Details for: GRP

Gene ID: 2922

Symbol: GRP

Ensembl ID: ENSG00000134443

Description: gastrin releasing peptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.58
    Marker Score: 867
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.55
    Marker Score: 1731
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 494
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.81
    Marker Score: 5407.5
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.78
    Marker Score: 1368
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1443
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.66
    Marker Score: 1059
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.58
    Marker Score: 648
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 455
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1113
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.52
    Marker Score: 8148
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.41
    Marker Score: 211
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.4
    Marker Score: 190
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.4
    Marker Score: 152
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 229
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.37
    Marker Score: 1819
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.37
    Marker Score: 3792.5
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.36
    Marker Score: 519
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.35
    Marker Score: 154
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2120
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 145.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.32
    Marker Score: 189
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.3
    Marker Score: 419
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.3
    Marker Score: 374
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.3
    Marker Score: 845
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.29
    Marker Score: 495
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.28
    Marker Score: 404
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.25
    Marker Score: 211
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.24
    Marker Score: 95
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.23
    Marker Score: 125
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.23
    Marker Score: 64.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.23
    Marker Score: 240
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.2
    Marker Score: 57
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.18
    Marker Score: 81
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.18
    Marker Score: 195
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.17
    Marker Score: 46
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 103
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 74
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 136
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.15
    Marker Score: 313
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.15
    Marker Score: 80
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.14
    Marker Score: 48
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 204
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 76
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.1
    Marker Score: 958
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.1
    Marker Score: 53
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.1
    Marker Score: 402
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.1
    Marker Score: 94
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.09
    Marker Score: 395
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 99
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 79
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.08
    Marker Score: 120
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.08
    Marker Score: 51
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.07
    Marker Score: 48
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.07
    Marker Score: 283.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.07
    Marker Score: 209
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 57
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: enucleate erythrocyte (CL0000595)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.06
    Marker Score: 24
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.06
    Marker Score: 19.5
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.05
    Marker Score: 17

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Other Information

**Key characteristics:** - GRP is a glycoprotein with a molecular weight of approximately 180 kDa. - It is a member of the immunoglobulin superfamily and shares homology with other gastrin receptors. - GRP is expressed in a variety of cell types, including sensory neurons, plasma cells, and gastrointestinal cells. - It is a key regulator of gastric hormone secretion. **Pathways and functions:** - GRP binds to receptors on the surface of target cells. - Binding of GRP to receptors triggers a cascade of intracellular events that lead to the release of gastrin. - Gastrin stimulates the parietal cells of the gastric glands to secrete hydrochloric acid. - The release of hydrochloric acid helps to maintain the acid-base balance of the body. **Clinical significance:** - Mutations in the GRP gene have been linked to a number of gastrointestinal diseases, including gastroesophageal reflux disease (GERD), gastric ulcers, and irritable bowel syndrome (IBS). - GRP is a potential target for the treatment of these disorders. - By blocking GRP signaling, it may be possible to inhibit gastric acid secretion and relieve symptoms of gastrointestinal diseases.

Genular Protein ID: 1205567144

Symbol: GRP_HUMAN

Name: Gastrin-releasing peptide

UniProtKB Accession Codes:

P07492 P07491 P81553 Q14454 Q53YA0 Q9BSY7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 3 ExpressionAtlas 1 GO 19 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3001723

Title: Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides.

PubMed ID: 3001723

DOI: 10.1073/pnas.83.1.19

PubMed ID: 3211139

Title: Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor.

PubMed ID: 3211139

DOI: 10.1128/mcb.8.8.3129-3135.1988

PubMed ID: 3003116

Title: Expression of the gastrin-releasing peptide gene in human small cell lung cancer. Evidence for alternative processing resulting in three distinct mRNAs.

PubMed ID: 3003116

DOI: 10.1016/s0021-9258(17)35956-2

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Title: Conformational ensembles of neuromedin C reveal a progressive coil-helix transition within a binding-induced folding mechanism.

DOI: 10.1039/C5RA12753J

Sequence Information:

  • Length: 148
  • Mass: 16213
  • Checksum: 6A9ED9E2748255BD
  • Sequence:
    • MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 
VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 
DVGSKGKVGR LSAPGSQREG RNPQLNQQ

Genular Protein ID: 4292405749

Symbol: A0A140VJM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJM7

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 1 RefSeq 1 SAM 2 SMR 1 VEuPathDB 1

Sequence Information:

  • Length: 141
  • Mass: 15533
  • Checksum: E2564E75ADAFCFCD
  • Sequence:
    • MRGRELPLVL LALVLCLAPR GRAVPLPAGG GTVLTKMYPR GNHWAVGHLM GKKSTGESSS 
VSERGSLKQQ LREYIRWEEA ARNLLGLIEA KENRNHQPPQ PKALGNQQPS WDSEDSSNFK 
DVGSKGKGSQ REGRNPQLNQ Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.