Details for: KLK6

Gene ID: 5653

Symbol: KLK6

Ensembl ID: ENSG00000167755

Description: kallikrein related peptidase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 7.3088
    Cell Significance Index: 124.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7111
    Cell Significance Index: 17.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4365
    Cell Significance Index: 56.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3656
    Cell Significance Index: 12.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2926
    Cell Significance Index: 202.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2130
    Cell Significance Index: 116.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1558
    Cell Significance Index: 18.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0902
    Cell Significance Index: 0.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0678
    Cell Significance Index: 3.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0319
    Cell Significance Index: 14.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0064
    Cell Significance Index: 0.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0012
    Cell Significance Index: -0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0115
    Cell Significance Index: -21.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0224
    Cell Significance Index: -41.3600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0232
    Cell Significance Index: -0.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0268
    Cell Significance Index: -41.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0303
    Cell Significance Index: -22.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0305
    Cell Significance Index: -41.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0337
    Cell Significance Index: -24.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0341
    Cell Significance Index: -21.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0393
    Cell Significance Index: -29.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0403
    Cell Significance Index: -5.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0432
    Cell Significance Index: -2.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0441
    Cell Significance Index: -24.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0530
    Cell Significance Index: -15.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0633
    Cell Significance Index: -28.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0665
    Cell Significance Index: -23.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0889
    Cell Significance Index: -2.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1005
    Cell Significance Index: -7.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1006
    Cell Significance Index: -18.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1024
    Cell Significance Index: -2.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1090
    Cell Significance Index: -21.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1186
    Cell Significance Index: -24.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1190
    Cell Significance Index: -23.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1385
    Cell Significance Index: -17.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1419
    Cell Significance Index: -24.2400
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1449
    Cell Significance Index: -1.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1473
    Cell Significance Index: -21.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1483
    Cell Significance Index: -18.2400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1965
    Cell Significance Index: -1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2100
    Cell Significance Index: -24.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2251
    Cell Significance Index: -22.9900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2603
    Cell Significance Index: -3.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2797
    Cell Significance Index: -20.8500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2985
    Cell Significance Index: -3.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3185
    Cell Significance Index: -9.3800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3448
    Cell Significance Index: -2.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3684
    Cell Significance Index: -24.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3894
    Cell Significance Index: -23.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4283
    Cell Significance Index: -8.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4368
    Cell Significance Index: -26.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4610
    Cell Significance Index: -8.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4779
    Cell Significance Index: -26.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5162
    Cell Significance Index: -18.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5598
    Cell Significance Index: -24.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5787
    Cell Significance Index: -14.4300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.6419
    Cell Significance Index: -16.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6557
    Cell Significance Index: -22.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6586
    Cell Significance Index: -24.9400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.6679
    Cell Significance Index: -7.8700
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.6718
    Cell Significance Index: -8.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6751
    Cell Significance Index: -14.1300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.6853
    Cell Significance Index: -9.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7132
    Cell Significance Index: -23.3500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.7157
    Cell Significance Index: -8.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7478
    Cell Significance Index: -23.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8329
    Cell Significance Index: -23.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.8476
    Cell Significance Index: -23.0700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.8584
    Cell Significance Index: -6.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8619
    Cell Significance Index: -30.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.8854
    Cell Significance Index: -22.1200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.8858
    Cell Significance Index: -5.8800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.8918
    Cell Significance Index: -12.0400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8925
    Cell Significance Index: -25.4700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8998
    Cell Significance Index: -24.0300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.9128
    Cell Significance Index: -8.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9158
    Cell Significance Index: -24.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9166
    Cell Significance Index: -24.5600
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.9310
    Cell Significance Index: -12.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9449
    Cell Significance Index: -23.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9645
    Cell Significance Index: -25.8000
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.9675
    Cell Significance Index: -10.6000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9875
    Cell Significance Index: -20.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0423
    Cell Significance Index: -30.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0483
    Cell Significance Index: -17.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0522
    Cell Significance Index: -23.0400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.0547
    Cell Significance Index: -17.3800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0745
    Cell Significance Index: -24.8300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -1.0912
    Cell Significance Index: -14.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0986
    Cell Significance Index: -23.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.0991
    Cell Significance Index: -12.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.1025
    Cell Significance Index: -26.4400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -1.1029
    Cell Significance Index: -12.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1162
    Cell Significance Index: -23.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1183
    Cell Significance Index: -23.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.1645
    Cell Significance Index: -12.6600
  • Cell Name: T cell (CL0000084)
    Fold Change: -1.1693
    Cell Significance Index: -13.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1966
    Cell Significance Index: -24.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2029
    Cell Significance Index: -30.0700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.2173
    Cell Significance Index: -24.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLK6 is a member of the kallikrein-related peptidase family, which consists of six enzymes (KLK1-6) with distinct substrate specificities and tissue distributions. KLK6 is characterized by its ability to cleave various peptides, proteins, and lipids, influencing cellular signaling pathways and modulating cellular behavior. Its expression is widespread, with significant levels detected in hematopoietic stem cells, epithelial cells, and neurons, highlighting its role in differentiating cell types and regulating tissue homeostasis. **Pathways and Functions:** KLK6 is involved in a diverse array of cellular processes, including: 1. **Cell differentiation:** KLK6 regulates the differentiation of various cell types, including neurons, epithelial cells, and hematopoietic stem cells, by modulating signaling pathways and protein processing. 2. **Tissue regeneration:** KLK6 is implicated in tissue repair and regeneration, as evidenced by its expression in wound-healing cells and its ability to cleave growth factors and cytokines involved in tissue repair. 3. **Neurodevelopment:** KLK6 plays a crucial role in the development of the central nervous system, particularly in the formation of neurons and glial cells. 4. **Hormone regulation:** KLK6 is involved in the regulation of hormone metabolism, including the processing and inactivation of hormones such as insulin and growth hormone. **Clinical Significance:** KLK6's broad expression and diverse functions make it an attractive target for the development of novel therapeutic strategies. Dysregulation of KLK6 has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** KLK6's role in neurodevelopment and neurodegeneration makes it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Cancer:** KLK6's involvement in cell differentiation and tissue regeneration suggests its potential as a biomarker for cancer diagnosis and prognosis. 3. **Wound healing:** KLK6's expression in wound-healing cells and its ability to cleave growth factors and cytokines make it a promising target for the development of novel wound-healing therapies. In conclusion, KLK6 is a multifaceted enzyme that plays a crucial role in regulating various cellular processes, including development, differentiation, and tissue regeneration. Its widespread expression and diverse functions make it an attractive target for the development of novel therapeutic strategies, and further research is needed to fully elucidate its clinical significance.

Genular Protein ID: 4077096994

Symbol: KLK6_HUMAN

Name: Kallikrein-6

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8898378

Title: A novel protease homolog differentially expressed in breast and ovarian cancer.

PubMed ID: 8898378

DOI: 10.1007/bf03401646

PubMed ID: 9003450

Title: Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain.

PubMed ID: 9003450

DOI: 10.1016/s0167-4781(96)00187-x

PubMed ID: 9312124

Title: Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain.

PubMed ID: 9312124

DOI: 10.1074/jbc.272.40.25135

PubMed ID: 10610719

Title: Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease.

PubMed ID: 10610719

DOI: 10.1006/geno.1999.6012

PubMed ID: 11054574

Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.

PubMed ID: 11054574

DOI: 10.1016/s0378-1119(00)00382-6

PubMed ID: 15207701

Title: Cloning and characterization of novel isoforms of the human kallikrein 6 gene.

PubMed ID: 15207701

DOI: 10.1016/j.bbrc.2004.04.205

PubMed ID: 16800739

Title: Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.

PubMed ID: 16800739

DOI: 10.1515/bc.2006.097

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11018688

Title: Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications.

PubMed ID: 11018688

DOI: 10.1016/s0009-9120(00)00145-4

PubMed ID: 10997858

Title: Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease.

PubMed ID: 10997858

DOI: 10.1046/j.1440-1819.2000.00731.x

PubMed ID: 11668196

Title: The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry.

PubMed ID: 11668196

DOI: 10.1177/002215540104901111

PubMed ID: 12878203

Title: Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors.

PubMed ID: 12878203

DOI: 10.1016/s0006-291x(03)01271-3

PubMed ID: 12928483

Title: Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.

PubMed ID: 12928483

DOI: 10.1093/hmg/ddg283

PubMed ID: 15557757

Title: Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells.

PubMed ID: 15557757

DOI: 10.1159/000081102

PubMed ID: 16987227

Title: Dynamic role of kallikrein 6 in traumatic spinal cord injury.

PubMed ID: 16987227

DOI: 10.1111/j.1460-9568.2006.05021.x

PubMed ID: 16321973

Title: Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects.

PubMed ID: 16321973

DOI: 10.1074/jbc.m510096200

PubMed ID: 17417874

Title: The autolytic regulation of human kallikrein-related peptidase 6.

PubMed ID: 17417874

DOI: 10.1021/bi6025006

PubMed ID: 12016211

Title: The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.

PubMed ID: 12016211

DOI: 10.1074/jbc.m201534200

PubMed ID: 11983703

Title: Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system.

PubMed ID: 11983703

DOI: 10.1074/jbc.m202392200

Sequence Information:

  • Length: 244
  • Mass: 26856
  • Checksum: AEA03F9145D87AAB
  • Sequence:
  • MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV LIHPLWVLTA 
    AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA ASHDQDIMLL RLARPAKLSE 
    LIQPLPLERD CSANTTSCHI LGWGKTADGD FPDTIQCAYI HLVSREECEH AYPGQITQNM 
    LCAGDEKYGK DSCQGDSGGP LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT 
    IQAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.