Details for: ANKRD1

Gene ID: 27063

Symbol: ANKRD1

Ensembl ID: ENSG00000148677

Description: ankyrin repeat domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 8.7265
    Cell Significance Index: 212.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 7.4763
    Cell Significance Index: 573.7200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 7.1223
    Cell Significance Index: 114.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 7.0837
    Cell Significance Index: 104.5800
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 5.2760
    Cell Significance Index: 15.1200
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 1.2505
    Cell Significance Index: 5.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.9205
    Cell Significance Index: 23.6600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.8844
    Cell Significance Index: 10.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4762
    Cell Significance Index: 260.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2560
    Cell Significance Index: 3.9600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2221
    Cell Significance Index: 3.1900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1705
    Cell Significance Index: 1.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1346
    Cell Significance Index: 248.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0473
    Cell Significance Index: 0.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0422
    Cell Significance Index: 4.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0381
    Cell Significance Index: 7.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0293
    Cell Significance Index: 3.3500
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.0262
    Cell Significance Index: 0.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0119
    Cell Significance Index: 1.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0085
    Cell Significance Index: 13.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0024
    Cell Significance Index: -1.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0027
    Cell Significance Index: -0.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0030
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0034
    Cell Significance Index: -2.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0047
    Cell Significance Index: -0.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0109
    Cell Significance Index: -7.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0127
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0154
    Cell Significance Index: -2.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0174
    Cell Significance Index: -7.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0263
    Cell Significance Index: -9.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0311
    Cell Significance Index: -5.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0317
    Cell Significance Index: -9.1400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0359
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0481
    Cell Significance Index: -5.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0505
    Cell Significance Index: -10.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0543
    Cell Significance Index: -7.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0591
    Cell Significance Index: -7.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0760
    Cell Significance Index: -10.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1102
    Cell Significance Index: -5.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1195
    Cell Significance Index: -3.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1461
    Cell Significance Index: -9.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1528
    Cell Significance Index: -9.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1531
    Cell Significance Index: -7.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1608
    Cell Significance Index: -9.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1615
    Cell Significance Index: -9.9000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1650
    Cell Significance Index: -9.2600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1691
    Cell Significance Index: -2.5300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1713
    Cell Significance Index: -2.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1827
    Cell Significance Index: -8.0800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1885
    Cell Significance Index: -2.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1889
    Cell Significance Index: -8.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1900
    Cell Significance Index: -9.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1950
    Cell Significance Index: -2.1200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1999
    Cell Significance Index: -3.7000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2095
    Cell Significance Index: -6.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2118
    Cell Significance Index: -7.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2142
    Cell Significance Index: -8.1100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2191
    Cell Significance Index: -3.6100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2196
    Cell Significance Index: -0.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2226
    Cell Significance Index: -4.6600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2428
    Cell Significance Index: -3.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2512
    Cell Significance Index: -9.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2519
    Cell Significance Index: -7.2200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2596
    Cell Significance Index: -8.2100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2725
    Cell Significance Index: -3.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2777
    Cell Significance Index: -9.7300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3009
    Cell Significance Index: -4.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3045
    Cell Significance Index: -8.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3164
    Cell Significance Index: -7.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3221
    Cell Significance Index: -8.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3235
    Cell Significance Index: -10.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3292
    Cell Significance Index: -5.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3356
    Cell Significance Index: -10.6900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.3363
    Cell Significance Index: -3.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3468
    Cell Significance Index: -8.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3471
    Cell Significance Index: -9.9100
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.3612
    Cell Significance Index: -3.4600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3671
    Cell Significance Index: -3.1200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3700
    Cell Significance Index: -9.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3705
    Cell Significance Index: -9.4400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.3726
    Cell Significance Index: -4.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3867
    Cell Significance Index: -9.8800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.3915
    Cell Significance Index: -5.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3971
    Cell Significance Index: -10.8100
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.4088
    Cell Significance Index: -5.1800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.4116
    Cell Significance Index: -5.1700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.4131
    Cell Significance Index: -5.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4215
    Cell Significance Index: -9.2300
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.4244
    Cell Significance Index: -4.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4261
    Cell Significance Index: -10.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4342
    Cell Significance Index: -10.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4371
    Cell Significance Index: -6.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4499
    Cell Significance Index: -7.9500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.4525
    Cell Significance Index: -4.3900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4695
    Cell Significance Index: -9.1800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4699
    Cell Significance Index: -9.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Ankyrin Repeat Domain**: ANKRD1 contains a conserved ankyrin repeat domain, which is a characteristic motif found in numerous proteins involved in protein-protein interactions. 2. **Transcriptional Regulation**: ANKRD1 acts as a transcriptional regulator, modulating the expression of genes involved in cardiac development, metabolism, and immune response. 3. **Cellular Response to Stimuli**: ANKRD1 is responsive to a range of cellular stimuli, including cytokines, lipopolysaccharides, and xenobiotics, which can trigger various signaling pathways. 4. **Interactions with Other Proteins**: ANKRD1 interacts with numerous proteins, including histone deacetylases, P53, and PPARα, which are involved in various cellular processes. **Pathways and Functions** ANKRD1 is involved in several signaling pathways, including: 1. **Cardiac Muscle Tissue Morphogenesis**: ANKRD1 regulates the development and organization of cardiac muscle tissue. 2. **Cellular Response to Interleukin-1 (IL-1)**: ANKRD1 modulates the expression of genes involved in inflammation and immune response. 3. **Cellular Response to Lipopolysaccharide (LPS)**: ANKRD1 is responsive to LPS, which can trigger the expression of genes involved in immune response and inflammation. 4. **Metabolism**: ANKRD1 regulates lipid metabolism by modulating the expression of genes involved in fatty acid synthesis and degradation. 5. **Apoptosis**: ANKRD1 promotes apoptosis in certain cell types, which is essential for maintaining tissue homeostasis. **Clinical Significance** The dysregulation of ANKRD1 has been implicated in various diseases, including: 1. **Cardiac Arrhythmias**: Alterations in ANKRD1 expression have been linked to cardiac arrhythmias, including atrial fibrillation. 2. **Metabolic Disorders**: ANKRD1 has been implicated in the regulation of lipid metabolism, which is essential for the development of metabolic disorders, such as type 2 diabetes and atherosclerosis. 3. **Cancer**: ANKRD1 has been identified as a tumor suppressor gene, which is involved in the regulation of cell growth and apoptosis. 4. **Inflammatory Disorders**: ANKRD1 has been implicated in the regulation of immune response and inflammation, which is essential for the development of inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, ANKRD1 is a critical regulator of cellular response and metabolism, with implications for various diseases, including cardiac arrhythmias, metabolic disorders, and cancer. Further research is necessary to fully understand the role of ANKRD1 in human disease and to develop therapeutic strategies to modulate its expression and activity.

Genular Protein ID: 448361120

Symbol: ANKR1_HUMAN

Name: Ankyrin repeat domain-containing protein 1

UniProtKB Accession Codes:

Q15327 Q96LE7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7730328

Title: Identification and characterization of a novel cytokine-inducible nuclear protein from human endothelial cells.

PubMed ID: 7730328

DOI: 10.1074/jbc.270.17.10236

PubMed ID: 15805281

Title: Identification of the genes involved in enhanced fenretinide-induced apoptosis by parthenolide in human hepatoma cells.

PubMed ID: 15805281

DOI: 10.1158/0008-5472.can-04-2221

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14583192

Title: The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules.

PubMed ID: 14583192

DOI: 10.1016/j.jmb.2003.09.012

PubMed ID: 18273862

Title: Transcriptional deregulation and a missense mutation define ANKRD1 as a candidate gene for total anomalous pulmonary venous return.

PubMed ID: 18273862

DOI: 10.1002/humu.20711

Sequence Information:

  • Length: 319
  • Mass: 36252
  • Checksum: 9AD91D2B1344A235
  • Sequence:
    • MMVLKVEELV TGKKNGNGEA GEFLPEDFRD GEYEAAVTLE KQEDLKTLLA HPVTLGEQQW 
KSEKQREAEL KKKKLEQRSK LENLEDLEII IQLKKRKKYR KTKVPVVKEP EPEIITEPVD 
VPTFLKAALE NKLPVVEKFL SDKNNPDVCD EYKRTALHRA CLEGHLAIVE KLMEAGAQIE 
FRDMLESTAI HWASRGGNLD VLKLLLNKGA KISARDKLLS TALHVAVRTG HYECAEHLIA 
CEADLNAKDR EGDTPLHDAV RLNRYKMIRL LIMYGADLNI KNCAGKTPMD LVLHWQNGTK 
AIFDSLRENS YKTSRIATF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.