HNRNPH1 | ENSG00000169045 | NCBI 3187

Details for: HNRNPH1

Gene ID: 3187

Symbol: HNRNPH1

Ensembl ID: ENSG00000169045

Description: heterogeneous nuclear ribonucleoprotein H1

Associated with

Fgfr2 alternative splicing
(R-HSA-6803529)
Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Catalytic step 2 spliceosome
(GO:0071013)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Mrna splicing, via spliceosome
(GO:0000398)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Poly(u) rna binding
(GO:0008266)
Protein binding
(GO:0005515)
Regulation of rna splicing
(GO:0043484)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna processing
(GO:0006396)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.57
Cell Significance Index: 2
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.16
Cell Significance Index: 1
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1
Cell Significance Index: 1
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: odontoblast (CL0000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: melanocyte (CL0000148)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: early promyelocyte (CL0002154)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: peridermal cell (CL0000078)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: articular chondrocyte (CL1001607)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: peg cell (CL4033014)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.98
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** The HNRNPH1 gene is characterized by its high expression in specific cell types, suggesting a specialized role in these tissues. The protein HNRH1_HUMAN is a ribonucleoprotein complex, composed of RNA and proteins, which interacts with various RNA molecules. Key features of HNRNPH1 include: 1. **Cell-specific expression**: High expression in fibroblasts from mammary glands, kidney collecting duct principal cells, and GABAergic neurons, indicating a specialized role in these tissues. 2. **Ribonucleoprotein complex**: HNRH1_HUMAN is a complex of RNA and proteins, which interacts with various RNA molecules. 3. **RNA processing and splicing**: HNRNPH1 is involved in RNA processing and splicing, influencing the fate and function of RNA molecules. **Pathways and Functions** HNRNPH1 is involved in various pathways and functions, including: 1. **Catalytic step 2 spliceosome**: HNRNPH1 is part of the catalytic step 2 spliceosome, which is responsible for the removal of introns from pre-mRNA. 2. **RNA binding**: HNRH1_HUMAN interacts with various RNA molecules, including pre-mRNA, introns, and small RNAs. 3. **RNA processing and splicing**: HNRNPH1 influences the processing and splicing of RNA molecules, affecting their fate and function. 4. **Signaling by FGFR2**: HNRNPH1 is involved in signaling by fibroblast growth factor receptor 2 (FGFR2), influencing cell proliferation and differentiation. 5. **Regulation of RNA splicing**: HNRNPH1 regulates RNA splicing, controlling the inclusion or exclusion of exons and introns in pre-mRNA. **Clinical Significance** The clinical significance of HNRNPH1 is not well established, but its involvement in RNA processing and splicing suggests potential implications in various diseases, including: 1. **Splicing disorders**: Mutations in HNRNPH1 may lead to splicing disorders, such as muscular dystrophy or other RNA-related disorders. 2. **Cancer**: Altered expression of HNRNPH1 may contribute to cancer development and progression, particularly in tissues with high expression levels. 3. **Neurological disorders**: HNRNPH1's role in RNA processing and splicing may be involved in neurological disorders, such as neurodegenerative diseases or synaptic dysfunction. In conclusion, HNRNPH1 is a gene that plays a critical role in RNA processing and splicing, particularly in specific cell types. Its involvement in signaling pathways and regulation of RNA splicing suggests potential implications in various diseases, highlighting the need for further research into the clinical significance of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.