Details for: G0S2

Gene ID: 50486

Symbol: G0S2

Ensembl ID: ENSG00000123689

Description: G0/G1 switch 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.9020
    Cell Significance Index: -21.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.8038
    Cell Significance Index: -24.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.9408
    Cell Significance Index: -28.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.1806
    Cell Significance Index: -21.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.1096
    Cell Significance Index: -24.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.2797
    Cell Significance Index: -24.3200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.0048
    Cell Significance Index: -24.1600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 33.8925
    Cell Significance Index: 147.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.0167
    Cell Significance Index: -21.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8733
    Cell Significance Index: -23.2700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.2106
    Cell Significance Index: 44.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1479
    Cell Significance Index: -24.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.0370
    Cell Significance Index: 89.0100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.3429
    Cell Significance Index: 12.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.7875
    Cell Significance Index: 51.5200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.7370
    Cell Significance Index: 8.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6268
    Cell Significance Index: 71.5000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 2.5216
    Cell Significance Index: 10.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1580
    Cell Significance Index: 213.4700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.9814
    Cell Significance Index: 34.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.8119
    Cell Significance Index: 44.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7891
    Cell Significance Index: 290.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7817
    Cell Significance Index: 123.2200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7409
    Cell Significance Index: 29.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7312
    Cell Significance Index: 1563.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7024
    Cell Significance Index: 80.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4966
    Cell Significance Index: 29.2100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1515
    Cell Significance Index: 14.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1287
    Cell Significance Index: 30.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8903
    Cell Significance Index: 25.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8809
    Cell Significance Index: 45.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8623
    Cell Significance Index: 470.9200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.8591
    Cell Significance Index: 6.1700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8545
    Cell Significance Index: 51.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7977
    Cell Significance Index: 20.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6373
    Cell Significance Index: 9.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5762
    Cell Significance Index: 74.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3953
    Cell Significance Index: 27.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3725
    Cell Significance Index: 47.7600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3545
    Cell Significance Index: 5.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2115
    Cell Significance Index: 155.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2102
    Cell Significance Index: 40.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2027
    Cell Significance Index: 5.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1437
    Cell Significance Index: 3.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1302
    Cell Significance Index: 5.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1267
    Cell Significance Index: 9.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1181
    Cell Significance Index: 2.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1083
    Cell Significance Index: 47.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0584
    Cell Significance Index: 44.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0545
    Cell Significance Index: 9.3000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0526
    Cell Significance Index: 0.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0352
    Cell Significance Index: 4.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0295
    Cell Significance Index: 3.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0218
    Cell Significance Index: 1.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0203
    Cell Significance Index: 0.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0157
    Cell Significance Index: 3.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0083
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0107
    Cell Significance Index: -20.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0126
    Cell Significance Index: -7.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0166
    Cell Significance Index: -11.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0222
    Cell Significance Index: -12.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0234
    Cell Significance Index: -6.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0239
    Cell Significance Index: -4.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0340
    Cell Significance Index: -12.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0367
    Cell Significance Index: -23.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0549
    Cell Significance Index: -24.9200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0630
    Cell Significance Index: -0.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0738
    Cell Significance Index: -15.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0890
    Cell Significance Index: -17.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0971
    Cell Significance Index: -7.2400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1109
    Cell Significance Index: -1.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1175
    Cell Significance Index: -13.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1343
    Cell Significance Index: -15.3900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1427
    Cell Significance Index: -16.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1590
    Cell Significance Index: -9.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1678
    Cell Significance Index: -24.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1916
    Cell Significance Index: -22.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1956
    Cell Significance Index: -2.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2239
    Cell Significance Index: -7.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2324
    Cell Significance Index: -24.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2385
    Cell Significance Index: -6.1300
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.2401
    Cell Significance Index: -2.3100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2689
    Cell Significance Index: -1.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2821
    Cell Significance Index: -14.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2823
    Cell Significance Index: -14.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2960
    Cell Significance Index: -15.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3228
    Cell Significance Index: -9.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3247
    Cell Significance Index: -15.1400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3268
    Cell Significance Index: -3.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3403
    Cell Significance Index: -20.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3654
    Cell Significance Index: -24.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3775
    Cell Significance Index: -24.3600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.3935
    Cell Significance Index: -2.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4366
    Cell Significance Index: -6.5800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4382
    Cell Significance Index: -6.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4679
    Cell Significance Index: -5.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4853
    Cell Significance Index: -27.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** G0S2 is a gene that belongs to the G0/G1 switch family of proteins, which are known to regulate cell cycle progression and apoptosis. The G0S2 gene is specifically involved in the regulation of lipid metabolism, thermogenesis, and apoptosis. Its expression is widespread across various cell types, including hematopoietic cells, adipocytes, and immune cells. G0S2 has been shown to interact with PPARα, a nuclear receptor that regulates lipid metabolism, and is involved in the regulation of the extrinsic apoptotic signaling pathway. **Pathways and Functions:** G0S2 is involved in several key signaling pathways, including: 1. **Extrinsic apoptotic signaling pathway:** G0S2 regulates the extrinsic apoptotic signaling pathway by interacting with pro-apoptotic proteins, such as BAX and BAK. 2. **Lipid droplet formation:** G0S2 is involved in the regulation of lipid droplet formation in adipocytes and hematopoietic cells. 3. **Thermogenesis:** G0S2 regulates thermogenesis by interacting with PPARα, a nuclear receptor that activates gene expression involved in heat production. 4. **Metabolism:** G0S2 is involved in the regulation of lipid metabolism by interacting with PPARα and other metabolic enzymes. **Clinical Significance:** The G0S2 gene has been implicated in the pathogenesis of several diseases, including: 1. **Metabolic disorders:** G0S2 dysregulation has been linked to metabolic disorders, such as obesity and insulin resistance. 2. **Cancer:** G0S2 is overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Autoimmune diseases:** G0S2 is involved in the regulation of immune responses and has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, the G0S2 gene plays a critical role in regulating lipid metabolism, apoptosis, and thermogenesis in various cell types. Its dysregulation has been implicated in the pathogenesis of several diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 1743879242

Symbol: G0S2_HUMAN

Name: G0/G1 switch protein 2

UniProtKB Accession Codes:

P27469 Q6FGC8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1930693

Title: A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated.

PubMed ID: 1930693

DOI: 10.1089/dna.1991.10.581

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19706769

Title: Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2.

PubMed ID: 19706769

DOI: 10.1158/0008-5472.can-09-0128

Sequence Information:

  • Length: 103
  • Mass: 11321
  • Checksum: 0FA91951D419E75C
  • Sequence:
    • METVQELIPL AKEMMAQKRK GKMVKLYVLG SVLALFGVVL GLMETVCSPF TAARRLRDQE 
AAVAELQAAL ERQALQKQAL QEKGKQQDTV LGGRALSNRQ HAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.