Details for: CLDN18

Gene ID: 51208

Symbol: CLDN18

Ensembl ID: ENSG00000066405

Description: claudin 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.9906
    Cell Significance Index: -4.4700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 3.9509
    Cell Significance Index: 450.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.5318
    Cell Significance Index: 49.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4730
    Cell Significance Index: 35.6800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4358
    Cell Significance Index: 23.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0056
    Cell Significance Index: 21.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.5506
    Cell Significance Index: -1.2100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3638
    Cell Significance Index: 1.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2474
    Cell Significance Index: 47.0800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.2152
    Cell Significance Index: 2.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2124
    Cell Significance Index: 160.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1565
    Cell Significance Index: 9.4000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.1366
    Cell Significance Index: 1.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1319
    Cell Significance Index: 2.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0927
    Cell Significance Index: 10.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0853
    Cell Significance Index: 1.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0707
    Cell Significance Index: 7.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0669
    Cell Significance Index: 41.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0630
    Cell Significance Index: 56.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0498
    Cell Significance Index: 8.1000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0478
    Cell Significance Index: 2.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0386
    Cell Significance Index: 2.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0338
    Cell Significance Index: 4.9200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0277
    Cell Significance Index: 0.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0275
    Cell Significance Index: 5.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0194
    Cell Significance Index: 29.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0193
    Cell Significance Index: 3.8300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.0151
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0110
    Cell Significance Index: 20.7900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0107
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0090
    Cell Significance Index: 16.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0086
    Cell Significance Index: 0.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0018
    Cell Significance Index: 2.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0017
    Cell Significance Index: 1.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.2100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.0021
    Cell Significance Index: -0.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0024
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0035
    Cell Significance Index: -1.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0060
    Cell Significance Index: -1.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0063
    Cell Significance Index: -2.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0067
    Cell Significance Index: -3.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0073
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0076
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0115
    Cell Significance Index: -1.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0136
    Cell Significance Index: -2.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0154
    Cell Significance Index: -0.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0193
    Cell Significance Index: -0.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0215
    Cell Significance Index: -2.5100
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0248
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0278
    Cell Significance Index: -3.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0300
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0311
    Cell Significance Index: -3.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0313
    Cell Significance Index: -3.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0317
    Cell Significance Index: -3.3000
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.0350
    Cell Significance Index: -0.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0351
    Cell Significance Index: -1.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0353
    Cell Significance Index: -2.1700
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0455
    Cell Significance Index: -0.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0472
    Cell Significance Index: -2.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0484
    Cell Significance Index: -3.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0494
    Cell Significance Index: -5.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0531
    Cell Significance Index: -1.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0557
    Cell Significance Index: -2.9000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0594
    Cell Significance Index: -2.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0711
    Cell Significance Index: -4.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0848
    Cell Significance Index: -2.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0869
    Cell Significance Index: -1.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0874
    Cell Significance Index: -3.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0927
    Cell Significance Index: -4.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0970
    Cell Significance Index: -2.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0995
    Cell Significance Index: -1.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1043
    Cell Significance Index: -3.9500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1051
    Cell Significance Index: -1.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1062
    Cell Significance Index: -1.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1070
    Cell Significance Index: -2.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1073
    Cell Significance Index: -3.7600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1100
    Cell Significance Index: -1.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1162
    Cell Significance Index: -3.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1226
    Cell Significance Index: -4.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1280
    Cell Significance Index: -3.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1282
    Cell Significance Index: -4.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1393
    Cell Significance Index: -1.6600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1411
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1435
    Cell Significance Index: -4.1000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1438
    Cell Significance Index: -1.7000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1479
    Cell Significance Index: -2.1600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1486
    Cell Significance Index: -1.7200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1487
    Cell Significance Index: -3.7100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1500
    Cell Significance Index: -4.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1524
    Cell Significance Index: -1.9000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1573
    Cell Significance Index: -3.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1578
    Cell Significance Index: -3.4100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1589
    Cell Significance Index: -3.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1609
    Cell Significance Index: -4.2300
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.1616
    Cell Significance Index: -1.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1626
    Cell Significance Index: -4.6600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1656
    Cell Significance Index: -2.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Claudin 18 is a type II transmembrane protein composed of 18 amino acids, with a characteristic four-helix bundle structure. It is a calcium-independent cell-cell adhesion molecule, meaning it does not require calcium ions to form tight junctions with other claudins. This unique property allows CLDN18 to maintain epithelial barrier function in calcium-depleted environments. CLDN18 is also known to interact with other proteins, including occludin and junctional adhesion molecule (JAM), to regulate tight junction assembly and function. **Pathways and Functions** Claudin 18 is involved in several key pathways, including: 1. **Bicellular tight junction assembly**: CLDN18 forms bicellular tight junctions with other claudins, such as CLDN16 and CLDN17, to regulate paracellular transport and maintain epithelial barrier function. 2. **Cell-cell communication**: CLDN18 is involved in regulating cell-cell communication between epithelial cells, including the regulation of paracellular signaling and the maintenance of epithelial polarity. 3. **Epithelial fluid transport**: CLDN18 regulates the passage of ions and molecules across epithelial barriers, including the transport of water and ions in the pancreas and colon. 4. **Organ growth**: CLDN18 is involved in regulating organ growth and development, including the regulation of epithelial cell proliferation and differentiation in the pancreas and colon. **Clinical Significance** Claudin 18 has been implicated in several human diseases, including: 1. **Pancreatitis**: CLDN18 has been shown to be overexpressed in pancreatic tissue in patients with pancreatitis, suggesting a role in the pathogenesis of the disease. 2. **Colorectal cancer**: CLDN18 has been found to be downregulated in colorectal cancer tissues, suggesting a potential role in the development and progression of the disease. 3. **Asthma**: CLDN18 has been implicated in asthma, with studies showing that CLDN18 is overexpressed in bronchial epithelial cells in patients with asthma. 4. **Liver disease**: CLDN18 has been found to be involved in liver disease, including liver fibrosis and cirrhosis. In conclusion, claudin 18 is a critical component of tight junctions and plays a key role in regulating epithelial barrier function, cell-cell communication, and organ growth. Its dysregulation has been implicated in several human diseases, highlighting the importance of further research into the molecular mechanisms underlying CLDN18 function and its role in human health and disease.

Genular Protein ID: 2163846225

Symbol: CLD18_HUMAN

Name: Claudin-18

UniProtKB Accession Codes:

P56856 A5PL21 Q96PH4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11585919

Title: Claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing.

PubMed ID: 11585919

DOI: 10.1128/mcb.21.21.7380-7390.2001

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19047087

Title: Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.

PubMed ID: 19047087

DOI: 10.1158/1078-0432.ccr-08-1547

PubMed ID: 19706394

Title: Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium.

PubMed ID: 19706394

DOI: 10.1073/pnas.0907724106

PubMed ID: 24787463

Title: Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.

PubMed ID: 24787463

DOI: 10.1165/rcmb.2013-0456oc

Sequence Information:

  • Length: 261
  • Mass: 27856
  • Checksum: 4362B590D3C2B387
  • Sequence:
    • MSTTTCQVVA FLLSILGLAG CIAATGMDMW STQDLYDNPV TSVFQYEGLW RSCVRQSSGF 
TECRPYFTIL GLPAMLQAVR ALMIVGIVLG AIGLLVSIFA LKCIRIGSME DSAKANMTLT 
SGIMFIVSGL CAIAGVSVFA NMLVTNFWMS TANMYTGMGG MVQTVQTRYT FGAALFVGWV 
AGGLTLIGGV MMCIACRGLA PEETNYKAVS YHASGHSVAY KPGGFKASTG FGSNTKNKKI 
YDGGARTEDE VQSYPSKHDY V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.