Details for: SAA1

Gene ID: 6288

Symbol: SAA1

Ensembl ID: ENSG00000173432

Description: serum amyloid A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 17.7414
    Cell Significance Index: 98.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 11.4005
    Cell Significance Index: 168.2700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 9.1523
    Cell Significance Index: 56.5600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 5.9540
    Cell Significance Index: 124.1800
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 5.8439
    Cell Significance Index: 25.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4340
    Cell Significance Index: 253.3600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 5.4319
    Cell Significance Index: 68.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.5183
    Cell Significance Index: 319.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4315
    Cell Significance Index: 443.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.2921
    Cell Significance Index: 55.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5629
    Cell Significance Index: 69.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.4661
    Cell Significance Index: 78.9900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.2483
    Cell Significance Index: 19.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.8764
    Cell Significance Index: 46.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.7161
    Cell Significance Index: 80.6600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.6604
    Cell Significance Index: 4.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5675
    Cell Significance Index: 96.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5202
    Cell Significance Index: 29.6700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.4881
    Cell Significance Index: 15.3500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.1576
    Cell Significance Index: 4.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0232
    Cell Significance Index: 452.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8853
    Cell Significance Index: 483.4600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 0.8727
    Cell Significance Index: 6.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7536
    Cell Significance Index: 21.0600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.7077
    Cell Significance Index: 5.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6611
    Cell Significance Index: 9.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.6557
    Cell Significance Index: 4.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5149
    Cell Significance Index: 26.7500
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.4552
    Cell Significance Index: 3.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4365
    Cell Significance Index: 83.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4347
    Cell Significance Index: 19.7100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3855
    Cell Significance Index: 2.2200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.3472
    Cell Significance Index: 3.4300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.3282
    Cell Significance Index: 0.7400
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.2408
    Cell Significance Index: 2.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2363
    Cell Significance Index: 17.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2220
    Cell Significance Index: 168.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2023
    Cell Significance Index: 182.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1880
    Cell Significance Index: 5.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.1553
    Cell Significance Index: 6.7500
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1517
    Cell Significance Index: 1.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1418
    Cell Significance Index: 14.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1187
    Cell Significance Index: 1.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0995
    Cell Significance Index: 16.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0587
    Cell Significance Index: 36.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0544
    Cell Significance Index: 5.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0462
    Cell Significance Index: 9.1700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0391
    Cell Significance Index: 0.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0025
    Cell Significance Index: 0.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0010
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0049
    Cell Significance Index: -3.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0072
    Cell Significance Index: -13.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.5200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0103
    Cell Significance Index: -13.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0122
    Cell Significance Index: -2.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0205
    Cell Significance Index: -0.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0211
    Cell Significance Index: -15.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0240
    Cell Significance Index: -4.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0251
    Cell Significance Index: -15.9700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0314
    Cell Significance Index: -0.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0323
    Cell Significance Index: -0.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0329
    Cell Significance Index: -14.9200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0368
    Cell Significance Index: -0.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0377
    Cell Significance Index: -13.5200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0389
    Cell Significance Index: -0.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0393
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0528
    Cell Significance Index: -6.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0535
    Cell Significance Index: -15.3900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0537
    Cell Significance Index: -0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0676
    Cell Significance Index: -13.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0696
    Cell Significance Index: -7.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0793
    Cell Significance Index: -9.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0799
    Cell Significance Index: -10.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0854
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0910
    Cell Significance Index: -10.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0997
    Cell Significance Index: -11.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1039
    Cell Significance Index: -15.1100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1157
    Cell Significance Index: -1.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1407
    Cell Significance Index: -14.6500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.1669
    Cell Significance Index: -1.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1805
    Cell Significance Index: -13.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1828
    Cell Significance Index: -3.2300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1934
    Cell Significance Index: -2.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1996
    Cell Significance Index: -12.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2085
    Cell Significance Index: -6.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2217
    Cell Significance Index: -3.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2324
    Cell Significance Index: -8.5300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2463
    Cell Significance Index: -5.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2584
    Cell Significance Index: -13.4600
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2874
    Cell Significance Index: -2.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3000
    Cell Significance Index: -16.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3071
    Cell Significance Index: -8.2000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.3143
    Cell Significance Index: -3.1500
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.3345
    Cell Significance Index: -2.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3398
    Cell Significance Index: -5.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3427
    Cell Significance Index: -8.8100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.3521
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SAA1 is a member of the serum amyloid A (SAA) protein family, which consists of six different genes (SAA1-6) that encode for proteins with distinct functions. SAA1 is a small, secreted protein that is highly expressed in the liver and other tissues during acute-phase responses. It has a molecular weight of approximately 40 kDa and is composed of two polypeptide chains linked by disulfide bonds. **Pathways and Functions** SAA1 participates in various cellular processes, including: 1. **Acute-Phase Response**: SAA1 is induced by pro-inflammatory cytokines, such as IL-6 and TNF-alpha, in response to tissue damage or infection. It plays a crucial role in regulating the acute-phase response, which is a systemic reaction to inflammation. 2. **Immune System Regulation**: SAA1 modulates the immune response by interacting with pattern recognition receptors (PRRs), such as TLR2 and TLR4, and activating signaling pathways that lead to the production of anti-inflammatory cytokines. 3. **Inflammation Modulation**: SAA1 has anti-inflammatory properties, which help to regulate the severity of inflammation and prevent tissue damage. 4. **Cell Signaling**: SAA1 interacts with various cell surface receptors, including G-protein coupled receptors (GPCRs) and scavenger receptors, to modulate signaling pathways involved in cell growth, differentiation, and survival. 5. **Protein Secretion**: SAA1 is involved in regulating the secretion of various proteins, including cytokines, chemokines, and growth factors, which are essential for immune response and tissue repair. **Signaling Pathways** SAA1 interacts with various signaling pathways, including: 1. **MyD88-dependent pathways**: SAA1 activates the MyD88-dependent signaling pathway, which is involved in the regulation of inflammatory responses and the production of anti-inflammatory cytokines. 2. **Traf6-mediated pathways**: SAA1 interacts with Traf6, which activates the NF-κB pathway and leads to the production of anti-inflammatory cytokines. 3. **GPCR signaling**: SAA1 interacts with GPCRs, which activate signaling pathways involved in cell growth, differentiation, and survival. **Clinical Significance** SAA1 plays a crucial role in various diseases, including: 1. **Inflammatory Disorders**: SAA1 is involved in the regulation of inflammatory responses, which is essential for the development of acute-phase responses. 2. **Autoimmune Diseases**: SAA1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: SAA1 has been shown to have anti-tumor properties, and its expression is often upregulated in cancer tissues. 4. **Infectious Diseases**: SAA1 has been shown to have anti-inflammatory properties, which can help to regulate the severity of infection. In conclusion, SAA1 is a multifunctional protein that plays a crucial role in regulating the immune response, modulating inflammation, and participating in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SAA1.

Genular Protein ID: 2658060118

Symbol: SAA1_HUMAN

Name: Serum amyloid A-1 protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3839415

Title: Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA.

PubMed ID: 3839415

DOI: 10.1021/bi00333a018

PubMed ID: 3183061

Title: Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person.

PubMed ID: 3183061

DOI: 10.1172/jci113779

PubMed ID: 1656519

Title: The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells.

PubMed ID: 1656519

DOI: 10.1111/j.1365-3083.1991.tb01570.x

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1971508

Title: Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis.

PubMed ID: 1971508

DOI: 10.1042/bj2680187

PubMed ID: 7115671

Title: Amino acid sequence of amyloid-related apoprotein (apoSAA1) from human high-density lipoprotein.

PubMed ID: 7115671

DOI: 10.1021/bi00257a008

PubMed ID: 1546977

Title: Human serum amyloid A protein. Complete amino acid sequence of a new variant.

PubMed ID: 1546977

DOI: 10.1042/bj2820615

PubMed ID: 6155694

Title: An unusually large (83 amino acid residues) amyloid fibril protein AA from a patient with Waldenstrom's macroglobulinaemia and amyloidosis.

PubMed ID: 6155694

DOI: 10.1111/j.1365-3083.1980.tb00023.x

PubMed ID: 5055786

Title: Amino acid sequence of an amyloid fibril protein of unknown origin.

PubMed ID: 5055786

DOI: 10.1016/s0021-9258(20)81154-5

PubMed ID: 5056669

Title: The amino acid sequence of a major nonimmunoglobulin component of some amyloid fibrils.

PubMed ID: 5056669

DOI: 10.1172/jci107098

PubMed ID: 4816450

Title: The complete amino-acid sequence of non-immunoglobulin amyloid fibril protein AS in rheumatoid arthritis.

PubMed ID: 4816450

DOI: 10.1111/j.1432-1033.1974.tb03251.x

PubMed ID: 1463770

Title: Identification of two novel amyloid A protein subsets coexisting in an individual patient of AA-amyloidosis.

PubMed ID: 1463770

DOI: 10.1016/0925-4439(92)90068-x

PubMed ID: 1259755

Title: The complete amino acid sequence of an amyloid fibril protein AA1 of unusual size (64 residues).

PubMed ID: 1259755

DOI: 10.1016/s0006-291x(76)80266-5

PubMed ID: 11946204

Title: The major proteins of human and monkey amyloid substance: common properties including unusual N-terminal amino acid sequences.

PubMed ID: 11946204

DOI: 10.1016/0014-5793(71)80506-9

PubMed ID: 3442653

Title: Degradation and deposition of amyloid AA fibrils are tissue specific.

PubMed ID: 3442653

DOI: 10.1021/bi00399a035

PubMed ID: 12973732

Title: Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.

PubMed ID: 12973732

DOI: 10.1002/pmic.200300514

PubMed ID: 8783012

Title: Characterization of human serum amyloid A protein isoforms separated by two-dimensional electrophoresis by liquid chromatography/electrospray ionization tandem mass spectrometry.

PubMed ID: 8783012

DOI: 10.1002/elps.1150170508

PubMed ID: 8670280

Title: A protein AA-variant derived from a novel serum AA protein, SAA1 delta, in an individual from Papua New Guinea.

PubMed ID: 8670280

DOI: 10.1006/bbrc.1996.0892

PubMed ID: 10211414

Title: Revised nomenclature for serum amyloid A (SAA). Nomenclature Committee of the International Society of Amyloidosis. Part 2.

PubMed ID: 10211414

DOI: 10.3109/13506129908993291

PubMed ID: 12606051

Title: Detection of novel truncated forms of human serum amyloid A protein in human plasma.

PubMed ID: 12606051

DOI: 10.1016/s0014-5793(03)00097-8

PubMed ID: 8512321

Title: A novel polymorphism of human serum amyloid A protein, SAA1 gamma, is characterized by alanines at both residues 52 and 57.

PubMed ID: 8512321

DOI: 10.1006/abbi.1993.1296

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24706838

Title: Structural mechanism of serum amyloid A-mediated inflammatory amyloidosis.

PubMed ID: 24706838

DOI: 10.1073/pnas.1322357111

Sequence Information:

  • Length: 122
  • Mass: 13546
  • Checksum: 8C43BF06AA47B179
  • Sequence:
  • MKLLTGLVFC SLVLGVSSRS FFSFLGEAFD GARDMWRAYS DMREANYIGS DKYFHARGNY 
    DAAKRGPGGA WAAEVITDAR ENIQRFFGHG AEDSLADQAA NEWGRSGKDP NHFRPAGLPE 
    KY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.