Details for: NMRK2

Gene ID: 27231

Symbol: NMRK2

Ensembl ID: ENSG00000077009

Description: nicotinamide riboside kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9677
    Cell Significance Index: 151.0000
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.8948
    Cell Significance Index: 5.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.5579
    Cell Significance Index: 23.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.4619
    Cell Significance Index: 35.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4522
    Cell Significance Index: 35.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9399
    Cell Significance Index: 24.1600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.7462
    Cell Significance Index: 12.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5152
    Cell Significance Index: 13.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.4391
    Cell Significance Index: 44.8600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3529
    Cell Significance Index: 2.6700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1936
    Cell Significance Index: 3.1900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1866
    Cell Significance Index: 2.0900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1484
    Cell Significance Index: 2.2200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.1267
    Cell Significance Index: 1.6600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0964
    Cell Significance Index: 1.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0488
    Cell Significance Index: 0.4100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0188
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0161
    Cell Significance Index: 30.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0070
    Cell Significance Index: 3.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0046
    Cell Significance Index: 0.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0038
    Cell Significance Index: 2.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0037
    Cell Significance Index: 0.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0026
    Cell Significance Index: 3.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0036
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0056
    Cell Significance Index: -3.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0057
    Cell Significance Index: -1.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0069
    Cell Significance Index: -1.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0082
    Cell Significance Index: -1.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0090
    Cell Significance Index: -1.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0106
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0130
    Cell Significance Index: -2.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0142
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0172
    Cell Significance Index: -2.1100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0179
    Cell Significance Index: -0.2300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0209
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0216
    Cell Significance Index: -2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0224
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0231
    Cell Significance Index: -2.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0242
    Cell Significance Index: -1.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0245
    Cell Significance Index: -0.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0364
    Cell Significance Index: -1.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0379
    Cell Significance Index: -2.5500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0434
    Cell Significance Index: -0.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0443
    Cell Significance Index: -2.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0457
    Cell Significance Index: -2.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0474
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0494
    Cell Significance Index: -0.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0520
    Cell Significance Index: -2.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0521
    Cell Significance Index: -1.0900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0526
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0540
    Cell Significance Index: -3.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0548
    Cell Significance Index: -1.5300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0555
    Cell Significance Index: -0.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0588
    Cell Significance Index: -2.6000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0628
    Cell Significance Index: -0.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0629
    Cell Significance Index: -1.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0637
    Cell Significance Index: -0.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0647
    Cell Significance Index: -3.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0667
    Cell Significance Index: -2.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0688
    Cell Significance Index: -2.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0706
    Cell Significance Index: -2.2500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0719
    Cell Significance Index: -0.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0721
    Cell Significance Index: -2.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0722
    Cell Significance Index: -2.9600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0794
    Cell Significance Index: -0.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0804
    Cell Significance Index: -2.9500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0818
    Cell Significance Index: -2.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0835
    Cell Significance Index: -2.2300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0890
    Cell Significance Index: -1.2000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0897
    Cell Significance Index: -1.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0901
    Cell Significance Index: -2.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0901
    Cell Significance Index: -1.0200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0902
    Cell Significance Index: -0.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0908
    Cell Significance Index: -2.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0911
    Cell Significance Index: -0.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0916
    Cell Significance Index: -3.2200
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0942
    Cell Significance Index: -1.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0966
    Cell Significance Index: -2.5900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0995
    Cell Significance Index: -1.0700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0996
    Cell Significance Index: -1.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1019
    Cell Significance Index: -2.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1039
    Cell Significance Index: -2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1047
    Cell Significance Index: -2.8500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1091
    Cell Significance Index: -1.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1095
    Cell Significance Index: -2.8800
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.1099
    Cell Significance Index: -1.1900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1103
    Cell Significance Index: -2.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1107
    Cell Significance Index: -3.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1119
    Cell Significance Index: -2.3800
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1119
    Cell Significance Index: -1.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1125
    Cell Significance Index: -2.4300
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1138
    Cell Significance Index: -1.1900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1147
    Cell Significance Index: -1.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1161
    Cell Significance Index: -2.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NMRK2 is a cytosolic enzyme that exhibits ribosylnicotinate kinase activity, converting nicotinamide riboside (NR) into nicotinamide mononucleotide (NMN). This reaction is a critical step in the biosynthesis of NAD+, a vital coenzyme involved in energy metabolism, DNA repair, and redox regulation. NMRK2 is specifically expressed in various cell types, including conventional dendritic cells, cardiac myocytes, plasma cells, and embryonic stem cells, suggesting its involvement in immune response, cardiovascular function, and cellular differentiation. **Pathways and Functions:** NMRK2 is implicated in several metabolic pathways, including: 1. **Nicotinate Metabolism:** NMRK2 catalyzes the conversion of NR into NMN, which is then converted into NAD+ by the enzyme NMN adenosine dinucleotide phosphoribosyltransferase (NAMPT). This pathway is essential for maintaining NAD+ levels, which are critical for energy metabolism, DNA repair, and redox regulation. 2. **NAD Biosynthetic Process:** NMRK2 is involved in the biosynthesis of NAD+, which is a key coenzyme in various cellular processes, including energy metabolism, DNA repair, and redox regulation. 3. **Negative Regulation of Myoblast Differentiation:** NMRK2 has been shown to inhibit myoblast differentiation, suggesting its role in regulating muscle development and function. 4. **Metal Ion Binding:** NMRK2 exhibits metal ion binding activity, which may be involved in its enzymatic activity and regulation. **Clinical Significance:** Dysregulation of NMRK2 has been implicated in various human diseases, including: 1. **Cardiovascular Disease:** Reduced NMRK2 expression has been observed in cardiac myocytes of patients with heart failure, suggesting its role in regulating cardiac function and metabolism. 2. **Immune System Disorders:** NMRK2 is expressed in conventional dendritic cells, suggesting its involvement in immune response and regulation. 3. **Cancer:** Abnormal NMRK2 expression has been observed in certain types of cancer, including breast and lung cancer, suggesting its role in tumorigenesis and cancer progression. In conclusion, NMRK2 is a novel enzyme that plays a crucial role in regulating cellular metabolism, particularly in the context of nicotinate metabolism and nucleotide biosynthesis. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 1673732774

Symbol: NRK2_HUMAN

Name: Nicotinamide riboside kinase 2

UniProtKB Accession Codes:

Q9NPI5 B7ZKR3 Q52M81 Q9NZK3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 16 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10613898

Title: A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates myogenic differentiation.

PubMed ID: 10613898

DOI: 10.1083/jcb.147.7.1391

PubMed ID: 15137942

Title: Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans.

PubMed ID: 15137942

DOI: 10.1016/s0092-8674(04)00416-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12941630

Title: The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition.

PubMed ID: 12941630

DOI: 10.1016/s0012-1606(03)00304-x

PubMed ID: 17914902

Title: Nicotinamide riboside kinase structures reveal new pathways to NAD+.

PubMed ID: 17914902

DOI: 10.1371/journal.pbio.0050263

Sequence Information:

  • Length: 230
  • Mass: 26046
  • Checksum: 27F8275A596758E7
  • Sequence:
    • MKLIVGIGGM TNGGKTTLTN SLLRALPNCC VIHQDDFFKP QDQIAVGEDG FKQWDVLESL 
DMEAMLDTVQ AWLSSPQKFA RAHGVSVQPE ASDTHILLLE GFLLYSYKPL VDLYSRRYFL 
TVPYEECKWR RSTRNYTVPD PPGLFDGHVW PMYQKYRQEM EANGVEVVYL DGMKSREELF 
REVLEDIQNS LLNRSQESAP SPARPARTQG PGRGCGHRTA RPAASQQDSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.