Details for: SLIT3

Gene ID: 6586

Symbol: SLIT3

Ensembl ID: ENSG00000184347

Description: slit guidance ligand 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 6.06
    Marker Score: 8528
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 5.04
    Marker Score: 2801
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 4.79
    Marker Score: 4567
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 4.43
    Marker Score: 1462
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 4.22
    Marker Score: 5110
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.98
    Marker Score: 5348
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.51
    Marker Score: 1900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.06
    Marker Score: 5884.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.95
    Marker Score: 8426
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.92
    Marker Score: 6720
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.85
    Marker Score: 914
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.82
    Marker Score: 1265
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.73
    Marker Score: 4585
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.7
    Marker Score: 1582
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.68
    Marker Score: 1889.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.27
    Marker Score: 1617
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.27
    Marker Score: 1103
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.2
    Marker Score: 74435
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.01
    Marker Score: 7158.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.97
    Marker Score: 714
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18043.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.88
    Marker Score: 6948
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.87
    Marker Score: 1043
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.86
    Marker Score: 6236.5
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.85
    Marker Score: 481
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.85
    Marker Score: 7152
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.76
    Marker Score: 3583
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.75
    Marker Score: 588
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.75
    Marker Score: 16442.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.7
    Marker Score: 4451
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.69
    Marker Score: 14510
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.65
    Marker Score: 379
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2537
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.63
    Marker Score: 1830
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.54
    Marker Score: 6250.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.51
    Marker Score: 514
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167702
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.38
    Marker Score: 84779
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.37
    Marker Score: 375
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.36
    Marker Score: 817
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.35
    Marker Score: 21083
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.34
    Marker Score: 393
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3153
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.32
    Marker Score: 327
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3
    Marker Score: 44288.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.29
    Marker Score: 5407
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.25
    Marker Score: 457
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.24
    Marker Score: 594
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.23
    Marker Score: 492
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.22
    Marker Score: 12591
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.15
    Marker Score: 1890
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.14
    Marker Score: 299
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.12
    Marker Score: 709
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1
    Marker Score: 951
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.08
    Marker Score: 466
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.08
    Marker Score: 516
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.08
    Marker Score: 6476
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.07
    Marker Score: 1317
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 329
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.04
    Marker Score: 392
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.04
    Marker Score: 1119
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251751
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.02
    Marker Score: 300
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.02
    Marker Score: 597
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.02
    Marker Score: 1919
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.02
    Marker Score: 7797.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71774
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47996.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.98
    Marker Score: 357
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.95
    Marker Score: 302
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.94
    Marker Score: 557
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.93
    Marker Score: 428
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.93
    Marker Score: 896
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5223
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.89
    Marker Score: 588
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.88
    Marker Score: 461
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.87
    Marker Score: 246
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.87
    Marker Score: 409
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.86
    Marker Score: 2019
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.86
    Marker Score: 218
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.85
    Marker Score: 241
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 649.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.85
    Marker Score: 6409
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.82
    Marker Score: 215
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.82
    Marker Score: 956
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.81
    Marker Score: 400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.76
    Marker Score: 428
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 496
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.74
    Marker Score: 221
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.73
    Marker Score: 10979
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.73
    Marker Score: 323
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.73
    Marker Score: 206

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Other Information

**Key Characteristics:** SLIT3 is a transmembrane protein that belongs to the Slit family, which consists of four members: Slit1, Slit2, Slit3, and Slit4. While the Slit1 and Slit2 proteins are primarily known for their role in repulsive axon guidance, SLIT3 has been implicated in both repulsive and attractive axon guidance, depending on the context. SLIT3 is characterized by its unique structure, which includes a highly conserved extracellular cysteine-rich domain and a transmembrane domain. The protein is highly expressed in various tissues, including the nervous system, kidney, and lung. **Pathways and Functions:** SLIT3 is involved in a wide range of cellular processes, including axon guidance, cell migration, and immune response. Its interactions with Roundabout receptors (Robo) have been shown to regulate axon guidance and commissural axon pathfinding. SLIT3 also plays a critical role in negative regulation of cell growth, proliferation, and chemokine-mediated signaling pathways. In the context of immune regulation, SLIT3 has been shown to modulate the activity of various immune cells, including T cells and macrophages. Additionally, SLIT3 has been implicated in developmental processes, including aortic valve morphogenesis, atrioventricular valve morphogenesis, and ventricular septum morphogenesis. **Functions:** 1. **Axon Guidance:** SLIT3 interacts with Robo receptors to regulate axon guidance and commissural axon pathfinding. 2. **Cell Migration:** SLIT3 modulates cell migration, including the migration of embryonic olfactory bulb interneuron precursors. 3. **Immune Regulation:** SLIT3 regulates the activity of various immune cells, including T cells and macrophages. 4. **Cell Growth and Proliferation:** SLIT3 negatively regulates cell growth and proliferation. 5. **Developmental Processes:** SLIT3 is involved in various developmental processes, including aortic valve morphogenesis, atrioventricular valve morphogenesis, and ventricular septum morphogenesis. **Clinical Significance:** SLIT3 has been implicated in various diseases, including autoimmune disorders, cancer, and developmental abnormalities. For example, mutations in the SLIT3 gene have been associated with autoimmune diseases, such as autoimmune hemolytic anemia. Additionally, SLIT3 has been shown to have a role in cancer progression, where it can promote tumor growth and metastasis. Furthermore, SLIT3 has been implicated in developmental abnormalities, including congenital heart defects and neural tube defects. In conclusion, SLIT3 is a multifunctional protein that plays a critical role in various cellular processes, including axon guidance, cell migration, and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of SLIT3 and its potential therapeutic applications. **References:** * [Insert references to relevant studies and reviews on SLIT3] Note: This article is a summary of the gene SLIT3, and it is not intended to be a comprehensive review of the literature. The references provided are fictional and are not real studies.

Genular Protein ID: 1627064980

Symbol: SLIT3_HUMAN

Name: Slit homolog 3 protein

UniProtKB Accession Codes:

O75094 A6H8U9 J3KNP3 O95804 Q9UFH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 8 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 2 SMART 10 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9813312

Title: Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

PubMed ID: 9813312

DOI: 10.1016/s0169-328x(98)00224-1

PubMed ID: 9693030

Title: Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

PubMed ID: 9693030

DOI: 10.1006/geno.1998.5341

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10349621

Title: Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.

PubMed ID: 10349621

DOI: 10.1016/s0925-4773(98)00174-9

Sequence Information:

  • Length: 1523
  • Mass: 167713
  • Checksum: CEB00887F6908554
  • Sequence:
    • MAPGWAGVGA AVRARLALAL ALASVLSGPP AVACPTKCTC SAASVDCHGL GLRAVPRGIP 
RNAERLDLDR NNITRITKMD FAGLKNLRVL HLEDNQVSVI ERGAFQDLKQ LERLRLNKNK 
LQVLPELLFQ STPKLTRLDL SENQIQGIPR KAFRGITDVK NLQLDNNHIS CIEDGAFRAL 
RDLEILTLNN NNISRILVTS FNHMPKIRTL RLHSNHLYCD CHLAWLSDWL RQRRTVGQFT 
LCMAPVHLRG FNVADVQKKE YVCPAPHSEP PSCNANSISC PSPCTCSNNI VDCRGKGLME 
IPANLPEGIV EIRLEQNSIK AIPAGAFTQY KKLKRIDISK NQISDIAPDA FQGLKSLTSL 
VLYGNKITEI VKGLFDGLVS LQLLLLNANK INCLRVNTFQ DLQNLNLLSL YDNKLQTISK 
GLFAPLQSIQ TLHLAQNPFV CDCHLKWLAD YLQDNPIETS GARCSSPRRL ANKRISQIKS 
KKFRCSGSED YRSRFSSECF MDLVCPEKCR CEGTIVDCSN QKLVRIPSHL PEYVTDLRLN 
DNEVSVLEAT GIFKKLPNLR KINLSNNKIK EVREGAFDGA ASVQELMLTG NQLETVHGRV 
FRGLSGLKTL MLRSNLIGCV SNDTFAGLSS VRLLSLYDNR ITTITPGAFT TLVSLSTINL 
LSNPFNCNCH LAWLGKWLRK RRIVSGNPRC QKPFFLKEIP IQDVAIQDFT CDGNEESSCQ 
LSPRCPEQCT CMETVVRCSN KGLRALPRGM PKDVTELYLE GNHLTAVPRE LSALRHLTLI 
DLSNNSISML TNYTFSNMSH LSTLILSYNR LRCIPVHAFN GLRSLRVLTL HGNDISSVPE 
GSFNDLTSLS HLALGTNPLH CDCSLRWLSE WVKAGYKEPG IARCSSPEPM ADRLLLTTPT 
HRFQCKGPVD INIVAKCNAC LSSPCKNNGT CTQDPVELYR CACPYSYKGK DCTVPINTCI 
QNPCQHGGTC HLSDSHKDGF SCSCPLGFEG QRCEINPDDC EDNDCENNAT CVDGINNYVC 
ICPPNYTGEL CDEVIDHCVP ELNLCQHEAK CIPLDKGFSC ECVPGYSGKL CETDNDDCVA 
HKCRHGAQCV DTINGYTCTC PQGFSGPFCE HPPPMVLLQT SPCDQYECQN GAQCIVVQQE 
PTCRCPPGFA GPRCEKLITV NFVGKDSYVE LASAKVRPQA NISLQVATDK DNGILLYKGD 
NDPLALELYQ GHVRLVYDSL SSPPTTVYSV ETVNDGQFHS VELVTLNQTL NLVVDKGTPK 
SLGKLQKQPA VGINSPLYLG GIPTSTGLSA LRQGTDRPLG GFHGCIHEVR INNELQDFKA 
LPPQSLGVSP GCKSCTVCKH GLCRSVEKDS VVCECRPGWT GPLCDQEARD PCLGHRCHHG 
KCVATGTSYM CKCAEGYGGD LCDNKNDSAN ACSAFKCHHG QCHISDQGEP YCLCQPGFSG 
EHCQQENPCL GQVVREVIRR QKGYASCATA SKVPIMECRG GCGPQCCQPT RSKRRKYVFQ 
CTDGSSFVEE VERHLECGCL ACS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.