Details for: TECRL

Gene ID: 253017

Symbol: TECRL

Ensembl ID: ENSG00000205678

Description: trans-2,3-enoyl-CoA reductase like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 7.9051
    Cell Significance Index: 606.6300
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 4.7072
    Cell Significance Index: 13.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.0302
    Cell Significance Index: 59.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.6698
    Cell Significance Index: 89.5400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 2.4362
    Cell Significance Index: 30.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1437
    Cell Significance Index: 16.4500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.1249
    Cell Significance Index: 9.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6027
    Cell Significance Index: 16.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5789
    Cell Significance Index: 7.1800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5300
    Cell Significance Index: 7.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4248
    Cell Significance Index: 10.9200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2908
    Cell Significance Index: 4.1700
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.2676
    Cell Significance Index: 2.5600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1818
    Cell Significance Index: 2.6100
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1406
    Cell Significance Index: 1.6000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.1271
    Cell Significance Index: 2.0500
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.0889
    Cell Significance Index: 1.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0846
    Cell Significance Index: 1.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0813
    Cell Significance Index: 4.2700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0561
    Cell Significance Index: 1.4000
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.0063
    Cell Significance Index: 0.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0061
    Cell Significance Index: 4.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0021
    Cell Significance Index: 3.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0012
    Cell Significance Index: 1.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0057
    Cell Significance Index: -3.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0065
    Cell Significance Index: -4.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0068
    Cell Significance Index: -3.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0070
    Cell Significance Index: -1.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -4.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0107
    Cell Significance Index: -3.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0121
    Cell Significance Index: -3.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0122
    Cell Significance Index: -2.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0153
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0168
    Cell Significance Index: -2.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0213
    Cell Significance Index: -3.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0215
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0246
    Cell Significance Index: -4.2100
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0290
    Cell Significance Index: -0.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0304
    Cell Significance Index: -3.5400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0314
    Cell Significance Index: -0.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0317
    Cell Significance Index: -3.9000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0364
    Cell Significance Index: -1.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0390
    Cell Significance Index: -1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0411
    Cell Significance Index: -2.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0418
    Cell Significance Index: -4.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0464
    Cell Significance Index: -4.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0539
    Cell Significance Index: -2.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0583
    Cell Significance Index: -1.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0583
    Cell Significance Index: -0.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0605
    Cell Significance Index: -0.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0620
    Cell Significance Index: -1.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0706
    Cell Significance Index: -4.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0715
    Cell Significance Index: -3.6100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0751
    Cell Significance Index: -1.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0763
    Cell Significance Index: -4.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0765
    Cell Significance Index: -3.9900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0773
    Cell Significance Index: -1.0000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0856
    Cell Significance Index: -0.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0940
    Cell Significance Index: -4.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0940
    Cell Significance Index: -1.6200
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1020
    Cell Significance Index: -1.0900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1033
    Cell Significance Index: -2.5800
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1052
    Cell Significance Index: -0.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1080
    Cell Significance Index: -3.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1082
    Cell Significance Index: -3.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1104
    Cell Significance Index: -1.2000
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1107
    Cell Significance Index: -1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1115
    Cell Significance Index: -4.9300
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1149
    Cell Significance Index: -1.5500
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1157
    Cell Significance Index: -1.1800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1210
    Cell Significance Index: -1.5500
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1219
    Cell Significance Index: -1.3100
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1237
    Cell Significance Index: -1.2000
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1267
    Cell Significance Index: -1.2400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1272
    Cell Significance Index: -0.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1279
    Cell Significance Index: -4.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1283
    Cell Significance Index: -4.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1295
    Cell Significance Index: -4.9100
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1305
    Cell Significance Index: -1.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1311
    Cell Significance Index: -3.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1326
    Cell Significance Index: -3.8200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1326
    Cell Significance Index: -0.8800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1344
    Cell Significance Index: -1.7200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1426
    Cell Significance Index: -3.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1429
    Cell Significance Index: -6.2100
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1430
    Cell Significance Index: -1.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1501
    Cell Significance Index: -2.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1558
    Cell Significance Index: -4.1600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1581
    Cell Significance Index: -2.2500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1598
    Cell Significance Index: -1.0200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.1600
    Cell Significance Index: -1.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1615
    Cell Significance Index: -2.7200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1686
    Cell Significance Index: -4.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1748
    Cell Significance Index: -3.5100
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1748
    Cell Significance Index: -2.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Function:** TECRL is an oxidoreductase enzyme that catalyzes the reduction of trans-2,3-enoyl-CoA, a key intermediate in the biosynthesis of very long-chain fatty acyl-CoAs. 2. **Cellular Expression:** TECRL is expressed in a wide range of cell types, including progenitor cells, cardiac myocytes, endothelial cells, and immune cells such as CD8-positive T cells. 3. **Pathway Involvement:** TECRL is integral to the synthesis of very long-chain fatty acyl-CoAs, a process that is crucial for maintaining cellular membrane fluidity and lipid homeostasis. 4. **Oxidoreductase Activity:** TECRL exhibits oxidoreductase activity, specifically acting on the ch-ch group of donors, which is essential for its enzymatic function. **Pathways and Functions:** 1. **Fatty Acid Metabolism:** TECRL plays a critical role in the biosynthesis of very long-chain fatty acyl-CoAs, a process that is essential for maintaining cellular membrane fluidity and lipid homeostasis. 2. **Fatty Acyl-CoA Biosynthesis:** TECRL is involved in the synthesis of very long-chain fatty acyl-CoAs, which are crucial for various cellular processes, including energy production and membrane synthesis. 3. **Endoplasmic Reticulum (ER) Function:** TECRL is localized to the ER, where it participates in the biosynthesis of very long-chain fatty acyl-CoAs. 4. **Immune Function:** TECRL has been found to be expressed in immune cells, suggesting its potential role in modulating immune responses and inflammation. **Clinical Significance:** 1. **Cardiovascular Diseases:** Dysregulation of fatty acid metabolism, including the biosynthesis of very long-chain fatty acyl-CoAs, has been implicated in the pathogenesis of cardiovascular diseases, such as atherosclerosis and cardiac arrhythmias. 2. **Immune-Related Disorders:** TECRL's involvement in immune function suggests its potential role in modulating immune responses and inflammation in disorders such as autoimmune diseases and cancer. 3. **Metabolic Disorders:** TECRL's role in fatty acid metabolism makes it a potential therapeutic target for metabolic disorders, such as obesity and type 2 diabetes. 4. **Cancer Research:** TECRL's expression in cancer cells suggests its potential role in cancer progression and metastasis. In conclusion, TECRL is a multifaceted gene that plays a critical role in lipid metabolism and immune function. Its dysregulation has been implicated in various diseases, including cardiovascular and immune-related disorders. Further research is needed to fully elucidate the mechanisms of TECRL and its potential therapeutic applications.

Genular Protein ID: 3612556827

Symbol: TECRL_HUMAN

Name: Trans-2,3-enoyl-CoA reductase-like

UniProtKB Accession Codes:

Q5HYJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 27861123

Title: TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.

PubMed ID: 27861123

DOI: 10.15252/emmm.201505719

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 363
  • Mass: 42009
  • Checksum: D68F53FC397397AC
  • Sequence:
    • MFKRHKSLAS ERKRALLSQR ATRFILKDDM RNFHFLSKLV LSAGPLRPTP AVKHSKTTHF 
EIEIFDAQTR KQICILDKVT QSSTIHDVKQ KFHKACPKWY PSRVGLQLEC GGPFLKDYIT 
IQSIAASSIV TLYATDLGQQ VSWTTVFLAE YTGPLLIYLL FYLRIPCIYD GKESARRLRH 
PVVHLACFCH CIHYIRYLLE TLFVHKVSAG HTPLKNLIMS CAFYWGFTSW IAYYINHPLY 
TPPSFGNRQI TVSAINFLIC EAGNHFINVM LSHPNHTGNN ACFPSPNYNP FTWMFFLVSC 
PNYTYEIGSW ISFTVMTQTL PVGIFTLLMS IQMSLWAQKK HKIYLRKFNS YIHRKSAMIP 
FIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.