Details for: RERGL

Gene ID: 79785

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: RERGL

Ensembl ID: ENSG00000111404

Description: RERG like

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • perivascular cell CL4033054
    CSI 18.59
    rCSI 25.41%
    PRS 99.75
  • myofibroblast cell CL0000186
    CSI 14.39
    rCSI 19.93%
    PRS 99.5
  • microcirculation associated smooth muscle cell CL0008035
    CSI 11.52
    rCSI 33.36%
    PRS 99.43
  • cerebral cortex endothelial cell CL1001602
    CSI 10.62
    rCSI 18.36%
    PRS 98.85
  • vascular associated smooth muscle cell CL0000359
    CSI 7.89
    rCSI 25.59%
    PRS 99.65
  • kidney connecting tubule epithelial cell CL1000768
    CSI 6.48
    rCSI 16.43%
    PRS 99.13
  • tracheobronchial smooth muscle cell CL0019019
    CSI 5.05
    rCSI 8.91%
    PRS 99.68
  • epithelial cell of proximal tubule CL0002306
    CSI 4.89
    rCSI 11.95%
    PRS 98.28
  • Bergmann glial cell CL0000644
    CSI 4.49
    rCSI 6.14%
    PRS 98.51
  • neural progenitor cell CL0011020
    CSI 4.26
    rCSI 18.76%
    PRS 96.38
  • glioblast CL0000030
    CSI 3.67
    rCSI 5.85%
    PRS 98.52
  • blood vessel smooth muscle cell CL0019018
    CSI 3.17
    rCSI 25.76%
    PRS 99.59
  • renal interstitial pericyte CL1001318
    CSI 2.96
    rCSI 8.16%
    PRS 99.56
  • contractile cell CL0000183
    CSI 2.83
    rCSI 8.34%
    PRS 99.66
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 1.3
    rCSI 9.93%
    PRS 99.68

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [RERGL](/details-gene/79785) (RERG like) is a protein-coding gene located on chromosome 12p12.3 in *Homo sapiens*. It encodes a member of the Ras superfamily of small GTPases, as indicated by its functional annotation for [G protein activity](/details-go/GO:0003925) and [Gtp binding](/details-go/GO:0005525). Expression data reveals a highly specific profile, with [RERGL](/details-gene/79785) serving as a significant marker for cells associated with the vasculature and contractile tissues. **Overall**, its highest significance is observed in [perivascular cells](/details-cell/CL4033054), [myofibroblast cells](/details-cell/CL0000186), and various types of smooth muscle cells, suggesting a primary role in regulating the structure and function of blood vessels and other contractile tissues. Its discovery and characterization are supported by large-scale cDNA sequencing and human genome projects [[Link](https://doi.org/10.1038/ng1285), [Link](https://doi.org/10.1101/gr.2596504), [Link](https://doi.org/10.1038/nature04569)]. ## Cellular Roles and Expression Landscape The expression pattern of [RERGL](/details-gene/79785) strongly indicates a specialized function in mesenchymal-derived cell types, particularly those involved in vascular and structural support. **Overall**, the gene shows the highest significance in [perivascular cells](/details-cell/CL4033054) (CSI: 18.59) and [myofibroblast cells](/details-cell/CL0000186) (CSI: 14.39), which are key players in tissue remodeling, fibrosis, and blood vessel integrity. This association with the vasculature is further reinforced by its high significance scores in a range of related cell types, including [microcirculation associated smooth muscle cells](/details-cell/CL0008035) (CSI: 11.52), [cerebral cortex endothelial cells](/details-cell/CL1001602) (CSI: 10.62), and [vascular associated smooth muscle cells](/details-cell/CL0000359) (CSI: 7.89). This consistent expression across the vascular tree suggests a fundamental role in maintaining vascular tone, structure, or signaling. Beyond the vasculature, [RERGL](/details-gene/79785) is also prominently expressed in specialized epithelial and glial cells. It shows notable significance in [kidney connecting tubule epithelial cells](/details-cell/CL1000768) and [epithelial cells of the proximal tubule](/details-cell/CL0002306), implying a potential role in renal physiology. Furthermore, its expression in [Bergmann glial cells](/details-cell/CL0000644) and [neural progenitor cells](/details-cell/CL0011020) suggests a secondary, though less defined, role within the central nervous system. ## Pathways and Molecular Function The molecular function of [RERGL](/details-gene/79785) is primarily associated with its identity as a small GTPase. Gene Ontology annotations confirm its involvement in [Gtp binding](/details-go/GO:0005525) and [G protein activity](/details-go/GO:0003925). Proteins in this class typically function as molecular switches, cycling between an active GTP-bound state and an inactive GDP-bound state to regulate a wide array of cellular processes. Given its high expression in contractile and perivascular cells, the GTPase activity of [RERGL](/details-gene/79785) likely regulates signaling pathways controlling cell shape, adhesion, migration, and proliferation. This function is critical for the physiological roles of [smooth muscle cells](/details-cell/CL0000359) in maintaining vascular tone and for the activity of [myofibroblasts](/details-cell/CL0000186) during wound healing and tissue repair. ## Research Directions The specific expression pattern of [RERGL](/details-gene/79785) in cells central to vascular biology and tissue remodeling presents several avenues for future investigation. **Proposed Hypotheses:** 1. **[RERGL](/details-gene/79785) regulates the contractile phenotype of vascular smooth muscle cells.** As a GTPase, it may act downstream of vasoactive signals to control cytoskeletal dynamics, and its dysregulation could contribute to pathologies like hypertension or atherosclerosis. 2. **[RERGL](/details-gene/79785) is a key mediator of myofibroblast activation and matrix deposition.** Its high expression in [myofibroblast cells](/details-cell/CL0000186) suggests it could be a critical node in signaling pathways that drive fibrotic diseases in organs such as the lung, liver, and kidney. **Experimental Approach:** To test the hypothesis that [RERGL](/details-gene/79785) is a key mediator of myofibroblast activation, an experiment could be designed using primary human lung or dermal fibroblasts. [RERGL](/details-gene/79785) expression could be silenced using siRNA or knocked out using CRISPR-Cas9. These cells would then be stimulated with TGF-β1, a potent inducer of myofibroblast differentiation. The effect of [RERGL](/details-gene/79785) loss would be assessed by measuring the expression of myofibroblast markers like alpha-smooth muscle actin (α-SMA) via western blot or immunofluorescence, and collagen production could be quantified using a Sircol assay. A significant reduction in these markers in the knockout/knockdown cells would support the hypothesis. **Therapeutic Potential:** As a member of the druggable GTPase family, [RERGL](/details-gene/79785) presents a potential therapeutic target. Its high expression in [myofibroblasts](/details-cell/CL0000186) and [perivascular cells](/details-cell/CL4033054) makes it an attractive target for diseases characterized by excessive fibrosis or vascular remodeling, such as idiopathic pulmonary fibrosis or pulmonary arterial hypertension. An inhibitory strategy, using small molecule inhibitors designed to lock [RERGL](/details-gene/79785) in an inactive GDP-bound state, could potentially suppress the pro-fibrotic activity of myofibroblasts and ameliorate disease progression. The specificity of its expression profile suggests that targeting [RERGL](/details-gene/79785) might offer a focused therapeutic effect with fewer off-target effects compared to broadly acting anti-fibrotic agents.

Genular Protein ID: 1428686665

Symbol: RERGL_HUMAN

Name: Ras-related and estrogen-regulated growth inhibitor-like protein

UniProtKB Accession Codes:

Q9H628

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 205
  • Mass: 23855
  • Checksum: E8FDF8DEA09EC44A
  • Sequence:
    • MSNFLHLKYN EKSVSVTKAL TVRFLTKRFI GEYASNFESI YKKHLCLERK QLNLEIYDPC 
SQTQKAKFSL TSELHWADGF VIVYDISDRS SFAFAKALIY RIREPQTSHC KRAVESAVFL 
VGNKRDLCHV REVGWEEGQK LALENRCQFC ELSAAEQSLE VEMMFIRIIK DILINFKLKE 
KRRPSGSKSM AKLINNVFGK RRKSV

Genular Protein ID: 2715945837

Symbol: F5H686_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H686

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MANE-Select 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 Pfam 1 Proteomes 2 RefSeq 1 Rhea 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 204
  • Mass: 23405
  • Checksum: C13A34EA16ECBB03
  • Sequence:
    • MNDVKLAVLG GEGTGKSALT VRFLTKRFIG EYASNFESIY KKHLCLERKQ LNLEIYDPCS 
QTQKAKFSLT SELHWADGFV IVYDISDRSS FAFAKALIYR IREPQTSHCK RAVESAVFLV 
GNKRDLCHVR EVGWEEGQKL ALENRCQFCE LSAAEQSLEV EMMFIRIIKD ILINFKLKEK 
RRPSGSKSMA KLINNVFGKR RKSV