Details for: DTNA

Gene ID: 1837

Symbol: DTNA

Ensembl ID: ENSG00000134769

Description: dystrobrevin alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 201.5631
    Cell Significance Index: -95.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 30.9081
    Cell Significance Index: -67.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.9075
    Cell Significance Index: -94.3400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 12.1436
    Cell Significance Index: 169.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 7.3745
    Cell Significance Index: 189.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 6.5506
    Cell Significance Index: 502.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.8454
    Cell Significance Index: 393.0500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.2854
    Cell Significance Index: 128.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.2448
    Cell Significance Index: 1522.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.0583
    Cell Significance Index: 52.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8587
    Cell Significance Index: 573.4500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.7614
    Cell Significance Index: 44.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6252
    Cell Significance Index: 116.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.5655
    Cell Significance Index: 97.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.4579
    Cell Significance Index: 70.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.9649
    Cell Significance Index: 204.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.9245
    Cell Significance Index: 1331.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.9201
    Cell Significance Index: 871.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5835
    Cell Significance Index: 19.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4049
    Cell Significance Index: 86.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.3862
    Cell Significance Index: 2610.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1280
    Cell Significance Index: 63.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0729
    Cell Significance Index: 212.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.0165
    Cell Significance Index: 645.5900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.7307
    Cell Significance Index: 8.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.7205
    Cell Significance Index: 979.7300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4626
    Cell Significance Index: 6.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4307
    Cell Significance Index: 794.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4186
    Cell Significance Index: 10.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3909
    Cell Significance Index: 601.7600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3465
    Cell Significance Index: 5.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1514
    Cell Significance Index: 7.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1331
    Cell Significance Index: 22.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0564
    Cell Significance Index: 8.2000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0088
    Cell Significance Index: -0.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0273
    Cell Significance Index: -24.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0505
    Cell Significance Index: -37.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0792
    Cell Significance Index: -49.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1022
    Cell Significance Index: -57.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1140
    Cell Significance Index: -83.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1143
    Cell Significance Index: -21.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1377
    Cell Significance Index: -104.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1643
    Cell Significance Index: -89.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.2145
    Cell Significance Index: -94.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2853
    Cell Significance Index: -82.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3549
    Cell Significance Index: -45.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3556
    Cell Significance Index: -45.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3638
    Cell Significance Index: -76.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3809
    Cell Significance Index: -68.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4092
    Cell Significance Index: -13.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4517
    Cell Significance Index: -73.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5079
    Cell Significance Index: -10.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5562
    Cell Significance Index: -7.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.6221
    Cell Significance Index: -85.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.6251
    Cell Significance Index: -63.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6264
    Cell Significance Index: -10.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6370
    Cell Significance Index: -78.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6617
    Cell Significance Index: -75.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.6828
    Cell Significance Index: -74.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6899
    Cell Significance Index: -51.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7196
    Cell Significance Index: -82.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7548
    Cell Significance Index: -87.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.7732
    Cell Significance Index: -76.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7964
    Cell Significance Index: -41.8200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.8035
    Cell Significance Index: -10.4200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.9262
    Cell Significance Index: -10.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0185
    Cell Significance Index: -14.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0308
    Cell Significance Index: -22.5700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.0449
    Cell Significance Index: -20.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0902
    Cell Significance Index: -86.3400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.2029
    Cell Significance Index: -15.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2413
    Cell Significance Index: -85.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2422
    Cell Significance Index: -76.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.2633
    Cell Significance Index: -75.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3308
    Cell Significance Index: -62.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.3862
    Cell Significance Index: -89.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3972
    Cell Significance Index: -44.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4106
    Cell Significance Index: -63.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.4713
    Cell Significance Index: -51.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.4802
    Cell Significance Index: -77.1000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.4851
    Cell Significance Index: -15.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6525
    Cell Significance Index: -104.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6765
    Cell Significance Index: -54.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.7005
    Cell Significance Index: -34.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.7159
    Cell Significance Index: -89.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.7929
    Cell Significance Index: -14.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.8442
    Cell Significance Index: -26.5300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.9612
    Cell Significance Index: -22.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.9619
    Cell Significance Index: -68.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.0700
    Cell Significance Index: -59.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.0738
    Cell Significance Index: -51.7300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -2.1033
    Cell Significance Index: -52.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.1965
    Cell Significance Index: -69.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.1969
    Cell Significance Index: -76.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -2.1988
    Cell Significance Index: -23.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.3698
    Cell Significance Index: -49.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.4479
    Cell Significance Index: -50.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.4915
    Cell Significance Index: -53.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -2.5051
    Cell Significance Index: -60.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -2.5254
    Cell Significance Index: -37.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** Dystrobrevin alpha is a cytoplasmic protein that interacts with dystrophin, a cytoskeletal protein essential for muscle function. The dystrophin-glycoprotein complex (DGC) is a transmembrane protein complex that spans the plasma membrane, anchoring the cytoskeleton to the extracellular matrix. 2. **Cellular Expression:** Dystrobrevin alpha is widely expressed in various tissues, including muscle cells, astrocytes, and neurons, highlighting its role in multiple cellular processes. 3. **Protein Binding:** Dystrobrevin alpha interacts with various proteins, including dystrophin, dystroglycan, and syntrophin, to regulate muscle function and signaling. **Pathways and Functions:** 1. **Muscle Contraction:** Dystrobrevin alpha plays a critical role in regulating muscle contraction by modulating the interaction between the cytoskeleton and the extracellular matrix. 2. **Synaptic Transmission:** Dystrobrevin alpha is involved in the regulation of synaptic transmission, particularly in the neuromuscular junction and chemical synaptic transmission. 3. **Cytoskeletal Organization:** Dystrobrevin alpha helps maintain the organization of the cytoskeleton, ensuring proper muscle contraction and signaling. 4. **Cell Signaling:** Dystrobrevin alpha regulates various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to modulate muscle function and cellular processes. **Clinical Significance:** 1. **Muscle Disorders:** Mutations in the dystrophin gene, which encodes dystrophin, lead to Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Dystrobrevin alpha plays a critical role in the pathogenesis of these disorders. 2. **Neurological Disorders:** Dystrobrevin alpha has been implicated in various neurological disorders, including epilepsy, migraines, and Parkinson's disease, highlighting its role in synaptic transmission and neuronal function. 3. **Cancer:** Dystrobrevin alpha has been identified as a potential oncogene, with its overexpression associated with cancer progression and metastasis. In conclusion, dystrobrevin alpha is a crucial protein that regulates muscle function, synaptic transmission, and cellular signaling. Its dysregulation has been implicated in various muscle-related and neurological disorders, highlighting the importance of further research into its molecular mechanisms and clinical significance.

Genular Protein ID: 2841911316

Symbol: DTNA_HUMAN

Name: Alpha-dystrobrevin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8845841

Title: Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane.

PubMed ID: 8845841

DOI: 10.1093/hmg/5.4.489

PubMed ID: 10735273

Title: The genomic organization of human dystrobrevin.

PubMed ID: 10735273

DOI: 10.1007/s100480050006

PubMed ID: 9701558

Title: Characterisation of alpha-dystrobrevin in muscle.

PubMed ID: 9701558

DOI: 10.1242/jcs.111.17.2595

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7844150

Title: Syntrophin binds to an alternatively spliced exon of dystrophin.

PubMed ID: 7844150

DOI: 10.1083/jcb.128.3.363

PubMed ID: 8576247

Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PubMed ID: 8576247

DOI: 10.1074/jbc.271.5.2724

PubMed ID: 10747910

Title: Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells.

PubMed ID: 10747910

DOI: 10.1074/jbc.m000439200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 11238270

Title: Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome.

PubMed ID: 11238270

DOI: 10.1161/01.cir.103.9.1256

Sequence Information:

  • Length: 743
  • Mass: 83901
  • Checksum: CFD77DAA57D050EC
  • Sequence:
  • MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 
    ALRENALNNL DPNTELNVSR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 
    PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 
    VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 
    VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
    NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF SHSVPSSGSP 
    FITRSSPPKD SEVEQNKLLA RAAPAFLKGK GIQYSLNVAD RLADEHVLIG LYVNMLRNNP 
    SCMLESSNRL DEEHRLIARY AARLAAESSS SQPPQQRSAP DISFTIDANK QQRQLIAELE 
    NKNREILQEI QRLRLEHEQA SQPTPEKAQQ NPTLLAELRL LRQRKDELEQ RMSALQESRR 
    ELMVQLEGLM KLLKTQGAGS PRSSPSHTIS RPIPMPIRSA SACSTPTHTP QDSLTGVGGD 
    VQEAFAQSSR RNLRNDLLVA ADSITNTMSS LVKELNSEVG SETESNVDSE FARTQFEDLV 
    PSPTSEKAFL AQIHARKPGY IHSGATTSTM RGDMVTEDAD PYVQPEDENY ENDSVRQLEN 
    ELQMEEYLKQ KLQDEAYQVS LQG

Genular Protein ID: 615000775

Symbol: B7Z3X3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 433
  • Mass: 48743
  • Checksum: 7C358E442520AD5B
  • Sequence:
  • MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT NALSKSLSCA 
    SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT RSMLESSNRL 
    DEEHRLIARY AARLAAESSS SQPPQQRSAP DISFTIDANK QQRQLIAELE NKNREILQEI 
    QRLRLEHEQA SQPTPEKAQQ NPTLLAELRL LRQRKDELEQ RMSALQESRR ELMVQLEGLM 
    KLLKTQGAGS PRSSPSHTIS RPIPMPIRSA SACSTPTHTP QDSLTGVGGD VQEAFAQSSR 
    RNLRNDLLVA ADSITNTMSS LVKELNSEVG SETESNVDSE FARTQFEDLV PSPTSEKAFL 
    AQIHARKPGY IHSGATTSTM RGDMVTEDAD PYVQPEDENY ENDSVRQLEN ELQMEEYLKQ 
    KLQDEAYQVS LQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.