Details for: FOXJ1

Gene ID: 2302

Symbol: FOXJ1

Ensembl ID: ENSG00000129654

Description: forkhead box J1

Associated with

  • Actin cytoskeleton organization
    (GO:0030036)
  • Activation of gtpase activity
    (GO:0090630)
  • Axoneme assembly
    (GO:0035082)
  • Brain development
    (GO:0007420)
  • Cell maturation
    (GO:0048469)
  • Central tolerance induction
    (GO:0002508)
  • Chromatin
    (GO:0000785)
  • Ciliary basal body organization
    (GO:0032053)
  • Cilium assembly
    (GO:0060271)
  • Determination of left/right symmetry
    (GO:0007368)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Epithelium development
    (GO:0060429)
  • Establishment of apical/basal cell polarity
    (GO:0035089)
  • Glomerular parietal epithelial cell development
    (GO:0072016)
  • Heart development
    (GO:0007507)
  • Humoral immune response
    (GO:0006959)
  • Leukocyte migration
    (GO:0050900)
  • Lung epithelium development
    (GO:0060428)
  • Metanephric part of ureteric bud development
    (GO:0035502)
  • Motile cilium assembly
    (GO:0044458)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of germinal center formation
    (GO:0002635)
  • Negative regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002924)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of t cell differentiation in thymus
    (GO:0033085)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Positive regulation of central b cell tolerance induction
    (GO:0002897)
  • Positive regulation of lung ciliated cell differentiation
    (GO:1901248)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein localization
    (GO:0008104)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Spermatogenesis
    (GO:0007283)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.2105
    Cell Significance Index: -7.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.1067
    Cell Significance Index: -7.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.2859
    Cell Significance Index: -6.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.3830
    Cell Significance Index: -7.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.7921
    Cell Significance Index: -5.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8066
    Cell Significance Index: 60.8100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.4069
    Cell Significance Index: 23.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.0121
    Cell Significance Index: -7.9400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9639
    Cell Significance Index: 15.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1973
    Cell Significance Index: 227.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0456
    Cell Significance Index: 571.0100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9253
    Cell Significance Index: 5.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8272
    Cell Significance Index: 19.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7126
    Cell Significance Index: 32.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6334
    Cell Significance Index: 13.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5163
    Cell Significance Index: 51.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4412
    Cell Significance Index: 22.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4361
    Cell Significance Index: 26.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3696
    Cell Significance Index: 333.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3563
    Cell Significance Index: 38.7600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.2709
    Cell Significance Index: 2.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2678
    Cell Significance Index: 43.5500
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.2569
    Cell Significance Index: 2.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1565
    Cell Significance Index: 10.8300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.1137
    Cell Significance Index: 0.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0906
    Cell Significance Index: 5.7100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0809
    Cell Significance Index: 0.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0632
    Cell Significance Index: 1.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0530
    Cell Significance Index: 0.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0331
    Cell Significance Index: 4.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0259
    Cell Significance Index: 11.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0255
    Cell Significance Index: 4.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0225
    Cell Significance Index: 0.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0207
    Cell Significance Index: 0.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0187
    Cell Significance Index: 1.3300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0172
    Cell Significance Index: 0.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0024
    Cell Significance Index: 0.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0041
    Cell Significance Index: -7.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0051
    Cell Significance Index: -0.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0072
    Cell Significance Index: -9.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0135
    Cell Significance Index: -1.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0162
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0185
    Cell Significance Index: -6.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0208
    Cell Significance Index: -9.4400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0224
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0227
    Cell Significance Index: -2.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0228
    Cell Significance Index: -6.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0366
    Cell Significance Index: -1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0379
    Cell Significance Index: -7.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0402
    Cell Significance Index: -8.4800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0426
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0459
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0469
    Cell Significance Index: -5.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0471
    Cell Significance Index: -0.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0471
    Cell Significance Index: -2.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0497
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0510
    Cell Significance Index: -8.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0521
    Cell Significance Index: -5.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0645
    Cell Significance Index: -8.3300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0681
    Cell Significance Index: -0.4300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0682
    Cell Significance Index: -0.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0727
    Cell Significance Index: -8.5700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0737
    Cell Significance Index: -1.1000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0744
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0851
    Cell Significance Index: -6.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0989
    Cell Significance Index: -5.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1040
    Cell Significance Index: -7.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1048
    Cell Significance Index: -6.4400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1076
    Cell Significance Index: -1.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1092
    Cell Significance Index: -1.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1108
    Cell Significance Index: -7.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1113
    Cell Significance Index: -7.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1152
    Cell Significance Index: -2.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1224
    Cell Significance Index: -5.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1266
    Cell Significance Index: -3.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1378
    Cell Significance Index: -7.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1413
    Cell Significance Index: -2.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1435
    Cell Significance Index: -6.6900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1494
    Cell Significance Index: -2.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1547
    Cell Significance Index: -8.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1577
    Cell Significance Index: -3.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1633
    Cell Significance Index: -6.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1771
    Cell Significance Index: -2.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1949
    Cell Significance Index: -8.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1970
    Cell Significance Index: -5.2700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: -0.1988
    Cell Significance Index: -2.1600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2082
    Cell Significance Index: -3.1200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2173
    Cell Significance Index: -3.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2184
    Cell Significance Index: -7.6500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2189
    Cell Significance Index: -3.1100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2226
    Cell Significance Index: -2.5200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: -0.2253
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** FOXJ1 is a transcription factor that belongs to the forkhead box (FOX) family of proteins. It is characterized by the presence of a conserved forkhead domain and a leucine-rich repeat (LRR) domain. FOXJ1 is highly specific to ciliated cells and is also expressed in other cell types involved in development and differentiation. Its expression is regulated by various signaling pathways, including those involved in cell maturation, differentiation, and development. **Pathways and Functions** FOXJ1 is involved in multiple signaling pathways, including: 1. **Actin cytoskeleton organization**: FOXJ1 regulates the organization of the actin cytoskeleton in ciliated cells, which is essential for the proper functioning of cilia. 2. **Activation of GTPase activity**: FOXJ1 activates the activity of GTPases, which are involved in various cellular processes, including cell maturation and differentiation. 3. **Axoneme assembly**: FOXJ1 is involved in the assembly of the axoneme, the core structure of cilia. 4. **Brain development**: FOXJ1 is expressed in cerebral cortex GABAergic interneurons and forebrain radial glial cells, and is involved in the development of the brain. 5. **Cell maturation**: FOXJ1 regulates the maturation of ciliated cells, which is essential for the proper functioning of cilia. 6. **Central tolerance induction**: FOXJ1 is involved in the induction of central tolerance, which is the process by which the immune system learns to distinguish between self and non-self. 7. **Chromatin**: FOXJ1 regulates chromatin structure and function, which is essential for gene expression. **Clinical Significance** FOXJ1 is involved in various diseases and disorders, including: 1. **Primary ciliary dyskinesia (PCD)**: FOXJ1 mutations are associated with PCD, a rare genetic disorder characterized by defective ciliary function. 2. **Respiratory epithelial cell defects**: FOXJ1 is involved in the development and function of respiratory epithelial cells, and defects in FOXJ1 can lead to respiratory epithelial cell defects. 3. **Neurodevelopmental disorders**: FOXJ1 is expressed in cerebral cortex GABAergic interneurons and forebrain radial glial cells, and mutations in FOXJ1 have been associated with neurodevelopmental disorders, including autism and schizophrenia. 4. **Immune system dysfunction**: FOXJ1 is involved in the regulation of the immune system, and defects in FOXJ1 can lead to immune system dysfunction. In conclusion, FOXJ1 is a critical transcription factor that regulates various cellular processes, including cell maturation, differentiation, and development. Its involvement in multiple signaling pathways and its ability to regulate transcription make it an essential regulator of gene expression in various tissues. Understanding the function and regulation of FOXJ1 can have significant implications for the diagnosis and treatment of diseases associated with FOXJ1 dysfunction.

Genular Protein ID: 2932526479

Symbol: FOXJ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92949 O00630

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 41 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9530170

Title: A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium.

PubMed ID: 9530170

DOI: 10.1152/ajplung.1998.274.3.l351

PubMed ID: 9073514

Title: The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.

PubMed ID: 9073514

DOI: 10.1006/geno.1996.4587

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16518568

Title: Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.

PubMed ID: 16518568

DOI: 10.1007/s10038-006-0359-8

PubMed ID: 31630787

Title: De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.

PubMed ID: 31630787

DOI: 10.1016/j.ajhg.2019.09.022

Sequence Information:

  • Length: 421
  • Mass: 45247
  • Checksum: A8BB0020CB67F97F
  • Sequence:
    • MAESWLRLSG AGPAEEAGPE GGLEEPDALD DSLTSLQWLQ EFSILNAKAP ALPPGGTDPH 
GYHQVPGSAA PGSPLAADPA CLGQPHTPGK PTSSCTSRSA PPGLQAPPPD DVDYATNPHV 
KPPYSYATLI CMAMQASKAT KITLSAIYKW ITDNFCYFRH ADPTWQNSIR HNLSLNKCFI 
KVPREKDEPG KGGFWRIDPQ YAERLLSGAF KKRRLPPVHI HPAFARQAAQ EPSAVPRAGP 
LTVNTEAQQL LREFEEATGE AGWGAGEGRL GHKRKQPLPK RVAKVPRPPS TLLPTPEEQG 
ELEPLKGNFD WEAIFDAGTL GGELGALEAL ELSPPLSPAS HVDVDLTIHG RHIDCPATWG 
PSVEQAADSL DFDETFLATS FLQHPWDESG SGCLPPEPLF EAGDATLASD LQDWASVGAF 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.