Details for: CL0000057

Cell ID: CL0000057

Cell Name: fibroblast

Marker Score Threshold: 966
(Derived using integrated single-cell and genomic data)

Description: A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.21
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.1
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.44
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.96
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.95
    Ensembl ID: ENSG00000145741
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.88
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.73
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.7
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.6
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.59
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.51
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.45
    Ensembl ID: ENSG00000133639
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.43
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.35
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.33
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 2.3
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.3
    Ensembl ID: ENSG00000135390
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.29
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.26
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.25
    Ensembl ID: ENSG00000152518
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.22
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.11
    Ensembl ID: ENSG00000179218
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 2.09
    Ensembl ID: ENSG00000159403
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.08
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.01
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.94
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.92
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.8
    Ensembl ID: ENSG00000154723
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.79
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.76
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.7
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.69
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.66
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.64
    Ensembl ID: ENSG00000069849
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.62
    Ensembl ID: ENSG00000155366
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.61
    Ensembl ID: ENSG00000151914
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.59
    Ensembl ID: ENSG00000106624
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.58
    Ensembl ID: ENSG00000122359
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.58
    Ensembl ID: ENSG00000115963
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.56
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.56
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.54
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.54
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.54
    Ensembl ID: ENSG00000177556
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.53
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.52
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.5
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.5
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.5
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.49
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.48
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.45
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.45
    Ensembl ID: ENSG00000197043
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.45
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.45
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.42
    Ensembl ID: ENSG00000072110
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.41
    Ensembl ID: ENSG00000189058
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.4
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.39
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.38
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.38
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.37
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.33
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.33
    Ensembl ID: ENSG00000162772
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.32
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.28
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.24
    Ensembl ID: ENSG00000149925
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.24
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.22
    Ensembl ID: ENSG00000140836
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.22
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.21
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.21
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.21
    Ensembl ID: ENSG00000116459
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.19
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.15
    Ensembl ID: ENSG00000131100
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.14
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.13
    Ensembl ID: ENSG00000198363
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.11
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.11
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.1
    Ensembl ID: ENSG00000148926
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.09
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.07
    Ensembl ID: ENSG00000174437
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.05
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.05
    Ensembl ID: ENSG00000143727
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.04
    Ensembl ID: ENSG00000182492
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.04
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.03
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.03
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.03
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.03
    Ensembl ID: ENSG00000107262
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000100823
  • Gene Symbol: C3 (ENSG00000125730)
    Fold Change: 1.01
    Ensembl ID: ENSG00000125730
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Shape and Structure**: Fibroblasts are flattened and irregular in outline, with branching processes that give them a fusiform or spindle-shaped appearance. 2. **Extracellular Matrix Production**: Fibroblasts produce an extracellular matrix rich in collagen and other macromolecules, which provides structural support and facilitates cell-cell interactions. 3. **Antigen Presentation**: Fibroblasts are involved in antigen presentation, including the assembly and loading of peptide antigens onto MHC class I and II molecules. 4. **Immune Response**: Fibroblasts play a role in regulating immune responses, including the production of cytokines and the activation of immune cells. 5. **Tissue Repair**: Fibroblasts are involved in tissue repair, including the production of growth factors and the regulation of cell proliferation and differentiation. **Clinical Significance** 1. **Wound Healing**: Fibroblasts play a crucial role in wound healing, including the production of collagen and other extracellular matrix components. 2. **Autoimmune Diseases**: Fibroblasts are involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where they can produce autoantibodies and regulate immune responses. 3. **Cancer**: Fibroblasts can play a role in cancer development and progression, including the production of growth factors and the regulation of cell proliferation and differentiation. 4. **Infectious Diseases**: Fibroblasts can interact with pathogens, such as HIV and Mycobacterium tuberculosis, to regulate immune responses and maintain tissue homeostasis. 5. **Regenerative Medicine**: Fibroblasts can be used in regenerative medicine to promote tissue repair and regeneration, including the use of fibroblast-derived extracellular matrix components. In conclusion, fibroblasts are a type of connective tissue cell that plays a crucial role in various cellular processes, including antigen presentation, immune response, and tissue repair. Their unique shape and structure, combined with their ability to produce extracellular matrix components and regulate immune responses, make them an important component of the immune system. Understanding the key characteristics and clinical significance of fibroblasts can provide insights into the development of new therapeutic strategies for various diseases and conditions.