Details for: ECM2

Gene ID: 1842

Symbol: ECM2

Ensembl ID: ENSG00000106823

Description: extracellular matrix protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.0276
    Cell Significance Index: -14.4700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 57.2457
    Cell Significance Index: -14.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 26.3279
    Cell Significance Index: -12.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7604
    Cell Significance Index: -14.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4686
    Cell Significance Index: -9.7800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 4.0477
    Cell Significance Index: 50.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.9125
    Cell Significance Index: 76.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5580
    Cell Significance Index: -14.0400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6374
    Cell Significance Index: 15.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.5491
    Cell Significance Index: 156.2900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.6304
    Cell Significance Index: 24.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1791
    Cell Significance Index: 53.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1406
    Cell Significance Index: 24.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.0209
    Cell Significance Index: 14.6600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.0073
    Cell Significance Index: 15.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9908
    Cell Significance Index: 188.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8614
    Cell Significance Index: 27.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7949
    Cell Significance Index: 13.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7594
    Cell Significance Index: 21.7700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.6538
    Cell Significance Index: 4.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6480
    Cell Significance Index: 128.6000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5689
    Cell Significance Index: 28.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.5441
    Cell Significance Index: 9.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5361
    Cell Significance Index: 68.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4026
    Cell Significance Index: 363.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3928
    Cell Significance Index: 38.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3824
    Cell Significance Index: 22.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3555
    Cell Significance Index: 48.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2923
    Cell Significance Index: 31.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2397
    Cell Significance Index: 7.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2381
    Cell Significance Index: 4.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2199
    Cell Significance Index: 35.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1706
    Cell Significance Index: 11.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1611
    Cell Significance Index: 32.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1015
    Cell Significance Index: 2.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0895
    Cell Significance Index: 5.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0718
    Cell Significance Index: 2.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0402
    Cell Significance Index: 74.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0393
    Cell Significance Index: 0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0386
    Cell Significance Index: 59.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0385
    Cell Significance Index: 52.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0329
    Cell Significance Index: 11.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0316
    Cell Significance Index: 0.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0179
    Cell Significance Index: 0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0139
    Cell Significance Index: 26.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0128
    Cell Significance Index: 8.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0014
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0055
    Cell Significance Index: -0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0061
    Cell Significance Index: -0.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0083
    Cell Significance Index: -3.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0150
    Cell Significance Index: -6.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0192
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0211
    Cell Significance Index: -15.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0211
    Cell Significance Index: -15.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0247
    Cell Significance Index: -7.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0271
    Cell Significance Index: -14.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0279
    Cell Significance Index: -17.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0291
    Cell Significance Index: -16.4300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0529
    Cell Significance Index: -1.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0581
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0725
    Cell Significance Index: -12.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0758
    Cell Significance Index: -15.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0951
    Cell Significance Index: -2.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0969
    Cell Significance Index: -6.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0981
    Cell Significance Index: -10.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0995
    Cell Significance Index: -12.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1109
    Cell Significance Index: -12.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1161
    Cell Significance Index: -13.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1223
    Cell Significance Index: -12.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1323
    Cell Significance Index: -15.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1418
    Cell Significance Index: -6.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1573
    Cell Significance Index: -12.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1660
    Cell Significance Index: -12.3700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1818
    Cell Significance Index: -1.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2026
    Cell Significance Index: -13.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2124
    Cell Significance Index: -5.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2125
    Cell Significance Index: -5.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2350
    Cell Significance Index: -14.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2435
    Cell Significance Index: -8.5300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2685
    Cell Significance Index: -8.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2747
    Cell Significance Index: -9.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2758
    Cell Significance Index: -12.8600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.3104
    Cell Significance Index: -3.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3148
    Cell Significance Index: -16.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3259
    Cell Significance Index: -16.9300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3312
    Cell Significance Index: -4.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3430
    Cell Significance Index: -7.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3623
    Cell Significance Index: -8.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3672
    Cell Significance Index: -12.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3688
    Cell Significance Index: -9.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3760
    Cell Significance Index: -10.0400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3827
    Cell Significance Index: -4.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4073
    Cell Significance Index: -14.9500
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4206
    Cell Significance Index: -5.1200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4257
    Cell Significance Index: -7.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** ECM2 is widely expressed in various cell types, including OFF-bipolar cells, retinal cone cells, vascular leptomeningeal cells, colon goblet cells, enterocytes, fat cells, fibroblasts, early T lineage precursors, extravillous trophoblasts, and GABAergic interneurons in the cerebral cortex. 2. **Protein Structure:** ECM2 is a type of extracellular matrix protein, consisting of a collagen-like triple-helical domain and a globular domain, which mediates interactions with other proteins and cells. 3. **Binding Partners:** ECM2 interacts with various binding partners, including integrins, collagen receptors, and heparin, to regulate cell-substrate adhesion, migration, and differentiation. **Pathways and Functions:** 1. **Cell-Matrix Adhesion:** ECM2 plays a crucial role in regulating cell-substrate adhesion by interacting with integrins and collagen receptors, which are essential for maintaining tissue architecture and function. 2. **Extracellular Matrix Organization:** ECM2 participates in the organization and remodeling of the ECM by regulating the deposition and degradation of extracellular matrix components. 3. **Cell Migration and Differentiation:** ECM2 influences cell migration and differentiation by modulating the activity of integrins and other signaling molecules. 4. **Heparin Binding:** ECM2 binds to heparin, which modulates its activity and interactions with other proteins and cells. **Clinical Significance:** 1. **Dysregulation in Diseases:** Disruptions in ECM2 expression and function have been implicated in various diseases, including cancer, fibrosis, and neurodegenerative disorders. 2. **Cancer Metastasis:** ECM2 has been shown to promote cancer cell migration and invasion by regulating cell-substrate adhesion and integrin signaling. 3. **Fibrosis and Tissue Repair:** ECM2 plays a role in regulating the deposition and remodeling of extracellular matrix components during tissue repair and fibrosis. 4. **Neurological Disorders:** ECM2 has been implicated in the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates cell-substrate adhesion and integrin signaling. In conclusion, ECM2 is a multifunctional protein that plays a crucial role in maintaining the integrity and organization of the extracellular matrix. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2868499919

Symbol: ECM2_HUMAN

Name: Extracellular matrix protein 2

UniProtKB Accession Codes:

O94769 B2R730 E2PU11 Q5T9F2 Q7Z3D0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9790758

Title: Identification of a novel gene (ECM2) encoding a putative extracellular matrix protein expressed predominantly in adipose and female-specific tissues and its chromosomal localization to 9q22.3.

PubMed ID: 9790758

DOI: 10.1006/geno.1998.5455

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 699
  • Mass: 79789
  • Checksum: E44E76A40A5C2742
  • Sequence:
    • MKIAVLFCFF LLIIFQTDFG KNEEIPRKQR RKIYHRRLRK SSTSHKHRSN RQLGIQQTTV 
FTPVARLPIV NFDYSMEEKF ESFSSFPGVE SSYNVLPGKK GHCLVKGITM YNKAVWSPEP 
CTTCLCSDGR VLCDETMCHP QRCPQTVIPE GECCPVCSAT VSYSLLSGIA LNDRNEFSGD 
SSEQREPTNL LHKQLPPPQV GMDRIVRKEA LQSEEDEEVK EEDTEQKRET PESRNQGQLY 
SEGDSRGGDR KQRPGEERRL AHQQQRQGRE EEEDEEEEGE EGEEDEEDEE DPVRGDMFRM 
PSRSPLPAPP RGTLRLPSGC SLSYRTISCI NAMLTQIPPL TAPQITSLEL TGNSIASIPD 
EAFNGLPNLE RLDLSKNNIT SSGIGPKAFK LLKKLMRLNM DGNNLIQIPS QLPSTLEELK 
VNENNLQAID EESLSDLNQL VTLELEGNNL SEANVNPLAF KPLKSLAYLR LGKNKFRIIP 
QGLPGSIEEL YLENNQIEEI TEICFNHTRK INVIVLRYNK IEENRIAPLA WINQENLESI 
DLSYNKLYHV PSYLPKSLLH LVLLGNQIER IPGYVFGHME PGLEYLYLSF NKLADDGMDR 
VSFYGAYHSL RELFLDHNDL KSIPPGIQEM KALHFLRLNN NKIRNILPEE ICNAEEDDDS 
NLEHLHLENN YIKIREIPSY TFSCIRSYSS IVLKPQNIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.