Details for: ETV4

Gene ID: 2118

Symbol: ETV4

Ensembl ID: ENSG00000175832

Description: ETS variant transcription factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.7158
    Cell Significance Index: -9.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.5811
    Cell Significance Index: -9.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.0446
    Cell Significance Index: -9.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6540
    Cell Significance Index: -3.6200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6217
    Cell Significance Index: 24.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4101
    Cell Significance Index: 49.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1202
    Cell Significance Index: 110.8200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.9925
    Cell Significance Index: 13.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9185
    Cell Significance Index: 829.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.8823
    Cell Significance Index: 12.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8673
    Cell Significance Index: 52.0700
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.8615
    Cell Significance Index: 6.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8417
    Cell Significance Index: 167.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8203
    Cell Significance Index: 89.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.6783
    Cell Significance Index: 16.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6597
    Cell Significance Index: 107.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6043
    Cell Significance Index: 4.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5427
    Cell Significance Index: 13.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4303
    Cell Significance Index: 29.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3535
    Cell Significance Index: 193.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3115
    Cell Significance Index: 4.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2616
    Cell Significance Index: 13.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2484
    Cell Significance Index: 17.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2218
    Cell Significance Index: 6.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2000
    Cell Significance Index: 88.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1893
    Cell Significance Index: 36.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1796
    Cell Significance Index: 5.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1255
    Cell Significance Index: 5.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1233
    Cell Significance Index: 4.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1202
    Cell Significance Index: 15.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0923
    Cell Significance Index: 2.0000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0886
    Cell Significance Index: 1.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0699
    Cell Significance Index: 25.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0623
    Cell Significance Index: 0.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0573
    Cell Significance Index: 1.2200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0529
    Cell Significance Index: 0.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0380
    Cell Significance Index: 6.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0373
    Cell Significance Index: 1.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0316
    Cell Significance Index: 1.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0249
    Cell Significance Index: 1.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0242
    Cell Significance Index: 4.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0206
    Cell Significance Index: 0.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0187
    Cell Significance Index: 0.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0136
    Cell Significance Index: 20.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0113
    Cell Significance Index: 21.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0107
    Cell Significance Index: 14.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0031
    Cell Significance Index: 2.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0030
    Cell Significance Index: 0.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0020
    Cell Significance Index: 3.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0014
    Cell Significance Index: 0.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0042
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0099
    Cell Significance Index: -1.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0108
    Cell Significance Index: -0.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0138
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0161
    Cell Significance Index: -11.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0176
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0186
    Cell Significance Index: -11.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0207
    Cell Significance Index: -5.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0239
    Cell Significance Index: -0.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0287
    Cell Significance Index: -3.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0314
    Cell Significance Index: -3.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0343
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0367
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0403
    Cell Significance Index: -4.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0423
    Cell Significance Index: -2.6000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0541
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0578
    Cell Significance Index: -12.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0587
    Cell Significance Index: -6.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0683
    Cell Significance Index: -9.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0698
    Cell Significance Index: -1.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0823
    Cell Significance Index: -9.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0832
    Cell Significance Index: -6.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0881
    Cell Significance Index: -9.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0886
    Cell Significance Index: -4.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0887
    Cell Significance Index: -2.8400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0951
    Cell Significance Index: -1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1041
    Cell Significance Index: -7.7600
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1065
    Cell Significance Index: -1.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1229
    Cell Significance Index: -3.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1259
    Cell Significance Index: -9.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1445
    Cell Significance Index: -8.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1624
    Cell Significance Index: -10.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1683
    Cell Significance Index: -10.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1764
    Cell Significance Index: -9.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1895
    Cell Significance Index: -9.9500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2210
    Cell Significance Index: -5.5200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2398
    Cell Significance Index: -7.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2412
    Cell Significance Index: -8.4500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2462
    Cell Significance Index: -1.5300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2480
    Cell Significance Index: -1.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2502
    Cell Significance Index: -7.9700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2518
    Cell Significance Index: -4.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2635
    Cell Significance Index: -4.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2640
    Cell Significance Index: -9.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2742
    Cell Significance Index: -4.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2806
    Cell Significance Index: -8.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain structure:** ETV4 contains the characteristic ETS domain, which is involved in DNA binding and transcriptional regulation. 2. **Cellular expression:** ETV4 is expressed in various cell types, including retinal cone cells, kidney proximal convoluted tubule epithelial cells, and cardiac endothelial cells. 3. **Functional roles:** ETV4 is involved in regulating transcription by RNA polymerase II, cell differentiation, and signal transduction pathways. 4. **Pathway involvement:** ETV4 is implicated in the regulation of cell differentiation, particularly in keratinocyte differentiation, and in the Mapk6/Mapk4 signaling pathway. **Pathways and Functions:** 1. **Cell differentiation:** ETV4 regulates transcription by RNA polymerase II, which is essential for the expression of genes involved in cell differentiation, such as keratinocyte differentiation. 2. **Signal transduction:** ETV4 is involved in the Mapk6/Mapk4 signaling pathway, which regulates cell proliferation, differentiation, and survival. 3. **DNA binding:** ETV4 binds to specific DNA sequences, which are involved in the regulation of transcription by RNA polymerase II. 4. **Chromatin regulation:** ETV4 regulates chromatin structure and function, which is essential for the expression of genes involved in cell differentiation. **Clinical Significance:** 1. **Cancer:** Alterations in ETV4 expression have been observed in various types of cancer, including breast cancer, lung cancer, and leukemia. ETV4 may play a role in tumorigenesis and cancer progression. 2. **Developmental disorders:** ETV4 is involved in the regulation of cell differentiation, which is essential for normal development. Aberrations in ETV4 expression may contribute to developmental disorders, such as congenital heart defects. 3. **Cardiovascular disease:** ETV4 is expressed in cardiac endothelial cells and may play a role in the regulation of cardiovascular function and disease. 4. **Regenerative medicine:** ETV4 may be involved in the regulation of stem cell differentiation and proliferation, which is essential for tissue repair and regeneration. In conclusion, ETV4 is a transcriptional regulator that plays a critical role in cell differentiation, signal transduction, and chromatin regulation. Its involvement in various cellular processes and diseases highlights the importance of ETV4 in human health and disease. Further studies are necessary to fully understand the functional roles of ETV4 and its implications in human disease.

Genular Protein ID: 3005643295

Symbol: ETV4_HUMAN

Name: ETS translocation variant 4

UniProtKB Accession Codes:

P43268 A8K314 B7Z5J3 B7Z9J6 Q96AW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7774926

Title: 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.

PubMed ID: 7774926

DOI: 10.1016/0888-7543(95)80133-7

PubMed ID: 10564827

Title: Genomic organization of the human e1af gene, a member of Ets transcription factors.

PubMed ID: 10564827

DOI: 10.1016/s0378-1119(99)00400-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441666

Title: Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.

PubMed ID: 8441666

DOI: 10.1093/nar/21.3.547

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19307308

Title: Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3.

PubMed ID: 19307308

DOI: 10.1128/mcb.01128-08

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31552090

Title: Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators.

PubMed ID: 31552090

DOI: 10.3389/fgene.2019.00775

Sequence Information:

  • Length: 484
  • Mass: 53938
  • Checksum: BA9864F3C690A8C1
  • Sequence:
    • MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS EDLFQDLSHF 
QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKPPLPYHH 
GEQCLYSSAY DPPRQIAIKS PAPGALGQSP LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE 
HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP 
AVDQGGVNGH RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE 
KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL LDDPTNAHFI 
AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR YYYEKGIMQK VAGERYVYKF 
VCEPEALFSL AFPDNQRPAL KAEFDRPVSE EDTVPLSHLD ESPAYLPELA GPAQPFGPKG 
GYSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.