: 2.63), and [fallopian tube secretory epithelial cells](/details-cell/CL4030006) (CSI: 2.56). Further supporting this pattern, it is also a significant marker in the progenitor layer of the skin, specifically in the [basal cell of epidermis](/details-cell/CL0002187) (CSI: 2.07), and in [melanocytes of the skin](/details-cell/CL1000458) (CSI: 1.61). The gene's notable expression in [promonocytes](/details-cell/CL0000559) (CSI: 1.77) suggests a potential, though less pronounced, role in myeloid lineage development. ## Pathways and Molecular Function Current functional annotations for [MROH6](/details-gene/642475) are sparse. Gene Ontology analysis indicates that the MROH6 protein is localized to the **Cytoplasm** ([GO:0005737](https://www.ebi.ac.uk/QuickGO/term/GO:0005737)). This cytoplasmic localization suggests it may be involved in intracellular signaling cascades, protein trafficking, or metabolic processes. However, its specific molecular function and the pathways it participates in remain to be elucidated. The "heat-like repeat" in its name suggests a potential structural role involving protein-protein interactions, but this requires experimental validation. ## Research Directions The specific expression pattern of [MROH6](/details-gene/642475) in progenitor and epithelial cells, coupled with a lack of detailed functional data, presents several avenues for future research. The gene's consistent high significance in tissues with high cellular turnover and barrier functions suggests it is a key component of cellular homeostasis. ### Testable Hypotheses 1. **Hypothesis 1:** Based on its high significance in [neural progenitor cells](/details-cell/CL0011020) and [basal cells of the epidermis](/details-cell/CL0002187), [MROH6](/details-gene/642475) may play a critical role in maintaining the self-renewal capacity or regulating the lineage commitment of multipotent progenitor cells. 2. **Hypothesis 2:** The widespread high expression of [MROH6](/details-gene/642475) across diverse epithelial barriers (lung, gut, skin) suggests it has a conserved function in establishing or maintaining epithelial cell polarity, intercellular junctions, or the response to environmental stress. ### Proposed Experimental Approach To test the hypothesis that [MROH6](/details-gene/642475) is involved in progenitor cell maintenance, a loss-of-function study could be performed. Specifically, one could use a CRISPR-Cas9 system to knock out [MROH6](/details-gene/642475) in human induced pluripotent stem cells (iPSCs). These knockout and wild-type control iPSCs could then be directed to differentiate towards either a neural progenitor or an epidermal keratinocyte fate. The impact of [MROH6](/details-gene/642475) loss would be assessed by measuring the efficiency of differentiation using flow cytometry for lineage-specific markers (e.g., PAX6/SOX2 for neural progenitors, KRT14/TP63 for basal keratinocytes) and by performing functional assays such as organoid formation or colony-forming assays to evaluate self-renewal and differentiation potential. ### Therapeutic Potential The therapeutic potential of [MROH6](/details-gene/642475) is currently speculative but could be relevant in diseases characterized by dysfunctional progenitor cells or epithelial barriers, such as cancer or inflammatory diseases. If its expression is found to be dysregulated in cancers originating from epithelial tissues (e.g., lung adenocarcinoma, colorectal cancer, or squamous cell carcinoma), it could represent a novel therapeutic target. Given its cytoplasmic localization, it would not be amenable to antibody-based therapies but might be a candidate for inhibition by small molecules if it possesses enzymatic activity or a druggable protein-protein interaction domain. Further research into its molecular function is required to assess its viability as a drug target.

Genular Protein ID: 2008478113

Symbol: MROH6_HUMAN

Name: Maestro heat-like repeat-containing protein family member 6

UniProtKB Accession Codes:

A6NGR9 A8MWB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

Sequence Information:

  • Length: 719
  • Mass: 77186
  • Checksum: E934473EF64302AC
  • Sequence:
    • MAGGVWGRSR AREAPVGALT LTALTEGIRA RQGQPQGPPS AGPQPKSWEV KPEAEPQTQA 
LTAPSEAEPG RGATVPEAGS EPCSLNSALE PAPEGPHQVP QSSWEEGVLA DLALYTAACL 
EEAGFAGTQA TVLTLSSALE ARGERLEDQV HALVRGLLAQ VPSLAEGRPW RAALRVLSAL 
ALEHARDVVC ALLPRSLPAD RVAAELWRSL SRNQRVNGQV LVQLLWALKG ASGPEPQALA 
ATRALGEMLA VSGCVGATRG FYPHLLLALV TQLHKLARSP CSPDMPKIWV LSHRGPPHSH 
ASCAVEALKA LLTGDGGRMV VTCMEQAGGW RRLVGAHTHL EGVLLLASAM VAHADHHLRG 
LFADLLPRLR SADDPQRLTA MAFFTGLLQS RPTARLLREE VILERLLTWQ GDPEPTVRWL 
GLLGLGHLAL NRRKVRHVST LLPALLGALG EGDARLVGAA LGALRRLLLR PRAPVRLLSA 
ELGPRLPPLL DDTRDSIRAS AVGLLGTLVR RGRGGLRLGL RGPLRKLVLQ SLVPLLLRLH 
DPSRDAAESS EWTLARCDHA FCWGLLEELV TVAHYDSPEA LSHLCCRLVQ RYPGHVPNFL 
SQTQGYLRSP QDPLRRAAAV LIGFLVHHAS PGCVNQDLLD SLFQDLGRLQ SDPKPAVAAA 
AHVSAQQVAM LARARGCPRG PRLLRIAPRP ARPPPVFADS PFQRRSVAGR WGCSGPRRA