Details for: EFNA4

Gene ID: 1945

Symbol: EFNA4

Ensembl ID: ENSG00000243364

Description: ephrin A4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.3619
    Cell Significance Index: -11.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.7014
    Cell Significance Index: -10.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.0393
    Cell Significance Index: -11.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5649
    Cell Significance Index: -9.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.0365
    Cell Significance Index: 577.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8535
    Cell Significance Index: -11.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5803
    Cell Significance Index: 94.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.5453
    Cell Significance Index: 23.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4304
    Cell Significance Index: 166.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0918
    Cell Significance Index: 16.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0136
    Cell Significance Index: 164.8600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8220
    Cell Significance Index: 22.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8112
    Cell Significance Index: 57.3700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7537
    Cell Significance Index: 680.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7189
    Cell Significance Index: 32.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7159
    Cell Significance Index: 316.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7123
    Cell Significance Index: 14.9100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6851
    Cell Significance Index: 5.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6492
    Cell Significance Index: 22.5600
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.5893
    Cell Significance Index: 2.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4976
    Cell Significance Index: 10.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4240
    Cell Significance Index: 22.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3318
    Cell Significance Index: 9.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3251
    Cell Significance Index: 15.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3081
    Cell Significance Index: 168.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2947
    Cell Significance Index: 7.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2400
    Cell Significance Index: 7.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2280
    Cell Significance Index: 10.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1838
    Cell Significance Index: 33.1400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.1828
    Cell Significance Index: 1.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1820
    Cell Significance Index: 4.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1807
    Cell Significance Index: 24.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1705
    Cell Significance Index: 20.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1312
    Cell Significance Index: 3.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1265
    Cell Significance Index: 1.3100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1015
    Cell Significance Index: 1.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0976
    Cell Significance Index: 67.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0945
    Cell Significance Index: 0.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0875
    Cell Significance Index: 5.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0780
    Cell Significance Index: 5.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0660
    Cell Significance Index: 0.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0533
    Cell Significance Index: 6.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0521
    Cell Significance Index: 1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0489
    Cell Significance Index: 6.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0479
    Cell Significance Index: 5.6500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0306
    Cell Significance Index: 0.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0284
    Cell Significance Index: 0.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0244
    Cell Significance Index: 0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0027
    Cell Significance Index: 0.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0026
    Cell Significance Index: -2.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0166
    Cell Significance Index: -12.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0169
    Cell Significance Index: -1.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0172
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0186
    Cell Significance Index: -10.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0225
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0225
    Cell Significance Index: -14.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0286
    Cell Significance Index: -10.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0298
    Cell Significance Index: -13.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0341
    Cell Significance Index: -5.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0349
    Cell Significance Index: -4.0000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0406
    Cell Significance Index: -0.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0480
    Cell Significance Index: -9.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0564
    Cell Significance Index: -11.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0597
    Cell Significance Index: -12.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0711
    Cell Significance Index: -0.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1028
    Cell Significance Index: -2.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1090
    Cell Significance Index: -3.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1135
    Cell Significance Index: -6.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1152
    Cell Significance Index: -9.1200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1165
    Cell Significance Index: -0.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1217
    Cell Significance Index: -7.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1246
    Cell Significance Index: -9.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1264
    Cell Significance Index: -3.2300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1374
    Cell Significance Index: -0.8600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1393
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1490
    Cell Significance Index: -4.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1490
    Cell Significance Index: -9.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1601
    Cell Significance Index: -2.5400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1756
    Cell Significance Index: -2.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1838
    Cell Significance Index: -4.5900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1847
    Cell Significance Index: -1.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1899
    Cell Significance Index: -11.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2114
    Cell Significance Index: -11.1000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2163
    Cell Significance Index: -3.1000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2215
    Cell Significance Index: -1.6100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2307
    Cell Significance Index: -2.3800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2528
    Cell Significance Index: -3.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2537
    Cell Significance Index: -11.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2565
    Cell Significance Index: -9.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2953
    Cell Significance Index: -4.3600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2960
    Cell Significance Index: -12.8700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2967
    Cell Significance Index: -3.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2971
    Cell Significance Index: -11.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3056
    Cell Significance Index: -7.0600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3172
    Cell Significance Index: -6.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3183
    Cell Significance Index: -11.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3383
    Cell Significance Index: -11.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** EFNA4 exhibits several key characteristics that distinguish it from other ephrins: 1. **Transmembrane structure**: EFNA4 possesses a unique transmembrane structure, with an extracellular domain that interacts with ephrin receptors, and a cytoplasmic domain that regulates signaling pathways. 2. **High expression levels**: EFNA4 is highly expressed in various tissues, including the nervous system, kidney, and intestine, suggesting its importance in maintaining tissue homeostasis. 3. **Specific cell-type restricted expression**: EFNA4 is specifically expressed in certain cell types, such as Leydig cells and cerebral cortex GABAergic interneurons, indicating its role in regulating specific cellular processes. 4. **Interaction with ephrin receptors**: EFNA4 interacts with ephrin receptors, which are tyrosine kinase receptors, to regulate signaling pathways involved in axon guidance, cell-cell signaling, and developmental biology. **Pathways and Functions** EFNA4 is involved in various signaling pathways that regulate cellular processes, including: 1. **Axon guidance**: EFNA4 interacts with ephrin receptors to regulate axon guidance, a critical process in nervous system development and maintenance. 2. **Cell-cell signaling**: EFNA4 is involved in cell-cell signaling, which regulates interactions between cells, including adhesion, migration, and differentiation. 3. **Developmental biology**: EFNA4 plays a crucial role in developmental biology, regulating processes such as cell proliferation, differentiation, and tissue morphogenesis. 4. **Ephrin receptor signaling pathway**: EFNA4 interacts with ephrin receptors to regulate the ephrin receptor signaling pathway, which is involved in various cellular processes, including growth cone collapse and cell migration. **Clinical Significance** EFNA4 has been implicated in various diseases and disorders, including: 1. **Neurodevelopmental disorders**: EFNA4 has been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: EFNA4 has been implicated in cancer, including colorectal cancer, where it regulates cell proliferation and migration. 3. **Kidney disease**: EFNA4 has been associated with kidney disease, including diabetic nephropathy, where it regulates cell proliferation and differentiation. 4. **Intestinal disorders**: EFNA4 has been implicated in intestinal disorders, including inflammatory bowel disease, where it regulates cell proliferation and differentiation. In conclusion, EFNA4 is a crucial member of the ephrin family, with specific characteristics and functions that make it an essential component in maintaining tissue homeostasis and regulating cellular interactions. Its involvement in various signaling pathways and its association with various diseases and disorders highlight its importance in understanding human biology and developing novel therapeutic strategies.

Genular Protein ID: 3328081962

Symbol: EFNA4_HUMAN

Name: Ephrin-A4

UniProtKB Accession Codes:

P52798 C9JHJ8 G3XAK2 O95457 Q5SR71 Q6FI57

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7838529

Title: Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.

PubMed ID: 7838529

PubMed ID: 10607706

Title: A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.

PubMed ID: 10607706

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

Sequence Information:

  • Length: 201
  • Mass: 22386
  • Checksum: ABE8D5443A9AF28D
  • Sequence:
    • MRLLPLLRTV LWAAFLGSPL RGGSSLRHVV YWNSSNPRLL RGDAVVELGL NDYLDIVCPH 
YEGPGPPEGP ETFALYMVDW PGYESCQAEG PRAYKRWVCS LPFGHVQFSE KIQRFTPFSL 
GFEFLPGETY YYISVPTPES SGQCLRLQVS VCCKERKSES AHPVGSPGES GTSGWRGGDT 
PSPLCLLLLL LLLILRLLRI L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.