Details for: DPT

Gene ID: 1805

Symbol: DPT

Ensembl ID: ENSG00000143196

Description: dermatopontin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 10.3161
    Cell Significance Index: 59.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.9857
    Cell Significance Index: 77.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.8750
    Cell Significance Index: 237.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1163
    Cell Significance Index: 89.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.5415
    Cell Significance Index: 17.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0709
    Cell Significance Index: 44.8700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.6502
    Cell Significance Index: 20.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4730
    Cell Significance Index: 66.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4461
    Cell Significance Index: 46.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0920
    Cell Significance Index: 207.8200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.8764
    Cell Significance Index: 14.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8383
    Cell Significance Index: 107.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8194
    Cell Significance Index: 81.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7465
    Cell Significance Index: 37.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6523
    Cell Significance Index: 588.9400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5968
    Cell Significance Index: 8.5700
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.4727
    Cell Significance Index: 4.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4154
    Cell Significance Index: 67.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4012
    Cell Significance Index: 8.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2658
    Cell Significance Index: 28.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1979
    Cell Significance Index: 4.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1488
    Cell Significance Index: 29.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1349
    Cell Significance Index: 9.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1213
    Cell Significance Index: 2.5400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1042
    Cell Significance Index: 1.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0933
    Cell Significance Index: 1.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0856
    Cell Significance Index: 11.7500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0388
    Cell Significance Index: 0.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0281
    Cell Significance Index: 0.8100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0168
    Cell Significance Index: 11.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0108
    Cell Significance Index: 0.3800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0032
    Cell Significance Index: 0.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0078
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0088
    Cell Significance Index: -16.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0121
    Cell Significance Index: -2.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0139
    Cell Significance Index: -21.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0159
    Cell Significance Index: -21.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0196
    Cell Significance Index: -7.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0202
    Cell Significance Index: -14.8200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0221
    Cell Significance Index: -16.7600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0224
    Cell Significance Index: -0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0246
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0261
    Cell Significance Index: -16.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0265
    Cell Significance Index: -19.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0268
    Cell Significance Index: -1.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0314
    Cell Significance Index: -17.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0340
    Cell Significance Index: -3.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0345
    Cell Significance Index: -19.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0451
    Cell Significance Index: -0.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0507
    Cell Significance Index: -14.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0529
    Cell Significance Index: -24.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0670
    Cell Significance Index: -13.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0948
    Cell Significance Index: -19.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1015
    Cell Significance Index: -17.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1020
    Cell Significance Index: -4.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1037
    Cell Significance Index: -15.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1128
    Cell Significance Index: -1.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1187
    Cell Significance Index: -14.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1259
    Cell Significance Index: -16.2600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1292
    Cell Significance Index: -1.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1480
    Cell Significance Index: -11.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1676
    Cell Significance Index: -17.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1679
    Cell Significance Index: -19.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1681
    Cell Significance Index: -11.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1939
    Cell Significance Index: -14.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1946
    Cell Significance Index: -15.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1977
    Cell Significance Index: -5.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2004
    Cell Significance Index: -5.1500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2334
    Cell Significance Index: -2.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2344
    Cell Significance Index: -10.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2606
    Cell Significance Index: -8.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2702
    Cell Significance Index: -7.5500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2983
    Cell Significance Index: -10.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3124
    Cell Significance Index: -16.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3153
    Cell Significance Index: -14.7000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3305
    Cell Significance Index: -5.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3405
    Cell Significance Index: -15.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3473
    Cell Significance Index: -19.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3488
    Cell Significance Index: -21.4400
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.3508
    Cell Significance Index: -0.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3956
    Cell Significance Index: -14.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3991
    Cell Significance Index: -20.7300
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4010
    Cell Significance Index: -5.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4116
    Cell Significance Index: -21.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4128
    Cell Significance Index: -15.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4175
    Cell Significance Index: -13.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4294
    Cell Significance Index: -10.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4434
    Cell Significance Index: -11.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4526
    Cell Significance Index: -4.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4767
    Cell Significance Index: -9.5700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.4804
    Cell Significance Index: -4.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4832
    Cell Significance Index: -11.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4903
    Cell Significance Index: -12.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5046
    Cell Significance Index: -14.4000
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5109
    Cell Significance Index: -5.2200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.5139
    Cell Significance Index: -5.0500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5338
    Cell Significance Index: -3.2700
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.5390
    Cell Significance Index: -3.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Dermatopontin is a small, cysteine-rich protein consisting of 47 amino acids. Its primary structure features a unique arrangement of cysteine residues, which confer its ability to form disulfide bonds, rendering it stable and soluble in aqueous environments. This protein is predominantly expressed in connective tissue cells, including fibroblasts, inflammatory cells, and epithelial cells. Its expression is also observed in various tissues, including the prostate, lung, intestine, mammary gland, and pancreas. **Pathways and Functions:** Dermatopontin's functional significance is multifaceted, involving various signaling pathways that regulate immune responses, cell adhesion, and tissue homeostasis. Some of the key pathways and functions of dermatopontin include: 1. **Cell adhesion:** Dermatopontin interacts with integrins and other adhesion molecules, facilitating cell-extracellular matrix (ECM) interactions and promoting cell migration, invasion, and survival. 2. **Negative regulation of cell population proliferation:** Dermatopontin has been shown to inhibit cell proliferation by interacting with growth factor receptors and modulating downstream signaling pathways. 3. **Extracellular matrix organization:** Dermatopontin contributes to the organization and remodeling of the ECM, influencing tissue architecture and function. 4. **Immune regulation:** Dermatopontin modulates immune responses by interacting with immune cells, such as T cells and macrophages, and regulating cytokine production. **Clinical Significance:** Dermatopontin's dysregulation has been implicated in various diseases, including: 1. **Cancer:** Elevated dermatopontin expression has been observed in various types of cancer, including prostate, lung, and breast cancer. Its role in tumor progression, metastasis, and immune evasion is still being explored. 2. **Inflammatory diseases:** Dermatopontin has been implicated in the pathogenesis of inflammatory diseases, such as atherosclerosis, arthritis, and asthma, where it modulates immune responses and tissue damage. 3. **Fibrosis:** Dermatopontin has been shown to contribute to fibrotic diseases, such as liver and kidney fibrosis, by promoting ECM remodeling and tissue scarring. In conclusion, dermatopontin is a multifunctional protein that plays a crucial role in immune regulation, cell adhesion, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 4125623246

Symbol: DERM_HUMAN

Name: Dermatopontin

UniProtKB Accession Codes:

Q07507 A8K981 Q8N4R2 Q9UIX8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8104875

Title: Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin).

PubMed ID: 8104875

DOI: 10.1006/geno.1993.1348

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10233760

Title: Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen.

PubMed ID: 10233760

DOI: 10.1046/j.1523-1747.1999.00563.x

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 201
  • Mass: 24005
  • Checksum: C886D2FB624DDB49
  • Sequence:
    • MDLSLLWVLL PLVTMAWGQY GDYGYPYQQY HDYSDDGWVN LNRQGFSYQC PQGQVIVAVR 
SIFSKKEGSD RQWNYACMPT PQSLGEPTEC WWEEINRAGM EWYQTCSNNG LVAGFQSRYF 
ESVLDREWQF YCCRYSKRCP YSCWLTTEYP GHYGEEMDMI SYNYDYYIRG ATTTFSAVER 
DRQWKFIMCR MTEYDCEFAN V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.