Details for: HBG1

Gene ID: 3047

Symbol: HBG1

Ensembl ID: ENSG00000213934

Description: hemoglobin subunit gamma 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.9954
    Cell Significance Index: -9.1300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 34.3309
    Cell Significance Index: -5.3400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 20.1254
    Cell Significance Index: 338.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 16.9189
    Cell Significance Index: 242.4500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 10.8958
    Cell Significance Index: 31.2300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 9.8210
    Cell Significance Index: 60.7600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 6.6106
    Cell Significance Index: 57.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5071
    Cell Significance Index: -6.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 4.5080
    Cell Significance Index: 36.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.3797
    Cell Significance Index: 64.6600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.6633
    Cell Significance Index: 30.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.4460
    Cell Significance Index: 65.5400
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 2.3534
    Cell Significance Index: 12.3800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.3326
    Cell Significance Index: 10.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3213
    Cell Significance Index: -9.1600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.4380
    Cell Significance Index: 8.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2119
    Cell Significance Index: 15.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.1751
    Cell Significance Index: 7.1000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.6380
    Cell Significance Index: 7.1000
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.4193
    Cell Significance Index: 1.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3080
    Cell Significance Index: 18.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2677
    Cell Significance Index: 7.0400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.1702
    Cell Significance Index: 2.1100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.1642
    Cell Significance Index: 1.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0871
    Cell Significance Index: 2.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0339
    Cell Significance Index: 0.9100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0054
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0079
    Cell Significance Index: -0.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0168
    Cell Significance Index: -9.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0274
    Cell Significance Index: -9.8400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0396
    Cell Significance Index: -0.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0466
    Cell Significance Index: -9.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0467
    Cell Significance Index: -6.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0469
    Cell Significance Index: -9.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0556
    Cell Significance Index: -9.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0807
    Cell Significance Index: -9.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0900
    Cell Significance Index: -9.1900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0947
    Cell Significance Index: -0.5800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0998
    Cell Significance Index: -1.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1391
    Cell Significance Index: -1.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1396
    Cell Significance Index: -7.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1543
    Cell Significance Index: -8.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1654
    Cell Significance Index: -5.4200
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1669
    Cell Significance Index: -2.2700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1731
    Cell Significance Index: -4.4100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1949
    Cell Significance Index: -2.8500
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.2046
    Cell Significance Index: -2.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2108
    Cell Significance Index: -6.7200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2140
    Cell Significance Index: -1.1600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2146
    Cell Significance Index: -1.5600
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2163
    Cell Significance Index: -2.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2193
    Cell Significance Index: -2.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2229
    Cell Significance Index: -4.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2230
    Cell Significance Index: -14.3900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2300
    Cell Significance Index: -1.3500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2486
    Cell Significance Index: -2.9600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.2494
    Cell Significance Index: -2.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2506
    Cell Significance Index: -8.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2570
    Cell Significance Index: -7.5700
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2646
    Cell Significance Index: -2.6000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2703
    Cell Significance Index: -3.4300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3007
    Cell Significance Index: -9.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3082
    Cell Significance Index: -7.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3328
    Cell Significance Index: -6.5800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.3336
    Cell Significance Index: -4.2700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3365
    Cell Significance Index: -4.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3370
    Cell Significance Index: -11.7100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3430
    Cell Significance Index: -4.8700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.3436
    Cell Significance Index: -2.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3752
    Cell Significance Index: -9.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3811
    Cell Significance Index: -4.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3830
    Cell Significance Index: -5.0900
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.3856
    Cell Significance Index: -4.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3863
    Cell Significance Index: -6.6200
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.3974
    Cell Significance Index: -3.9200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4130
    Cell Significance Index: -4.5000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4197
    Cell Significance Index: -8.3700
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.4233
    Cell Significance Index: -4.5900
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.4322
    Cell Significance Index: -6.9500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4332
    Cell Significance Index: -9.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4348
    Cell Significance Index: -10.8600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4387
    Cell Significance Index: -7.3900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4403
    Cell Significance Index: -6.1800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4408
    Cell Significance Index: -6.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4433
    Cell Significance Index: -8.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4481
    Cell Significance Index: -9.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4498
    Cell Significance Index: -9.8500
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4521
    Cell Significance Index: -4.7700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4701
    Cell Significance Index: -7.1400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4709
    Cell Significance Index: -5.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.4800
    Cell Significance Index: -7.1800
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.4838
    Cell Significance Index: -4.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4918
    Cell Significance Index: -6.7100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.4970
    Cell Significance Index: -6.9800
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.4976
    Cell Significance Index: -5.8200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4995
    Cell Significance Index: -5.9900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.5009
    Cell Significance Index: -5.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The gamma 1 subunit of hemoglobin is the smallest subunit of hemoglobin, comprising approximately 30% of the total hemoglobin protein. It is encoded by the HBG1 gene, which is located on chromosome 22. The gamma 1 subunit is highly conserved across species, indicating its essential role in oxygen transport and cellular homeostasis. The gamma 1 subunit is also characterized by its ability to bind to heme, a crucial cofactor for various enzymatic reactions, and its involvement in the regulation of oxidative stress through its interaction with peroxidases. **Pathways and Functions:** The gamma 1 subunit of hemoglobin is integral to various cellular pathways, including: 1. **Oxygen transport**: The gamma 1 subunit binds to oxygen and facilitates its transport to tissues, where it is released and released to other tissues. 2. **Cellular oxidant detoxification**: The gamma 1 subunit interacts with peroxidases to regulate oxidative stress and protect cells from damage. 3. **Megakaryocyte development and platelet production**: The gamma 1 subunit is involved in the regulation of megakaryocyte development and platelet production, which is essential for maintaining hemostasis. 4. **Haptoglobin-hemoglobin complex**: The gamma 1 subunit forms a complex with haptoglobin, a protein that binds to free hemoglobin in the bloodstream to prevent oxidative damage. 5. **Heme binding**: The gamma 1 subunit binds to heme, which is a crucial cofactor for various enzymatic reactions. **Clinical Significance:** Dysregulation of the gamma 1 subunit of hemoglobin has been implicated in various diseases, including: 1. **Sickle cell disease**: A genetic disorder caused by a mutation in the HBG1 gene, leading to the production of abnormal hemoglobin that can cause vaso-occlusive crises. 2. **Thalassemia**: A group of genetic disorders that affect the production of hemoglobin, leading to anemia and other complications. 3. **Oxygen transport disorders**: Conditions such as hemoglobinopathies and anemia, which can lead to impaired oxygen delivery to tissues. 4. **Immune system disorders**: The gamma 1 subunit is also involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases such as rheumatoid arthritis. In conclusion, the gamma 1 subunit of hemoglobin is a critical component of oxygen transport and a key regulator of various cellular processes. Its dysregulation can lead to a range of diseases, highlighting the importance of understanding its function and regulation in maintaining human health.

Genular Protein ID: 730414054

Symbol: HBG1_HUMAN

Name: Hemoglobin subunit gamma-1

UniProtKB Accession Codes:

P69891 P02096 P62027 Q549G1 Q8TDA1 Q96FH7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7438203

Title: Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.

PubMed ID: 7438203

DOI: 10.1016/0092-8674(80)90426-2

PubMed ID: 7332928

Title: A history of the human fetal globin gene duplication.

PubMed ID: 7332928

DOI: 10.1016/0092-8674(81)90302-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7690768

Title: The M gamma chain of human fetal hemoglobin is an A gamma chain with an in vitro modification of gamma 141 leucine to hydroxyleucine.

PubMed ID: 7690768

DOI: 10.1016/0378-4347(93)80418-4

PubMed ID: 16131492

Title: {gamma}-Globin gene expression in chemical inducer of dimerization (CID)-dependent multipotential cells established from human {beta}-globin locus yeast artificial chromosome ({beta}-YAC) transgenic mice.

PubMed ID: 16131492

DOI: 10.1074/jbc.m504402200

PubMed ID: 20925047

Title: Haemoglobin level, proportion of haemoglobin Bart's and haemoglobin Portland in fetuses affected by homozygous alpha0-thalassemia from 12 to 40 weeks' gestation.

PubMed ID: 20925047

DOI: 10.1002/pd.2619

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21747884

Title: Hemoglobin F level in different hemoglobin variants.

PubMed ID: 21747884

DOI: 10.5045/kjh.2011.46.2.118

PubMed ID: 22096240

Title: Fetal hemoglobin levels and morbidity in untransfused patients with beta-thalassemia intermedia.

PubMed ID: 22096240

DOI: 10.1182/blood-2011-09-382408

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 11514664

Title: Oligomerization and ligand binding in a homotetrameric hemoglobin: two high-resolution crystal structures of hemoglobin Bart's (gamma(4)), a marker for alpha-thalassemia.

PubMed ID: 11514664

DOI: 10.1110/ps.11701

PubMed ID: 5554303

Title: Human fetal hemoglobin F 1. Acetylation status.

PubMed ID: 5554303

DOI: 10.1016/s0021-9258(18)62282-3

PubMed ID: 2454900

Title: Hb F-Baskent or alpha 2A gamma 128(H6)Ala-->Thr.

PubMed ID: 2454900

DOI: 10.3109/03630268808996888

PubMed ID: 2417989

Title: Hb F-Beech Island or alpha 2A gamma 2(53)(D4)Ala-->Asp.

PubMed ID: 2417989

DOI: 10.3109/03630268508997032

PubMed ID: 6186637

Title: Hb F-Bonaire-Ga or alpha 2 A gamma 2 39(C5) Gln replaced by Arg, characterized by high pressure liquid chromatographic and microsequencing procedures.

PubMed ID: 6186637

DOI: 10.3109/03630268209046453

PubMed ID: 6199326

Title: Hb F-Calluna or alpha 2 gamma 2(12 Thr replaced by Arg; 75Ile; 136Ala) in a Caucasian baby.

PubMed ID: 6199326

DOI: 10.3109/03630268309027936

PubMed ID: 2419280

Title: Hb F-Cobb or alpha(2)A gamma(2)37(C3)Trp-->Gly.

PubMed ID: 2419280

DOI: 10.3109/03630268508997043

PubMed ID: 2411679

Title: Hb F-Dammam or alpha 2A gamma 2(79) (EF3) Asp-->Asn.

PubMed ID: 2411679

DOI: 10.3109/03630268508996998

PubMed ID: 4455303

Title: Genetic haemoglobin abnormalities in about 9000 Black and 7000 White newborns; haemoglobin F Dickinson (Agamma97His-Arg), a new variant.

PubMed ID: 4455303

DOI: 10.1111/j.1365-2141.1974.tb06670.x

PubMed ID: 2467893

Title: Hb F-Fukuyama or A gamma T43(CD2)Asp-->Asn.

PubMed ID: 2467893

DOI: 10.3109/03630268908998058

PubMed ID: 6038320

Title: Haemoglobin F Hull (gamma-121 glutamic acid-->lysine), homologous with haemoglobins O Arab and O Indonesia.

PubMed ID: 6038320

DOI: 10.1136/bmj.3.5564.531

PubMed ID: 6163752

Title: Survey of cord blood hemoglobin in Japan and identification of two new gamma chain variants.

PubMed ID: 6163752

DOI: 10.3109/03630268108996920

PubMed ID: 6197997

Title: Characterization of a new fetal hemoglobin variant, Hb F Izumi A gamma 6Glu replaced by Gly, by molecular secondary ion mass spectrometry.

PubMed ID: 6197997

DOI: 10.1016/0167-4838(83)90231-5

PubMed ID: 5491586

Title: Haemoglobin F Jamaica (alpha-2 gamma-2 61 Lys leads to Glu; 136 Ala).

PubMed ID: 5491586

DOI: 10.1111/j.1365-2141.1970.tb01450.x

PubMed ID: 1703137

Title: Hb F-Jiangsu, the first gamma chain variant with a valine->methionine substitution: alpha 2A gamma 2 134(H12)Val->Met.

PubMed ID: 1703137

DOI: 10.3109/03630269009046959

PubMed ID: 6175602

Title: A new gamma chain variant, HB F Kotobuki or AI gamma 6 (A3) Glu leads to Gly.

PubMed ID: 6175602

DOI: 10.3109/03630268208996931

PubMed ID: 4765089

Title: Structural identification of haemoglobin F Kuala Lumpur: alpha2 gamma2 22(B4)Asp leads to Gly; 136 Ala.

PubMed ID: 4765089

DOI: 10.1016/0005-2795(73)90297-3

PubMed ID: 7928382

Title: Hb F-Macedonia-I or alpha 2A gamma (2)2(NA2)His-->Gln.

PubMed ID: 7928382

DOI: 10.3109/03630269409043626

PubMed ID: 2581920

Title: Hb F-Pendergrass, an A gamma I variant with a Pro-->Arg substitution at position gamma 36(C2).

PubMed ID: 2581920

DOI: 10.3109/03630268508996985

PubMed ID: 6183236

Title: A new gamma chain variant: Hb F-Pordenone [gamma 6(A3) Glu replaced by Gln: 75ILE: 136ALA].

PubMed ID: 6183236

DOI: 10.3109/03630268208996945

PubMed ID: 808940

Title: A new Hb variant: Hb F Sardinia gamma75(E19) isoleucine leads to threonine found in a family with Hb G Philadelphia, beta-chain deficiency and a Lepore-like haemoglobin indistinguishable from Hb A2.

PubMed ID: 808940

DOI: 10.1159/000208204

PubMed ID: 6188719

Title: Hb F-Siena (alpha 2 a gamma t2 121 (GH4) Glu leads to Lys). A new fetal hemoglobin variant.

PubMed ID: 6188719

DOI: 10.3109/03630268309038403

PubMed ID: 6019034

Title: Haemoglobin F Texas I(alpha-2,gamma-2-5glu-lys): a variant of haemoglobin F.

PubMed ID: 6019034

DOI: 10.1111/j.1365-2141.1967.tb08737.x

PubMed ID: 1138921

Title: Haemoglobin F Victoria Jubilee (alpha 2 A gamma 2 80 Asp-Try).

PubMed ID: 1138921

DOI: 10.1016/0005-2795(75)90230-5

PubMed ID: 1802881

Title: Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations.

PubMed ID: 1802881

DOI: 10.3109/03630269108998857

PubMed ID: 2448269

Title: Hb F-Xin-Su or A gamma I73(E17)Asp-->His: a new slow-moving fetal hemoglobin variant.

PubMed ID: 2448269

DOI: 10.3109/03630268708998007

PubMed ID: 2448268

Title: Hb F-Xinjiang or A gamma T25(B7)Gly-->Arg: a new slow-moving unstable fetal hemoglobin variant.

PubMed ID: 2448268

DOI: 10.3109/03630268708998006

PubMed ID: 6198905

Title: HB F-Yamaguchi (gamma 75Thr, gamma 80Asn, gamma 136Ala) is associated with G gamma-thalassemia.

PubMed ID: 6198905

DOI: 10.1002/ajh.2830160212

Sequence Information:

  • Length: 147
  • Mass: 16128
  • Checksum: 0CE4D9E932416DCF
  • Sequence:
    • MGHFTEEDKA TITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPK 
VKAHGKKVLT SLGDATKHLD DLKGTFAQLS ELHCDKLHVD PENFKLLGNV LVTVLAIHFG 
KEFTPEVQAS WQKMVTAVAS ALSSRYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.