Details for: ROS1

Gene ID: 6098

Symbol: ROS1

Ensembl ID: ENSG00000047936

Description: ROS proto-oncogene 1, receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.1229
    Cell Significance Index: -3.3000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.8544
    Cell Significance Index: -3.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.6040
    Cell Significance Index: 98.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.3754
    Cell Significance Index: 71.6400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.2616
    Cell Significance Index: 30.5600
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.7052
    Cell Significance Index: 7.3000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.5243
    Cell Significance Index: 8.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4621
    Cell Significance Index: 87.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3451
    Cell Significance Index: 34.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2651
    Cell Significance Index: 239.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2155
    Cell Significance Index: 4.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2036
    Cell Significance Index: 5.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1852
    Cell Significance Index: 37.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1782
    Cell Significance Index: 28.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1746
    Cell Significance Index: 4.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1713
    Cell Significance Index: 18.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1402
    Cell Significance Index: 4.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1221
    Cell Significance Index: 5.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1068
    Cell Significance Index: 6.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0726
    Cell Significance Index: 5.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0449
    Cell Significance Index: 1.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0339
    Cell Significance Index: 25.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0334
    Cell Significance Index: 0.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0132
    Cell Significance Index: 4.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0071
    Cell Significance Index: 0.2500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.0023
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0015
    Cell Significance Index: -2.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0021
    Cell Significance Index: -2.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0075
    Cell Significance Index: -4.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0077
    Cell Significance Index: -3.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0086
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.2100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0129
    Cell Significance Index: -0.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0133
    Cell Significance Index: -3.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0186
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0195
    Cell Significance Index: -3.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0201
    Cell Significance Index: -4.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0214
    Cell Significance Index: -1.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0232
    Cell Significance Index: -4.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0275
    Cell Significance Index: -1.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0277
    Cell Significance Index: -4.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0278
    Cell Significance Index: -3.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0307
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0325
    Cell Significance Index: -4.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0336
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0339
    Cell Significance Index: -3.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0374
    Cell Significance Index: -2.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0496
    Cell Significance Index: -2.3300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0517
    Cell Significance Index: -0.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0531
    Cell Significance Index: -0.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0566
    Cell Significance Index: -0.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0576
    Cell Significance Index: -1.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0592
    Cell Significance Index: -3.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0604
    Cell Significance Index: -3.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0648
    Cell Significance Index: -2.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0721
    Cell Significance Index: -2.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0765
    Cell Significance Index: -4.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0800
    Cell Significance Index: -2.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0841
    Cell Significance Index: -2.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0900
    Cell Significance Index: -3.9800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0952
    Cell Significance Index: -3.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1025
    Cell Significance Index: -3.8800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1140
    Cell Significance Index: -1.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1199
    Cell Significance Index: -2.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1264
    Cell Significance Index: -2.9200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1268
    Cell Significance Index: -1.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1347
    Cell Significance Index: -2.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1409
    Cell Significance Index: -4.0200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1426
    Cell Significance Index: -1.1600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1430
    Cell Significance Index: -2.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1449
    Cell Significance Index: -3.1300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1451
    Cell Significance Index: -3.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1454
    Cell Significance Index: -1.5100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1478
    Cell Significance Index: -1.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1511
    Cell Significance Index: -4.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1530
    Cell Significance Index: -4.1000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1545
    Cell Significance Index: -3.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1552
    Cell Significance Index: -3.8700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1557
    Cell Significance Index: -1.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1584
    Cell Significance Index: -3.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1603
    Cell Significance Index: -3.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1604
    Cell Significance Index: -3.2200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1625
    Cell Significance Index: -1.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1633
    Cell Significance Index: -4.1600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1645
    Cell Significance Index: -2.4600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1651
    Cell Significance Index: -3.2500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1663
    Cell Significance Index: -4.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1735
    Cell Significance Index: -3.0000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1743
    Cell Significance Index: -2.3500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1748
    Cell Significance Index: -2.2900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1790
    Cell Significance Index: -3.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1826
    Cell Significance Index: -3.5700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1869
    Cell Significance Index: -2.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ROS1 is a transmembrane receptor tyrosine kinase with a single extracellular immunoglobulin-like domain, a single transmembrane domain, and a cytoplasmic domain containing the catalytic tyrosine kinase domain. It is activated by its ligand, which is still unknown, and triggers a cascade of downstream signaling events that regulate cell growth, survival, and migration. ROS1 is also known for its high affinity for ATP, which is necessary for its kinase activity. **Pathways and Functions:** ROS1 is involved in several signaling pathways that regulate cell growth, differentiation, and survival. These pathways include: 1. **Regulation of cell growth:** ROS1 activates the PI3K/AKT and MAPK/ERK signaling pathways, which regulate cell proliferation and survival. 2. **Regulation of differentiation:** ROS1 is involved in the differentiation of epithelial cells, particularly in the development of the lower respiratory tract. 3. **Regulation of angiogenesis:** ROS1 promotes angiogenesis by activating the VEGF signaling pathway. 4. **Regulation of tor signaling:** ROS1 is involved in the regulation of the target of rapamycin (TOR) signaling pathway, which regulates cell growth and metabolism. ROS1 also interacts with other proteins, including protein phosphatases and kinases, to regulate its activity and downstream signaling events. **Clinical Significance:** ROS1 has been implicated in the development and progression of several cancers, including: 1. **Non-small cell lung cancer (NSCLC):** ROS1 is overexpressed in a subset of NSCLC patients, particularly those with adenocarcinoma. 2. **Neuroendocrine tumors:** ROS1 is overexpressed in a subset of neuroendocrine tumors, including small cell lung cancer and medullary thyroid cancer. 3. **Other cancers:** ROS1 has also been implicated in other cancers, including breast cancer, prostate cancer, and ovarian cancer. Targeted therapies against ROS1 have been developed, including small molecule inhibitors and monoclonal antibodies. These therapies have shown promising results in clinical trials, particularly in patients with ROS1-positive NSCLC and neuroendocrine tumors. In summary, ROS1 is a receptor tyrosine kinase that plays a critical role in cellular processes, including cell growth, differentiation, and survival. Its overexpression has been implicated in the development and progression of several cancers, and targeted therapies against ROS1 have shown promise in clinical trials. Further research is needed to fully understand the role of ROS1 in cancer and to develop more effective therapies against this oncogene.

Genular Protein ID: 3210487002

Symbol: ROS1_HUMAN

Name: Proto-oncogene tyrosine-protein kinase ROS

UniProtKB Accession Codes:

P08922 Q15368 Q5TDB5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2352949

Title: Characterization of ROS1 cDNA from a human glioblastoma cell line.

PubMed ID: 2352949

DOI: 10.1073/pnas.87.12.4799

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 3023956

Title: Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule.

PubMed ID: 3023956

DOI: 10.1128/mcb.6.8.3000-3004.1986

PubMed ID: 3785223

Title: Characterization of an activated human ros gene.

PubMed ID: 3785223

DOI: 10.1128/mcb.6.9.3109-3116.1986

PubMed ID: 8143271

Title: Analysis of oncogene expression in primary human gliomas: evidence for increased expression of the ros oncogene.

PubMed ID: 8143271

DOI: 10.1016/0165-4608(94)90128-7

PubMed ID: 11094073

Title: Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.

PubMed ID: 11094073

DOI: 10.1128/mcb.20.24.9212-9224.2000

PubMed ID: 12661006

Title: Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).

PubMed ID: 12661006

DOI: 10.1002/gcc.10207

PubMed ID: 12538861

Title: Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma.

PubMed ID: 12538861

DOI: 10.1073/pnas.242741799

PubMed ID: 16885344

Title: ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.

PubMed ID: 16885344

DOI: 10.1158/0008-5472.can-06-1193

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 2347
  • Mass: 263915
  • Checksum: 98902B9A59ACB8F5
  • Sequence:
    • MKNIYCLIPK LVNFATLGCL WISVVQCTVL NSCLKSCVTN LGQQLDLGTP HNLSEPCIQG 
CHFWNSVDQK NCALKCRESC EVGCSSAEGA YEEEVLENAD LPTAPFASSI GSHNMTLRWK 
SANFSGVKYI IQWKYAQLLG SWTYTKTVSR PSYVVKPLHP FTEYIFRVVW IFTAQLQLYS 
PPSPSYRTHP HGVPETAPLI RNIESSSPDT VEVSWDPPQF PGGPILGYNL RLISKNQKLD 
AGTQRTSFQF YSTLPNTIYR FSIAAVNEVG EGPEAESSIT TSSSAVQQEE QWLFLSRKTS 
LRKRSLKHLV DEAHCLRLDA IYHNITGISV DVHQQIVYFS EGTLIWAKKA ANMSDVSDLR 
IFYRGSGLIS SISIDWLYQR MYFIMDELVC VCDLENCSNI EEITPPSISA PQKIVADSYN 
GYVFYLLRDG IYRADLPVPS GRCAEAVRIV ESCTLKDFAI KPQAKRIIYF NDTAQVFMST 
FLDGSASHLI LPRIPFADVK SFACENNDFL VTDGKVIFQQ DALSFNEFIV GCDLSHIEEF 
GFGNLVIFGS SSQLHPLPGR PQELSVLFGS HQALVQWKPP ALAIGANVIL ISDIIELFEL 
GPSAWQNWTY EVKVSTQDPP EVTHIFLNIS GTMLNVPELQ SAMKYKVSVR ASSPKRPGPW 
SEPSVGTTLV PASEPPFIMA VKEDGLWSKP LNSFGPGEFL SSDIGNVSDM DWYNNSLYYS 
DTKGDVFVWL LNGTDISENY HLPSIAGAGA LAFEWLGHFL YWAGKTYVIQ RQSVLTGHTD 
IVTHVKLLVN DMVVDSVGGY LYWTTLYSVE STRLNGESSL VLQTQPWFSG KKVIALTLDL 
SDGLLYWLVQ DSQCIHLYTA VLRGQSTGDT TITEFAAWST SEISQNALMY YSGRLFWING 
FRIITTQEIG QKTSVSVLEP ARFNQFTIIQ TSLKPLPGNF SFTPKVIPDS VQESSFRIEG 
NASSFQILWN GPPAVDWGVV FYSVEFSAHS KFLASEQHSL PVFTVEGLEP YALFNLSVTP 
YTYWGKGPKT SLSLRAPETV PSAPENPRIF ILPSGKCCNK NEVVVEFRWN KPKHENGVLT 
KFEIFYNISN QSITNKTCED WIAVNVTPSV MSFQLEGMSP RCFIAFQVRA FTSKGPGPYA 
DVVKSTTSEI NPFPHLITLL GNKIVFLDMD QNQVVWTFSA ERVISAVCYT ADNEMGYYAE 
GDSLFLLHLH NRSSSELFQD SLVFDITVIT IDWISRHLYF ALKESQNGMQ VFDVDLEHKV 
KYPREVKIHN RNSTIISFSV YPLLSRLYWT EVSNFGYQMF YYSIISHTLH RILQPTATNQ 
QNKRNQCSCN VTEFELSGAM AIDTSNLEKP LIYFAKAQEI WAMDLEGCQC WRVITVPAML 
AGKTLVSLTV DGDLIYWIIT AKDSTQIYQA KKGNGAIVSQ VKALRSRHIL AYSSVMQPFP 
DKAFLSLASD TVEPTILNAT NTSLTIRLPL AKTNLTWYGI TSPTPTYLVY YAEVNDRKNS 
SDLKYRILEF QDSIALIEDL QPFSTYMIQI AVKNYYSDPL EHLPPGKEIW GKTKNGVPEA 
VQLINTTVRS DTSLIISWRE SHKPNGPKES VRYQLAISHL ALIPETPLRQ SEFPNGRLTL 
LVTRLSGGNI YVLKVLACHS EEMWCTESHP VTVEMFNTPE KPYSLVPENT SLQFNWKAPL 
NVNLIRFWVE LQKWKYNEFY HVKTSCSQGP AYVCNITNLQ PYTSYNVRVV VVYKTGENST 
SLPESFKTKA GVPNKPGIPK LLEGSKNSIQ WEKAEDNGCR ITYYILEIRK STSNNLQNQN 
LRWKMTFNGS CSSVCTWKSK NLKGIFQFRV VAANNLGFGE YSGISENIIL VGDDFWIPET 
SFILTIIVGI FLVVTIPLTF VWHRRLKNQK SAKEGVTVLI NEDKELAELR GLAAGVGLAN 
ACYAIHTLPT QEEIENLPAF PREKLTLRLL LGSGAFGEVY EGTAVDILGV GSGEIKVAVK 
TLKKGSTDQE KIEFLKEAHL MSKFNHPNIL KQLGVCLLNE PQYIILELME GGDLLTYLRK 
ARMATFYGPL LTLVDLVDLC VDISKGCVYL ERMHFIHRDL AARNCLVSVK DYTSPRIVKI 
GDFGLARDIY KNDYYRKRGE GLLPVRWMAP ESLMDGIFTT QSDVWSFGIL IWEILTLGHQ 
PYPAHSNLDV LNYVQTGGRL EPPRNCPDDL WNLMTQCWAQ EPDQRPTFHR IQDQLQLFRN 
FFLNSIYKSR DEANNSGVIN ESFEGEDGDV ICLNSDDIMP VALMETKNRE GLNYMVLATE 
CGQGEEKSEG PLGSQESESC GLRKEEKEPH ADKDFCQEKQ VAYCPSGKPE GLNYACLTHS 
GYGDGSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.