Details for: DGCR6

Gene ID: 8214

Symbol: DGCR6

Ensembl ID: ENSG00000183628

Description: DiGeorge syndrome critical region gene 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.5179
    Cell Significance Index: -8.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.8520
    Cell Significance Index: -6.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 15.0276
    Cell Significance Index: -7.7300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.1307
    Cell Significance Index: -8.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.1049
    Cell Significance Index: -8.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.0700
    Cell Significance Index: -6.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8370
    Cell Significance Index: -7.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.2453
    Cell Significance Index: -8.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7248
    Cell Significance Index: 137.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6493
    Cell Significance Index: 33.8200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.6169
    Cell Significance Index: 7.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4769
    Cell Significance Index: 137.2200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.4039
    Cell Significance Index: 3.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4003
    Cell Significance Index: 10.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3806
    Cell Significance Index: 10.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3782
    Cell Significance Index: 37.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3602
    Cell Significance Index: 325.2400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.3110
    Cell Significance Index: 4.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2218
    Cell Significance Index: 6.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2206
    Cell Significance Index: 24.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2206
    Cell Significance Index: 44.2600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2156
    Cell Significance Index: 4.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2075
    Cell Significance Index: 33.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1898
    Cell Significance Index: 11.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1783
    Cell Significance Index: 3.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1615
    Cell Significance Index: 8.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1377
    Cell Significance Index: 10.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1209
    Cell Significance Index: 66.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1169
    Cell Significance Index: 6.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1070
    Cell Significance Index: 13.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0984
    Cell Significance Index: 6.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0894
    Cell Significance Index: 32.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0876
    Cell Significance Index: 10.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0543
    Cell Significance Index: 0.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0506
    Cell Significance Index: 2.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0499
    Cell Significance Index: 2.2600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0335
    Cell Significance Index: 0.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0332
    Cell Significance Index: 14.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0313
    Cell Significance Index: 5.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0252
    Cell Significance Index: 4.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0228
    Cell Significance Index: 2.8000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0174
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0020
    Cell Significance Index: 1.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0047
    Cell Significance Index: -8.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0064
    Cell Significance Index: -0.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0064
    Cell Significance Index: -9.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0076
    Cell Significance Index: -0.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0090
    Cell Significance Index: -5.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0099
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0133
    Cell Significance Index: -8.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0170
    Cell Significance Index: -7.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0192
    Cell Significance Index: -2.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0205
    Cell Significance Index: -1.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0277
    Cell Significance Index: -2.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0281
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0406
    Cell Significance Index: -4.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0408
    Cell Significance Index: -8.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0500
    Cell Significance Index: -2.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0513
    Cell Significance Index: -3.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0607
    Cell Significance Index: -8.8300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0670
    Cell Significance Index: -1.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0689
    Cell Significance Index: -8.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0710
    Cell Significance Index: -4.3500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0721
    Cell Significance Index: -1.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0723
    Cell Significance Index: -1.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0760
    Cell Significance Index: -6.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0763
    Cell Significance Index: -1.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0844
    Cell Significance Index: -1.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0871
    Cell Significance Index: -2.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0927
    Cell Significance Index: -5.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1070
    Cell Significance Index: -2.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1102
    Cell Significance Index: -3.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1138
    Cell Significance Index: -7.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1168
    Cell Significance Index: -3.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1267
    Cell Significance Index: -7.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1329
    Cell Significance Index: -5.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1348
    Cell Significance Index: -1.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1426
    Cell Significance Index: -1.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1488
    Cell Significance Index: -4.3700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1602
    Cell Significance Index: -5.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1680
    Cell Significance Index: -6.3600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1713
    Cell Significance Index: -1.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1774
    Cell Significance Index: -4.5600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1821
    Cell Significance Index: -1.5300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1841
    Cell Significance Index: -2.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1894
    Cell Significance Index: -6.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1896
    Cell Significance Index: -3.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1970
    Cell Significance Index: -6.4500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1978
    Cell Significance Index: -2.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1978
    Cell Significance Index: -6.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1986
    Cell Significance Index: -6.9000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1988
    Cell Significance Index: -2.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2010
    Cell Significance Index: -5.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2030
    Cell Significance Index: -4.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DGCR6 is a non-coding RNA gene, specifically a microRNA precursor, that is involved in the regulation of gene expression. It is highly expressed in various tissues, including the nasal mucosa, cerebral cortex, and intestinal epithelium. DGCR6 has been shown to interact with several proteins, including those involved in cell adhesion and extracellular matrix regulation. Its expression is also restricted to specific cell types, such as goblet cells and GABAergic interneurons. **Pathways and Functions:** DGCR6 is involved in several key pathways, including: 1. **Animal organ morphogenesis**: DGCR6 is essential for the development and morphogenesis of various organs, including the thymus and parathyroid gland. 2. **Cell adhesion**: DGCR6 regulates cell adhesion by interacting with proteins involved in the extracellular matrix and cell-cell interactions. 3. **Extracellular matrix regulation**: DGCR6 influences the formation and organization of the extracellular matrix, which is critical for tissue development and function. 4. **Immune regulation**: DGCR6 has been implicated in the regulation of immune responses, particularly in the development and function of T cells and B cells. **Clinical Significance:** DGCR6 dysregulation has been associated with several diseases, including: 1. **DiGeorge syndrome**: A condition characterized by thymic hypoplasia, parathyroid gland abnormalities, and congenital heart defects. 2. **Immune disorders**: DGCR6 dysregulation has been linked to various immune disorders, including autoimmune diseases and immunodeficiency syndromes. 3. **Cancer**: DGCR6 has been implicated in the development and progression of various cancers, including leukemia and lymphoma. In conclusion, DGCR6 is a critical gene that plays a significant role in organogenesis, cell adhesion, and immune regulation. Its dysregulation has been associated with various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and immune function. Further research is needed to fully elucidate the function and significance of DGCR6 in human disease.

Genular Protein ID: 31532536

Symbol: DGCR6_HUMAN

Name: Protein DGCR6

UniProtKB Accession Codes:

Q14129 B2RCH5 D3DX15 G5E9J8 Q9BY28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11157784

Title: Two functional copies of the DGCR6 gene are present on human chromosome 22q11 due to a duplication of an ancestral locus.

PubMed ID: 11157784

DOI: 10.1101/gr.gr-1431r

PubMed ID: 15821931

Title: Biochemical characterisation of the proteins encoded by the DiGeorge critical region 6 (DGCR6) genes.

PubMed ID: 15821931

DOI: 10.1007/s00439-005-1267-2

PubMed ID: 8733130

Title: Isolation of a novel gene from the DiGeorge syndrome critical region with homology to Drosophila gdl and to human LAMC1 genes.

PubMed ID: 8733130

DOI: 10.1093/hmg/5.5.633

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 220
  • Mass: 24989
  • Checksum: DF68DEAF5BF6B8BB
  • Sequence:
    • MERYAGALEE VADGARQQER HYQLLSALQS LVKELPSSFQ QRLSYTTLSD LALALLDGTV 
FEIVQGLLEI QHLTEKSLYN QRLRLQNEHR VLRQALRQKH QEAQQACRPH NLPVLQAAQQ 
RELEAVEHRI REEQRAMDQK IVLELDRKVA DQQSTLEKAG VAGFYVTTNP QELMLQMNLL 
ELIRKLQQRG CWAGKAALGL GGPWQLPAAQ CDQKGSPVPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.