Details for: SFTPD

Gene ID: 6441

Symbol: SFTPD

Ensembl ID: ENSG00000133661

Description: surfactant protein D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 42.7207
    Cell Significance Index: -6.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 26.2968
    Cell Significance Index: -6.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.8582
    Cell Significance Index: -5.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.2111
    Cell Significance Index: -5.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.3931
    Cell Significance Index: 1811.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7969
    Cell Significance Index: 93.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3792
    Cell Significance Index: 29.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.1124
    Cell Significance Index: 68.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5891
    Cell Significance Index: 12.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5503
    Cell Significance Index: 104.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3685
    Cell Significance Index: 16.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3652
    Cell Significance Index: 13.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2602
    Cell Significance Index: 19.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2112
    Cell Significance Index: 20.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2031
    Cell Significance Index: 40.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1977
    Cell Significance Index: 4.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1702
    Cell Significance Index: 24.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1683
    Cell Significance Index: 151.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1577
    Cell Significance Index: 45.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1499
    Cell Significance Index: 9.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1471
    Cell Significance Index: 16.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1467
    Cell Significance Index: 3.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1242
    Cell Significance Index: 20.2000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.1173
    Cell Significance Index: 0.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0639
    Cell Significance Index: 22.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0470
    Cell Significance Index: 3.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0410
    Cell Significance Index: 63.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0180
    Cell Significance Index: 33.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0106
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0089
    Cell Significance Index: 16.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0083
    Cell Significance Index: 11.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0042
    Cell Significance Index: 1.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0014
    Cell Significance Index: 0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0008
    Cell Significance Index: -0.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0011
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0055
    Cell Significance Index: -0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0071
    Cell Significance Index: -0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0080
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0098
    Cell Significance Index: -5.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0104
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0113
    Cell Significance Index: -7.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0146
    Cell Significance Index: -2.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0160
    Cell Significance Index: -2.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0181
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0186
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0203
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0299
    Cell Significance Index: -6.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0315
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0333
    Cell Significance Index: -4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0333
    Cell Significance Index: -4.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0334
    Cell Significance Index: -1.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0367
    Cell Significance Index: -2.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0394
    Cell Significance Index: -4.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0420
    Cell Significance Index: -5.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0472
    Cell Significance Index: -0.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0482
    Cell Significance Index: -0.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0539
    Cell Significance Index: -4.0200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0545
    Cell Significance Index: -0.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0580
    Cell Significance Index: -6.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0710
    Cell Significance Index: -2.2600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0719
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0813
    Cell Significance Index: -6.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0907
    Cell Significance Index: -5.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0911
    Cell Significance Index: -2.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0919
    Cell Significance Index: -3.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0923
    Cell Significance Index: -5.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1014
    Cell Significance Index: -5.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1068
    Cell Significance Index: -5.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1076
    Cell Significance Index: -1.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1091
    Cell Significance Index: -3.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1109
    Cell Significance Index: -2.6600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1121
    Cell Significance Index: -2.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1138
    Cell Significance Index: -1.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1155
    Cell Significance Index: -1.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1158
    Cell Significance Index: -1.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1200
    Cell Significance Index: -4.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1253
    Cell Significance Index: -5.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1266
    Cell Significance Index: -3.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1426
    Cell Significance Index: -1.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1436
    Cell Significance Index: -5.2700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1490
    Cell Significance Index: -1.8800
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1498
    Cell Significance Index: -1.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1519
    Cell Significance Index: -3.7900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1563
    Cell Significance Index: -3.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1579
    Cell Significance Index: -1.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1583
    Cell Significance Index: -3.1300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1626
    Cell Significance Index: -2.3100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1642
    Cell Significance Index: -1.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1650
    Cell Significance Index: -3.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1654
    Cell Significance Index: -3.3200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1677
    Cell Significance Index: -1.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1719
    Cell Significance Index: -5.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1779
    Cell Significance Index: -4.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1782
    Cell Significance Index: -4.4500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1821
    Cell Significance Index: -3.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SFTPD is a secreted protein that belongs to the collectin family, which consists of surfactant proteins A, B, C, D, E, and F. These proteins are primarily expressed in the lungs and are involved in the regulation of surfactant homeostasis and the modulation of immune responses. SFTPD is characterized by its ability to bind to carbohydrates, such as galactose and mannose, and its capacity to induce the production of cytokines and chemokines. **Pathways and Functions:** SFTPD is involved in various biological processes, including: 1. **Adaptive Immune Response:** SFTPD regulates the production of cytokines, such as IL-2 and IL-12, and the activation of T cells, thereby modulating the adaptive immune response. 2. **Innate Immune Response:** SFTPD interacts with Toll-like receptors (TLRs), particularly TLR2 and TLR4, to regulate the production of pro-inflammatory cytokines and chemokines. 3. **Surfactant Homeostasis:** SFTPD plays a crucial role in maintaining surfactant homeostasis in the lungs by regulating the production and clearance of surfactant proteins. 4. **Cell-Cell Communication:** SFTPD interacts with other cells, such as epithelial cells and macrophages, to regulate cell-cell communication and the modulation of immune responses. **Clinical Significance:** Dysregulation of SFTPD has been implicated in various diseases, including: 1. **Surfactant Metabolic Disorders:** Defects in SFTPD have been associated with surfactant metabolic disorders, such as respiratory distress syndrome (RDS) and chronic lung disease. 2. **Infectious Diseases:** SFTPD has been shown to play a role in the regulation of innate immune responses to viral infections, such as SARS-CoV-2 and SARS-CoV-1. 3. **Cancer:** SFTPD has been implicated in the regulation of immune responses to cancer, particularly in the context of tumor-associated macrophages. 4. **Autoimmune Diseases:** Dysregulation of SFTPD has been associated with autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, SFTPD plays a crucial role in regulating the adaptive and innate immune responses, particularly in the context of surfactant homeostasis and cell-cell communication. Dysregulation of SFTPD has been implicated in various diseases, highlighting the importance of this protein in maintaining immune homeostasis and preventing disease pathogenesis.

Genular Protein ID: 266940519

Symbol: SFTPD_HUMAN

Name: Pulmonary surfactant-associated protein D

UniProtKB Accession Codes:

P35247 Q5T0M3 Q6FH08 Q86YK9 Q8TCD8 Q9UCJ2 Q9UCJ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 10 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1339284

Title: Purification, characterization and cDNA cloning of human lung surfactant protein D.

PubMed ID: 1339284

DOI: 10.1042/bj2840795

PubMed ID: 8428971

Title: Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1.

PubMed ID: 8428971

DOI: 10.1016/s0021-9258(18)53869-2

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8424457

Title: Accumulation of surfactant protein D in human pulmonary alveolar proteinosis.

PubMed ID: 8424457

PubMed ID: 1898081

Title: Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain.

PubMed ID: 1898081

DOI: 10.1016/0003-9861(91)90597-c

PubMed ID: 23478426

Title: The lung innate immune gene surfactant protein-D is expressed in adipose tissue and linked to obesity status.

PubMed ID: 23478426

DOI: 10.1038/ijo.2013.23

PubMed ID: 10368295

Title: Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D.

PubMed ID: 10368295

DOI: 10.1016/s0969-2126(99)80036-7

PubMed ID: 19100526

Title: Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer.

PubMed ID: 19100526

DOI: 10.1016/j.ajhg.2008.11.010

Sequence Information:

  • Length: 375
  • Mass: 37728
  • Checksum: 298917699FC40F6A
  • Sequence:
    • MLLFLLSALV LLTQPLGYLE AEMKTYSHRT MPSACTLVMC SSVESGLPGR DGRDGREGPR 
GEKGDPGLPG AAGQAGMPGQ AGPVGPKGDN GSVGEPGPKG DTGPSGPPGP PGVPGPAGRE 
GPLGKQGNIG PQGKPGPKGE AGPKGEVGAP GMQGSAGARG LAGPKGERGV PGERGVPGNT 
GAAGSAGAMG PQGSPGARGP PGLKGDKGIP GDKGAKGESG LPDVASLRQQ VEALQGQVQH 
LQAAFSQYKK VELFPNGQSV GEKIFKTAGF VKPFTEAQLL CTQAGGQLAS PRSAAENAAL 
QQLVVAKNEA AFLSMTDSKT EGKFTYPTGE SLVYSNWAPG EPNDDGGSED CVEIFTNGKW 
NDRACGEKRL VVCEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.