Details for: ETV4

Gene ID: 2118

Symbol: ETV4

Ensembl ID: ENSG00000175832

Description: ETS variant transcription factor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.41
    Marker Score: 6928
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.74
    Marker Score: 3595
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169072.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.44
    Marker Score: 2732.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.38
    Marker Score: 1724
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.06
    Marker Score: 2207
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251787
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.02
    Marker Score: 648
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.01
    Marker Score: 15730
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1869
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5210
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4724
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.75
    Marker Score: 176
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2966
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.68
    Marker Score: 718
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.66
    Marker Score: 207
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.66
    Marker Score: 1116
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.62
    Marker Score: 332
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.62
    Marker Score: 660
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6
    Marker Score: 664
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6
    Marker Score: 20702
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6
    Marker Score: 620
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 386
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.58
    Marker Score: 7772
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.56
    Marker Score: 377
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.56
    Marker Score: 530
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 318
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.52
    Marker Score: 523
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.51
    Marker Score: 784
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.51
    Marker Score: 191
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 235
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.47
    Marker Score: 222
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.46
    Marker Score: 2485
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.46
    Marker Score: 394
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.45
    Marker Score: 262
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.44
    Marker Score: 196
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.44
    Marker Score: 277
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 114
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.44
    Marker Score: 287
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.44
    Marker Score: 156
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 139
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1015
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.42
    Marker Score: 132
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 364
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.37
    Marker Score: 890.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.37
    Marker Score: 574
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.37
    Marker Score: 1956
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.36
    Marker Score: 82
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 367
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.36
    Marker Score: 256
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 146
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.34
    Marker Score: 2930
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.34
    Marker Score: 3210
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.32
    Marker Score: 148
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.32
    Marker Score: 19589
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.32
    Marker Score: 409
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.32
    Marker Score: 298
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.31
    Marker Score: 380
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.3
    Marker Score: 686.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.3
    Marker Score: 268.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3
    Marker Score: 297
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.29
    Marker Score: 121
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.29
    Marker Score: 78
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.28
    Marker Score: 236
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.28
    Marker Score: 757
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.28
    Marker Score: 347
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.28
    Marker Score: 2632
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.28
    Marker Score: 851
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.26
    Marker Score: 105
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.26
    Marker Score: 357.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.25
    Marker Score: 173
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 74
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.25
    Marker Score: 130
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.25
    Marker Score: 1047
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 145
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 141.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.24
    Marker Score: 106
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.24
    Marker Score: 284
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.23
    Marker Score: 156

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Other Information

**Key characteristics:** * ETV4 is a protein of the ETS family of transcription factors. * It is a key regulator of keratinocyte differentiation. * It is required for the expression of genes that are involved in the development of the skin and eyes. * It is a key regulator of cell cycle progression and survival. **Pathways and functions:** * ETV4 is involved in the regulation of keratinocyte differentiation by binding to the Rna polymerase II cis-regulatory region sequence of the keratinocyte differentiation-associated homeobox gene KRT71. * This binding triggers a cascade of transcriptional events that lead to the expression of keratin genes. * ETV4 also regulates the expression of genes involved in cell cycle progression and survival. **Clinical significance:** * Mutations in the ETV4 gene have been linked to a number of human diseases, including retinitis pigmentosa, psoriasis, and cancer. * These mutations can lead to the loss of ETV4 function, which can result in the development of these diseases. * Therefore, ETV4 is a promising target for the treatment of human diseases that are caused by mutations in this gene.

Genular Protein ID: 3005643295

Symbol: ETV4_HUMAN

Name: ETS translocation variant 4

UniProtKB Accession Codes:

P43268 A8K314 B7Z5J3 B7Z9J6 Q96AW9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7774926

Title: 22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors.

PubMed ID: 7774926

DOI: 10.1016/0888-7543(95)80133-7

PubMed ID: 10564827

Title: Genomic organization of the human e1af gene, a member of Ets transcription factors.

PubMed ID: 10564827

DOI: 10.1016/s0378-1119(99)00400-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8441666

Title: Isolation of a cDNA encoding the adenovirus E1A enhancer binding protein: a new human member of the ets oncogene family.

PubMed ID: 8441666

DOI: 10.1093/nar/21.3.547

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19307308

Title: Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3.

PubMed ID: 19307308

DOI: 10.1128/mcb.01128-08

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31552090

Title: Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators.

PubMed ID: 31552090

DOI: 10.3389/fgene.2019.00775

Sequence Information:

  • Length: 484
  • Mass: 53938
  • Checksum: BA9864F3C690A8C1
  • Sequence:
    • MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS EDLFQDLSHF 
QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ SPRTDPALSC SRKPPLPYHH 
GEQCLYSSAY DPPRQIAIKS PAPGALGQSP LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE 
HSSVFQQPLD ICHSFTSQGG GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP 
AVDQGGVNGH RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE 
KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL LDDPTNAHFI 
AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR YYYEKGIMQK VAGERYVYKF 
VCEPEALFSL AFPDNQRPAL KAEFDRPVSE EDTVPLSHLD ESPAYLPELA GPAQPFGPKG 
GYSY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.