PDGFRA | ENSG00000134853 | NCBI 5156

Details for: PDGFRA

Gene ID: 5156

Symbol: PDGFRA

Ensembl ID: ENSG00000134853

Description: platelet derived growth factor receptor alpha

Associated with

Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Drug resistance of pdgfr mutants
(R-HSA-9674415)
Imatinib-resistant pdgfr mutants
(R-HSA-9674396)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Pdgfr mutants bind tkis
(R-HSA-9674428)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Regorafenib-resistant pdgfr mutants
(R-HSA-9674403)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfra extracellular domain mutants
(R-HSA-9673770)
Signaling by pdgfra transmembrane, juxtamembrane and kinase domain mutants
(R-HSA-9673767)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Sorafenib-resistant pdgfr mutants
(R-HSA-9674404)
Sunitinib-resistant pdgfr mutants
(R-HSA-9674401)
Adrenal gland development
(GO:0030325)
Atp binding
(GO:0005524)
Cardiac myofibril assembly
(GO:0055003)
Cell activation
(GO:0001775)
Cell chemotaxis
(GO:0060326)
Cell junction
(GO:0030054)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to reactive oxygen species
(GO:0034614)
Cilium
(GO:0005929)
Cytoplasm
(GO:0005737)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic skeletal system morphogenesis
(GO:0048704)
Endoplasmic reticulum membrane
(GO:0005789)
Estrogen metabolic process
(GO:0008210)
External side of plasma membrane
(GO:0009897)
Extracellular matrix organization
(GO:0030198)
Face morphogenesis
(GO:0060325)
Golgi apparatus
(GO:0005794)
Hematopoietic progenitor cell differentiation
(GO:0002244)
In utero embryonic development
(GO:0001701)
Leydig cell differentiation
(GO:0033327)
Lung development
(GO:0030324)
Luteinization
(GO:0001553)
Male genitalia development
(GO:0030539)
Membrane
(GO:0016020)
Metanephric glomerular capillary formation
(GO:0072277)
Microvillus
(GO:0005902)
Multicellular organism development
(GO:0007275)
Negative regulation of platelet activation
(GO:0010544)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phospholipase c activator activity
(GO:0160185)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor alpha-receptor activity
(GO:0005018)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor receptor-alpha signaling pathway
(GO:0035790)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Platelet aggregation
(GO:0070527)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell proliferation by vegf-activated platelet derived growth factor receptor signaling pathway
(GO:0038091)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Receptor complex
(GO:0043235)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of mesenchymal stem cell differentiation
(GO:2000739)
Retina vasculature development in camera-type eye
(GO:0061298)
Roof of mouth development
(GO:0060021)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Vascular endothelial growth factor binding
(GO:0038085)
Vascular endothelial growth factor receptor activity
(GO:0005021)
White fat cell differentiation
(GO:0050872)
Wound healing
(GO:0042060)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 77.2344
Cell Significance Index: -19.5900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 40.9882
Cell Significance Index: -16.8900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 37.7444
Cell Significance Index: -17.8200
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 35.0517
Cell Significance Index: -14.2400
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.3130
Cell Significance Index: -14.6200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 8.4921
Cell Significance Index: 108.7600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.8580
Cell Significance Index: -19.1700
Cell Name: theca cell (CL0000503)
Fold Change: 4.6842
Cell Significance Index: 27.5200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.2425
Cell Significance Index: 582.6100
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.8447
Cell Significance Index: 26.0500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.3571
Cell Significance Index: 70.2700
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 3.2794
Cell Significance Index: 54.0400
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.2352
Cell Significance Index: 18.5500
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.9543
Cell Significance Index: 57.6600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.8927
Cell Significance Index: 82.9200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 2.8900
Cell Significance Index: 146.0500
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.6792
Cell Significance Index: 25.9800
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.5089
Cell Significance Index: 9.3400
Cell Name: odontoblast (CL0000060)
Fold Change: 1.4593
Cell Significance Index: 187.0800
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6676
Cell Significance Index: 14.2700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6253
Cell Significance Index: 32.5700
Cell Name: chondroblast (CL0000058)
Fold Change: 0.4804
Cell Significance Index: 2.8200
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.4738
Cell Significance Index: 4.3000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.3489
Cell Significance Index: 5.0100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0893
Cell Significance Index: 1.5000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0730
Cell Significance Index: 13.1600
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0696
Cell Significance Index: 128.4200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0672
Cell Significance Index: 103.4200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0650
Cell Significance Index: 23.3100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0520
Cell Significance Index: 32.4700
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0265
Cell Significance Index: 36.0000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0073
Cell Significance Index: 5.0800
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0048
Cell Significance Index: -0.0600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0071
Cell Significance Index: -13.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0073
Cell Significance Index: -5.3900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0115
Cell Significance Index: -6.4600
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: -0.0146
Cell Significance Index: -0.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0217
Cell Significance Index: -4.5700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0224
Cell Significance Index: -16.4100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0225
Cell Significance Index: -14.2900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0251
Cell Significance Index: -19.0200
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0252
Cell Significance Index: -5.0500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0271
Cell Significance Index: -14.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0331
Cell Significance Index: -15.0400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0391
Cell Significance Index: -1.8400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0437
Cell Significance Index: -7.4600
Cell Name: fibroblast of breast (CL4006000)
Fold Change: -0.0509
Cell Significance Index: -0.3200
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.0575
Cell Significance Index: -0.3600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0626
Cell Significance Index: -18.0000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0737
Cell Significance Index: -14.6200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0813
Cell Significance Index: -8.3000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0831
Cell Significance Index: -5.1100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0856
Cell Significance Index: -1.8500
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0857
Cell Significance Index: -1.3600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0868
Cell Significance Index: -9.9100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0934
Cell Significance Index: -13.5800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0975
Cell Significance Index: -11.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0989
Cell Significance Index: -7.5900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1053
Cell Significance Index: -13.6100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1255
Cell Significance Index: -14.6300
Cell Name: connective tissue cell (CL0002320)
Fold Change: -0.1691
Cell Significance Index: -1.6300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1785
Cell Significance Index: -20.4600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1826
Cell Significance Index: -19.0100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1948
Cell Significance Index: -10.9300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2215
Cell Significance Index: -16.5100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2601
Cell Significance Index: -17.4900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2902
Cell Significance Index: -17.7900
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: -0.3015
Cell Significance Index: -3.9400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3118
Cell Significance Index: -13.7900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3245
Cell Significance Index: -9.0700
Cell Name: muscle fibroblast (CL1001609)
Fold Change: -0.3298
Cell Significance Index: -2.0200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3362
Cell Significance Index: -21.1900
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3586
Cell Significance Index: -9.4300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3770
Cell Significance Index: -9.6900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4011
Cell Significance Index: -15.1900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.4103
Cell Significance Index: -9.8400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4139
Cell Significance Index: -21.7300
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4175
Cell Significance Index: -21.6900
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.4243
Cell Significance Index: -10.5800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4266
Cell Significance Index: -14.8300
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4296
Cell Significance Index: -15.7700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.4320
Cell Significance Index: -10.4700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.4472
Cell Significance Index: -20.8500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.4487
Cell Significance Index: -15.7200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4785
Cell Significance Index: -12.8000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.4902
Cell Significance Index: -7.0200
Cell Name: stromal cell (CL0000499)
Fold Change: -0.4918
Cell Significance Index: -5.0300
Cell Name: fibroblast (CL0000057)
Fold Change: -0.4932
Cell Significance Index: -4.6300
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.5134
Cell Significance Index: -5.3600
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5191
Cell Significance Index: -15.2900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5192
Cell Significance Index: -17.0000
Cell Name: Leydig cell (CL0000178)
Fold Change: -0.5412
Cell Significance Index: -2.7000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5579
Cell Significance Index: -17.7700
Cell Name: skin fibroblast (CL0002620)
Fold Change: -0.5760
Cell Significance Index: -1.3300
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5764
Cell Significance Index: -12.0300
Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.5781
Cell Significance Index: -18.2900
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: -0.5799
Cell Significance Index: -5.6100
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.5804
Cell Significance Index: -6.3100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5812
Cell Significance Index: -15.5200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.5972
Cell Significance Index: -17.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Receptor Tyrosine Kinase**: PDGFR is a receptor tyrosine kinase that undergoes autophosphorylation upon binding to its ligand, platelet-derived growth factor (PDGF). 2. **Dimerization**: PDGFR exists as a homodimer, consisting of two alpha subunits, which facilitates ligand binding and activation. 3. **Signaling Pathways**: PDGFR activation triggers a cascade of downstream signaling pathways, including the PI3K/AKT, MAPK/ERK, and JAK/STAT pathways. 4. **Cellular Expression**: PDGFR is expressed in various cell types, including fibroblasts, endothelial cells, and mesenchymal stem cells. **Pathways and Functions:** 1. **Cell Growth and Proliferation**: PDGFR signaling regulates cell growth, proliferation, and survival by activating downstream pathways, including the PI3K/AKT and MAPK/ERK pathways. 2. **Cell Migration and Chemotaxis**: PDGFR signaling promotes cell migration and chemotaxis by activating the Rho GTPase pathway. 3. **Differentiation and Morphogenesis**: PDGFR signaling regulates cell differentiation and morphogenesis in various tissues, including embryonic development and tissue repair. 4. **Angiogenesis**: PDGFR signaling promotes angiogenesis by regulating the expression of vascular endothelial growth factor (VEGF). **Clinical Significance:** 1. **Cancer**: Mutations in the PDGFR gene have been implicated in the pathogenesis of several cancers, including gastrointestinal stromal tumors (GISTs), breast cancer, and ovarian cancer. 2. **Cardiovascular Diseases**: PDGFR signaling plays a critical role in the development and progression of cardiovascular diseases, including atherosclerosis and hypertension. 3. **Autoimmune Disorders**: PDGFR signaling has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. 4. **Therapeutic Targeting**: PDGFR inhibitors, such as imatinib and sunitinib, have been developed to target PDGFR in cancer therapy. In conclusion, the PDGFRA gene plays a critical role in regulating cell growth, migration, and differentiation in various tissues. Aberrant activation of PDGFR has been implicated in the pathogenesis of several diseases, and targeting PDGFR has emerged as a promising therapeutic strategy in cancer therapy and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Platelet-derived growth factor receptor alpha

Genular Protein ID: 3155912552

Symbol: PGFRA_HUMAN

Name: Platelet-derived growth factor receptor alpha

UniProtKB Accession Codes:

P16234 B2RE69 E9PBH0 Q6P4H5 Q96KZ7 Q9UD28

Database IDs:

Citations:

PubMed ID: 2544881

Title: cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor.

PubMed ID: 2544881

DOI: 10.1073/pnas.86.13.4917

PubMed ID: 2536956

Title: Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.

PubMed ID: 2536956

DOI: 10.1126/science.2536956

PubMed ID: 8586421

Title: Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA.

PubMed ID: 8586421

DOI: 10.1006/geno.1995.9883

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12808148

Title: Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome.

PubMed ID: 12808148

DOI: 10.1073/pnas.0932698100

PubMed ID: 7896447

Title: Receptor tyrosine kinases expressed in metastatic colon cancer.

PubMed ID: 7896447

DOI: 10.1002/ijc.2910600611

PubMed ID: 2554309

Title: Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways.

PubMed ID: 2554309

DOI: 10.1073/pnas.86.21.8314

PubMed ID: 2173144

Title: Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors.

PubMed ID: 2173144

DOI: 10.1126/science.2173144

PubMed ID: 1709159

Title: Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation.

PubMed ID: 1709159

DOI: 10.1016/s0021-9258(18)31541-2

PubMed ID: 1646396

Title: Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

PubMed ID: 1646396

DOI: 10.1128/mcb.11.7.3780-3785.1991

PubMed ID: 7679113

Title: Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor.

PubMed ID: 7679113

DOI: 10.1016/s0021-9258(18)53739-x

PubMed ID: 8188664

Title: Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.

PubMed ID: 8188664

DOI: 10.1016/s0021-9258(17)36728-5

PubMed ID: 7535778

Title: Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors.

PubMed ID: 7535778

DOI: 10.1074/jbc.270.13.7773

PubMed ID: 8760137

Title: Maximal PDGF-induced lung fibroblast chemotaxis requires PDGF receptor-alpha.

PubMed ID: 8760137

DOI: 10.1152/ajplung.1996.271.1.l93

PubMed ID: 8617789

Title: Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis.

PubMed ID: 8617789

DOI: 10.1074/jbc.271.9.5101

PubMed ID: 8940081

Title: Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors.

PubMed ID: 8940081

DOI: 10.1074/jbc.271.48.30942

PubMed ID: 8943348

Title: Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.

PubMed ID: 8943348

DOI: 10.1128/mcb.16.12.6926

PubMed ID: 10733900

Title: Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.

PubMed ID: 10733900

DOI: 10.1006/bbrc.2000.2374

PubMed ID: 11095946

Title: Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis.

PubMed ID: 11095946

DOI: 10.1006/bbrc.2000.3847

PubMed ID: 10947961

Title: Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation.

PubMed ID: 10947961

DOI: 10.1042/bj3500469

PubMed ID: 10734113

Title: Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression.

PubMed ID: 10734113

DOI: 10.1074/jbc.275.13.9620

PubMed ID: 11297552

Title: Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor.

PubMed ID: 11297552

DOI: 10.1074/jbc.m101056200

PubMed ID: 14644164

Title: The role of c-Src in platelet-derived growth factor alpha receptor internalization.

PubMed ID: 14644164

DOI: 10.1016/j.yexcr.2003.08.001

PubMed ID: 12660384

Title: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.

PubMed ID: 12660384

DOI: 10.1056/nejmoa025217

PubMed ID: 12522257

Title: PDGFRA activating mutations in gastrointestinal stromal tumors.

PubMed ID: 12522257

DOI: 10.1126/science.1079666

PubMed ID: 15928335

Title: PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib.

PubMed ID: 15928335

DOI: 10.1200/jco.2005.14.068

PubMed ID: 17141222

Title: PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.

PubMed ID: 17141222

DOI: 10.1016/j.febslet.2006.11.034

PubMed ID: 17604334

Title: Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer.

PubMed ID: 17604334

DOI: 10.1158/1535-7163.mct-06-0720

PubMed ID: 20660204

Title: The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry.

PubMed ID: 20660204

DOI: 10.1128/jvi.00710-10

PubMed ID: 21224473

Title: Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease.

PubMed ID: 21224473

DOI: 10.1182/blood-2010-05-286757

PubMed ID: 21596750

Title: The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination.

PubMed ID: 21596750

DOI: 10.1074/jbc.m110.197525

PubMed ID: 20972453

Title: The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro.

PubMed ID: 20972453

DOI: 10.1038/onc.2010.476

PubMed ID: 9739761

Title: Signal transduction via platelet-derived growth factor receptors.

PubMed ID: 9739761

DOI: 10.1016/s0304-419x(98)00015-8

PubMed ID: 15207817

Title: PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma.

PubMed ID: 15207817

DOI: 10.1016/j.cytogfr.2004.03.002

PubMed ID: 17419949

Title: PDGF receptors as targets in tumor treatment.

PubMed ID: 17419949

DOI: 10.1016/s0065-230x(06)97011-0

PubMed ID: 18483217

Title: Role of platelet-derived growth factors in physiology and medicine.

PubMed ID: 18483217

DOI: 10.1101/gad.1653708

PubMed ID: 28403202

Title: Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-alpha as a key for entry.

PubMed ID: 28403202

DOI: 10.1371/journal.ppat.1006281

PubMed ID: 11882663

Title: Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors.

PubMed ID: 11882663

DOI: 10.1074/jbc.m201507200

PubMed ID: 33626330

Title: Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.

PubMed ID: 33626330

DOI: 10.1016/j.cell.2021.01.036

PubMed ID: 14699510

Title: PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor.

PubMed ID: 14699510

DOI: 10.1053/j.gastro.2003.10.079

PubMed ID: 17087943

Title: Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA.

PubMed ID: 17087943

DOI: 10.1053/j.gastro.2006.07.002

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 25975287

Title: PDGFRA-mutant syndrome.

PubMed ID: 25975287

DOI: 10.1038/modpathol.2015.56

Sequence Information:

Length: 1089
Mass: 122670
Checksum: 5E3FB9940ACD1BE8
Sequence:

MGTSHPAFLV LGCLLTGLSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWQYP 
MSEEESSDVE IRNEENNSGL FVTVLEVSSA SAAHTGLYTC YYNHTQTEEN ELEGRHIYIY 
VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LHNSEGVVPA SYDSRQGFNG 
TFTVGPYICE ATVKGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 
EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLTVPEA TVKDSGDYEC AARQATREVK 
EMKKVTISVH EKGFIEIKPT FSQLEAVNLH EVKHFVVEVR AYPPPRISWL KNNLTLIENL 
TEITTDVEKI QEIRYRSKLK LIRAKEEDSG HYTIVAQNED AVKSYTFELL TQVPSSILDL 
VDDHHGSTGG QTVRCTAEGT PLPDIEWMIC KDIKKCNNET SWTILANNVS NIITEIHSRD 
RSTVEGRVTF AKVEETIAVR CLAKNLLGAE NRELKLVAPT LRSELTVAAA VLVLLVIVII 
SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRVLG 
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 
LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY 
VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 
LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 
RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 
SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 
PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 
SDLVEDSFL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PDGFRA

Associated with

Cells (max top 100)

Other Information

cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. PubMed ID: 2544881

Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. PubMed ID: 2536956

Structure, organization, and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA. PubMed ID: 8586421

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. PubMed ID: 12808148

Receptor tyrosine kinases expressed in metastatic colon cancer. PubMed ID: 7896447

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. PubMed ID: 2554309

Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. PubMed ID: 2173144

Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation. PubMed ID: 1709159

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. PubMed ID: 1646396

Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor. PubMed ID: 7679113

Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor. PubMed ID: 8188664

Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors. PubMed ID: 7535778

Maximal PDGF-induced lung fibroblast chemotaxis requires PDGF receptor-alpha. PubMed ID: 8760137

Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis. PubMed ID: 8617789

Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors. PubMed ID: 8940081

Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation. PubMed ID: 8943348

Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. PubMed ID: 10733900

Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. PubMed ID: 11095946

Platelet-derived-growth-factor-induced signalling in human platelets: phosphoinositide-3-kinase-dependent inhibition of platelet activation. PubMed ID: 10947961

Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression. PubMed ID: 10734113

Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. PubMed ID: 11297552

The role of c-Src in platelet-derived growth factor alpha receptor internalization. PubMed ID: 14644164

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. PubMed ID: 12660384

PDGFRA activating mutations in gastrointestinal stromal tumors. PubMed ID: 12522257

PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. PubMed ID: 15928335

PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases. PubMed ID: 17141222

Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer. PubMed ID: 17604334

The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. PubMed ID: 20660204

Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease. PubMed ID: 21224473

The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination. PubMed ID: 21596750

The low frequency of clinical resistance to PDGFR inhibitors in myeloid neoplasms with abnormalities of PDGFRA might be related to the limited repertoire of possible PDGFRA kinase domain mutations in vitro. PubMed ID: 20972453

Signal transduction via platelet-derived growth factor receptors. PubMed ID: 9739761

PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. PubMed ID: 15207817

PDGF receptors as targets in tumor treatment. PubMed ID: 17419949

Role of platelet-derived growth factors in physiology and medicine. PubMed ID: 18483217

Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-alpha as a key for entry. PubMed ID: 28403202

Structural determinants of the Na+/H+ exchanger regulatory factor interaction with the beta 2 adrenergic and platelet-derived growth factor receptors. PubMed ID: 11882663

Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry. PubMed ID: 33626330

PDGFRA germline mutation in a family with multiple cases of gastrointestinal stromal tumor. PubMed ID: 14699510

Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA. PubMed ID: 17087943

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

PDGFRA-mutant syndrome. PubMed ID: 25975287