Details for: MIA

Gene ID: 8190

Symbol: MIA

Ensembl ID: ENSG00000261857

Description: MIA SH3 domain containing

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.2265
    Cell Significance Index: -4.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1515
    Cell Significance Index: 219.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1159
    Cell Significance Index: 143.0500
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.9241
    Cell Significance Index: 6.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7830
    Cell Significance Index: 77.4600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.7325
    Cell Significance Index: 4.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7133
    Cell Significance Index: 33.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6975
    Cell Significance Index: 629.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6531
    Cell Significance Index: 84.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5776
    Cell Significance Index: 13.9900
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.5731
    Cell Significance Index: 2.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4079
    Cell Significance Index: 66.3500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3839
    Cell Significance Index: 3.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3721
    Cell Significance Index: 40.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2810
    Cell Significance Index: 5.9900
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.2266
    Cell Significance Index: 2.5700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1822
    Cell Significance Index: 10.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1683
    Cell Significance Index: 2.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1422
    Cell Significance Index: 6.6300
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.0818
    Cell Significance Index: 0.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0595
    Cell Significance Index: 1.2900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0575
    Cell Significance Index: 0.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0285
    Cell Significance Index: 1.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0202
    Cell Significance Index: 0.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0178
    Cell Significance Index: 7.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0156
    Cell Significance Index: 5.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0088
    Cell Significance Index: 1.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0071
    Cell Significance Index: 1.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0065
    Cell Significance Index: 1.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0024
    Cell Significance Index: -0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0066
    Cell Significance Index: -0.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0075
    Cell Significance Index: -4.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -7.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0121
    Cell Significance Index: -6.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0140
    Cell Significance Index: -6.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0191
    Cell Significance Index: -5.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0265
    Cell Significance Index: -1.9800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0317
    Cell Significance Index: -1.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0321
    Cell Significance Index: -1.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0351
    Cell Significance Index: -5.1000
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.0391
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0404
    Cell Significance Index: -6.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0407
    Cell Significance Index: -8.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0473
    Cell Significance Index: -5.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0480
    Cell Significance Index: -1.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0490
    Cell Significance Index: -5.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0502
    Cell Significance Index: -6.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0513
    Cell Significance Index: -2.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0567
    Cell Significance Index: -6.6900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0581
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0599
    Cell Significance Index: -0.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0619
    Cell Significance Index: -0.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0630
    Cell Significance Index: -0.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0667
    Cell Significance Index: -6.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0757
    Cell Significance Index: -3.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0773
    Cell Significance Index: -4.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0779
    Cell Significance Index: -2.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0825
    Cell Significance Index: -5.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0860
    Cell Significance Index: -6.6000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0884
    Cell Significance Index: -1.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0904
    Cell Significance Index: -6.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0908
    Cell Significance Index: -5.8600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0975
    Cell Significance Index: -1.3900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0977
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0987
    Cell Significance Index: -3.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1030
    Cell Significance Index: -1.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1032
    Cell Significance Index: -3.7900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1113
    Cell Significance Index: -4.8400
  • Cell Name: serous cell of epithelium of trachea (CL1000330)
    Fold Change: -0.1130
    Cell Significance Index: -0.8700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1182
    Cell Significance Index: -2.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1190
    Cell Significance Index: -4.1700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1272
    Cell Significance Index: -1.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1310
    Cell Significance Index: -6.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1439
    Cell Significance Index: -3.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1450
    Cell Significance Index: -5.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1475
    Cell Significance Index: -4.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1546
    Cell Significance Index: -6.8400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1606
    Cell Significance Index: -4.0100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1612
    Cell Significance Index: -4.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1700
    Cell Significance Index: -4.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1771
    Cell Significance Index: -5.6400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1772
    Cell Significance Index: -2.4500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1785
    Cell Significance Index: -2.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1796
    Cell Significance Index: -5.8800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1811
    Cell Significance Index: -2.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1849
    Cell Significance Index: -7.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1881
    Cell Significance Index: -3.9300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1944
    Cell Significance Index: -3.2700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1979
    Cell Significance Index: -6.2600
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1983
    Cell Significance Index: -1.8000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2009
    Cell Significance Index: -5.3800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2024
    Cell Significance Index: -1.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2043
    Cell Significance Index: -6.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The MIA gene exhibits several distinct characteristics that contribute to its multifunctional role: 1. **SH3 domain**: The MIA protein contains a SH3 domain, a conserved structural motif found in many proteins involved in signal transduction and cell adhesion. The SH3 domain is crucial for protein-protein interactions and is thought to play a key role in the regulation of cell growth and differentiation. 2. **Epithelial expression**: MIA is primarily expressed in epithelial cells, which are the primary cell type of the lining of organs and glands. This expression pattern suggests that MIA plays a role in the development and maintenance of epithelial tissues. 3. **Tissue-specific expression**: MIA is differentially expressed in various tissues, including the lung, mammary gland, colon, and small intestine. This tissue-specific expression pattern suggests that MIA has distinct functions in different tissues. **Pathways and Functions:** The MIA gene is involved in several signaling pathways that regulate cell growth, differentiation, and survival. Some of the key pathways and functions of MIA include: 1. **Extracellular matrix organization**: MIA has been implicated in the organization of the extracellular matrix, a complex network of proteins and polysaccharides that provide structural support to cells. 2. **Growth factor activity**: MIA has been shown to interact with growth factors, such as fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF), which are involved in cell growth and differentiation. 3. **Signal transduction**: The SH3 domain of MIA is thought to play a key role in signal transduction, allowing MIA to interact with other proteins and regulate cellular responses. 4. **Cell adhesion**: MIA has been shown to interact with cell adhesion molecules, such as integrins and cadherins, which are involved in cell-cell and cell-extracellular matrix interactions. **Clinical Significance:** The MIA gene has been implicated in various diseases, including cancer. The overexpression of MIA has been observed in several types of cancer, including melanoma, breast cancer, and lung cancer. MIA has been shown to promote cell growth, invasion, and metastasis in these cancers, suggesting that it may play a role in the development and progression of these diseases. In addition to its role in cancer, MIA has also been implicated in other diseases, including inflammatory bowel disease (IBD) and asthma. MIA has been shown to regulate the expression of genes involved in inflammation and immune response, suggesting that it may play a role in the pathogenesis of these diseases. In conclusion, the MIA gene is a multifunctional gene involved in various cellular processes, including cell growth, differentiation, and survival. Its expression is significantly elevated in epithelial cells and has been implicated in several diseases, including cancer and inflammatory bowel disease. Further research is needed to fully understand the role of MIA in human disease.

Genular Protein ID: 115512627

Symbol: MIA_HUMAN

Name: Melanoma-derived growth regulatory protein

UniProtKB Accession Codes:

Q16674 Q6FHV3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7923218

Title: Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA.

PubMed ID: 7923218

PubMed ID: 8550608

Title: Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA.

PubMed ID: 8550608

DOI: 10.1074/jbc.271.1.490

PubMed ID: 12230496

Title: Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP).

PubMed ID: 12230496

DOI: 10.1046/j.1523-1747.2002.00501.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 22419821

Title: Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis.

PubMed ID: 22419821

DOI: 10.1091/mbc.e11-11-0934

PubMed ID: 11331761

Title: Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.

PubMed ID: 11331761

DOI: 10.1073/pnas.091601698

Sequence Information:

  • Length: 131
  • Mass: 14509
  • Checksum: 4D3BB30BD6008BDC
  • Sequence:
    • MARSLVCLGV IILLSAFSGP GVRGGPMPKL ADRKLCADQE CSHPISMAVA LQDYMAPDCR 
FLTIHRGQVV YVFSKLKGRG RLFWGGSVQG DYYGDLAARL GYFPSSIVRE DQTLKPGKVD 
VKTDKWDFYC Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.