Details for: TCEA1

Gene ID: 6917

Symbol: TCEA1

Ensembl ID: ENSG00000187735

Description: transcription elongation factor A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 291.2658
    Cell Significance Index: -45.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 242.0327
    Cell Significance Index: -61.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 181.6736
    Cell Significance Index: -74.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 170.0155
    Cell Significance Index: -69.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 169.3840
    Cell Significance Index: -79.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 152.6871
    Cell Significance Index: -78.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 119.5639
    Cell Significance Index: -80.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.0458
    Cell Significance Index: -69.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.2355
    Cell Significance Index: -66.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.8824
    Cell Significance Index: -63.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.2344
    Cell Significance Index: -75.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.0305
    Cell Significance Index: -55.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.7936
    Cell Significance Index: -28.0000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 5.6899
    Cell Significance Index: 13.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.4313
    Cell Significance Index: 522.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3350
    Cell Significance Index: 287.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2213
    Cell Significance Index: 400.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0625
    Cell Significance Index: 283.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5418
    Cell Significance Index: 842.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5294
    Cell Significance Index: 71.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3575
    Cell Significance Index: 96.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3535
    Cell Significance Index: 268.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3326
    Cell Significance Index: 589.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3085
    Cell Significance Index: 84.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1809
    Cell Significance Index: 55.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1109
    Cell Significance Index: 10.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0942
    Cell Significance Index: 140.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0401
    Cell Significance Index: 28.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9994
    Cell Significance Index: 29.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.9422
    Cell Significance Index: 27.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8804
    Cell Significance Index: 20.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8683
    Cell Significance Index: 45.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8361
    Cell Significance Index: 17.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8273
    Cell Significance Index: 61.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7656
    Cell Significance Index: 153.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6773
    Cell Significance Index: 17.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6728
    Cell Significance Index: 73.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6096
    Cell Significance Index: 27.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6021
    Cell Significance Index: 102.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5993
    Cell Significance Index: 214.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5867
    Cell Significance Index: 36.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5785
    Cell Significance Index: 30.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5004
    Cell Significance Index: 64.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4914
    Cell Significance Index: 10.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3983
    Cell Significance Index: 13.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3482
    Cell Significance Index: 18.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2678
    Cell Significance Index: 185.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2218
    Cell Significance Index: 21.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1256
    Cell Significance Index: 23.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1230
    Cell Significance Index: 3.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1003
    Cell Significance Index: 7.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0999
    Cell Significance Index: 16.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0809
    Cell Significance Index: 4.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0769
    Cell Significance Index: 141.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0725
    Cell Significance Index: 136.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0409
    Cell Significance Index: 0.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0279
    Cell Significance Index: 21.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0259
    Cell Significance Index: 39.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0187
    Cell Significance Index: 0.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0173
    Cell Significance Index: 12.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0312
    Cell Significance Index: -19.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0414
    Cell Significance Index: -25.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0428
    Cell Significance Index: -19.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0484
    Cell Significance Index: -4.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0917
    Cell Significance Index: -51.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1310
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1461
    Cell Significance Index: -30.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1685
    Cell Significance Index: -10.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2295
    Cell Significance Index: -66.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2351
    Cell Significance Index: -26.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2709
    Cell Significance Index: -39.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3214
    Cell Significance Index: -5.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3641
    Cell Significance Index: -42.4300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4629
    Cell Significance Index: -16.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4762
    Cell Significance Index: -12.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5601
    Cell Significance Index: -63.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6414
    Cell Significance Index: -50.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6455
    Cell Significance Index: -67.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6506
    Cell Significance Index: -20.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6623
    Cell Significance Index: -16.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6798
    Cell Significance Index: -7.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7764
    Cell Significance Index: -52.2100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.8245
    Cell Significance Index: -6.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8678
    Cell Significance Index: -11.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9116
    Cell Significance Index: -24.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9408
    Cell Significance Index: -47.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1062
    Cell Significance Index: -48.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.1232
    Cell Significance Index: -12.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.1848
    Cell Significance Index: -9.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2449
    Cell Significance Index: -14.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2907
    Cell Significance Index: -79.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3181
    Cell Significance Index: -32.9500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.3239
    Cell Significance Index: -16.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3315
    Cell Significance Index: -50.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5322
    Cell Significance Index: -12.8700
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.5376
    Cell Significance Index: -11.6100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.5493
    Cell Significance Index: -9.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.6572
    Cell Significance Index: -28.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TCEA1 is a 45-kDa protein that belongs to the TEA family of transcription factors. It is highly expressed in cells of the immune system, including B cells, T cells, and dendritic cells. TCEA1 is also expressed in other cell types, including malignant cells, basal cells of epithelial tissues, and germinal center B cells. Its expression is tightly regulated by various transcription factors, including TP53, which is a tumor suppressor protein that regulates the expression of genes involved in DNA repair and transcription. **Pathways and Functions** TCEA1 plays a critical role in the regulation of transcription elongation, which is a complex process that involves the interaction of RNAPII, transcription factors, and other proteins. TCEA1 acts as a co-activator for RNAPII, facilitating the progression of transcription elongation by interacting with the RNAPII complex and other transcription factors. TCEA1 is also involved in the regulation of transcription by RNAPII, influencing the accuracy and efficiency of transcription. TCEA1 has been implicated in various cellular processes, including: * Transcription elongation: TCEA1 regulates the progression of transcription elongation by interacting with RNAPII and other transcription factors. * DNA repair: TCEA1 is involved in the regulation of DNA repair processes, including nucleotide excision repair (NER) and base excision repair (BER). * HIV infection: TCEA1 is a host factor that regulates the replication of HIV-1, influencing the progression of viral transcription and replication. * Cancer: TCEA1 is overexpressed in various types of cancer, including leukemia, lymphoma, and solid tumors, and is associated with poor prognosis. **Clinical Significance** Dysregulation of TCEA1 has been implicated in various diseases, including: * Cancer: Overexpression of TCEA1 is associated with poor prognosis and increased risk of relapse in various types of cancer. * HIV infection: TCEA1 is a host factor that regulates the replication of HIV-1, and its dysregulation can contribute to the development of HIV-related diseases. * Autoimmune diseases: TCEA1 is involved in the regulation of immune responses, and its dysregulation can contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. * Neurological disorders: TCEA1 is involved in the regulation of neuronal function and plasticity, and its dysregulation can contribute to the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TCEA1 is a multifunctional protein that plays a critical role in the regulation of transcription elongation and DNA repair. Its dysregulation has been implicated in various diseases, including cancer, HIV infection, and other infectious diseases. Further research is needed to fully understand the mechanisms of TCEA1 and its role in human disease.

Genular Protein ID: 3425720244

Symbol: TCEA1_HUMAN

Name: Transcription elongation factor A protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1708494

Title: Cloning, expression and characterization of the human transcription elongation factor, TFIIS.

PubMed ID: 1708494

DOI: 10.1093/nar/19.5.1073

PubMed ID: 1378807

Title: Characterization of a HeLa cDNA clone encoding the human SII protein, an elongation factor for RNA polymerase II.

PubMed ID: 1378807

DOI: 10.1016/0378-1119(92)90522-q

PubMed ID: 8112616

Title: Characterization of the gene encoding the human transcriptional elongation factor TFIIS.

PubMed ID: 8112616

DOI: 10.1016/0378-1119(94)90767-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10029085

Title: Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene.

PubMed ID: 10029085

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21127351

Title: Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

PubMed ID: 21127351

DOI: 10.1074/jbc.m110.176628

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 7626141

Title: Structure of a new nucleic-acid-binding motif in eukaryotic transcriptional elongation factor TFIIS.

PubMed ID: 7626141

DOI: 10.1038/365277a0

PubMed ID: 27193682

Title: Near-atomic resolution visualization of human transcription promoter opening.

PubMed ID: 27193682

DOI: 10.1038/nature17970

Sequence Information:

  • Length: 301
  • Mass: 33970
  • Checksum: 8A685107A56D2DA1
  • Sequence:
  • MEDEVVRFAK KMDKMVQKKN AAGALDLLKE LKNIPMTLEL LQSTRIGMSV NAIRKQSTDE 
    EVTSLAKSLI KSWKKLLDGP STEKDLDEKK KEPAITSQNS PEAREESTSS GNVSNRKDET 
    NARDTYVSSF PRAPSTSDSV RLKCREMLAA ALRTGDDYIA IGADEEELGS QIEEAIYQEI 
    RNTDMKYKNR VRSRISNLKD AKNPNLRKNV LCGNIPPDLF ARMTAEEMAS DELKEMRKNL 
    TKEAIREHQM AKTGGTQTDL FTCGKCKKKN CTYTQVQTRS ADEPMTTFVV CNECGNRWKF 
    C

Genular Protein ID: 2899840048

Symbol: B7Z4W0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 280
  • Mass: 31674
  • Checksum: 318336FC090137F0
  • Sequence:
  • MEDEVVRFAK KMDKMVQKKN APTRIGMSVN AIRKQSTDEE VTSLAKSLIK SWKKLLDGPS 
    TEKDLDEKKK EPAITSQNSP EAREESTSSG NVSNRKDETN ARDTYVSSFP RAPSTSDSVR 
    LKCREMLAAA LRTGDDYIAI GADEEELGSQ IEEAIYQEIR NTDMKYKNRV RSRISNLKDA 
    KNPNLRKNVL CGNIPPDLFA RMTAEEMASD ELKEMRKNLT KEAIREHQMA KTGGTQTDLF 
    TCGKCKKKNC TYTQVQTRSA DEPMTTFVVC NECGNRWKFC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.