Details for: TNFSF9

Gene ID: 8744

Symbol: TNFSF9

Ensembl ID: ENSG00000125657

Description: TNF superfamily member 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 52.0749
    Cell Significance Index: -8.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 32.4471
    Cell Significance Index: -8.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5615
    Cell Significance Index: -8.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4027
    Cell Significance Index: -3.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8929
    Cell Significance Index: 169.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7947
    Cell Significance Index: 36.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7226
    Cell Significance Index: 71.4800
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.6578
    Cell Significance Index: 6.8200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5888
    Cell Significance Index: 4.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5223
    Cell Significance Index: 471.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4248
    Cell Significance Index: 231.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3799
    Cell Significance Index: 10.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3667
    Cell Significance Index: 59.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3130
    Cell Significance Index: 34.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2527
    Cell Significance Index: 7.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1644
    Cell Significance Index: 9.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1511
    Cell Significance Index: 10.4500
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1342
    Cell Significance Index: 0.5000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1240
    Cell Significance Index: 14.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1091
    Cell Significance Index: 5.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0942
    Cell Significance Index: 6.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0927
    Cell Significance Index: 2.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0859
    Cell Significance Index: 1.8600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0685
    Cell Significance Index: 0.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0541
    Cell Significance Index: 1.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0521
    Cell Significance Index: 1.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0474
    Cell Significance Index: 20.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0374
    Cell Significance Index: 7.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0227
    Cell Significance Index: 2.7900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0147
    Cell Significance Index: 0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0097
    Cell Significance Index: 1.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0084
    Cell Significance Index: 3.0000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0026
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0037
    Cell Significance Index: -0.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0048
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0057
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0081
    Cell Significance Index: -0.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0097
    Cell Significance Index: -2.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0103
    Cell Significance Index: -7.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0118
    Cell Significance Index: -8.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0137
    Cell Significance Index: -1.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0180
    Cell Significance Index: -8.1600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0185
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0325
    Cell Significance Index: -5.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0329
    Cell Significance Index: -6.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0362
    Cell Significance Index: -3.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0394
    Cell Significance Index: -0.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0485
    Cell Significance Index: -3.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0494
    Cell Significance Index: -5.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0521
    Cell Significance Index: -7.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0529
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0561
    Cell Significance Index: -6.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0579
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0597
    Cell Significance Index: -1.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0684
    Cell Significance Index: -8.8400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.0701
    Cell Significance Index: -0.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0742
    Cell Significance Index: -1.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0744
    Cell Significance Index: -3.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0783
    Cell Significance Index: -8.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0844
    Cell Significance Index: -2.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0895
    Cell Significance Index: -5.4900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0954
    Cell Significance Index: -4.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0976
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0978
    Cell Significance Index: -1.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1101
    Cell Significance Index: -7.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1115
    Cell Significance Index: -8.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1162
    Cell Significance Index: -5.4200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1221
    Cell Significance Index: -3.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1222
    Cell Significance Index: -9.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1231
    Cell Significance Index: -1.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1411
    Cell Significance Index: -8.6700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1503
    Cell Significance Index: -2.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1513
    Cell Significance Index: -5.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1515
    Cell Significance Index: -8.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1537
    Cell Significance Index: -8.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1548
    Cell Significance Index: -8.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1673
    Cell Significance Index: -4.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1703
    Cell Significance Index: -6.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1745
    Cell Significance Index: -7.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1750
    Cell Significance Index: -5.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1756
    Cell Significance Index: -4.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1774
    Cell Significance Index: -5.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1856
    Cell Significance Index: -4.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1872
    Cell Significance Index: -2.9700
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1952
    Cell Significance Index: -2.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1969
    Cell Significance Index: -5.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2028
    Cell Significance Index: -7.6800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2031
    Cell Significance Index: -3.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2046
    Cell Significance Index: -2.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2099
    Cell Significance Index: -5.9900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2102
    Cell Significance Index: -3.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2133
    Cell Significance Index: -3.5200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2226
    Cell Significance Index: -3.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2333
    Cell Significance Index: -6.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2437
    Cell Significance Index: -8.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFSF9 is a type II membrane-bound protein that belongs to the TNF superfamily. It is primarily expressed on the surface of specific cell types, including immature innate lymphoid cells, alpha-beta memory T cells, keratinocytes, and intestinal epithelial cells. The protein's structure consists of a disulfide-linked dimeric form, which facilitates its interaction with the TNF receptor superfamily. **Pathways and Functions:** TNFSF9 plays a critical role in modulating immune responses through its interaction with TNF receptors, particularly TNFR2. This interaction activates the non-canonical NF-κB pathway, which regulates the expression of genes involved in cell proliferation, differentiation, and survival. Specifically, TNFSF9 promotes the positive regulation of activated T cell proliferation and cytotoxic T cell differentiation. Additionally, it regulates the regulation of apoptotic processes and T cell proliferation. TNFSF9 also participates in the extracellular signaling processes, influencing the binding of Tnfs to their physiological receptors and the regulation of tumor necrosis factor receptor binding. Furthermore, it is involved in the signaling receptor binding and signal transduction pathways, highlighting its role in modulating the immune response. **Clinical Significance:** The dysregulation of TNFSF9 has been implicated in various diseases, including autoimmune disorders, inflammatory conditions, and cancer. For instance, alterations in TNFSF9 expression have been observed in patients with rheumatoid arthritis, psoriasis, and multiple sclerosis. Additionally, TNFSF9 has been shown to play a role in the development of certain types of cancer, such as colorectal cancer, where it may contribute to tumor growth and metastasis. In the context of immunotherapy, TNFSF9 has been explored as a potential target for cancer treatment. The use of TNFSF9 inhibitors has been investigated as a therapeutic strategy to modulate the immune response and enhance anti-tumor activity. **Conclusion:** In conclusion, TNFSF9 is a vital component of the immune system, playing a critical role in regulating immune responses, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, and its potential as a therapeutic target has been explored. Further studies are needed to fully elucidate the functions and significance of TNFSF9, but its importance in the regulation of immune responses cannot be overstated. **Recommendations for Future Research:** 1. Investigate the specific mechanisms by which TNFSF9 regulates immune responses and cell proliferation. 2. Explore the therapeutic potential of TNFSF9 inhibitors in cancer treatment and autoimmune disorders. 3. Investigate the role of TNFSF9 in other diseases, such as inflammatory conditions and neurodegenerative disorders. 4. Determine the optimal expression levels of TNFSF9 in different cell types and tissues to better understand its regulation. By continuing to study TNFSF9, we can gain a deeper understanding of the complex immune system and develop novel therapeutic strategies to modulate immune responses and treat various diseases.

Genular Protein ID: 963932159

Symbol: TNFL9_HUMAN

Name: Tumor necrosis factor ligand superfamily member 9

UniProtKB Accession Codes:

P41273 Q2M3S2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8088337

Title: Molecular and biological characterization of human 4-1BB and its ligand.

PubMed ID: 8088337

DOI: 10.1002/eji.1830240943

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20032458

Title: The structure of the trimer of human 4-1BB ligand is unique among members of the tumor necrosis factor superfamily.

PubMed ID: 20032458

DOI: 10.1074/jbc.m109.084442

Sequence Information:

  • Length: 254
  • Mass: 26625
  • Checksum: 827551F34563E508
  • Sequence:
    • MEYASDASLD PEAPWPPAPR ARACRVLPWA LVAGLLLLLL LAAACAVFLA CPWAVSGARA 
SPGSAASPRL REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL 
TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA 
LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV 
TPEIPAGLPS PRSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.