Details for: FOXJ1

Gene ID: 2302

Symbol: FOXJ1

Ensembl ID: ENSG00000129654

Description: forkhead box J1

Associated with

  • Actin cytoskeleton organization
    (GO:0030036)
  • Activation of gtpase activity
    (GO:0090630)
  • Axoneme assembly
    (GO:0035082)
  • Brain development
    (GO:0007420)
  • Cell maturation
    (GO:0048469)
  • Central tolerance induction
    (GO:0002508)
  • Chromatin
    (GO:0000785)
  • Ciliary basal body organization
    (GO:0032053)
  • Cilium assembly
    (GO:0060271)
  • Determination of left/right symmetry
    (GO:0007368)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Epithelium development
    (GO:0060429)
  • Establishment of apical/basal cell polarity
    (GO:0035089)
  • Glomerular parietal epithelial cell development
    (GO:0072016)
  • Heart development
    (GO:0007507)
  • Humoral immune response
    (GO:0006959)
  • Leukocyte migration
    (GO:0050900)
  • Lung epithelium development
    (GO:0060428)
  • Metanephric part of ureteric bud development
    (GO:0035502)
  • Motile cilium assembly
    (GO:0044458)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of germinal center formation
    (GO:0002635)
  • Negative regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002924)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of t cell differentiation in thymus
    (GO:0033085)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Positive regulation of central b cell tolerance induction
    (GO:0002897)
  • Positive regulation of lung ciliated cell differentiation
    (GO:1901248)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein localization
    (GO:0008104)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Spermatogenesis
    (GO:0007283)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.84
    Marker Score: 24675
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.95
    Marker Score: 6721
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.9
    Marker Score: 3612
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.66
    Marker Score: 758
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.26
    Marker Score: 693
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.23
    Marker Score: 42553
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.98
    Marker Score: 466
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.92
    Marker Score: 1898
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 615
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9
    Marker Score: 602
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 357
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.75
    Marker Score: 147
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 560
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.72
    Marker Score: 313
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.7
    Marker Score: 163
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1310
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.66
    Marker Score: 1560
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.54
    Marker Score: 357
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.54
    Marker Score: 403
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 169
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.52
    Marker Score: 403.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 314
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 211
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 320.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.48
    Marker Score: 2002
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.48
    Marker Score: 1171
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6563
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.37
    Marker Score: 250
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.36
    Marker Score: 730
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.35
    Marker Score: 180
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.33
    Marker Score: 115
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.33
    Marker Score: 302.5
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.32
    Marker Score: 165
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.3
    Marker Score: 3999
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.3
    Marker Score: 119
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.28
    Marker Score: 64
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.28
    Marker Score: 244
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.27
    Marker Score: 85
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.26
    Marker Score: 67
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.26
    Marker Score: 539
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 81
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.24
    Marker Score: 75
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.24
    Marker Score: 1247
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.23
    Marker Score: 1376
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.23
    Marker Score: 352
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.21
    Marker Score: 56
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.21
    Marker Score: 104
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.19
    Marker Score: 197
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.19
    Marker Score: 209.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 91
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.18
    Marker Score: 134
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.18
    Marker Score: 194
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.18
    Marker Score: 313
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.16
    Marker Score: 49
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.16
    Marker Score: 222
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.16
    Marker Score: 426
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.15
    Marker Score: 37532
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.15
    Marker Score: 159
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.15
    Marker Score: 222
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.15
    Marker Score: 79
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.15
    Marker Score: 76
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.14
    Marker Score: 89
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.14
    Marker Score: 108
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 0.13
    Marker Score: 50
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.13
    Marker Score: 206
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 457
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.13
    Marker Score: 154
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.13
    Marker Score: 1435
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 25

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary FOXJ1 is a transcription factor that plays a crucial role in various developmental processes, including brain development, humoral immune response, and heart development. It is highly expressed in different cell types, including neuronal and epithelial cells. ## Key characteristics * FOXJ1 is a forkhead domain-containing protein with a conserved N-terminal forkhead domain and a C-terminal transcriptional domain. * It is a key regulator of gene expression and plays a significant role in the development and function of various cell types. * FOXJ1 is involved in central tolerance induction, patterning of the cerebral cortex, regulation of the humoral immune response, and heart development. ## Pathways and functions * FOXJ1 is a key transcription factor that is involved in the development and function of the central nervous system. * It is expressed in neurons, oligodendrocytes, and astrocytes, where it regulates the expression of genes involved in neuronal differentiation, survival, and plasticity. * It is also involved in the development and function of the immune system. * FOXJ1 is expressed in immune cells, including dendritic cells, T cells, and B cells, where it regulates the development and function of immune responses. * It is also involved in the regulation of cardiac development and function. ## Clinical significance * Mutations in FOXJ1 have been linked to a number of human diseases, including autism, schizophrenia, and cancer. * FOXJ1 is a potential target for therapeutic intervention in these diseases. **Additional notes:** * FOXJ1 is a highly conserved protein with similar expression patterns in different species. * It is a member of the forkhead family of transcription factors, which are known for their role in controlling gene expression in response to various environmental cues. * FOXJ1 is a key regulator of brain development and function, and its dysfunction can lead to a variety of neurological and psychiatric disorders.

Genular Protein ID: 2932526479

Symbol: FOXJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92949 O00630

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9530170

Title: A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium.

PubMed ID: 9530170

DOI: 10.1152/ajplung.1998.274.3.l351

PubMed ID: 9073514

Title: The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.

PubMed ID: 9073514

DOI: 10.1006/geno.1996.4587

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16518568

Title: Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.

PubMed ID: 16518568

DOI: 10.1007/s10038-006-0359-8

PubMed ID: 31630787

Title: De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.

PubMed ID: 31630787

DOI: 10.1016/j.ajhg.2019.09.022

Sequence Information:

  • Length: 421
  • Mass: 45247
  • Checksum: A8BB0020CB67F97F
  • Sequence:
    • MAESWLRLSG AGPAEEAGPE GGLEEPDALD DSLTSLQWLQ EFSILNAKAP ALPPGGTDPH 
GYHQVPGSAA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA PPGLQAPPPD DVDYATNPHV 
KPPYSYATLI CMAMQASKAT KITLSAIYKW ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI 
KVPREKDEPG KGGFWRIDPQ YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSAVPRAGP 
LTVNTEAQQL LREFEEATGE AGWGAGEGRL GHKRKQPLPK RVAKVPRPPS TLLPTPEEQG 
ELEPLKGNFD WEAIFDAGTL GGELGALEAL ELSPPLSPAS HVDVDLTIHG RHIDCPATWG 
PSVEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPLF EAGDATLASD LQDWASVGAF 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.