Details for: TNNT3

Gene ID: 7140

Symbol: TNNT3

Ensembl ID: ENSG00000130595

Description: troponin T3, fast skeletal type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 9.48
    Marker Score: 7217
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.49
    Marker Score: 2191
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170165
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.18
    Marker Score: 1303.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.14
    Marker Score: 1204
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2537
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.99
    Marker Score: 299
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.93
    Marker Score: 273
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 631
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.71
    Marker Score: 1343
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.65
    Marker Score: 234
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.64
    Marker Score: 147
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1154
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6
    Marker Score: 2354
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.48
    Marker Score: 95
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.48
    Marker Score: 615
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.46
    Marker Score: 114
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 299
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.44
    Marker Score: 3831
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.42
    Marker Score: 694.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4
    Marker Score: 13746
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.39
    Marker Score: 264
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.32
    Marker Score: 793
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.31
    Marker Score: 363
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.31
    Marker Score: 141
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.3
    Marker Score: 140
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 94
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.29
    Marker Score: 249
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.27
    Marker Score: 419
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.27
    Marker Score: 924.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.27
    Marker Score: 992
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.27
    Marker Score: 211
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.26
    Marker Score: 274
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.26
    Marker Score: 373
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.25
    Marker Score: 72
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.24
    Marker Score: 234
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.24
    Marker Score: 238
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.23
    Marker Score: 86
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.23
    Marker Score: 154
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.23
    Marker Score: 598
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.22
    Marker Score: 465
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.22
    Marker Score: 92
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.22
    Marker Score: 1651
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.17
    Marker Score: 92
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.17
    Marker Score: 159
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.17
    Marker Score: 85
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.16
    Marker Score: 115
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 32
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.16
    Marker Score: 284
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.15
    Marker Score: 611
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.14
    Marker Score: 245
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.14
    Marker Score: 150
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.13
    Marker Score: 135
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.12
    Marker Score: 796
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 194.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.12
    Marker Score: 778.5
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.11
    Marker Score: 132
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.11
    Marker Score: 51
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1
    Marker Score: 254
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.1
    Marker Score: 72
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1
    Marker Score: 89
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1
    Marker Score: 597
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1
    Marker Score: 106
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.09
    Marker Score: 181
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 52

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Other Information

**Key Characteristics:** TNNT3 is a member of the troponin T family, which is essential for regulating muscle contraction and relaxation. It is characterized by its high affinity for actin and its ability to bind to tropomyosin, thereby regulating the interaction between actin and myosin. TNNT3 is unique in its fast skeletal type isoform, which is different from the slow skeletal type isoform (TNNT2). This difference in isoform is thought to contribute to the distinct muscle contraction properties of fast and slow skeletal muscles. **Pathways and Functions:** TNNT3 is involved in several key pathways, including: 1. **Muscle Contraction:** TNNT3 plays a critical role in regulating muscle contraction by binding to actin and tropomyosin, thereby controlling the interaction between actin and myosin. 2. **Calcium-dependent Protein Binding:** TNNT3 interacts with calcium-dependent proteins, such as troponin C, to regulate muscle contraction and relaxation. 3. **Sarcomere Organization:** TNNT3 is involved in the organization of sarcomeres, the functional units of skeletal muscle tissue. 4. **Regulation of Calcium-dependent ATPase Activity:** TNNT3 regulates the activity of calcium-dependent ATPases, which are essential for muscle contraction and relaxation. **Clinical Significance:** Dysregulation of TNNT3 has been implicated in various diseases, including: 1. **Muscle Disorders:** Mutations in TNNT3 have been associated with muscle disorders such as malignant hyperthermia and myotonia congenita. 2. **Cardiovascular Conditions:** TNNT3 has been linked to cardiovascular conditions such as arrhythmias and cardiac hypertrophy. 3. **Neurological Disorders:** TNNT3 has been implicated in neurological disorders such as epilepsy and schizophrenia. In conclusion, TNNT3 is a critical component of the troponin complex in skeletal muscle, playing a vital role in regulating muscle contraction and relaxation. Its dysregulation has been implicated in various diseases, highlighting the importance of TNNT3 in human health and disease. Further research is needed to fully understand the mechanisms by which TNNT3 regulates muscle function and to develop effective therapeutic strategies for TNNT3-related diseases.

Genular Protein ID: 1242827858

Symbol: TNNT3_HUMAN

Name: Troponin T, fast skeletal muscle

UniProtKB Accession Codes:

P45378 A8MQ76 A8MSW1 B3KPX3 B7WP64 B7ZL26 B7ZVV9 Q12975 Q12976 Q12977 Q12978 Q17RG9 Q6FH29 Q6N056 Q86TH6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 18 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 5 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 Reactome 1 RefSeq 10 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8172653

Title: Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family.

PubMed ID: 8172653

DOI: 10.1089/dna.1994.13.217

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8062920

Title: Identification of a fetal exon in the human fast troponin T gene.

PubMed ID: 8062920

DOI: 10.1016/0014-5793(94)00729-2

PubMed ID: 12865991

Title: Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B.

PubMed ID: 12865991

DOI: 10.1086/376418

PubMed ID: 19142688

Title: Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot.

PubMed ID: 19142688

DOI: 10.1007/s11999-008-0694-5

PubMed ID: 21402185

Title: A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus.

PubMed ID: 21402185

DOI: 10.1016/j.ejmg.2011.03.002

PubMed ID: 25337069

Title: Exome sequencing identifies a dominant TNNT3 mutation in a large family with distal arthrogryposis.

PubMed ID: 25337069

DOI: 10.1159/000365057

Sequence Information:

  • Length: 269
  • Mass: 31825
  • Checksum: 87B25AF8773D742F
  • Sequence:
    • MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEVQEDT AEEDAEEEKP RPKLTAPKIP 
EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL VALKERIEKR RAERAEQQRI 
RAEKERERQN RLAEEKARRE EEDAKRRAED DLKKKKALSS MGANYSSYLA KADQKRGKKQ 
TAREMKKKIL AERRKPLNID HLGEDKLRDK AKELWETLHQ LEIDKFEFGE KLKRQKYDIT 
TLRSRIDQAQ KHSKKAGTPA KGKVGGRWK

Genular Protein ID: 910730038

Symbol: H9KVA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

H9KVA2

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 239
  • Mass: 28313
  • Checksum: D0A7B59378041E4D
  • Sequence:
    • MSDEEVEQVE EEAQEEEEKP RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF 
EARKKEEEEL VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAED 
DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL AERRKPLNID HLGEDKLRDK 
AKELWETLHQ LEIDKFEFGE KLKRQKYDIT TLRSRIDQAQ KHSKKAGTPA KGKVGGRWK

Genular Protein ID: 860925938

Symbol: A0A9L9PY19_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PY19

Database IDs:

ARBA 4 EMBL 2 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 256
  • Mass: 30359
  • Checksum: 31D4815E4046B54C
  • Sequence:
    • MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEKPRPK LTAPKIPEGE KVDFDDIQKK 
RQNKDLMELQ ALIDSHFEAR KKEEEELVAL KERIEKRRAE RAEQQRIRAE KERERQNRLA 
EEKARREEED AKRRAEDDLK KKKALSSMGA NYSSYLAKAD QKRGKKQTAR EMKKKILAER 
RKPLNIDHLG EDKLRDKAKE LWETLHQLEI DKFEFGEKLK RQKYDIMNVR ARVQMLAKFS 
KKAGTPAKGK VGGRWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.