Details for: NT5DC3

Gene ID: 51559

Symbol: NT5DC3

Ensembl ID: ENSG00000111696

Description: 5'-nucleotidase domain containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.5244
    Cell Significance Index: -15.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.6901
    Cell Significance Index: -15.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.4822
    Cell Significance Index: -15.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9077
    Cell Significance Index: -15.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6370
    Cell Significance Index: -7.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.6305
    Cell Significance Index: 46.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0727
    Cell Significance Index: 48.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0711
    Cell Significance Index: 212.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0153
    Cell Significance Index: 27.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8728
    Cell Significance Index: 175.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7574
    Cell Significance Index: 74.9200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.7476
    Cell Significance Index: 8.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7136
    Cell Significance Index: 255.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6217
    Cell Significance Index: 15.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5605
    Cell Significance Index: 37.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5487
    Cell Significance Index: 157.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4829
    Cell Significance Index: 13.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4783
    Cell Significance Index: 12.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4683
    Cell Significance Index: 6.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4454
    Cell Significance Index: 402.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4300
    Cell Significance Index: 26.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3810
    Cell Significance Index: 41.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3691
    Cell Significance Index: 10.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3641
    Cell Significance Index: 59.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3590
    Cell Significance Index: 21.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3190
    Cell Significance Index: 6.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1985
    Cell Significance Index: 4.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1977
    Cell Significance Index: 136.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1865
    Cell Significance Index: 3.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1739
    Cell Significance Index: 4.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1398
    Cell Significance Index: 26.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1092
    Cell Significance Index: 7.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1061
    Cell Significance Index: 6.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1000
    Cell Significance Index: 2.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0903
    Cell Significance Index: 49.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0583
    Cell Significance Index: 2.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0497
    Cell Significance Index: 6.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0495
    Cell Significance Index: 2.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0466
    Cell Significance Index: 2.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0408
    Cell Significance Index: 7.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0306
    Cell Significance Index: 13.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0285
    Cell Significance Index: 3.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0275
    Cell Significance Index: 1.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0253
    Cell Significance Index: 1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0198
    Cell Significance Index: 12.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0143
    Cell Significance Index: 1.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0084
    Cell Significance Index: 11.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0044
    Cell Significance Index: 0.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0027
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0018
    Cell Significance Index: 3.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0058
    Cell Significance Index: -0.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0090
    Cell Significance Index: -6.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0116
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0179
    Cell Significance Index: -13.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0198
    Cell Significance Index: -15.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0219
    Cell Significance Index: -12.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0274
    Cell Significance Index: -17.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0306
    Cell Significance Index: -3.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0347
    Cell Significance Index: -0.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0422
    Cell Significance Index: -2.3700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0481
    Cell Significance Index: -0.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0570
    Cell Significance Index: -8.2900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0699
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0702
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0748
    Cell Significance Index: -15.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0897
    Cell Significance Index: -1.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0919
    Cell Significance Index: -6.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1000
    Cell Significance Index: -6.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1081
    Cell Significance Index: -5.0800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1101
    Cell Significance Index: -2.2100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1114
    Cell Significance Index: -1.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1138
    Cell Significance Index: -1.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1171
    Cell Significance Index: -13.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1404
    Cell Significance Index: -14.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1463
    Cell Significance Index: -3.1600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1483
    Cell Significance Index: -2.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1492
    Cell Significance Index: -10.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1783
    Cell Significance Index: -3.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1805
    Cell Significance Index: -5.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1831
    Cell Significance Index: -14.5000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1866
    Cell Significance Index: -2.4200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2000
    Cell Significance Index: -4.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2066
    Cell Significance Index: -6.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2073
    Cell Significance Index: -3.0600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2112
    Cell Significance Index: -2.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2153
    Cell Significance Index: -13.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2196
    Cell Significance Index: -11.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2261
    Cell Significance Index: -4.4700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.2451
    Cell Significance Index: -1.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2474
    Cell Significance Index: -5.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2708
    Cell Significance Index: -3.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2746
    Cell Significance Index: -9.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3012
    Cell Significance Index: -3.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3112
    Cell Significance Index: -4.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3332
    Cell Significance Index: -12.2300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3451
    Cell Significance Index: -4.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NT5DC3 is characterized by its unique expression profile, which is evident across multiple cell types and tissues, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and Langerhans cells. Its expression is also noted in neurons, including hippocampal pyramidal cells and cortical neurons of the adrenal gland. Notably, NT5DC3 is significantly upregulated in neoplastic cells, suggesting potential involvement in cancer progression. The protein's structural homology to 5'-nucleotidase highlights its potential role in nucleotide degradation and energy metabolism. **Pathways and Functions:** The pathways and functions associated with NT5DC3 are multifaceted and far-reaching. Its involvement in energy metabolism is evident through its expression in mitochondria, where it may play a role in nucleotide degradation and ATP production. Additionally, NT5DC3's expression in neurons suggests a potential role in neurotransmission, possibly through the regulation of nucleotide levels in synaptic clefts. Furthermore, its presence in Langerhans cells and other immune cells implies a potential role in immune function and antigen presentation. The gene's involvement in cancer progression is also noteworthy, as its upregulation in neoplastic cells may contribute to tumor growth and metastasis. **Clinical Significance:** The clinical significance of NT5DC3 is an area of ongoing research, with potential implications for various diseases and disorders. Its expression in neoplastic cells has led to speculation about its role in cancer development and progression. Moreover, NT5DC3's involvement in energy metabolism and neurotransmission may have implications for the treatment of metabolic disorders and neurological diseases, such as Alzheimer's and Parkinson's. Further studies are needed to fully elucidate the clinical significance of NT5DC3 and its potential therapeutic applications. In conclusion, NT5DC3 is a gene of great interest due to its diverse expression patterns and multifunctional role in cellular processes. Further research is necessary to fully understand the mechanisms by which NT5DC3 operates and its potential clinical significance. As our understanding of this gene continues to evolve, we may uncover new avenues for therapeutic intervention and treatment of various diseases.

Genular Protein ID: 2232280074

Symbol: NT5D3_HUMAN

Name: 5'-nucleotidase domain-containing protein 3

UniProtKB Accession Codes:

Q86UY8 Q9NUM7 Q9P2T2 Q9P2T3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15547748

Title: TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells.

PubMed ID: 15547748

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 548
  • Mass: 63420
  • Checksum: 93B1C8CD7C2E0434
  • Sequence:
    • MTMAAAAVVA RGAGARAATA AALRGGCGTA ARGRPCAGPA RPLCTAPGTA PDMKRYLWER 
YREAKRSTEE LVPSIMSNLL NPDAIFSNNE MSLSDIEIYG FDYDYTLVFY SKHLHTLIFN 
AARDLLINEH RYPAEIRKYE YDPNFAIRGL HYDVQRAVLM KIDAFHYIQL GTVYRGLSVV 
PDEEVIEMYE GSHVPLEQMS DFYGKSSHGN TMKQFMDIFS LPEMTLLSCV NEYFLKNNID 
YEPVHLYKDV KDSIRDVHIK GIMYRAIEAD IEKYICYAEQ TRAVLAKLAD HGKKMFLITN 
SPSSFVDKGM SYIVGKDWRD LFDVVIVQAE KPNFFNDKRR PFRKMNEKGV LLWDKIHKLQ 
KGQIYKQGNL YEFLKLTGWR GSRVLYFGDH IYSDLADLTL KHGWRTGAII PELRSELKIM 
NTEQYIQTMT WLQTLTGLLE QMQVHRDAES QLVLQEWKKE RKEMREMTKS FFNAQFGSLF 
RTDQNPTYFL RRLSRFADIY MASLSCLLNY DVSHTFYPRR TPLQHELPAW SERPPTFGTP 
LLQEAQAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.