Details for: HOXD1

Gene ID: 3231

Symbol: HOXD1

Ensembl ID: ENSG00000128645

Description: homeobox D1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 8.6193
    Cell Significance Index: 73.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.6695
    Cell Significance Index: -9.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6509
    Cell Significance Index: 24.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5250
    Cell Significance Index: 79.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4858
    Cell Significance Index: 51.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4784
    Cell Significance Index: 67.0100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 1.0264
    Cell Significance Index: 3.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9457
    Cell Significance Index: 65.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9406
    Cell Significance Index: 7.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8503
    Cell Significance Index: 84.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6361
    Cell Significance Index: 11.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6166
    Cell Significance Index: 556.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5390
    Cell Significance Index: 32.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5132
    Cell Significance Index: 55.8200
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.4690
    Cell Significance Index: 4.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4459
    Cell Significance Index: 72.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3925
    Cell Significance Index: 11.3100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3900
    Cell Significance Index: 9.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2463
    Cell Significance Index: 7.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2332
    Cell Significance Index: 42.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2023
    Cell Significance Index: 7.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2010
    Cell Significance Index: 24.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1983
    Cell Significance Index: 37.7300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1637
    Cell Significance Index: 1.8600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1126
    Cell Significance Index: 1.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1029
    Cell Significance Index: 2.2300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0712
    Cell Significance Index: 0.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0051
    Cell Significance Index: 3.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0012
    Cell Significance Index: -0.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0084
    Cell Significance Index: -6.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0088
    Cell Significance Index: -1.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0089
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0114
    Cell Significance Index: -6.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0133
    Cell Significance Index: -7.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0135
    Cell Significance Index: -0.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0204
    Cell Significance Index: -2.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0219
    Cell Significance Index: -9.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0258
    Cell Significance Index: -2.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0320
    Cell Significance Index: -9.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0368
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0368
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0376
    Cell Significance Index: -7.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0402
    Cell Significance Index: -8.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0409
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0423
    Cell Significance Index: -7.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0567
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0632
    Cell Significance Index: -7.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0686
    Cell Significance Index: -8.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0703
    Cell Significance Index: -4.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0749
    Cell Significance Index: -2.0900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0766
    Cell Significance Index: -0.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1077
    Cell Significance Index: -8.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1150
    Cell Significance Index: -8.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1164
    Cell Significance Index: -7.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1167
    Cell Significance Index: -5.4400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1253
    Cell Significance Index: -3.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1537
    Cell Significance Index: -9.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1585
    Cell Significance Index: -2.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1618
    Cell Significance Index: -4.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1738
    Cell Significance Index: -4.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1785
    Cell Significance Index: -2.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1829
    Cell Significance Index: -8.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1904
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.1981
    Cell Significance Index: -2.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2043
    Cell Significance Index: -7.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2139
    Cell Significance Index: -9.4600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2285
    Cell Significance Index: -6.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2357
    Cell Significance Index: -10.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2474
    Cell Significance Index: -8.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2489
    Cell Significance Index: -8.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2501
    Cell Significance Index: -9.4700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2541
    Cell Significance Index: -2.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2548
    Cell Significance Index: -2.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2572
    Cell Significance Index: -8.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2599
    Cell Significance Index: -2.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2620
    Cell Significance Index: -3.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2755
    Cell Significance Index: -7.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2768
    Cell Significance Index: -7.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2785
    Cell Significance Index: -7.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2793
    Cell Significance Index: -3.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2833
    Cell Significance Index: -7.5900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2951
    Cell Significance Index: -2.9000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2991
    Cell Significance Index: -2.0300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.3112
    Cell Significance Index: -3.0000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3211
    Cell Significance Index: -3.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3239
    Cell Significance Index: -8.0800
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3249
    Cell Significance Index: -2.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3303
    Cell Significance Index: -8.8200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3339
    Cell Significance Index: -8.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3435
    Cell Significance Index: -6.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3474
    Cell Significance Index: -8.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3505
    Cell Significance Index: -4.9800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3742
    Cell Significance Index: -6.0600
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3746
    Cell Significance Index: -4.3100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3749
    Cell Significance Index: -8.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3761
    Cell Significance Index: -2.8400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3829
    Cell Significance Index: -7.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3832
    Cell Significance Index: -9.3500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3847
    Cell Significance Index: -5.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HOXD1 gene is a transcription factor that belongs to the homeobox gene family, which is characterized by the presence of a highly conserved homeodomain. This domain is responsible for the specific binding of the gene to its target DNA sequences, allowing for the regulation of gene expression. The HOXD1 gene is a member of the Hox gene family, which is involved in the regulation of embryonic development and patterning. It is specifically expressed in the hindbrain region of the embryo and plays a crucial role in the development of the anterior-posterior axis. **Pathways and Functions** The HOXD1 gene is involved in several signaling pathways that regulate cell development, differentiation, and patterning. These pathways include: 1. **Activation of anterior hox genes**: The HOXD1 gene is involved in the regulation of anterior hox genes in the hindbrain region of the embryo, which is crucial for the development of the anterior-posterior axis. 2. **Activation of hox genes during differentiation**: The HOXD1 gene is also involved in the regulation of hox genes during cell differentiation, which is necessary for the development of specific cell types. 3. **Chromatin regulation**: The HOXD1 gene is involved in the regulation of chromatin structure and function, which is necessary for the proper expression of target genes. 4. **RNA polymerase II-specific transcription**: The HOXD1 gene is a transcription factor that regulates the expression of target genes by binding to RNA polymerase II-specific sequences. **Clinical Significance** Dysregulation or mutation of the HOXD1 gene has been associated with various developmental disorders and diseases, including: 1. **Scoliosis**: Mutations in the HOXD1 gene have been associated with scoliosis, a curvature of the spine that can lead to respiratory and musculoskeletal problems. 2. **Spina bifida**: The HOXD1 gene is also involved in the development of the neural tube, and mutations in this gene have been associated with spina bifida, a congenital defect that affects the development of the spine and nervous system. 3. **Neurological disorders**: The HOXD1 gene is also involved in the development of the nervous system, and mutations in this gene have been associated with various neurological disorders, including autism and schizophrenia. 4. **Cancer**: The HOXD1 gene is also involved in the regulation of cell growth and differentiation, and mutations in this gene have been associated with various types of cancer, including breast and lung cancer. In conclusion, the HOXD1 gene is a crucial member of the homeobox gene family, which plays a pivotal role in the development and patterning of various tissues and organs during embryogenesis. Its dysregulation or mutation has been associated with various developmental disorders and diseases, highlighting the importance of this gene in human development and disease.

Genular Protein ID: 2047165387

Symbol: HXD1_HUMAN

Name: Homeobox protein Hox-D1

UniProtKB Accession Codes:

Q9GZZ0 B2RAB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11455954

Title: Isolation and characterization of the human homeobox gene HOX D1.

PubMed ID: 11455954

DOI: 10.1023/a:1011048931477

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 328
  • Mass: 34093
  • Checksum: 1B9EBBF4E2DA0301
  • Sequence:
    • MSSYLEYVSC SSSGGVGGDV LSLAPKFCRS DARPVALQPA FPLGNGDGAF VSCLPLAAAR 
PSPSPPAAPA RPSVPPPAAP QYAQCTLEGA YEPGAAPAAA AGGADYGFLG SGPAYDFPGV 
LGRAADDGGS HVHYATSAVF SGGGSFLLSG QVDYAAFGEP GPFPACLKAS ADGHPGAFQT 
ASPAPGTYPK SVSPASGLPA AFSTFEWMKV KRNASKKGKL AEYGAASPSS AIRTNFSTKQ 
LTELEKEFHF NKYLTRARRI EIANCLHLND TQVKIWFQNR RMKQKKRERE GLLATAIPVA 
PLQLPLSGTT PTKFIKNPGS PSQSQEPS

Genular Protein ID: 1227728381

Symbol: Q96CA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96CA4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 328
  • Mass: 34083
  • Checksum: 24A1B8072CEBE113
  • Sequence:
    • MSSYLEYVSC SSSGGVGGDV LSLAPKFCRS DARPVALQPA FPLGNGDGAF VSCLPLAAAR 
PSPSPPAAPA RPSVPPPAAP QYAQCTLEGA YEPGAAPAAA AGGADYGFLG SGPAYDFPGV 
LGRAADDGGS HVHYATSAVF SGGGSFLLSG QVDYAAFGEP GPFSACLKAS ADGHPGAFQT 
ASPAPGTYPK SVSPASGLPA AFSTFEWMKV KRNASKKGKL AEYGAASPSS AIRTNFSTKQ 
LTELEKEFHF NKYLTRARRI EIANCLHLND TQVKIWFQNR RMKQKKRERE GLLATAIPVA 
PLQLPLSGTT PTKFIKNPGS PSQSQEPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.