Details for: SLC4A3

Gene ID: 6508

Symbol: SLC4A3

Ensembl ID: ENSG00000114923

Description: solute carrier family 4 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 94.2491
    Cell Significance Index: -14.6600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7354
    Cell Significance Index: -14.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3505
    Cell Significance Index: 180.3700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.0512
    Cell Significance Index: 590.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8312
    Cell Significance Index: 18.2000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7108
    Cell Significance Index: 10.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.6692
    Cell Significance Index: 9.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5979
    Cell Significance Index: 113.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5352
    Cell Significance Index: 24.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4785
    Cell Significance Index: 15.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4707
    Cell Significance Index: 325.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3927
    Cell Significance Index: 17.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3832
    Cell Significance Index: 14.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3788
    Cell Significance Index: 10.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3749
    Cell Significance Index: 75.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3724
    Cell Significance Index: 8.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3588
    Cell Significance Index: 128.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3431
    Cell Significance Index: 21.0900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2745
    Cell Significance Index: 3.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2482
    Cell Significance Index: 13.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2203
    Cell Significance Index: 198.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2109
    Cell Significance Index: 20.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1926
    Cell Significance Index: 3.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1026
    Cell Significance Index: 6.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1022
    Cell Significance Index: 16.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0769
    Cell Significance Index: 8.3700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0412
    Cell Significance Index: 0.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0411
    Cell Significance Index: 5.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0333
    Cell Significance Index: 3.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0218
    Cell Significance Index: 0.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0176
    Cell Significance Index: 7.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0163
    Cell Significance Index: 30.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0117
    Cell Significance Index: 18.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0104
    Cell Significance Index: 0.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0096
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0047
    Cell Significance Index: 8.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0014
    Cell Significance Index: 0.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0031
    Cell Significance Index: -4.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0057
    Cell Significance Index: -0.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0139
    Cell Significance Index: -0.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0148
    Cell Significance Index: -0.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0172
    Cell Significance Index: -7.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0199
    Cell Significance Index: -2.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0221
    Cell Significance Index: -0.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0231
    Cell Significance Index: -17.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0232
    Cell Significance Index: -13.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0260
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0278
    Cell Significance Index: -17.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0282
    Cell Significance Index: -1.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0344
    Cell Significance Index: -2.3800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0395
    Cell Significance Index: -0.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0431
    Cell Significance Index: -7.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0433
    Cell Significance Index: -2.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0441
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0545
    Cell Significance Index: -9.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0547
    Cell Significance Index: -6.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0556
    Cell Significance Index: -1.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0600
    Cell Significance Index: -11.9000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0641
    Cell Significance Index: -0.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0725
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0777
    Cell Significance Index: -16.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0805
    Cell Significance Index: -9.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0852
    Cell Significance Index: -1.4600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0862
    Cell Significance Index: -1.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0936
    Cell Significance Index: -12.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0985
    Cell Significance Index: -2.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0990
    Cell Significance Index: -2.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1053
    Cell Significance Index: -10.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1068
    Cell Significance Index: -7.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1092
    Cell Significance Index: -1.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1421
    Cell Significance Index: -14.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1593
    Cell Significance Index: -11.8700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1679
    Cell Significance Index: -2.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1708
    Cell Significance Index: -13.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1714
    Cell Significance Index: -3.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1731
    Cell Significance Index: -4.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1733
    Cell Significance Index: -9.0000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1823
    Cell Significance Index: -2.6100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1846
    Cell Significance Index: -1.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1883
    Cell Significance Index: -2.3500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1926
    Cell Significance Index: -2.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1961
    Cell Significance Index: -12.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2372
    Cell Significance Index: -11.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2418
    Cell Significance Index: -15.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2441
    Cell Significance Index: -8.5500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2464
    Cell Significance Index: -2.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2482
    Cell Significance Index: -5.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2482
    Cell Significance Index: -13.9300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2554
    Cell Significance Index: -5.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2642
    Cell Significance Index: -5.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2749
    Cell Significance Index: -3.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2804
    Cell Significance Index: -9.1800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2923
    Cell Significance Index: -9.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2924
    Cell Significance Index: -7.9600
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.3419
    Cell Significance Index: -4.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3421
    Cell Significance Index: -7.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bicarbonate Transporter:** SLC4A3 is a bicarbonate transporter that facilitates the exchange of bicarbonate ions for chloride ions across the plasma membrane. 2. **Cardiac Conduction:** The SLC4A3 gene is significantly expressed in cardiac muscle cells, where it regulates the cardiac muscle cell action potential. 3. **Intracellular pH Regulation:** SLC4A3 helps maintain intracellular pH by regulating the transport of bicarbonate ions. 4. **Protein Binding:** The SLC4A3 protein binds to various proteins, including chloride channels, to regulate the transport of ions across the plasma membrane. 5. **Expression in Multiple Tissues:** SLC4A3 is expressed in various tissues, including cardiac muscle cells, enterocytes, neurons, and intestinal crypt stem cells. **Pathways and Functions:** 1. **Bicarbonate Transmembrane Transport:** SLC4A3 facilitates the transport of bicarbonate ions across the plasma membrane, regulating the balance of bicarbonate ions in the body. 2. **Cardiac Muscle Cell Action Potential:** The SLC4A3 gene regulates the cardiac muscle cell action potential by controlling the influx of chloride ions. 3. **Intracellular pH Regulation:** SLC4A3 helps maintain intracellular pH by regulating the transport of bicarbonate ions. 4. **Chloride:Bicarbonate Antiporter Activity:** The SLC4A3 protein exhibits chloride:bicarbonate antiporter activity, regulating the exchange of chloride ions for bicarbonate ions. 5. **Regulation of Cardiac Conduction:** SLC4A3 regulates the cardiac muscle cell action potential by controlling the influx of chloride ions. **Clinical Significance:** 1. **Cardiovascular Disease:** Abnormal expression or function of SLC4A3 has been linked to various cardiovascular diseases, including arrhythmias and cardiac conduction disorders. 2. **Respiratory Disease:** SLC4A3 has been implicated in respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and pulmonary hypertension. 3. **Neurological Disorders:** The SLC4A3 gene has been linked to various neurological disorders, including epilepsy and Parkinson's disease. 4. **Gastrointestinal Disorders:** Abnormal expression of SLC4A3 has been linked to gastrointestinal disorders, such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). In conclusion, the SLC4A3 gene plays a critical role in regulating bicarbonate transport and cardiac function. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 2488590404

Symbol: B3A3_HUMAN

Name: Anion exchange protein 3

UniProtKB Accession Codes:

P48751 A6H8L2 A8K1Q9 B7ZVX6 B9EGD1 Q6YIQ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 4 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7923606

Title: Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.

PubMed ID: 7923606

DOI: 10.1161/01.res.75.4.603

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29167417

Title: Loss-of-activity-mutation in the cardiac chloride-bicarbonate exchanger AE3 causes short QT syndrome.

PubMed ID: 29167417

DOI: 10.1038/s41467-017-01630-0

PubMed ID: 36806574

Title: Genetic analysis identifies the SLC4A3 anion exchanger as a major gene for short QT syndrome.

PubMed ID: 36806574

DOI: 10.1016/j.hrthm.2023.02.010

Sequence Information:

  • Length: 1232
  • Mass: 135791
  • Checksum: BA0B360E9D30030A
  • Sequence:
    • MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE 
KPSRSYSERD FEFHRHTSHH THHPLSARLP PPHKLRRLPP TSARHTRRKR KKEKTSAPPS 
EGTPPIQEEG GAGVDEEEEE EEEEEGESEA EPVEPPHSGT PQKAKFSIGS DEDDSPGLPG 
RAAVTKPLPS VGPHTDKSPQ HSSSSPSPRA RASRLAGEKS RPWSPSASYD LRERLCPGSA 
LGNPGGPEQQ VPTDEAEAQM LGSADLDDMK SHRLEDNPGV RRHLVKKPSR TQGGRGSPSG 
LAPILRRKKK KKKLDRRPHE VFVELNELML DRSQEPHWRE TARWIKFEED VEEETERWGK 
PHVASLSFRS LLELRRTIAH GAALLDLEQT TLPGIAHLVV ETMIVSDQIR PEDRASVLRT 
LLLKHSHPND DKDSGFFPRN PSSSSMNSVL GNHHPTPSHG PDGAVPTMAD DLGEPAPLWP 
HDPDAKEKPL HMPGGDGHRG KSLKLLEKIP EDAEATVVLV GCVPFLEQPA AAFVRLNEAV 
LLESVLEVPV PVRFLFVMLG PSHTSTDYHE LGRSIATLMS DKLFHEAAYQ ADDRQDLLSA 
ISEFLDGSIV IPPSEVEGRD LLRSVAAFQR ELLRKRRERE QTKVEMTTRG GYTAPGKELS 
LELGGSEATP EDDPLLRTGS VFGGLVRDVR RRYPHYPSDL RDALHSQCVA AVLFIYFAAL 
SPAITFGGLL GEKTEGLMGV SELIVSTAVL GVLFSLLGAQ PLLVVGFSGP LLVFEEAFFK 
FCRAQDLEYL TGRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF 
YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQP NTALLSLILM 
LGTFFIAFFL RKFRNSRFLG GKARRIIGDF GIPISILVMV LVDYSITDTY TQKLTVPTGL 
SVTSPDKRSW FIPPLGSARP FPPWMMVAAA VPALLVLILI FMETQITALI VSQKARRLLK 
GSGFHLDLLL IGSLGGLCGL FGLPWLTAAT VRSVTHVNAL TVMRTAIAPG DKPQIQEVRE 
QRVTGVLIAS LVGLSIVMGA VLRRIPLAVL FGIFLYMGVT SLSGIQLSQR LLLILMPAKH 
HPEQPYVTKV KTWRMHLFTC IQLGCIALLW VVKSTAASLA FPFLLLLTVP LRHCLLPRLF 
QDRELQALDS EDAEPNFDED GQDEYNELHM PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.