OXTR | ENSG00000180914 | NCBI 5021

Details for: OXTR

Gene ID: 5021

Symbol: OXTR

Ensembl ID: ENSG00000180914

Description: oxytocin receptor

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Vasopressin-like receptors
(R-HSA-388479)
Adherens junction
(GO:0005912)
Apical plasma membrane
(GO:0016324)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to hormone stimulus
(GO:0032870)
Digestive tract development
(GO:0048565)
Eating behavior
(GO:0042755)
Erk1 and erk2 cascade
(GO:0070371)
Estrous cycle
(GO:0044849)
Female pregnancy
(GO:0007565)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Ionotropic glutamate receptor binding
(GO:0035255)
Lactation
(GO:0007595)
Maternal behavior
(GO:0042711)
Maternal process involved in parturition
(GO:0060137)
Memory
(GO:0007613)
Microvillus
(GO:0005902)
Muscle contraction
(GO:0006936)
Oxytocin receptor activity
(GO:0004990)
Peptide hormone binding
(GO:0017046)
Plasma membrane
(GO:0005886)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of norepinephrine secretion
(GO:0010701)
Positive regulation of penile erection
(GO:0060406)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of uterine smooth muscle contraction
(GO:0070474)
Positive regulation of vasoconstriction
(GO:0045907)
Regulation of systemic arterial blood pressure by vasopressin
(GO:0001992)
Response to amphetamine
(GO:0001975)
Response to anoxia
(GO:0034059)
Response to cocaine
(GO:0042220)
Response to cytokine
(GO:0034097)
Response to estradiol
(GO:0032355)
Response to peptide hormone
(GO:0043434)
Response to progesterone
(GO:0032570)
Response to xenobiotic stimulus
(GO:0009410)
Social behavior
(GO:0035176)
Sperm ejaculation
(GO:0042713)
Suckling behavior
(GO:0001967)
Telencephalon development
(GO:0021537)
Vasopressin receptor activity
(GO:0005000)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 37.9632
Cell Significance Index: -5.9100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 23.4581
Cell Significance Index: -5.9500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 4.8380
Cell Significance Index: -5.9700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.4061
Cell Significance Index: 45.0400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6884
Cell Significance Index: 14.9200
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.4298
Cell Significance Index: 6.2400
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.4254
Cell Significance Index: 7.0100
Cell Name: cytotoxic T cell (CL0000910)
Fold Change: 0.3110
Cell Significance Index: 4.5300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2887
Cell Significance Index: 28.5600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2598
Cell Significance Index: 49.4500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2388
Cell Significance Index: 6.8800
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.1889
Cell Significance Index: 2.7100
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.1837
Cell Significance Index: 1.3600
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.1789
Cell Significance Index: 2.5100
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1672
Cell Significance Index: 3.6600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1608
Cell Significance Index: 145.1500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1525
Cell Significance Index: 24.8100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1397
Cell Significance Index: 28.0200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0976
Cell Significance Index: 10.6200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0838
Cell Significance Index: 24.1100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0640
Cell Significance Index: 39.9500
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0556
Cell Significance Index: 19.9300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0504
Cell Significance Index: 10.0000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0207
Cell Significance Index: 2.3600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0203
Cell Significance Index: 2.3700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0194
Cell Significance Index: 0.8600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0184
Cell Significance Index: 0.4600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0174
Cell Significance Index: 11.0600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0157
Cell Significance Index: 8.6000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0142
Cell Significance Index: 0.8500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0116
Cell Significance Index: 0.4400
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0102
Cell Significance Index: 0.7100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0082
Cell Significance Index: 5.6500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0034
Cell Significance Index: 0.1200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.0022
Cell Significance Index: 0.1400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0006
Cell Significance Index: -1.1100
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0012
Cell Significance Index: -0.0300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0022
Cell Significance Index: -4.0900
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0031
Cell Significance Index: -2.3200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0037
Cell Significance Index: -5.6700
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0038
Cell Significance Index: -0.0600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0042
Cell Significance Index: -2.3800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0051
Cell Significance Index: -6.9700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0056
Cell Significance Index: -1.1800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0080
Cell Significance Index: -6.0600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0081
Cell Significance Index: -5.9100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0108
Cell Significance Index: -4.9100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0127
Cell Significance Index: -2.1700
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0153
Cell Significance Index: -1.9600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0165
Cell Significance Index: -0.7500
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0207
Cell Significance Index: -1.3900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0237
Cell Significance Index: -3.4500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0238
Cell Significance Index: -1.1100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0239
Cell Significance Index: -0.5100
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0241
Cell Significance Index: -0.5000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0261
Cell Significance Index: -2.0000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0263
Cell Significance Index: -3.4000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0281
Cell Significance Index: -5.0600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0289
Cell Significance Index: -1.3600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0300
Cell Significance Index: -4.1200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0339
Cell Significance Index: -3.8900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0350
Cell Significance Index: -1.0000
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0397
Cell Significance Index: -2.0700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0407
Cell Significance Index: -5.0100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0530
Cell Significance Index: -1.3600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0534
Cell Significance Index: -5.4500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0539
Cell Significance Index: -4.0200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0540
Cell Significance Index: -6.3700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0578
Cell Significance Index: -6.0200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0581
Cell Significance Index: -1.6200
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0628
Cell Significance Index: -2.5700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0654
Cell Significance Index: -3.6700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0688
Cell Significance Index: -4.2300
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0692
Cell Significance Index: -0.9600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0695
Cell Significance Index: -2.2200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0703
Cell Significance Index: -4.4300
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0722
Cell Significance Index: -3.6500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0741
Cell Significance Index: -3.8500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0795
Cell Significance Index: -2.2800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0800
Cell Significance Index: -2.6200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0800
Cell Significance Index: -4.2000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0809
Cell Significance Index: -2.8400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0896
Cell Significance Index: -1.3500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0925
Cell Significance Index: -5.9700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1067
Cell Significance Index: -2.8600
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1074
Cell Significance Index: -2.6800
Cell Name: peg cell (CL4033014)
Fold Change: -0.1125
Cell Significance Index: -2.6000
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1201
Cell Significance Index: -2.5500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1214
Cell Significance Index: -2.4000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1286
Cell Significance Index: -4.7200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1293
Cell Significance Index: -3.4000
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1319
Cell Significance Index: -2.7600
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1384
Cell Significance Index: -2.9900
Cell Name: thymocyte (CL0000893)
Fold Change: -0.1520
Cell Significance Index: -1.9200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1544
Cell Significance Index: -2.6700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1626
Cell Significance Index: -5.6500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1674
Cell Significance Index: -3.3600
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1705
Cell Significance Index: -4.1300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1783
Cell Significance Index: -4.7600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1785
Cell Significance Index: -2.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The OXTR gene encodes a receptor that is highly expressed in various tissues, including the brain, uterus, and reproductive organs. The receptor is a transmembrane GPCR, consisting of seven transmembrane domains and a third intracellular loop. OXTR is a ligand-activated receptor, meaning that its activation by oxytocin binding triggers a signaling cascade that modulates downstream cellular processes. **Pathways and Functions** OXTR is involved in a wide range of signaling pathways, including: 1. **G-protein coupled receptor signaling pathway**: OXTR activates G-proteins, which in turn modulate various cellular processes, including ion channel activity, cytoskeleton dynamics, and gene expression. 2. **ERK1/2 cascade**: OXTR activation leads to the activation of the extracellular signal-regulated kinase (ERK) pathway, which regulates cell proliferation, differentiation, and survival. 3. **NMDA receptor signaling**: OXTR interacts with NMDA receptors, modulating glutamatergic synaptic transmission and learning and memory processes. 4. **Vasopressin receptor activity**: OXTR shares a common ligand binding domain with vasopressin receptors, suggesting a potential role in modulating vasopressin-mediated functions. OXTR plays a critical role in various physiological and psychological processes, including: 1. **Social behavior**: OXTR is involved in social recognition, attachment, and bonding, and is implicated in anxiety disorders, such as social anxiety disorder. 2. **Reproductive functions**: OXTR regulates uterine contractions, lactation, and reproductive behavior, including mating and parental care. 3. **Cellular signaling**: OXTR modulates cellular processes, including proliferation, differentiation, and survival, in various tissues, including the brain, uterus, and reproductive organs. **Clinical Significance** Dysregulation of the OXTR gene has been implicated in various psychiatric and neurological disorders, including: 1. **Anxiety disorders**: OXTR has been shown to be associated with social anxiety disorder, and oxytocin-based therapies have been proposed as a potential treatment. 2. **Autism spectrum disorder**: OXTR has been found to be underexpressed in individuals with autism spectrum disorder, suggesting a potential role in social behavior and communication. 3. **Depression**: OXTR has been implicated in depression, with studies suggesting that oxytocin-based therapies may have therapeutic benefits. 4. **Neurodegenerative diseases**: OXTR has been shown to be involved in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the OXTR gene plays a critical role in various physiological and psychological processes, including social behavior, reproductive functions, and cellular signaling. Dysregulation of the OXTR gene has been implicated in various psychiatric and neurological disorders, highlighting the potential for oxytocin-based therapies as a novel treatment strategy. Further research is needed to fully understand the mechanisms and clinical significance of OXTR in humans.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Oxytocin receptor

Genular Protein ID: 2329073427

Symbol: OXYR_HUMAN

Name: Oxytocin receptor

UniProtKB Accession Codes:

P30559 Q15071

Database IDs:

Citations:

PubMed ID: 1313946

Title: Structure and expression of a human oxytocin receptor.

PubMed ID: 1313946

DOI: 10.1038/356526a0

PubMed ID: 7798245

Title: Structural organization of the human oxytocin receptor gene.

PubMed ID: 7798245

DOI: 10.1016/s0021-9258(18)31656-9

Sequence Information:

Length: 389
Mass: 42772
Checksum: 97E1845DA9676439
Sequence:

MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV 
LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV 
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV 
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA 
AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW 
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET 
SASKKSNSSS FVLSHRSSSQ RSCSQPSTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.