Details for: CL0000183

Cell ID: CL0000183

Cell Name: contractile cell

Marker Score Threshold: 542
(Derived using integrated single-cell and genomic data)

Description: A cell whose primary function is to shorten.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 6.74
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 6.73
    Ensembl ID: ENSG00000151067
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 5.36
    Ensembl ID: ENSG00000163697
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 5.08
    Ensembl ID: ENSG00000165995
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 4.73
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 4.67
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 3.61
    Ensembl ID: ENSG00000047648
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.58
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 3.49
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 3.37
    Ensembl ID: ENSG00000135218
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 3.31
    Ensembl ID: ENSG00000135298
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.15
    Ensembl ID: ENSG00000151914
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.88
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.88
    Ensembl ID: ENSG00000145349
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 2.77
    Ensembl ID: ENSG00000175899
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.7
    Ensembl ID: ENSG00000204217
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.69
    Ensembl ID: ENSG00000143878
  • Gene Symbol: JAG1 (ENSG00000101384)
    Fold Change: 2.57
    Ensembl ID: ENSG00000101384
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: 2.56
    Ensembl ID: ENSG00000138031
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 2.52
    Ensembl ID: ENSG00000167601
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.49
    Ensembl ID: ENSG00000157764
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.44
    Ensembl ID: ENSG00000221869
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 2.29
    Ensembl ID: ENSG00000114423
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.28
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.23
    Ensembl ID: ENSG00000072110
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 2.16
    Ensembl ID: ENSG00000079102
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 2.15
    Ensembl ID: ENSG00000058668
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.14
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.1
    Ensembl ID: ENSG00000113916
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 2.08
    Ensembl ID: ENSG00000164692
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 2.03
    Ensembl ID: ENSG00000173175
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.98
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.93
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.92
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.91
    Ensembl ID: ENSG00000170634
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.89
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.86
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 1.83
    Ensembl ID: ENSG00000107779
  • Gene Symbol: CDH6 (ENSG00000113361)
    Fold Change: 1.82
    Ensembl ID: ENSG00000113361
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.76
    Ensembl ID: ENSG00000097007
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.74
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.73
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.72
    Ensembl ID: ENSG00000156273
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.72
    Ensembl ID: ENSG00000099622
  • Gene Symbol: COL3A1 (ENSG00000168542)
    Fold Change: 1.71
    Ensembl ID: ENSG00000168542
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.71
    Ensembl ID: ENSG00000174437
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 1.68
    Ensembl ID: ENSG00000105971
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 1.66
    Ensembl ID: ENSG00000140945
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.61
    Ensembl ID: ENSG00000156110
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.6
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.59
    Ensembl ID: ENSG00000004897
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 1.52
    Ensembl ID: ENSG00000145741
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.49
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BGN (ENSG00000182492)
    Fold Change: 1.48
    Ensembl ID: ENSG00000182492
  • Gene Symbol: ANGPT1 (ENSG00000154188)
    Fold Change: 1.48
    Ensembl ID: ENSG00000154188
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.48
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.48
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.46
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.45
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.44
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BMP5 (ENSG00000112175)
    Fold Change: 1.4
    Ensembl ID: ENSG00000112175
  • Gene Symbol: ANGPT2 (ENSG00000091879)
    Fold Change: 1.37
    Ensembl ID: ENSG00000091879
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.34
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 1.29
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 1.28
    Ensembl ID: ENSG00000148660
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.28
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.23
    Ensembl ID: ENSG00000116489
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.22
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 1.2
    Ensembl ID: ENSG00000151746
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.18
    Ensembl ID: ENSG00000105974
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.18
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.18
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 1.18
    Ensembl ID: ENSG00000128656
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 1.15
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CACNA1A (ENSG00000141837)
    Fold Change: 1.13
    Ensembl ID: ENSG00000141837
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.13
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.13
    Ensembl ID: ENSG00000145362
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.13
    Ensembl ID: ENSG00000070831
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.13
    Ensembl ID: ENSG00000143669
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.12
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.11
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: 1.11
    Ensembl ID: ENSG00000174233
  • Gene Symbol: AGT (ENSG00000135744)
    Fold Change: 1.11
    Ensembl ID: ENSG00000135744
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.1
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.08
    Ensembl ID: ENSG00000278540
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.08
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.07
    Ensembl ID: ENSG00000019582
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.07
    Ensembl ID: ENSG00000119138
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 1.05
    Ensembl ID: ENSG00000171791
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.05
    Ensembl ID: ENSG00000173575
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.04
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.03
    Ensembl ID: ENSG00000143322
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159216
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 1.01
    Ensembl ID: ENSG00000085063
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.01
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1
    Ensembl ID: ENSG00000018625
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1
    Ensembl ID: ENSG00000140743
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: N/A
    Ensembl ID: ENSG00000141367
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Primary function**: Shortening and contraction 2. **Genes**: * CALD1 (Ensembl ID: ENSG00000122786): involved in actin binding and muscle contraction * CACNA1C (Ensembl ID: ENSG00000151067): involved in calcium-mediated signaling and muscle contraction * APBB2 (Ensembl ID: ENSG00000163697): involved in amyloid-beta binding and muscle contraction * CACNB2 (Ensembl ID: ENSG00000165995): involved in calcium channel activity and muscle contraction * ACTA2 (Ensembl ID: ENSG00000107796): involved in muscle contraction and smooth muscle contraction * ZFHX3 (Ensembl ID: ENSG00000140836): involved in chromatin and muscle organ development * ARHGAP6 (Ensembl ID: ENSG00000047648): involved in actin cytoskeleton and signal transduction 3. **Pathways**: * Actin binding * Actin cap * Actin cytoskeleton * Actin filament bundle assembly * Angiogenesis * Cadherin binding * Calmodulin binding * Cytoskeleton * Cytosol * Muscle contraction * Myofibril * Myosin binding * Plasma membrane * Protein binding * Smooth muscle contraction * Stress fiber * Tropomyosin binding **Clinical Significance** The contractile cell plays a crucial role in various physiological processes, including: 1. **Muscle contraction**: The contractile cell is essential for muscle contraction and movement, which is critical for maintaining posture, facilitating movement, and regulating blood pressure. 2. **Cardiac function**: The contractile cell is involved in cardiac contraction and relaxation, which is critical for maintaining cardiac function and regulating heart rate. 3. **Smooth muscle contraction**: The contractile cell is involved in smooth muscle contraction, which is critical for regulating blood pressure, digestive motility, and other physiological processes. 4. **Neurological function**: The contractile cell is involved in neuronal signaling and transmission, which is critical for regulating neural function and behavior. 5. **Developmental biology**: The contractile cell is involved in embryonic development, including muscle organogenesis and cardiac development. Dysregulation of the contractile cell has been implicated in various diseases, including: 1. **Muscular dystrophy**: A group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac hypertrophy**: A condition characterized by the thickening of the heart muscle, which can lead to heart failure. 3. **Hypertension**: A condition characterized by elevated blood pressure, which can lead to cardiovascular disease. 4. **Neurological disorders**: Diseases such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS) have been implicated in contractile cell dysfunction. Understanding the contractile cell and its role in various physiological processes is essential for developing effective treatments for these diseases.