Gene XIST - ENSG00000229807 | NCBI Gene ID: 7503

Details for: XIST

Gene ID: 7503

Symbol: XIST

Ensembl ID: ENSG00000229807

Description: X inactive specific transcript

Associated with

Chromatin-protein adaptor activity
(GO:0140463)
Constitutive heterochromatin formation
(GO:0140719)
Dosage compensation complex
(GO:0046536)
Lncrna-mediated post-transcriptional gene silencing
(GO:0000512)
Mirna inhibitor activity via base-pairing
(GO:0140869)
Positive regulation of mirna catabolic process
(GO:2000627)
Random inactivation of x chromosome
(GO:0060816)
Ribonucleoprotein complex
(GO:1990904)
X chromosome
(GO:0000805)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 5.87
Marker Score: 16568
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 5.43
Marker Score: 26692
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 5.08
Marker Score: 30513
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 4.21
Marker Score: 10337
Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.68
Marker Score: 4590
Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.61
Marker Score: 5085
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.43
Marker Score: 116632
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.14
Marker Score: 55668
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.98
Marker Score: 103182
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.86
Marker Score: 32230
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.86
Marker Score: 1660
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.85
Marker Score: 3021
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.85
Marker Score: 5688
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.84
Marker Score: 1621
Cell Name: supporting cell (CL0000630)
Fold Change: 2.81
Marker Score: 5283
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.78
Marker Score: 2402
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 2.69
Marker Score: 11221
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.63
Marker Score: 4652
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.61
Marker Score: 7219
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 2.58
Marker Score: 1999
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.57
Marker Score: 1440
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.56
Marker Score: 1104
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 2.56
Marker Score: 3936
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.55
Marker Score: 9819
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.54
Marker Score: 1701
Cell Name: microglial cell (CL0000129)
Fold Change: 2.54
Marker Score: 4621
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.53
Marker Score: 6557
Cell Name: hepatoblast (CL0005026)
Fold Change: 2.52
Marker Score: 8249
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.5
Marker Score: 3259
Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.46
Marker Score: 1183
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.4
Marker Score: 4626
Cell Name: leukocyte (CL0000738)
Fold Change: 2.35
Marker Score: 1347
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.32
Marker Score: 2481
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.31
Marker Score: 676
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.31
Marker Score: 3706
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 2.28
Marker Score: 50848
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.24
Marker Score: 7497
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.21
Marker Score: 1812
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.19
Marker Score: 631
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.14
Marker Score: 21644
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.12
Marker Score: 2025
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 2.12
Marker Score: 2073
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.11
Marker Score: 1599
Cell Name: renal principal cell (CL0005009)
Fold Change: 2.11
Marker Score: 1626
Cell Name: stellate neuron (CL0000122)
Fold Change: 2.11
Marker Score: 11325
Cell Name: decidual cell (CL2000002)
Fold Change: 2.1
Marker Score: 9048
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.07
Marker Score: 2377
Cell Name: classical monocyte (CL0000860)
Fold Change: 2.06
Marker Score: 8563
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.05
Marker Score: 1082
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.99
Marker Score: 1561
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.99
Marker Score: 1108
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.98
Marker Score: 1350
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.95
Marker Score: 2124
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.94
Marker Score: 437
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.94
Marker Score: 2818
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.91
Marker Score: 667
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.91
Marker Score: 64423
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.9
Marker Score: 601
Cell Name: stromal cell (CL0000499)
Fold Change: 1.89
Marker Score: 2209.5
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.87
Marker Score: 649
Cell Name: late pro-B cell (CL0002048)
Fold Change: 1.84
Marker Score: 2168.5
Cell Name: germ cell (CL0000586)
Fold Change: 1.83
Marker Score: 3196.5
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.82
Marker Score: 1211
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.81
Marker Score: 4563
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.78
Marker Score: 38036
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.77
Marker Score: 1772
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.76
Marker Score: 1326
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.76
Marker Score: 1026
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1.76
Marker Score: 656
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.76
Marker Score: 516
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.76
Marker Score: 423
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.76
Marker Score: 2973
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.75
Marker Score: 439
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.75
Marker Score: 850
Cell Name: podocyte (CL0000653)
Fold Change: 1.74
Marker Score: 645
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.74
Marker Score: 405
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.74
Marker Score: 1236
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.73
Marker Score: 379.5
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.73
Marker Score: 22837
Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.73
Marker Score: 398
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.72
Marker Score: 566
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.71
Marker Score: 891
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.69
Marker Score: 2495
Cell Name: IgA plasmablast (CL0000984)
Fold Change: 1.69
Marker Score: 444
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.69
Marker Score: 377
Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.69
Marker Score: 431
Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.68
Marker Score: 402
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.68
Marker Score: 1257
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.67
Marker Score: 7749
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.67
Marker Score: 3494.5
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 1.66
Marker Score: 1639
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.66
Marker Score: 4457
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 1.66
Marker Score: 429
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.65
Marker Score: 2742
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.64
Marker Score: 1728
Cell Name: theca cell (CL0000503)
Fold Change: 1.64
Marker Score: 1173
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.64
Marker Score: 404
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.63
Marker Score: 8573
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.63
Marker Score: 355
Cell Name: oocyte (CL0000023)
Fold Change: 1.63
Marker Score: 403

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Other Information

Description

**Key Characteristics:** 1. **Non-coding RNA**: XIST is a long non-coding RNA (lncRNA) that does not encode a protein but instead regulates gene expression through epigenetic mechanisms. 2. **Specific expression**: XIST is specifically expressed from the inactive X chromosome, which is crucial for the proper inactivation of the X chromosome. 3. **Heterochromatin formation**: XIST recruits proteins that compact chromatin into heterochromatin, thereby preventing gene expression from the X chromosome. 4. **Dosage compensation complex**: XIST interacts with the dosage compensation complex (DCC) to maintain the silencing of the X chromosome. 5. **Cell-specific expression**: XIST is expressed in various cell types, including tracheal goblet cells, myoepithelial cells of the mammary gland, and cardiac neurons. **Pathways and Functions:** 1. **Chromatin-protein adaptor activity**: XIST interacts with chromatin-binding proteins to recruit histone-modifying enzymes and chromatin-remodeling complexes, leading to the formation of heterochromatin. 2. **Constitutive heterochromatin formation**: XIST promotes the formation of constitutive heterochromatin, which is a type of chromatin that is highly compact and transcriptionally inactive. 3. **Dosage compensation complex**: XIST interacts with the DCC to maintain the silencing of the X chromosome, ensuring that gene expression from the X chromosome is reduced to match the expression levels of the Y chromosome. 4. **LncRNA-mediated post-transcriptional gene silencing**: XIST regulates gene expression through post-transcriptional gene silencing, which involves the degradation of mRNA or inhibition of translation. 5. **Mirna inhibitor activity**: XIST inhibits the activity of microRNAs (miRNAs) that target genes involved in X-chromosome inactivation. **Clinical Significance:** Dysregulation of XIST expression has been implicated in various diseases, including: 1. **X-chromosome inactivation disorders**: Mutations in XIST can lead to X-chromosome inactivation disorders, such as Turner syndrome and X-chromosome inactivation (XCI) disorders. 2. **Cancer**: Aberrant XIST expression has been observed in various types of cancer, including breast cancer and ovarian cancer. 3. **Neurological disorders**: XIST has been implicated in the regulation of gene expression in the brain, and dysregulation of XIST expression has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, XIST is a critical regulator of X-chromosome inactivation, and its dysregulation can have significant consequences for human health. Further research is needed to fully understand the mechanisms by which XIST regulates X-chromosome inactivation and its role in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.