Details for: TNNT3

Gene ID: 7140

Symbol: TNNT3

Ensembl ID: ENSG00000130595

Description: troponin T3, fast skeletal type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.0644
    Cell Significance Index: -8.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.5046
    Cell Significance Index: -7.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 18.8693
    Cell Significance Index: 304.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.0121
    Cell Significance Index: -4.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9629
    Cell Significance Index: -8.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 4.1284
    Cell Significance Index: 214.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1680
    Cell Significance Index: 29.5800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.0146
    Cell Significance Index: 49.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2606
    Cell Significance Index: 18.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1772
    Cell Significance Index: 30.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0353
    Cell Significance Index: -3.1800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.7826
    Cell Significance Index: 11.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3963
    Cell Significance Index: 11.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3639
    Cell Significance Index: 65.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2905
    Cell Significance Index: 5.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2733
    Cell Significance Index: 33.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2395
    Cell Significance Index: 3.4300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.2313
    Cell Significance Index: 3.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1659
    Cell Significance Index: 4.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1473
    Cell Significance Index: 7.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1280
    Cell Significance Index: 1.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0470
    Cell Significance Index: 0.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0340
    Cell Significance Index: 0.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0272
    Cell Significance Index: 0.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0246
    Cell Significance Index: 13.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0039
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0075
    Cell Significance Index: -5.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0086
    Cell Significance Index: -5.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0103
    Cell Significance Index: -1.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0132
    Cell Significance Index: -7.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0135
    Cell Significance Index: -6.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0190
    Cell Significance Index: -6.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0211
    Cell Significance Index: -2.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0334
    Cell Significance Index: -7.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0350
    Cell Significance Index: -6.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0357
    Cell Significance Index: -6.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0370
    Cell Significance Index: -7.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0383
    Cell Significance Index: -0.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0411
    Cell Significance Index: -5.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0478
    Cell Significance Index: -0.4400
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.0517
    Cell Significance Index: -0.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0518
    Cell Significance Index: -6.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0526
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0532
    Cell Significance Index: -7.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0553
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0595
    Cell Significance Index: -6.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0605
    Cell Significance Index: -6.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0616
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0669
    Cell Significance Index: -3.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0775
    Cell Significance Index: -5.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0825
    Cell Significance Index: -5.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0838
    Cell Significance Index: -8.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0863
    Cell Significance Index: -6.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0911
    Cell Significance Index: -4.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1103
    Cell Significance Index: -6.9500
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1153
    Cell Significance Index: -0.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1246
    Cell Significance Index: -4.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1319
    Cell Significance Index: -2.8200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1401
    Cell Significance Index: -0.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1551
    Cell Significance Index: -7.0300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1590
    Cell Significance Index: -1.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1596
    Cell Significance Index: -4.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1632
    Cell Significance Index: -5.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1648
    Cell Significance Index: -1.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1690
    Cell Significance Index: -4.6000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1763
    Cell Significance Index: -1.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1804
    Cell Significance Index: -4.3700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1820
    Cell Significance Index: -7.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1827
    Cell Significance Index: -10.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1827
    Cell Significance Index: -8.5200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1843
    Cell Significance Index: -2.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1851
    Cell Significance Index: -4.9600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.1871
    Cell Significance Index: -1.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1907
    Cell Significance Index: -6.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1952
    Cell Significance Index: -10.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1954
    Cell Significance Index: -3.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2070
    Cell Significance Index: -6.0800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2163
    Cell Significance Index: -1.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2175
    Cell Significance Index: -7.1200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2215
    Cell Significance Index: -3.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2286
    Cell Significance Index: -5.7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2303
    Cell Significance Index: -7.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2338
    Cell Significance Index: -10.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2365
    Cell Significance Index: -2.0100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.2383
    Cell Significance Index: -2.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2438
    Cell Significance Index: -6.4100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2458
    Cell Significance Index: -1.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2491
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.2501
    Cell Significance Index: -3.1500
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2611
    Cell Significance Index: -2.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2681
    Cell Significance Index: -6.8300
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.2707
    Cell Significance Index: -2.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2725
    Cell Significance Index: -6.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2731
    Cell Significance Index: -10.3400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2777
    Cell Significance Index: -1.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNNT3 is a member of the troponin T family, which is essential for regulating muscle contraction and relaxation. It is characterized by its high affinity for actin and its ability to bind to tropomyosin, thereby regulating the interaction between actin and myosin. TNNT3 is unique in its fast skeletal type isoform, which is different from the slow skeletal type isoform (TNNT2). This difference in isoform is thought to contribute to the distinct muscle contraction properties of fast and slow skeletal muscles. **Pathways and Functions:** TNNT3 is involved in several key pathways, including: 1. **Muscle Contraction:** TNNT3 plays a critical role in regulating muscle contraction by binding to actin and tropomyosin, thereby controlling the interaction between actin and myosin. 2. **Calcium-dependent Protein Binding:** TNNT3 interacts with calcium-dependent proteins, such as troponin C, to regulate muscle contraction and relaxation. 3. **Sarcomere Organization:** TNNT3 is involved in the organization of sarcomeres, the functional units of skeletal muscle tissue. 4. **Regulation of Calcium-dependent ATPase Activity:** TNNT3 regulates the activity of calcium-dependent ATPases, which are essential for muscle contraction and relaxation. **Clinical Significance:** Dysregulation of TNNT3 has been implicated in various diseases, including: 1. **Muscle Disorders:** Mutations in TNNT3 have been associated with muscle disorders such as malignant hyperthermia and myotonia congenita. 2. **Cardiovascular Conditions:** TNNT3 has been linked to cardiovascular conditions such as arrhythmias and cardiac hypertrophy. 3. **Neurological Disorders:** TNNT3 has been implicated in neurological disorders such as epilepsy and schizophrenia. In conclusion, TNNT3 is a critical component of the troponin complex in skeletal muscle, playing a vital role in regulating muscle contraction and relaxation. Its dysregulation has been implicated in various diseases, highlighting the importance of TNNT3 in human health and disease. Further research is needed to fully understand the mechanisms by which TNNT3 regulates muscle function and to develop effective therapeutic strategies for TNNT3-related diseases.

Genular Protein ID: 1242827858

Symbol: TNNT3_HUMAN

Name: Troponin T, fast skeletal muscle

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8172653

Title: Isolation and characterization of human fast skeletal beta troponin T cDNA: comparative sequence analysis of isoforms and insight into the evolution of members of a multigene family.

PubMed ID: 8172653

DOI: 10.1089/dna.1994.13.217

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8062920

Title: Identification of a fetal exon in the human fast troponin T gene.

PubMed ID: 8062920

DOI: 10.1016/0014-5793(94)00729-2

PubMed ID: 12865991

Title: Mutations in TNNT3 cause multiple congenital contractures: a second locus for distal arthrogryposis type 2B.

PubMed ID: 12865991

DOI: 10.1086/376418

PubMed ID: 19142688

Title: Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot.

PubMed ID: 19142688

DOI: 10.1007/s11999-008-0694-5

PubMed ID: 21402185

Title: A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus.

PubMed ID: 21402185

DOI: 10.1016/j.ejmg.2011.03.002

PubMed ID: 25337069

Title: Exome sequencing identifies a dominant TNNT3 mutation in a large family with distal arthrogryposis.

PubMed ID: 25337069

DOI: 10.1159/000365057

Sequence Information:

  • Length: 269
  • Mass: 31825
  • Checksum: 87B25AF8773D742F
  • Sequence:
  • MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEVQEDT AEEDAEEEKP RPKLTAPKIP 
    EGEKVDFDDI QKKRQNKDLM ELQALIDSHF EARKKEEEEL VALKERIEKR RAERAEQQRI 
    RAEKERERQN RLAEEKARRE EEDAKRRAED DLKKKKALSS MGANYSSYLA KADQKRGKKQ 
    TAREMKKKIL AERRKPLNID HLGEDKLRDK AKELWETLHQ LEIDKFEFGE KLKRQKYDIT 
    TLRSRIDQAQ KHSKKAGTPA KGKVGGRWK

Genular Protein ID: 860925938

Symbol: A0A9L9PY19_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 256
  • Mass: 30359
  • Checksum: 31D4815E4046B54C
  • Sequence:
  • MSDEEVEQVE EQYEEEEEAQ EEAAEVHEEV HEPEEKPRPK LTAPKIPEGE KVDFDDIQKK 
    RQNKDLMELQ ALIDSHFEAR KKEEEELVAL KERIEKRRAE RAEQQRIRAE KERERQNRLA 
    EEKARREEED AKRRAEDDLK KKKALSSMGA NYSSYLAKAD QKRGKKQTAR EMKKKILAER 
    RKPLNIDHLG EDKLRDKAKE LWETLHQLEI DKFEFGEKLK RQKYDIMNVR ARVQMLAKFS 
    KKAGTPAKGK VGGRWK

Genular Protein ID: 910730038

Symbol: H9KVA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

Sequence Information:

  • Length: 239
  • Mass: 28313
  • Checksum: D0A7B59378041E4D
  • Sequence:
  • MSDEEVEQVE EEAQEEEEKP RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF 
    EARKKEEEEL VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE EEDAKRRAED 
    DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL AERRKPLNID HLGEDKLRDK 
    AKELWETLHQ LEIDKFEFGE KLKRQKYDIT TLRSRIDQAQ KHSKKAGTPA KGKVGGRWK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.