Details for: HOXD1

Gene ID: 3231

Symbol: HOXD1

Ensembl ID: ENSG00000128645

Description: homeobox D1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.1
    Marker Score: 1631
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.64
    Marker Score: 3397
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.39
    Marker Score: 580
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.32
    Marker Score: 604
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2264
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5306
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.87
    Marker Score: 1518
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 320
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 473
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.73
    Marker Score: 1232
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2949
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.69
    Marker Score: 988
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.65
    Marker Score: 616
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.65
    Marker Score: 432
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.61
    Marker Score: 3214
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.57
    Marker Score: 341
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.53
    Marker Score: 597
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.53
    Marker Score: 528
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.53
    Marker Score: 167
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.5
    Marker Score: 189
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.49
    Marker Score: 121
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.49
    Marker Score: 1164
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.48
    Marker Score: 511
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.48
    Marker Score: 255
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.47
    Marker Score: 3131
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.47
    Marker Score: 1112
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.46
    Marker Score: 725
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.45
    Marker Score: 106
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.45
    Marker Score: 660
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.45
    Marker Score: 254
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.43
    Marker Score: 2829
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.42
    Marker Score: 128
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.42
    Marker Score: 5653
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 391
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.4
    Marker Score: 1266
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.39
    Marker Score: 393
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.38
    Marker Score: 538
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.35
    Marker Score: 588
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.35
    Marker Score: 167
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.35
    Marker Score: 118
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.35
    Marker Score: 185
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.33
    Marker Score: 535
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.33
    Marker Score: 94
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 320
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.3
    Marker Score: 929
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3
    Marker Score: 138
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.29
    Marker Score: 740
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.28
    Marker Score: 137
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.28
    Marker Score: 101
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.28
    Marker Score: 174
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.26
    Marker Score: 2628
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.25
    Marker Score: 476
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.24
    Marker Score: 59
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.24
    Marker Score: 164
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.24
    Marker Score: 1155
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.24
    Marker Score: 217
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.23
    Marker Score: 556
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.23
    Marker Score: 84
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 528
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.22
    Marker Score: 344
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.22
    Marker Score: 67
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.22
    Marker Score: 212
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.22
    Marker Score: 43
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.21
    Marker Score: 375
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.21
    Marker Score: 223
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.19
    Marker Score: 133
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.19
    Marker Score: 44
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.19
    Marker Score: 45
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.18
    Marker Score: 52
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 161
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.18
    Marker Score: 473
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 35
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.17
    Marker Score: 52
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41

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Other Information

**Key characteristics** * HOXD1 is a protein that is highly expressed in the developing hindbrain. * It is a member of the homeobox D family of transcription factors. * It is involved in the regulation of anterior hox genes, which are responsible for the development of the forebrain, midbrain, and hindbrain. * It is also involved in the differentiation of various cell types in the adult, including hematopoietic stem cells, kidney cells, and neurons. **Pathways and functions** * HOXD1 is a key transcription factor that is involved in the activation of anterior hox genes during early embryogenesis. * It does this by binding to specific DNA sequences in the promoters of these genes and promoting their expression. * It is also involved in the regulation of differentiation. * It is expressed in a variety of cell types, including hematopoietic stem cells, kidney cells, and neurons. * In hematopoietic stem cells, HOXD1 is essential for the development of the fetal liver and bone marrow. * In kidney cells, HOXD1 is involved in the regulation of nephron development. * In neurons, HOXD1 is involved in the specification of motor neuron identity. **Clinical significance** HOXD1 is a promising target for the treatment of a variety of neurological diseases, including autism, schizophrenia, and epilepsy. Mutations in the HOXD1 gene have been linked to these disorders, and HOXD1 inhibitors are being investigated as potential treatments.

Genular Protein ID: 2047165387

Symbol: HXD1_HUMAN

Name: Homeobox protein Hox-D1

UniProtKB Accession Codes:

Q9GZZ0 B2RAB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11455954

Title: Isolation and characterization of the human homeobox gene HOX D1.

PubMed ID: 11455954

DOI: 10.1023/a:1011048931477

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 328
  • Mass: 34093
  • Checksum: 1B9EBBF4E2DA0301
  • Sequence:
    • MSSYLEYVSC SSSGGVGGDV LSLAPKFCRS DARPVALQPA FPLGNGDGAF VSCLPLAAAR 
PSPSPPAAPA RPSVPPPAAP QYAQCTLEGA YEPGAAPAAA AGGADYGFLG SGPAYDFPGV 
LGRAADDGGS HVHYATSAVF SGGGSFLLSG QVDYAAFGEP GPFPACLKAS ADGHPGAFQT 
ASPAPGTYPK SVSPASGLPA AFSTFEWMKV KRNASKKGKL AEYGAASPSS AIRTNFSTKQ 
LTELEKEFHF NKYLTRARRI EIANCLHLND TQVKIWFQNR RMKQKKRERE GLLATAIPVA 
PLQLPLSGTT PTKFIKNPGS PSQSQEPS

Genular Protein ID: 1227728381

Symbol: Q96CA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96CA4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 328
  • Mass: 34083
  • Checksum: 24A1B8072CEBE113
  • Sequence:
    • MSSYLEYVSC SSSGGVGGDV LSLAPKFCRS DARPVALQPA FPLGNGDGAF VSCLPLAAAR 
PSPSPPAAPA RPSVPPPAAP QYAQCTLEGA YEPGAAPAAA AGGADYGFLG SGPAYDFPGV 
LGRAADDGGS HVHYATSAVF SGGGSFLLSG QVDYAAFGEP GPFSACLKAS ADGHPGAFQT 
ASPAPGTYPK SVSPASGLPA AFSTFEWMKV KRNASKKGKL AEYGAASPSS AIRTNFSTKQ 
LTELEKEFHF NKYLTRARRI EIANCLHLND TQVKIWFQNR RMKQKKRERE GLLATAIPVA 
PLQLPLSGTT PTKFIKNPGS PSQSQEPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.