Details for: SULT1A2

Gene ID: 6799

Symbol: SULT1A2

Ensembl ID: ENSG00000197165

Description: sulfotransferase family 1A member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 31.2449
    Cell Significance Index: -4.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.2002
    Cell Significance Index: -4.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8123
    Cell Significance Index: -4.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7986
    Cell Significance Index: 51.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2595
    Cell Significance Index: -4.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9070
    Cell Significance Index: 19.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6371
    Cell Significance Index: 121.2400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6174
    Cell Significance Index: 6.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5084
    Cell Significance Index: 459.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4560
    Cell Significance Index: 9.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4542
    Cell Significance Index: 44.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4428
    Cell Significance Index: 23.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4333
    Cell Significance Index: 47.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4141
    Cell Significance Index: 6.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3614
    Cell Significance Index: 11.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3378
    Cell Significance Index: 15.3100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3250
    Cell Significance Index: 4.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2852
    Cell Significance Index: 19.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2658
    Cell Significance Index: 52.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2572
    Cell Significance Index: 41.8300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2428
    Cell Significance Index: 3.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2018
    Cell Significance Index: 40.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1976
    Cell Significance Index: 5.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1778
    Cell Significance Index: 2.9300
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1158
    Cell Significance Index: 0.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1081
    Cell Significance Index: 13.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0982
    Cell Significance Index: 17.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0725
    Cell Significance Index: 26.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0583
    Cell Significance Index: 2.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0578
    Cell Significance Index: 1.2300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0527
    Cell Significance Index: 0.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0409
    Cell Significance Index: 22.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0383
    Cell Significance Index: 11.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0347
    Cell Significance Index: 0.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0303
    Cell Significance Index: 1.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0293
    Cell Significance Index: 0.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0292
    Cell Significance Index: 0.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0197
    Cell Significance Index: 14.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0194
    Cell Significance Index: 2.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0161
    Cell Significance Index: 1.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0116
    Cell Significance Index: 1.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0082
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0003
    Cell Significance Index: 0.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0003
    Cell Significance Index: -0.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0012
    Cell Significance Index: -1.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0022
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0023
    Cell Significance Index: -0.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0064
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0128
    Cell Significance Index: -1.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0134
    Cell Significance Index: -1.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0135
    Cell Significance Index: -0.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0206
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0237
    Cell Significance Index: -1.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0249
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0257
    Cell Significance Index: -1.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0278
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0296
    Cell Significance Index: -0.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0307
    Cell Significance Index: -2.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0314
    Cell Significance Index: -0.3300
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0372
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0390
    Cell Significance Index: -5.0400
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0425
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0456
    Cell Significance Index: -4.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0473
    Cell Significance Index: -3.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0492
    Cell Significance Index: -3.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0494
    Cell Significance Index: -1.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0495
    Cell Significance Index: -5.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0524
    Cell Significance Index: -4.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0552
    Cell Significance Index: -3.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0554
    Cell Significance Index: -0.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0564
    Cell Significance Index: -1.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0587
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0588
    Cell Significance Index: -0.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0592
    Cell Significance Index: -3.1100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0603
    Cell Significance Index: -0.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0749
    Cell Significance Index: -4.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0767
    Cell Significance Index: -2.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0767
    Cell Significance Index: -1.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0772
    Cell Significance Index: -2.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0786
    Cell Significance Index: -1.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0812
    Cell Significance Index: -3.8200
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0822
    Cell Significance Index: -0.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0845
    Cell Significance Index: -2.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0871
    Cell Significance Index: -1.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0876
    Cell Significance Index: -3.0700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0899
    Cell Significance Index: -1.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0902
    Cell Significance Index: -2.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0957
    Cell Significance Index: -2.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0978
    Cell Significance Index: -1.4000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1020
    Cell Significance Index: -1.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1084
    Cell Significance Index: -3.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SULT1A2 is a cytosolic enzyme that belongs to the sulfotransferase family, which consists of a diverse group of enzymes that catalyze the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to various substrates. SULT1A2 is specifically characterized by its high affinity for PAPS and its ability to efficiently sulfonate a wide range of compounds, including steroids, catecholamines, and phenolic compounds. The enzyme is highly expressed in various tissues, including the brain, retina, and colon, where it plays a crucial role in the regulation of neurotransmitter metabolism and the detoxification of xenobiotics. **Pathways and Functions:** SULT1A2 is involved in several metabolic pathways, including: 1. **3'-phosphoadenosine 5'-phosphosulfate metabolic process**: SULT1A2 catalyzes the sulfonation of PAPS, which is a crucial step in the sulfonation of various compounds. 2. **Amine biosynthetic process**: SULT1A2 is involved in the sulfonation of amines, which is essential for the regulation of neurotransmitter metabolism. 3. **Aryl sulfotransferase activity**: SULT1A2 exhibits high affinity for aryl sulfonates, which are compounds that are commonly used as therapeutic agents. 4. **Biological oxidations**: SULT1A2 participates in the regulation of oxidative stress by catalyzing the sulfonation of reactive oxygen species. 5. **Catecholamine metabolic process**: SULT1A2 is involved in the sulfonation of catecholamines, which is essential for the regulation of neurotransmitter metabolism. **Clinical Significance:** SULT1A2 has significant clinical implications, particularly in the context of: 1. **Neurological disorders**: Alterations in SULT1A2 expression have been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cancer**: SULT1A2 has been implicated in the regulation of cancer cell growth and metastasis, and its expression is often upregulated in cancer cells. 3. **Xenobiotic metabolism**: SULT1A2 plays a crucial role in the detoxification of xenobiotics, and its dysfunction can lead to increased susceptibility to toxic compounds. 4. **Pharmacokinetics**: SULT1A2 influences the pharmacokinetics of various therapeutic agents, including steroids and catecholamines. In conclusion, SULT1A2 is a multifunctional enzyme that plays a critical role in the sulfonation of various endogenous and exogenous compounds. Its dysregulation has significant clinical implications, particularly in the context of neurological disorders, cancer, and xenobiotic metabolism. Further research is needed to fully elucidate the complexities of SULT1A2 and its role in human health and disease.

Genular Protein ID: 2997784078

Symbol: ST1A2_HUMAN

Name: Sulfotransferase 1A2

UniProtKB Accession Codes:

P50226 A9QY25 P78393 Q14CJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 3 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 2 EMBL 17 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8697101

Title: cDNA cloning and expression of a new form of human aryl sulfotransferase.

PubMed ID: 8697101

DOI: 10.1016/1357-2725(95)00164-6

PubMed ID: 7581483

Title: Primary structures and properties of two related forms of aryl sulfotransferases in human liver.

PubMed ID: 7581483

DOI: 10.1097/00008571-199512001-00015

PubMed ID: 8033246

Title: Structural similarity and diversity of sulfotransferases.

PubMed ID: 8033246

DOI: 10.1016/0009-2797(94)90057-4

PubMed ID: 8661000

Title: Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization.

PubMed ID: 8661000

DOI: 10.1006/geno.1996.0216

PubMed ID: 8912648

Title: Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16.

PubMed ID: 8912648

DOI: 10.1006/bbrc.1996.1628

PubMed ID: 9119390

Title: Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene.

PubMed ID: 9119390

DOI: 10.1006/geno.1996.4575

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7889867

Title: Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds.

PubMed ID: 7889867

DOI: 10.1289/ehp.94102s699

PubMed ID: 20417180

Title: Crystal structures of SULT1A2 and SULT1A1 *3: insights into the substrate inhibition and the role of Tyr149 in SULT1A2.

PubMed ID: 20417180

DOI: 10.1016/j.bbrc.2010.04.109

PubMed ID: 10762004

Title: Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.

PubMed ID: 10762004

DOI: 10.1097/00008571-200003000-00008

Sequence Information:

  • Length: 295
  • Mass: 34310
  • Checksum: EB505BBDAA3A2E09
  • Sequence:
    • MELIQDISRP PLEYVKGVPL IKYFAEALGP LQSFQARPDD LLISTYPKSG TTWVSQILDM 
IYQGGDLEKC HRAPIFMRVP FLEFKVPGIP SGMETLKNTP APRLLKTHLP LALLPQTLLD 
QKVKVVYVAR NAKDVAVSYY HFYHMAKVYP HPGTWESFLE KFMAGEVSYG SWYQHVQEWW 
ELSRTHPVLY LFYEDMKENP KREIQKILEF VGRSLPEETV DLMVEHTSFK EMKKNPMTNY 
TTVRREFMDH SISPFMRKGM AGDWKTTFTV AQNERFDADY AKKMAGCSLS FRSEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.