Details for: DPT

Gene ID: 1805

Symbol: DPT

Ensembl ID: ENSG00000143196

Description: dermatopontin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.69
    Marker Score: 2293
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.34
    Marker Score: 1006
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.03
    Marker Score: 5316
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1992
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.93
    Marker Score: 65555
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.79
    Marker Score: 1131
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.57
    Marker Score: 763
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.49
    Marker Score: 2054
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.48
    Marker Score: 618
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169026.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.25
    Marker Score: 1207
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.22
    Marker Score: 19037
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.18
    Marker Score: 2228
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.17
    Marker Score: 770
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.1
    Marker Score: 612
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.06
    Marker Score: 263
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.06
    Marker Score: 264
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.05
    Marker Score: 264
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251805
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.98
    Marker Score: 407
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1949.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.92
    Marker Score: 212
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.88
    Marker Score: 471
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.85
    Marker Score: 240
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.84
    Marker Score: 11124
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.71
    Marker Score: 407
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 380
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.59
    Marker Score: 217
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.59
    Marker Score: 914
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 467
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.55
    Marker Score: 642
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.55
    Marker Score: 122
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 227
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.51
    Marker Score: 619
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 240
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.5
    Marker Score: 462
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.46
    Marker Score: 569
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.43
    Marker Score: 147
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.4
    Marker Score: 104
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.39
    Marker Score: 3747
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.37
    Marker Score: 111
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.37
    Marker Score: 83
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.36
    Marker Score: 89
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.36
    Marker Score: 554
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.36
    Marker Score: 13500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.35
    Marker Score: 3328
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.33
    Marker Score: 3750
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.32
    Marker Score: 403
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.32
    Marker Score: 1359
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.31
    Marker Score: 737
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.31
    Marker Score: 113
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.3
    Marker Score: 569
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.28
    Marker Score: 17251
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.28
    Marker Score: 108
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.27
    Marker Score: 2108
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.27
    Marker Score: 110
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 390
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.24
    Marker Score: 151
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.23
    Marker Score: 159
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.23
    Marker Score: 118
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.23
    Marker Score: 1509
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.21
    Marker Score: 287
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.2
    Marker Score: 97
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.2
    Marker Score: 144
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.2
    Marker Score: 131
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.2
    Marker Score: 796
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.19
    Marker Score: 329
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.19
    Marker Score: 87
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.19
    Marker Score: 7083
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.17
    Marker Score: 1493
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.17
    Marker Score: 2312
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** - Dermatopontin is a secreted glycoprotein with a molecular weight of approximately 140 kDa. - It is a transmembrane protein that is expressed in various cell types, including fibroblasts, epithelial cells, and immune cells. - It is a major component of the skin barrier, where it helps to maintain the integrity of the barrier by interacting with other ECM proteins. - It is also involved in cell adhesion, migration, and tissue remodeling. **Pathways and functions** - Dermatopontin is involved in cell adhesion by interacting with other ECM proteins, such as collagen and fibronectin. - It is also involved in cell migration by binding to extracellular matrix proteins and facilitating cell movement. - It is also involved in tissue remodeling by promoting the formation of new blood vessels and the migration of fibroblasts to sites of injury. **Clinical significance** - Mutations in the DPT gene have been linked to a number of skin and lung diseases, including psoriasis, acne, and lung fibrosis. - In psoriasis, mutations in DPT lead to the production of a mutated protein that is more stable and more effective at interacting with collagen. This results in the formation of a strong and rigid ECM that can lead to inflammation and tissue damage. - In lung fibrosis, mutations in DPT lead to the production of a mutated protein that is more prone to aggregation. This can lead to the formation of a fibrillar ECM that can trap and kill lung cells. **Conclusion** Dermatopontin is a critical component of the skin barrier and plays a crucial role in cell adhesion, migration, and tissue remodeling. Mutations in the DPT gene have been linked to a number of skin and lung diseases, highlighting its importance in human health.

Genular Protein ID: 4125623246

Symbol: DERM_HUMAN

Name: Dermatopontin

UniProtKB Accession Codes:

Q07507 A8K981 Q8N4R2 Q9UIX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8104875

Title: Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin).

PubMed ID: 8104875

DOI: 10.1006/geno.1993.1348

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10233760

Title: Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen.

PubMed ID: 10233760

DOI: 10.1046/j.1523-1747.1999.00563.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 201
  • Mass: 24005
  • Checksum: C886D2FB624DDB49
  • Sequence:
    • MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC PQGQVIVAVR 
SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM EWYQTCSNNG LVAGFQSRYF 
ESVLDREWQF YCCRYSKRCP YSCWLTTEYP GHYGEEMDMI SYNYDYYIRG ATTTFSAVER 
DRQWKFIMCR MTEYDCEFAN V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.