Details for: KLK6
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 7.3088
Cell Significance Index: 124.9400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.7111
Cell Significance Index: 17.2300 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4365
Cell Significance Index: 56.4000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3656
Cell Significance Index: 12.7100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2926
Cell Significance Index: 202.3600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2130
Cell Significance Index: 116.3300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1558
Cell Significance Index: 18.1600 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.0902
Cell Significance Index: 0.7200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0678
Cell Significance Index: 3.1900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0319
Cell Significance Index: 14.1100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0064
Cell Significance Index: 0.3000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0012
Cell Significance Index: -0.0500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0115
Cell Significance Index: -21.6600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0224
Cell Significance Index: -41.3600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0232
Cell Significance Index: -0.9500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0268
Cell Significance Index: -41.2200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0303
Cell Significance Index: -22.2200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0305
Cell Significance Index: -41.5100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0337
Cell Significance Index: -24.9500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0341
Cell Significance Index: -21.6700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0393
Cell Significance Index: -29.7700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0403
Cell Significance Index: -5.5400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0432
Cell Significance Index: -2.1900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0441
Cell Significance Index: -24.8800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0530
Cell Significance Index: -15.2400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0633
Cell Significance Index: -28.7300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0665
Cell Significance Index: -23.8600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0889
Cell Significance Index: -2.4900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1005
Cell Significance Index: -7.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1006
Cell Significance Index: -18.1400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1024
Cell Significance Index: -2.6300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.1090
Cell Significance Index: -21.8700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1186
Cell Significance Index: -24.9800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1190
Cell Significance Index: -23.6100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1385
Cell Significance Index: -17.7500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1419
Cell Significance Index: -24.2400 - Cell Name: eosinophil (CL0000771)
Fold Change: -0.1449
Cell Significance Index: -1.2800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1473
Cell Significance Index: -21.4100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1483
Cell Significance Index: -18.2400 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1965
Cell Significance Index: -1.6700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2100
Cell Significance Index: -24.0600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2251
Cell Significance Index: -22.9900 - Cell Name: fast muscle cell (CL0000190)
Fold Change: -0.2603
Cell Significance Index: -3.4100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2797
Cell Significance Index: -20.8500 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.2985
Cell Significance Index: -3.2000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3185
Cell Significance Index: -9.3800 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.3448
Cell Significance Index: -2.3400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3684
Cell Significance Index: -24.7700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3894
Cell Significance Index: -23.9400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4283
Cell Significance Index: -8.3600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4368
Cell Significance Index: -26.7800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.4610
Cell Significance Index: -8.5200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4779
Cell Significance Index: -26.8200 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.5162
Cell Significance Index: -18.9500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5598
Cell Significance Index: -24.7600 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.5787
Cell Significance Index: -14.4300 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.6419
Cell Significance Index: -16.3600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6557
Cell Significance Index: -22.9700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.6586
Cell Significance Index: -24.9400 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.6679
Cell Significance Index: -7.8700 - Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.6718
Cell Significance Index: -8.6000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6751
Cell Significance Index: -14.1300 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.6853
Cell Significance Index: -9.4700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7132
Cell Significance Index: -23.3500 - Cell Name: monocyte (CL0000576)
Fold Change: -0.7157
Cell Significance Index: -8.2400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7478
Cell Significance Index: -23.8200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.8329
Cell Significance Index: -23.8800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8476
Cell Significance Index: -23.0700 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.8584
Cell Significance Index: -6.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.8619
Cell Significance Index: -30.2900 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.8854
Cell Significance Index: -22.1200 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.8858
Cell Significance Index: -5.8800 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.8918
Cell Significance Index: -12.0400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.8925
Cell Significance Index: -25.4700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.8998
Cell Significance Index: -24.0300 - Cell Name: Langerhans cell (CL0000453)
Fold Change: -0.9128
Cell Significance Index: -8.7000 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.9158
Cell Significance Index: -24.0800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9166
Cell Significance Index: -24.5600 - Cell Name: tendon cell (CL0000388)
Fold Change: -0.9310
Cell Significance Index: -12.6600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.9449
Cell Significance Index: -23.5700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.9645
Cell Significance Index: -25.8000 - Cell Name: glial cell (CL0000125)
Fold Change: -0.9675
Cell Significance Index: -10.6000 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.9875
Cell Significance Index: -20.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.0423
Cell Significance Index: -30.0300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.0483
Cell Significance Index: -17.5500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.0522
Cell Significance Index: -23.0400 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -1.0547
Cell Significance Index: -17.3800 - Cell Name: peg cell (CL4033014)
Fold Change: -1.0745
Cell Significance Index: -24.8300 - Cell Name: precursor B cell (CL0000817)
Fold Change: -1.0912
Cell Significance Index: -14.1200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.0986
Cell Significance Index: -23.7400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -1.0991
Cell Significance Index: -12.4900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.1025
Cell Significance Index: -26.4400 - Cell Name: macroglial cell (CL0000126)
Fold Change: -1.1029
Cell Significance Index: -12.7700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1162
Cell Significance Index: -23.6900 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.1183
Cell Significance Index: -23.3400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -1.1645
Cell Significance Index: -12.6600 - Cell Name: T cell (CL0000084)
Fold Change: -1.1693
Cell Significance Index: -13.8100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.1966
Cell Significance Index: -24.0200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.2029
Cell Significance Index: -30.0700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.2173
Cell Significance Index: -24.0700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4077096994
Symbol: KLK6_HUMAN
Name: Kallikrein-6
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8898378
Title: A novel protease homolog differentially expressed in breast and ovarian cancer.
PubMed ID: 8898378
DOI: 10.1007/bf03401646
PubMed ID: 9003450
Title: Molecular cloning of a novel trypsin-like serine protease (neurosin) preferentially expressed in brain.
PubMed ID: 9003450
PubMed ID: 9312124
Title: Zyme, a novel and potentially amyloidogenic enzyme cDNA isolated from Alzheimer's disease brain.
PubMed ID: 9312124
PubMed ID: 10610719
Title: Molecular characterization of Zyme/protease M/neurosin(PRSS9), a hormonally regulated kallikrein-like serine protease.
PubMed ID: 10610719
PubMed ID: 11054574
Title: Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region.
PubMed ID: 11054574
PubMed ID: 15207701
Title: Cloning and characterization of novel isoforms of the human kallikrein 6 gene.
PubMed ID: 15207701
PubMed ID: 16800739
Title: Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.
PubMed ID: 16800739
DOI: 10.1515/bc.2006.097
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11018688
Title: Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications.
PubMed ID: 11018688
PubMed ID: 10997858
Title: Localization of a novel type trypsin-like serine protease, neurosin, in brain tissues of Alzheimer's disease and Parkinson's disease.
PubMed ID: 10997858
PubMed ID: 11668196
Title: The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues as assessed by immunohistochemistry.
PubMed ID: 11668196
PubMed ID: 12878203
Title: Characterization of the enzymatic activity of human kallikrein 6: autoactivation, substrate specificity, and regulation by inhibitors.
PubMed ID: 12878203
PubMed ID: 12928483
Title: Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.
PubMed ID: 12928483
DOI: 10.1093/hmg/ddg283
PubMed ID: 15557757
Title: Human kallikrein 6 degrades extracellular matrix proteins and may enhance the metastatic potential of tumour cells.
PubMed ID: 15557757
DOI: 10.1159/000081102
PubMed ID: 16987227
Title: Dynamic role of kallikrein 6 in traumatic spinal cord injury.
PubMed ID: 16987227
PubMed ID: 16321973
Title: Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects.
PubMed ID: 16321973
PubMed ID: 17417874
Title: The autolytic regulation of human kallikrein-related peptidase 6.
PubMed ID: 17417874
DOI: 10.1021/bi6025006
PubMed ID: 12016211
Title: The structure of human prokallikrein 6 reveals a novel activation mechanism for the kallikrein family.
PubMed ID: 12016211
PubMed ID: 11983703
Title: Crystal structure and biochemical characterization of human kallikrein 6 reveals that a trypsin-like kallikrein is expressed in the central nervous system.
PubMed ID: 11983703
Sequence Information:
- Length: 244
- Mass: 26856
- Checksum: AEA03F9145D87AAB
- Sequence:
MKKLMVVLSL IAAAWAEEQN KLVHGGPCDK TSHPYQAALY TSGHLLCGGV LIHPLWVLTA AHCKKPNLQV FLGKHNLRQR ESSQEQSSVV RAVIHPDYDA ASHDQDIMLL RLARPAKLSE LIQPLPLERD CSANTTSCHI LGWGKTADGD FPDTIQCAYI HLVSREECEH AYPGQITQNM LCAGDEKYGK DSCQGDSGGP LVCGDHLRGL VSWGNIPCGS KEKPGVYTNV CRYTNWIQKT IQAK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.