Details for: HNRNPH1

Gene ID: 3187

Symbol: HNRNPH1

Ensembl ID: ENSG00000169045

Description: heterogeneous nuclear ribonucleoprotein H1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 618.9840
    Cell Significance Index: -96.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 409.4331
    Cell Significance Index: -103.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 292.0032
    Cell Significance Index: -120.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 252.3771
    Cell Significance Index: -102.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 252.3073
    Cell Significance Index: -119.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 225.8230
    Cell Significance Index: -116.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 177.8630
    Cell Significance Index: -119.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 108.2386
    Cell Significance Index: -103.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.9579
    Cell Significance Index: -113.3800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 41.5289
    Cell Significance Index: -111.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 30.2290
    Cell Significance Index: -119.2900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.0523
    Cell Significance Index: -83.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.0932
    Cell Significance Index: -52.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 6.9215
    Cell Significance Index: 102.1600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.4290
    Cell Significance Index: 126.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7567
    Cell Significance Index: 242.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.6938
    Cell Significance Index: 103.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.1235
    Cell Significance Index: 146.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.8211
    Cell Significance Index: 306.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8100
    Cell Significance Index: 385.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.7743
    Cell Significance Index: 1226.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.7646
    Cell Significance Index: 75.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.6896
    Cell Significance Index: 161.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.4357
    Cell Significance Index: 136.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3928
    Cell Significance Index: 474.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.3427
    Cell Significance Index: 300.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0611
    Cell Significance Index: 107.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.9706
    Cell Significance Index: 89.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7777
    Cell Significance Index: 51.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7739
    Cell Significance Index: 355.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6864
    Cell Significance Index: 119.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6381
    Cell Significance Index: 295.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5932
    Cell Significance Index: 195.9000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.5912
    Cell Significance Index: 9.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4863
    Cell Significance Index: 31.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4389
    Cell Significance Index: 50.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3047
    Cell Significance Index: 712.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1362
    Cell Significance Index: 407.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0783
    Cell Significance Index: 127.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9885
    Cell Significance Index: 46.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9443
    Cell Significance Index: 24.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7945
    Cell Significance Index: 102.6400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6753
    Cell Significance Index: 50.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6453
    Cell Significance Index: 10.8700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4621
    Cell Significance Index: 12.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4381
    Cell Significance Index: 33.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4355
    Cell Significance Index: 393.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4206
    Cell Significance Index: 41.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3866
    Cell Significance Index: 66.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3850
    Cell Significance Index: 724.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3459
    Cell Significance Index: 3.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3344
    Cell Significance Index: 11.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3077
    Cell Significance Index: 473.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2906
    Cell Significance Index: 184.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2750
    Cell Significance Index: 17.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2311
    Cell Significance Index: 426.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1681
    Cell Significance Index: 2.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1656
    Cell Significance Index: 31.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1566
    Cell Significance Index: 7.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1366
    Cell Significance Index: 185.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1017
    Cell Significance Index: 46.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0703
    Cell Significance Index: 3.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0645
    Cell Significance Index: 1.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0072
    Cell Significance Index: -0.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0221
    Cell Significance Index: -16.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0412
    Cell Significance Index: -30.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0614
    Cell Significance Index: -45.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0736
    Cell Significance Index: -45.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1528
    Cell Significance Index: -24.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1580
    Cell Significance Index: -89.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1582
    Cell Significance Index: -16.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1766
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2054
    Cell Significance Index: -23.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2244
    Cell Significance Index: -4.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2517
    Cell Significance Index: -53.0100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3211
    Cell Significance Index: -2.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3318
    Cell Significance Index: -48.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3577
    Cell Significance Index: -102.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5344
    Cell Significance Index: -5.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6209
    Cell Significance Index: -71.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6594
    Cell Significance Index: -21.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6765
    Cell Significance Index: -9.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7174
    Cell Significance Index: -83.6000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8027
    Cell Significance Index: -11.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8175
    Cell Significance Index: -12.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8837
    Cell Significance Index: -92.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0777
    Cell Significance Index: -26.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1330
    Cell Significance Index: -24.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.2264
    Cell Significance Index: -31.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.2277
    Cell Significance Index: -21.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2358
    Cell Significance Index: -85.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2739
    Cell Significance Index: -32.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3260
    Cell Significance Index: -105.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.3710
    Cell Significance Index: -25.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4944
    Cell Significance Index: -32.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5911
    Cell Significance Index: -70.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.6044
    Cell Significance Index: -34.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.7590
    Cell Significance Index: -25.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.8451
    Cell Significance Index: -22.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8911
    Cell Significance Index: -55.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The HNRNPH1 gene is characterized by its high expression in specific cell types, suggesting a specialized role in these tissues. The protein HNRH1_HUMAN is a ribonucleoprotein complex, composed of RNA and proteins, which interacts with various RNA molecules. Key features of HNRNPH1 include: 1. **Cell-specific expression**: High expression in fibroblasts from mammary glands, kidney collecting duct principal cells, and GABAergic neurons, indicating a specialized role in these tissues. 2. **Ribonucleoprotein complex**: HNRH1_HUMAN is a complex of RNA and proteins, which interacts with various RNA molecules. 3. **RNA processing and splicing**: HNRNPH1 is involved in RNA processing and splicing, influencing the fate and function of RNA molecules. **Pathways and Functions** HNRNPH1 is involved in various pathways and functions, including: 1. **Catalytic step 2 spliceosome**: HNRNPH1 is part of the catalytic step 2 spliceosome, which is responsible for the removal of introns from pre-mRNA. 2. **RNA binding**: HNRH1_HUMAN interacts with various RNA molecules, including pre-mRNA, introns, and small RNAs. 3. **RNA processing and splicing**: HNRNPH1 influences the processing and splicing of RNA molecules, affecting their fate and function. 4. **Signaling by FGFR2**: HNRNPH1 is involved in signaling by fibroblast growth factor receptor 2 (FGFR2), influencing cell proliferation and differentiation. 5. **Regulation of RNA splicing**: HNRNPH1 regulates RNA splicing, controlling the inclusion or exclusion of exons and introns in pre-mRNA. **Clinical Significance** The clinical significance of HNRNPH1 is not well established, but its involvement in RNA processing and splicing suggests potential implications in various diseases, including: 1. **Splicing disorders**: Mutations in HNRNPH1 may lead to splicing disorders, such as muscular dystrophy or other RNA-related disorders. 2. **Cancer**: Altered expression of HNRNPH1 may contribute to cancer development and progression, particularly in tissues with high expression levels. 3. **Neurological disorders**: HNRNPH1's role in RNA processing and splicing may be involved in neurological disorders, such as neurodegenerative diseases or synaptic dysfunction. In conclusion, HNRNPH1 is a gene that plays a critical role in RNA processing and splicing, particularly in specific cell types. Its involvement in signaling pathways and regulation of RNA splicing suggests potential implications in various diseases, highlighting the need for further research into the clinical significance of this gene.

Genular Protein ID: 3549899953

Symbol: HNRH1_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein H

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7499401

Title: Heterogeneous nuclear ribonucleoproteins H, H', and F are members of a ubiquitously expressed subfamily of related but distinct proteins encoded by genes mapping to different chromosomes.

PubMed ID: 7499401

DOI: 10.1074/jbc.270.48.28780

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7512260

Title: The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization.

PubMed ID: 7512260

DOI: 10.1093/nar/22.6.1059

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11003644

Title: Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein.

PubMed ID: 11003644

DOI: 10.1128/mcb.20.20.7463-7479.2000

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16946708

Title: Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.

PubMed ID: 16946708

DOI: 10.1038/sj.emboj.7601296

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29938792

Title: Evidence for HNRNPH1 being another gene for Bain type syndromic mental retardation.

PubMed ID: 29938792

DOI: 10.1111/cge.13410

PubMed ID: 32335897

Title: HNRNPH1-related syndromic intellectual disability: Seven additional cases suggestive of a distinct syndromic neurodevelopmental syndrome.

PubMed ID: 32335897

DOI: 10.1111/cge.13765

Sequence Information:

  • Length: 449
  • Mass: 49229
  • Checksum: 4ECF7A075C2526FF
  • Sequence:
  • MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE GRPSGEAFVE 
    LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT GPNSPDTAND GFVRLRGLPF 
    GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY 
    IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY 
    GGYDDYNGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA 
    TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA NMQHRYVELF 
    LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY 
    GGGYGGQSSM SGYDQVLQEN SSDFQSNIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.