Details for: EFNA4

Gene ID: 1945

Symbol: EFNA4

Ensembl ID: ENSG00000243364

Description: ephrin A4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.4
    Marker Score: 1512
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.3
    Marker Score: 2695
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48016
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.96
    Marker Score: 765
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.95
    Marker Score: 9549.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1654
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5250.5
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.91
    Marker Score: 1122
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.85
    Marker Score: 906
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.85
    Marker Score: 1998
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.81
    Marker Score: 191
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.76
    Marker Score: 1808
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.76
    Marker Score: 1581
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.74
    Marker Score: 409
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.74
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 380
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7
    Marker Score: 449
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.69
    Marker Score: 871
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 524
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.68
    Marker Score: 457
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.68
    Marker Score: 1847
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.67
    Marker Score: 1277
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.65
    Marker Score: 8602
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 9985
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.63
    Marker Score: 5447
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.62
    Marker Score: 2603
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.56
    Marker Score: 468
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.55
    Marker Score: 18980
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.54
    Marker Score: 4231.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.51
    Marker Score: 2433
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.5
    Marker Score: 120
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.5
    Marker Score: 187
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.49
    Marker Score: 1539
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.48
    Marker Score: 3124
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.48
    Marker Score: 94
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.47
    Marker Score: 313
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.46
    Marker Score: 2267
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.46
    Marker Score: 460
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 433
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.46
    Marker Score: 163
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.46
    Marker Score: 189
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.44
    Marker Score: 2596
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 563
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.42
    Marker Score: 978
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.41
    Marker Score: 130
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.4
    Marker Score: 1482
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.39
    Marker Score: 897
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.39
    Marker Score: 211
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.39
    Marker Score: 405
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 382
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.38
    Marker Score: 2815
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.38
    Marker Score: 107
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.37
    Marker Score: 405
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.37
    Marker Score: 593
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 746
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.36
    Marker Score: 351
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 558
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.36
    Marker Score: 104
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.36
    Marker Score: 78
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.36
    Marker Score: 525
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.36
    Marker Score: 196
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.36
    Marker Score: 123
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 252
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.35
    Marker Score: 104.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 207
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.34
    Marker Score: 831
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.34
    Marker Score: 1767
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.34
    Marker Score: 911
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.33
    Marker Score: 96
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.32
    Marker Score: 311
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 135
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.32
    Marker Score: 159
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.32
    Marker Score: 285
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.32
    Marker Score: 100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.31
    Marker Score: 161
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.31
    Marker Score: 279
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.31
    Marker Score: 364
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.31
    Marker Score: 207
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.3
    Marker Score: 309
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.3
    Marker Score: 686
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.29
    Marker Score: 215.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.29
    Marker Score: 1152
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138

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Other Information

**Key characteristics:** - EFNA4 is a glycoprotein belonging to the Eph family of cell surface receptors. - It is expressed in high levels in the developing cerebral cortex, where it is involved in regulating neuronal survival and migration. - It is also expressed in the developing kidney, where it is involved in regulating epithelial cell migration and differentiation. - It is a key regulator of the Eph-ephrin signaling pathway, which is essential for the development and maintenance of the nervous system. **Pathways and functions:** - The Eph-ephrin signaling pathway is a complex network of cell surface receptors and signaling molecules that is involved in various cellular processes, including cell migration, adhesion, and differentiation. - EFNA4 is a key component of the Eph-ephrin signaling pathway, and its overexpression leads to the formation of cell-cell contacts and the formation of stable cell lines. - In the developing nervous system, the Eph-ephrin signaling pathway is essential for the survival, migration, and differentiation of neural cells. - Dysregulation of the Eph-ephrin signaling pathway has been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. **Clinical significance:** - Targeting the Eph-ephrin signaling pathway is a promising therapeutic strategy for a variety of neurological disorders, including autism, schizophrenia, and epilepsy. - Drugs that block Eph-ephrin signaling have been shown to be effective in animal models of these disorders, suggesting that they could be used to treat these conditions in humans. **Additional notes:** - EFNA4 is a highly conserved protein, with a similar sequence found in vertebrates. - It is a transmembrane protein with a single extracellular domain and a cytoplasmic domain that is rich in cysteine residues. - It is a member of the Eph family of cell surface receptors, which are known for their role in cell adhesion and migration.

Genular Protein ID: 3328081962

Symbol: EFNA4_HUMAN

Name: Ephrin-A4

UniProtKB Accession Codes:

P52798 C9JHJ8 G3XAK2 O95457 Q5SR71 Q6FI57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 3 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7838529

Title: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

PubMed ID: 7838529

PubMed ID: 10607706

Title: A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.

PubMed ID: 10607706

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 201
  • Mass: 22386
  • Checksum: ABE8D5443A9AF28D
  • Sequence:
    • MRLLPLLRTV LWAAFLGSPL RGGSSLRHVV YWNSSNPRLL RGDAVVELGL NDYLDIVCPH 
YEGPGPPEGP ETFALYMVDW PGYESCQAEG PRAYKRWVCS LPFGHVQFSE KIQRFTPFSL 
GFEFLPGETY YYISVPTPES SGQCLRLQVS VCCKERKSES AHPVGSPGES GTSGWRGGDT 
PSPLCLLLLL LLLILRLLRI L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.