Details for: HSPB8

Gene ID: 26353

Symbol: HSPB8

Ensembl ID: ENSG00000152137

Description: heat shock protein family B (small) member 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.3160
    Cell Significance Index: -21.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.7286
    Cell Significance Index: -21.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 6.9633
    Cell Significance Index: 185.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 6.3692
    Cell Significance Index: 155.4100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.2430
    Cell Significance Index: 100.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0300
    Cell Significance Index: -8.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3261
    Cell Significance Index: 90.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5481
    Cell Significance Index: 296.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3295
    Cell Significance Index: 59.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2696
    Cell Significance Index: 118.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.8389
    Cell Significance Index: 141.1200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.8223
    Cell Significance Index: 11.2200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.1716
    Cell Significance Index: 9.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1120
    Cell Significance Index: 10.2400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.9707
    Cell Significance Index: 11.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.8483
    Cell Significance Index: 11.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5531
    Cell Significance Index: 41.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4924
    Cell Significance Index: 7.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4842
    Cell Significance Index: 55.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4110
    Cell Significance Index: 21.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2763
    Cell Significance Index: 122.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2361
    Cell Significance Index: 27.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2255
    Cell Significance Index: 80.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2032
    Cell Significance Index: 40.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1788
    Cell Significance Index: 2.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1321
    Cell Significance Index: 248.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0999
    Cell Significance Index: 54.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0592
    Cell Significance Index: 7.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0502
    Cell Significance Index: 2.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0299
    Cell Significance Index: 5.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0272
    Cell Significance Index: 18.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0172
    Cell Significance Index: 26.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0162
    Cell Significance Index: 10.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0083
    Cell Significance Index: 1.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0073
    Cell Significance Index: 0.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0062
    Cell Significance Index: 0.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0044
    Cell Significance Index: 3.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0042
    Cell Significance Index: 1.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0025
    Cell Significance Index: 0.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0069
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0142
    Cell Significance Index: -8.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0270
    Cell Significance Index: -15.2300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0284
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0342
    Cell Significance Index: -25.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0438
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0442
    Cell Significance Index: -12.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0468
    Cell Significance Index: -6.8100
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0547
    Cell Significance Index: -0.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0551
    Cell Significance Index: -10.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0573
    Cell Significance Index: -4.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0701
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0774
    Cell Significance Index: -16.3100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1059
    Cell Significance Index: -0.6400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1071
    Cell Significance Index: -2.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1474
    Cell Significance Index: -19.0400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1738
    Cell Significance Index: -2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2020
    Cell Significance Index: -5.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2092
    Cell Significance Index: -21.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2283
    Cell Significance Index: -26.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2476
    Cell Significance Index: -2.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2535
    Cell Significance Index: -2.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2739
    Cell Significance Index: -14.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2997
    Cell Significance Index: -18.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3067
    Cell Significance Index: -12.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3207
    Cell Significance Index: -25.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3477
    Cell Significance Index: -23.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3698
    Cell Significance Index: -17.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4149
    Cell Significance Index: -25.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4212
    Cell Significance Index: -18.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4262
    Cell Significance Index: -15.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4557
    Cell Significance Index: -25.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4774
    Cell Significance Index: -12.2000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4827
    Cell Significance Index: -6.1900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4885
    Cell Significance Index: -7.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5109
    Cell Significance Index: -16.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.5234
    Cell Significance Index: -9.0500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5498
    Cell Significance Index: -4.2300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.5890
    Cell Significance Index: -3.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5957
    Cell Significance Index: -20.8700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6003
    Cell Significance Index: -17.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6140
    Cell Significance Index: -19.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6153
    Cell Significance Index: -12.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6208
    Cell Significance Index: -10.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6245
    Cell Significance Index: -13.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6319
    Cell Significance Index: -20.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6384
    Cell Significance Index: -28.2400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.6490
    Cell Significance Index: -6.9800
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.6767
    Cell Significance Index: -4.8800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6820
    Cell Significance Index: -7.8100
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.7045
    Cell Significance Index: -7.6900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7047
    Cell Significance Index: -11.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7322
    Cell Significance Index: -25.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7323
    Cell Significance Index: -18.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7473
    Cell Significance Index: -28.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8224
    Cell Significance Index: -19.0000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8256
    Cell Significance Index: -16.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8435
    Cell Significance Index: -29.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSPB8 is a 18-kDa protein that belongs to the HSPB family, which consists of seven members. HSPB8 is predominantly expressed in various cell types, including fibroblasts, epithelial cells, and endothelial cells. It is also highly expressed in the placenta and the heart, where it plays a critical role in maintaining cellular homeostasis under stress conditions. **Pathways and Functions:** HSPB8 is involved in various cellular pathways that regulate stress response, including: 1. **Heat shock response:** HSPB8 is activated by heat shock proteins (HSPs) and other stress-inducing agents, leading to the formation of a protein complex that protects cells against heat-induced damage. 2. **Unfolded protein response (UPR):** HSPB8 interacts with other HSPs to regulate the UPR, which is a critical response to protein misfolding and aggregation. 3. **Aggrephagy:** HSPB8 is involved in the regulation of aggrephagy, a process by which cells eliminate protein aggregates through autophagy. 4. **Protein folding chaperone complex:** HSPB8 forms a protein complex with other HSPs to regulate protein folding and prevent protein misfolding. **Clinical Significance:** HSPB8 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** HSPB8 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where protein misfolding and aggregation play a critical role. 2. **Cardiovascular disease:** HSPB8 has been implicated in the development of cardiovascular disease, where it regulates protein folding and prevent protein misfolding. 3. **Cancer:** HSPB8 has been linked to cancer, where it regulates protein folding and prevent protein misfolding, leading to the development of cancer cells. 4. **Infectious diseases:** HSPB8 has been implicated in infectious diseases, such as sepsis, where it regulates the immune response and prevent cell death. **Conclusion:** In conclusion, HSPB8 plays a critical role in regulating cellular stress response, including heat shock, oxidative stress, and protein misfolding. Its dysregulation has been implicated in various diseases, including neurodegenerative disorders, cardiovascular disease, cancer, and infectious diseases. Further research is needed to understand the mechanisms by which HSPB8 regulates cellular stress response and to develop therapeutic strategies to target its dysregulation in disease.

Genular Protein ID: 1444945805

Symbol: HSPB8_HUMAN

Name: Heat shock protein beta-8

UniProtKB Accession Codes:

Q9UJY1 B2R6A6 Q6FIH3 Q9UKS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11085516

Title: Effects of estrogen on global gene expression: identification of novel targets of estrogen action.

PubMed ID: 11085516

PubMed ID: 11342557

Title: HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 (3DHSP27).

PubMed ID: 11342557

DOI: 10.1074/jbc.m103001200

PubMed ID: 10833516

Title: A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells.

PubMed ID: 10833516

DOI: 10.1074/jbc.m002140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11816564

Title: Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry.

PubMed ID: 11816564

DOI: 10.1021/ac0104227

PubMed ID: 11470154

Title: Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9.

PubMed ID: 11470154

DOI: 10.1016/s0167-4781(01)00237-8

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19464326

Title: HSPB7 is a SC35 speckle resident small heat shock protein.

PubMed ID: 19464326

DOI: 10.1016/j.bbamcr.2009.05.005

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22366786

Title: Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.

PubMed ID: 22366786

DOI: 10.1038/ng.1103

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15122253

Title: Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy.

PubMed ID: 15122253

DOI: 10.1038/ng1328

PubMed ID: 15565283

Title: Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L.

PubMed ID: 15565283

DOI: 10.1007/s00439-004-1218-3

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 28144995

Title: Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations.

PubMed ID: 28144995

DOI: 10.1002/humu.23189

Sequence Information:

  • Length: 196
  • Mass: 21604
  • Checksum: B76058CED52292CB
  • Sequence:
    • MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLSSAW 
PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE 
VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD PVTVFASLSP EGLLIIEAPQ VPPYSTFGES 
SFNNELPQDS QEVTCT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.