Details for: TNNI3

Gene ID: 7137

Symbol: TNNI3

Ensembl ID: ENSG00000129991

Description: troponin I3, cardiac type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 6.99
    Marker Score: 3528
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 5.62
    Marker Score: 2329
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 5.2
    Marker Score: 31273
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.57
    Marker Score: 102155
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.47
    Marker Score: 1141
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.22
    Marker Score: 11458.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.2
    Marker Score: 13065.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.98
    Marker Score: 2471
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.98
    Marker Score: 26377
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.78
    Marker Score: 3112
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.61
    Marker Score: 517
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169119
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18001
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 703.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251807
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.01
    Marker Score: 420
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71825
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.94
    Marker Score: 1358
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5328
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.89
    Marker Score: 495
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.79
    Marker Score: 987
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.78
    Marker Score: 225
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.71
    Marker Score: 12689
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.7
    Marker Score: 2414
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 434
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.65
    Marker Score: 161
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.6
    Marker Score: 955
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.45
    Marker Score: 105
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.44
    Marker Score: 294
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.42
    Marker Score: 156
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.41
    Marker Score: 102
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.41
    Marker Score: 841
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.41
    Marker Score: 300
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.32
    Marker Score: 154
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.32
    Marker Score: 2750
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.31
    Marker Score: 272
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.31
    Marker Score: 324
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.3
    Marker Score: 148
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.29
    Marker Score: 3856
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.28
    Marker Score: 555
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 164
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 134
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.28
    Marker Score: 526
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.27
    Marker Score: 747
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.27
    Marker Score: 129
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.27
    Marker Score: 418
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.27
    Marker Score: 124
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.26
    Marker Score: 286
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.25
    Marker Score: 102
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.24
    Marker Score: 152
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.24
    Marker Score: 229
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.24
    Marker Score: 208
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.23
    Marker Score: 899
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 708
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.23
    Marker Score: 427
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.21
    Marker Score: 226
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.2
    Marker Score: 152
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2
    Marker Score: 2000.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 110
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.18
    Marker Score: 124
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.18
    Marker Score: 90
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.17
    Marker Score: 351
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 74
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.16
    Marker Score: 61
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.15
    Marker Score: 62
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.15
    Marker Score: 279
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.14
    Marker Score: 103
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.14
    Marker Score: 4936

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Other Information

**Key Characteristics:** TNNI3 is a member of the troponin family, which is essential for the regulation of muscle contraction. The cardiac type of troponin I, TNNI3, is specifically expressed in cardiac muscle cells and is involved in the regulation of cardiac muscle contraction. TNNI3 shares structural and functional similarities with other troponin isoforms, but its unique expression pattern and regulatory mechanisms set it apart from other troponin isoforms. **Pathways and Functions:** TNNI3 is involved in several key pathways that regulate cardiac muscle contraction, including: 1. **Cardiac Contraction:** TNNI3 interacts with troponin C and troponin T to modulate the interaction between actin and myosin, thereby controlling the contraction and relaxation of cardiac muscle cells. 2. **Calcium-dependent Protein Binding:** TNNI3 binds to calcium ions, which triggers a conformational change in the troponin complex, ultimately leading to the regulation of muscle contraction. 3. **Regulation of Cardiac Muscle Contraction by Calcium Ion Signaling:** TNNI3 plays a crucial role in the regulation of cardiac muscle contraction by calcium ion signaling, which is essential for maintaining cardiac function. 4. **Intracellular Calcium Ion Homeostasis:** TNNI3 is involved in maintaining intracellular calcium ion homeostasis, which is critical for regulating cardiac muscle contraction. **Clinical Significance:** Dysregulation of TNNI3 has been implicated in various cardiac disorders, including: 1. **Cardiac Hypertrophy:** Alterations in TNNI3 expression have been linked to cardiac hypertrophy, a condition characterized by an increase in cardiac muscle mass. 2. **Cardiac Arrhythmias:** Abnormalities in TNNI3 expression have been associated with cardiac arrhythmias, which are irregular heartbeats that can lead to cardiac dysfunction. 3. **Heart Failure:** TNNI3 dysregulation has been implicated in the development of heart failure, a condition characterized by the inability of the heart to pump sufficient blood to meet the body's needs. In conclusion, TNNI3 plays a critical role in regulating cardiac muscle contraction and maintaining cardiac function. Dysregulation of TNNI3 has been implicated in various cardiac disorders, highlighting the importance of this gene in understanding the pathogenesis of cardiac diseases. Further research is needed to elucidate the molecular mechanisms underlying TNNI3 dysregulation and to develop novel therapeutic strategies for the treatment of cardiac disorders.

Genular Protein ID: 2290306481

Symbol: TNNI3_HUMAN

Name: Troponin I, cardiac muscle

UniProtKB Accession Codes:

P19429

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 3 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 9 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 31 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2226790

Title: Molecular cloning of human cardiac troponin I using polymerase chain reaction.

PubMed ID: 2226790

DOI: 10.1016/0014-5793(90)81234-f

PubMed ID: 8406024

Title: Cloning and expression in Escherichia coli of the cDNA encoding human cardiac troponin I.

PubMed ID: 8406024

DOI: 10.1016/0378-1119(93)90308-p

PubMed ID: 1934363

Title: Troponin I isoform expression in human heart.

PubMed ID: 1934363

DOI: 10.1161/01.res.69.5.1409

PubMed ID: 8661099

Title: Isolation and characterization of the human cardiac troponin I gene (TNNI3).

PubMed ID: 8661099

DOI: 10.1006/geno.1996.0317

PubMed ID: 2226863

Title: A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I.

PubMed ID: 2226863

DOI: 10.1016/0014-5793(90)81046-q

PubMed ID: 9346285

Title: The ordered phosphorylation of cardiac troponin I by the cAMP-dependent protein kinase -- structural consequences and functional implications.

PubMed ID: 9346285

DOI: 10.1111/j.1432-1033.1997.00329.x

PubMed ID: 12242269

Title: p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.

PubMed ID: 12242269

DOI: 10.1161/01.res.0000035246.27856.53

PubMed ID: 15514163

Title: Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function.

PubMed ID: 15514163

DOI: 10.1161/01.res.0000149299.34793.3c

PubMed ID: 15601779

Title: Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.

PubMed ID: 15601779

DOI: 10.1073/pnas.0404341102

PubMed ID: 18986304

Title: Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1.

PubMed ID: 18986304

DOI: 10.1042/bj20081340

PubMed ID: 22972900

Title: Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart.

PubMed ID: 22972900

DOI: 10.1161/circulationaha.112.096388

PubMed ID: 10387074

Title: Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.

PubMed ID: 10387074

DOI: 10.1021/bi9901679

PubMed ID: 12060657

Title: Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil.

PubMed ID: 12060657

DOI: 10.1074/jbc.m203896200

PubMed ID: 9241277

Title: Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy.

PubMed ID: 9241277

DOI: 10.1038/ng0897-379

PubMed ID: 11815426

Title: Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.

PubMed ID: 11815426

DOI: 10.1161/hc0402.102990

PubMed ID: 12531876

Title: Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations.

PubMed ID: 12531876

DOI: 10.1172/jci16336

PubMed ID: 12707239

Title: Hypertrophic cardiomyopathy: distribution of disease genes, spectrum of mutations, and implications for a molecular diagnosis strategy.

PubMed ID: 12707239

DOI: 10.1161/01.cir.0000066323.15244.54

PubMed ID: 12974739

Title: Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy.

PubMed ID: 12974739

DOI: 10.1034/j.1399-0004.2003.00151.x

PubMed ID: 15070570

Title: Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy.

PubMed ID: 15070570

DOI: 10.1016/s0140-6736(04)15468-8

PubMed ID: 16199542

Title: Compound and double mutations in patients with hypertrophic cardiomyopathy: implications for genetic testing and counselling.

PubMed ID: 16199542

DOI: 10.1136/jmg.2005.033886

PubMed ID: 19590045

Title: Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy.

PubMed ID: 19590045

DOI: 10.1161/circresaha.109.196055

PubMed ID: 21846512

Title: Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy.

PubMed ID: 21846512

DOI: 10.1016/j.ejmg.2011.07.005

Sequence Information:

  • Length: 210
  • Mass: 24008
  • Checksum: 20A804F8C24AE1B0
  • Sequence:
    • MADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK TLLLQIAKQE 
LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL HARVDKVDEE RYDIEAKVTK 
NITEIADLTQ KIFDLRGKFK RPTLRRVRIS ADAMMQALLG ARAKESLDLR AHLKQVKKED 
TEKENREVGD WRKNIDALSG MEGRKKKFES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.