Details for: NDFIP1
Gene ID: 80762
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NDFIP1
Ensembl ID: ENSG00000131507
Description: Nedd4 family interacting protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 77.7rCSI 76.42%PRS 8.45
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CSI 70.2rCSI 73.55%PRS 8.28
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CSI 67.84rCSI 100%PRS 7.33
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CSI 56.03rCSI 90.1%PRS 5.07
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CSI 55.65rCSI 69.23%PRS 4.22
-
CSI 55.03rCSI 74.98%PRS 6.99
-
CSI 54.58rCSI 65.19%PRS 4.57
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CSI 51.83rCSI 66.82%PRS 4.87
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CSI 51.1rCSI 85.77%PRS 4.57
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CSI 45.68rCSI 100%PRS 5.58
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CSI 41.76rCSI 51.66%PRS 6.84
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CSI 41.11rCSI 72.6%PRS 4.6
-
CSI 39.35rCSI 95.63%PRS 4.44
-
CSI 37.33rCSI 26.22%PRS 21.81
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CSI 36.97rCSI 59.51%PRS 5.96
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CSI 35.42rCSI 44.51%PRS 37.75
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CSI 35.07rCSI 77.64%PRS 7.22
-
CSI 34.65rCSI 92.27%PRS 6.51
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CSI 33.46rCSI 45.75%PRS 13.21
-
CSI 32.16rCSI 62.55%PRS 7.94
-
CSI 30.63rCSI 95.72%PRS 4.91
-
CSI 28.76rCSI 89.95%PRS 5.3
-
CSI 28.08rCSI 41.74%PRS 9.73
-
CSI 27.07rCSI 97.4%PRS 4.21
-
CSI 25.65rCSI 40.91%PRS 6.73
-
CSI 24.86rCSI 93.97%PRS 4.71
-
CSI 24.56rCSI 25.67%PRS 8.2
-
CSI 23.87rCSI 51.78%PRS 3.76
-
CSI 23.62rCSI 30.31%PRS 7.63
-
CSI 22.17rCSI 39.08%PRS 7.88
-
CSI 22.14rCSI 71.04%PRS 11.64
-
CSI 20.3rCSI 80.82%PRS 13.81
-
CSI 19.71rCSI 67.51%PRS 7.79
-
CSI 19.36rCSI 42.26%PRS 15.88
-
CSI 18.9rCSI 54.72%PRS 8.84
-
CSI 17.72rCSI 25.93%PRS 8.26
-
CSI 17.64rCSI 69.86%PRS 13.12
-
CSI 16.02rCSI 38.52%PRS 12.05
-
CSI 15.79rCSI 78.51%PRS 9.61
-
CSI 15.77rCSI 92.83%PRS 4.84
-
CSI 14.57rCSI 33.24%PRS 7.09
-
CSI 14.48rCSI 19.24%PRS 8.47
-
CSI 14.22rCSI 66.3%PRS 19.14
-
CSI 14.12rCSI 8.34%PRS 10.78
-
CSI 13.36rCSI 31.95%PRS 4.03
-
CSI 13.03rCSI 18.78%PRS 12.6
-
CSI 12.64rCSI 12.16%PRS 8.07
-
CSI 12.15rCSI 9.61%PRS 5.38
-
CSI 11.93rCSI 16.58%PRS 8.08
-
CSI 11.9rCSI 11%PRS 14.29
-
CSI 11.77rCSI 11.99%PRS 11.2
-
CSI 11.74rCSI 46.91%PRS 17.25
-
CSI 11.44rCSI 15.64%PRS 8.84
-
CSI 11.21rCSI 8.63%PRS 7.06
-
CSI 10.57rCSI 13.45%PRS 9.05
-
CSI 10.49rCSI 36.79%PRS 14.19
-
CSI 10.23rCSI 44.97%PRS 5.85
-
CSI 10.07rCSI 20.22%PRS 5.78
-
CSI 10.05rCSI 73.88%PRS 3.73
-
CSI 9.29rCSI 54.03%PRS 11.77
-
CSI 9.17rCSI 17.51%PRS 18.84
-
CSI 9.12rCSI 42.12%PRS 16.74
-
CSI 8.48rCSI 95.4%PRS 23.24
-
CSI 8.42rCSI 24.41%PRS 6.37
-
CSI 8.42rCSI 11.5%PRS 8.63
-
CSI 7.79rCSI 10.41%PRS 10.41
-
CSI 7.59rCSI 26.96%PRS 12.83
-
CSI 7.48rCSI 10.58%PRS 11.21
-
CSI 7.38rCSI 13.42%PRS 11.9
-
CSI 7.36rCSI 10.11%PRS 16.53
-
CSI 6.61rCSI 12.48%PRS 9.69
-
CSI 6.49rCSI 15.58%PRS 14.53
-
CSI 6.33rCSI 20.8%PRS 3.61
-
CSI 6.2rCSI 88.02%PRS 5.33
-
CSI 6.11rCSI 4.12%PRS 9.38
-
CSI 6.08rCSI 11.39%PRS 5.81
-
CSI 6.06rCSI 59.63%PRS 24.11
-
CSI 5.96rCSI 32.04%PRS 14.14
-
CSI 5.88rCSI 31.99%PRS 19.75
-
CSI 5.82rCSI 27.31%PRS 21.26
-
CSI 5.79rCSI 37.07%PRS 12.9
-
CSI 5.69rCSI 16.78%PRS 9.76
-
CSI 5.54rCSI 8.14%PRS 7.54
-
CSI 5.35rCSI 58.23%PRS 14.97
-
CSI 5.19rCSI 13.48%PRS 23.25
-
CSI 5.14rCSI 28.1%PRS 16.01
-
CSI 5.07rCSI 31.31%PRS 25.82
-
CSI 5.04rCSI 4.35%PRS 12.83
-
CSI 4.9rCSI 5.12%PRS 8
-
CSI 4.75rCSI 13.35%PRS 11.23
-
CSI 4.55rCSI 25.9%PRS 35.42
-
CSI 4.5rCSI 66.48%PRS 20.95
-
CSI 4.48rCSI 91.22%PRS 6.44
-
CSI 4.36rCSI 88.67%PRS 7.09
-
CSI 4.26rCSI 11.7%PRS 12.95
-
CSI 4.23rCSI 3.55%PRS 9.32
-
CSI 4.19rCSI 17.07%PRS 8.52
-
CSI 4.15rCSI 6.37%PRS 11.19
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CSI 4.02rCSI 8%PRS 13.29
-
CSI 4.01rCSI 3.87%PRS 4.94
-
CSI -7.4rCSI -41.7%PRS 2.7%
-
CSI -7.4rCSI -13.0%PRS 10.3%
-
CSI -5.0rCSI -8.8%PRS 5.9%
-
CSI -2.4rCSI -4.6%PRS 12.5%
-
CSI -2.4rCSI -1.7%PRS 8.2%
-
CSI -2.1rCSI -2.8%PRS 14.9%
-
CSI -1.8rCSI -6.6%PRS 14.0%
-
CSI -1.6rCSI -1.6%PRS 14.8%
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CSI -1.5rCSI -3.3%PRS 10.6%
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CSI -1.4rCSI -3.6%PRS 9.3%
-
CSI -1.3rCSI -1.5%PRS 9.3%
-
CSI -1.0rCSI -4.5%PRS 11.2%
-
CSI -0.8rCSI -1.1%PRS 12.0%
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CSI -0.8rCSI -2.6%PRS 10.7%
-
CSI -0.4rCSI -0.8%PRS 18.7%
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CSI -0.4rCSI -0.8%PRS 21.7%
-
CSI -0.3rCSI -0.2%PRS 13.2%
-
CSI -0.3rCSI -0.4%PRS 10.7%
-
CSI -0.2rCSI -0.2%PRS 13.6%
-
CSI 0.0rCSI 0.1%PRS 9.8%
-
CSI 0.1rCSI 0.2%PRS 33.0%
-
CSI 0.1rCSI 0.2%PRS 7.3%
-
CSI 0.1rCSI 1.9%PRS 51.2%
-
CSI 0.1rCSI 0.8%PRS 30.1%
-
CSI 0.1rCSI 2.1%PRS 52.0%
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CSI 0.1rCSI 3.5%PRS 18.8%
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CSI 0.1rCSI 0.1%PRS 8.7%
-
CSI 0.1rCSI 0.6%PRS 15.7%
-
CSI 0.1rCSI 0.5%PRS 6.7%
-
CSI 0.1rCSI 0.4%PRS 33.8%
-
CSI 0.1rCSI 0.2%PRS 12.7%
-
CSI 0.1rCSI 2.1%PRS 25.7%
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CSI 0.2rCSI 1.0%PRS 20.6%
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CSI 0.2rCSI 0.2%PRS 8.5%
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CSI 0.2rCSI 1.2%PRS 9.2%
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CSI 0.2rCSI 0.6%PRS 5.7%
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CSI 0.2rCSI 1.4%PRS 17.9%
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CSI 0.2rCSI 1.9%PRS 8.8%
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CSI 0.2rCSI 1.4%PRS 11.8%
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CSI 0.3rCSI 0.9%PRS 13.4%
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CSI 0.3rCSI 1.2%PRS 28.8%
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CSI 0.3rCSI 0.7%PRS 13.2%
-
CSI 0.3rCSI 1.4%PRS 16.3%
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CSI 0.3rCSI 1.2%PRS 14.3%
-
CSI 0.3rCSI 2.2%PRS 33.9%
-
CSI 0.3rCSI 0.7%PRS 12.5%
-
CSI 0.3rCSI 1.1%PRS 12.1%
-
CSI 0.3rCSI 1.3%PRS 14.6%
-
CSI 0.3rCSI 0.5%PRS 13.4%
-
CSI 0.3rCSI 0.6%PRS 15.4%
-
CSI 0.3rCSI 0.3%PRS 12.4%
-
CSI 0.3rCSI 1.0%PRS 8.9%
-
CSI 0.3rCSI 3.1%PRS 34.0%
-
CSI 0.3rCSI 0.4%PRS 13.5%
-
CSI 0.4rCSI 1.0%PRS 7.9%
-
CSI 0.4rCSI 1.8%PRS 10.3%
-
CSI 0.4rCSI 1.3%PRS 13.4%
-
CSI 0.4rCSI 1.6%PRS 19.5%
-
CSI 0.4rCSI 1.1%PRS 11.3%
-
CSI 0.4rCSI 2.9%PRS 21.8%
-
CSI 0.4rCSI 0.9%PRS 16.7%
-
CSI 0.4rCSI 1.0%PRS 11.7%
-
CSI 0.4rCSI 2.2%PRS 14.6%
-
CSI 0.4rCSI 2.2%PRS 11.0%
-
CSI 0.4rCSI 4.2%PRS 23.2%
-
CSI 0.4rCSI 0.5%PRS 11.1%
-
CSI 0.4rCSI 1.4%PRS 13.8%
-
CSI 0.4rCSI 1.7%PRS 8.3%
-
CSI 0.4rCSI 8.6%PRS 26.8%
-
CSI 0.5rCSI 0.7%PRS 8.5%
-
CSI 0.5rCSI 1.2%PRS 7.9%
-
CSI 0.5rCSI 2.1%PRS 12.5%
-
CSI 0.5rCSI 4.2%PRS 8.2%
-
CSI 0.5rCSI 4.4%PRS 8.8%
-
CSI 0.5rCSI 6.8%PRS 53.4%
-
CSI 0.5rCSI 0.4%PRS 7.7%
-
CSI 0.5rCSI 2.9%PRS 26.6%
-
CSI 0.5rCSI 1.0%PRS 17.3%
-
CSI 0.6rCSI 2.7%PRS 4.9%
-
CSI 0.6rCSI 0.5%PRS 6.9%
-
CSI 0.6rCSI 3.3%PRS 11.1%
-
CSI 0.6rCSI 1.3%PRS 8.2%
-
CSI 0.6rCSI 3.7%PRS 6.4%
-
CSI 0.6rCSI 3.5%PRS 9.4%
-
CSI 0.6rCSI 0.5%PRS 9.6%
-
CSI 0.6rCSI 0.6%PRS 12.1%
-
CSI 0.6rCSI 4.5%PRS 58.4%
-
CSI 0.6rCSI 0.5%PRS 11.7%
-
CSI 0.6rCSI 1.6%PRS 7.2%
-
CSI 0.6rCSI 2.6%PRS 11.2%
-
CSI 0.6rCSI 1.5%PRS 19.6%
-
CSI 0.6rCSI 0.8%PRS 9.9%
-
CSI 0.7rCSI 3.0%PRS 2.5%
-
CSI 0.7rCSI 1.8%PRS 8.1%
-
CSI 0.7rCSI 4.8%PRS 15.5%
-
CSI 0.7rCSI 3.2%PRS 7.8%
-
CSI 0.7rCSI 3.4%PRS 8.7%
-
CSI 0.7rCSI 2.1%PRS 9.9%
-
CSI 0.8rCSI 1.2%PRS 7.9%
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CSI 0.8rCSI 19.0%PRS 58.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2526136289
Symbol: NFIP1_HUMAN
Name: NEDD4 family-interacting protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12761501
Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
PubMed ID: 12761501
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16303743
Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
PubMed ID: 16303743
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 11748237
Title: N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.
PubMed ID: 11748237
PubMed ID: 18776082
Title: Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
PubMed ID: 18776082
PubMed ID: 18819914
Title: Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins.
PubMed ID: 18819914
PubMed ID: 19343052
Title: Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.
PubMed ID: 19343052
PubMed ID: 19706893
Title: Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.
PubMed ID: 19706893
PubMed ID: 20534535
Title: Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.
PubMed ID: 20534535
PubMed ID: 23087404
Title: Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation.
PubMed ID: 23087404
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 26319551
Title: Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells.
PubMed ID: 26319551
PubMed ID: 26363003
Title: Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).
PubMed ID: 26363003
DOI: 10.1042/bj20141282
PubMed ID: 25631046
Title: Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.
PubMed ID: 25631046
PubMed ID: 25632008
Title: Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
PubMed ID: 25632008
PubMed ID: 25801959
Title: Ndfip1 represses cell proliferation by controlling Pten localization and signaling specificity.
PubMed ID: 25801959
DOI: 10.1093/jmcb/mjv020
Sequence Information:
- Length: 221
- Mass: 24899
- Checksum: 526A579D7B32FCA4
- Sequence:
MALALAALAA VEPACGSRYQ QLQNEEESGE PEQAAGDAPP PYSSISAESA AYFDYKDESG FPKPPSYNVA TTLPSYDEAE RTKAEATIPL VPGRDEDFVG RDDFDDADQL RIGNDGIFML TFFMAFLFNW IGFFLSFCLT TSAAGRYGAI SGFGLSLIKW ILIVRFSTYF PGYFDGQYWL WWVFLVLGFL LFLRGFINYA KVRKMPETFS NLPRTRVLFI Y