Details for: DTNA

Gene ID: 1837

Symbol: DTNA

Ensembl ID: ENSG00000134769

Description: dystrobrevin alpha

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 7.48
    Marker Score: 4,920
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 4.74
    Marker Score: 105,819
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.52
    Marker Score: 10,390
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.99
    Marker Score: 8,753
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.58
    Marker Score: 12,725
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.56
    Marker Score: 14,919
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.41
    Marker Score: 15,791
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.4
    Marker Score: 18,281
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.33
    Marker Score: 1,851
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 3.27
    Marker Score: 69,880
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.19
    Marker Score: 4,293
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.09
    Marker Score: 16,193
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.94
    Marker Score: 22,190
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.94
    Marker Score: 3,558
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.92
    Marker Score: 854
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.89
    Marker Score: 8,247
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.88
    Marker Score: 910
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.87
    Marker Score: 56,998
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.74
    Marker Score: 2,375
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.72
    Marker Score: 1,591
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.71
    Marker Score: 91,680
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.7
    Marker Score: 6,767
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.69
    Marker Score: 3,791
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.63
    Marker Score: 20,156
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.62
    Marker Score: 1,996
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.59
    Marker Score: 10,751
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.59
    Marker Score: 6,190
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.57
    Marker Score: 1,075
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.48
    Marker Score: 3,088
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90,239
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.44
    Marker Score: 92,479
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.38
    Marker Score: 1,289
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.32
    Marker Score: 8,963
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.29
    Marker Score: 3,845
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.29
    Marker Score: 725
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20,589
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.17
    Marker Score: 7,285
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.14
    Marker Score: 772
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.09
    Marker Score: 2,580
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125,206
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.03
    Marker Score: 974
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.01
    Marker Score: 20,752
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.98
    Marker Score: 8,043
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.92
    Marker Score: 18,232
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.9
    Marker Score: 28,350
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.89
    Marker Score: 517
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.89
    Marker Score: 1,060
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,639
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.72
    Marker Score: 1,001
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.71
    Marker Score: 657
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2,538
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.62
    Marker Score: 3,296
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,161
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.54
    Marker Score: 1,536
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.54
    Marker Score: 764
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,533
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.46
    Marker Score: 1,030
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.44
    Marker Score: 1,798
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.42
    Marker Score: 4,657
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.41
    Marker Score: 359
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.35
    Marker Score: 21,138
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.35
    Marker Score: 1,554
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.29
    Marker Score: 525
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.25
    Marker Score: 454
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 740
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.16
    Marker Score: 352
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.13
    Marker Score: 581
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.12
    Marker Score: 650
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.09
    Marker Score: 372
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 343
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.06
    Marker Score: 1,884
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.05
    Marker Score: 4,377
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.05
    Marker Score: 2,471
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.03
    Marker Score: 375
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.02
    Marker Score: 526
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,786
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,011
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1
    Marker Score: 475
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 666
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 362
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.98
    Marker Score: 368
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.94
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,310
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.92
    Marker Score: 423
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.91
    Marker Score: 289
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.91
    Marker Score: 314
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.9
    Marker Score: 858
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.88
    Marker Score: 3,423
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.87
    Marker Score: 5,248
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.85
    Marker Score: 509

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** Dystrobrevin alpha is a cytoplasmic protein that interacts with dystrophin, a cytoskeletal protein essential for muscle function. The dystrophin-glycoprotein complex (DGC) is a transmembrane protein complex that spans the plasma membrane, anchoring the cytoskeleton to the extracellular matrix. 2. **Cellular Expression:** Dystrobrevin alpha is widely expressed in various tissues, including muscle cells, astrocytes, and neurons, highlighting its role in multiple cellular processes. 3. **Protein Binding:** Dystrobrevin alpha interacts with various proteins, including dystrophin, dystroglycan, and syntrophin, to regulate muscle function and signaling. **Pathways and Functions:** 1. **Muscle Contraction:** Dystrobrevin alpha plays a critical role in regulating muscle contraction by modulating the interaction between the cytoskeleton and the extracellular matrix. 2. **Synaptic Transmission:** Dystrobrevin alpha is involved in the regulation of synaptic transmission, particularly in the neuromuscular junction and chemical synaptic transmission. 3. **Cytoskeletal Organization:** Dystrobrevin alpha helps maintain the organization of the cytoskeleton, ensuring proper muscle contraction and signaling. 4. **Cell Signaling:** Dystrobrevin alpha regulates various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to modulate muscle function and cellular processes. **Clinical Significance:** 1. **Muscle Disorders:** Mutations in the dystrophin gene, which encodes dystrophin, lead to Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Dystrobrevin alpha plays a critical role in the pathogenesis of these disorders. 2. **Neurological Disorders:** Dystrobrevin alpha has been implicated in various neurological disorders, including epilepsy, migraines, and Parkinson's disease, highlighting its role in synaptic transmission and neuronal function. 3. **Cancer:** Dystrobrevin alpha has been identified as a potential oncogene, with its overexpression associated with cancer progression and metastasis. In conclusion, dystrobrevin alpha is a crucial protein that regulates muscle function, synaptic transmission, and cellular signaling. Its dysregulation has been implicated in various muscle-related and neurological disorders, highlighting the importance of further research into its molecular mechanisms and clinical significance.

Genular Protein ID: 2841911316

Symbol: DTNA_HUMAN

Name: Alpha-dystrobrevin

UniProtKB Accession Codes:

Q9Y4J8 A8K541 A8MSZ0 A8MUY4 B4DGS6 B4DIR0 B4DIU8 M0QYX6 M0R397 O15332 O15333 O75697 Q13197 Q13198 Q13199 Q13498 Q13499 Q13500 Q59GK7 Q9BS59

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 15 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 70 EPD 1 Ensembl 29 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 11 Pumba 1 RNAct 1 RefSeq 27 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8845841

Title: Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane.

PubMed ID: 8845841

DOI: 10.1093/hmg/5.4.489

PubMed ID: 10735273

Title: The genomic organization of human dystrobrevin.

PubMed ID: 10735273

DOI: 10.1007/s100480050006

PubMed ID: 9701558

Title: Characterisation of alpha-dystrobrevin in muscle.

PubMed ID: 9701558

DOI: 10.1242/jcs.111.17.2595

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7844150

Title: Syntrophin binds to an alternatively spliced exon of dystrophin.

PubMed ID: 7844150

DOI: 10.1083/jcb.128.3.363

PubMed ID: 8576247

Title: The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives.

PubMed ID: 8576247

DOI: 10.1074/jbc.271.5.2724

PubMed ID: 10747910

Title: Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells.

PubMed ID: 10747910

DOI: 10.1074/jbc.m000439200

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 11238270

Title: Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome.

PubMed ID: 11238270

DOI: 10.1161/01.cir.103.9.1256

Sequence Information:

  • Length: 743
  • Mass: 83901
  • Checksum: CFD77DAA57D050EC
  • Sequence:
    • MIEDSGKRGN TMAERRQLFA EMRAQDLDRI RLSTYRTACK LRFVQKKCNL HLVDIWNVIE 
ALRENALNNL DPNTELNVSR LEAVLSTIFY QLNKRMPTTH QIHVEQSISL LLNFLLAAFD 
PEGHGKISVF AVKMALATLC GGKIMDKLRY IFSMISDSSG VMVYGRYDQF LREVLKLPTA 
VFEGPSFGYT EQSARSCFSQ QKKVTLNGFL DTLMSDPPPQ CLVWLPLLHR LANVENVFHP 
VECSYCHSES MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT 
NALSKSLSCA SSREPLHPMF PDQPEKPLNL AHIVDTWPPR PVTSMNDTLF SHSVPSSGSP 
FITRSSPPKD SEVEQNKLLA RAAPAFLKGK GIQYSLNVAD RLADEHVLIG LYVNMLRNNP 
SCMLESSNRL DEEHRLIARY AARLAAESSS SQPPQQRSAP DISFTIDANK QQRQLIAELE 
NKNREILQEI QRLRLEHEQA SQPTPEKAQQ NPTLLAELRL LRQRKDELEQ RMSALQESRR 
ELMVQLEGLM KLLKTQGAGS PRSSPSHTIS RPIPMPIRSA SACSTPTHTP QDSLTGVGGD 
VQEAFAQSSR RNLRNDLLVA ADSITNTMSS LVKELNSEVG SETESNVDSE FARTQFEDLV 
PSPTSEKAFL AQIHARKPGY IHSGATTSTM RGDMVTEDAD PYVQPEDENY ENDSVRQLEN 
ELQMEEYLKQ KLQDEAYQVS LQG

Genular Protein ID: 615000775

Symbol: B7Z3X3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3X3

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 433
  • Mass: 48743
  • Checksum: 7C358E442520AD5B
  • Sequence:
    • MMGFRYRCQQ CHNYQLCQDC FWRGHAGGSH SNQHQMKEYT SWKSPAKKLT NALSKSLSCA 
SSREPLHPMF PDQPEKPLNL AHIVPPRPVT SMNDTLFSHS VPSSGSPFIT RSMLESSNRL 
DEEHRLIARY AARLAAESSS SQPPQQRSAP DISFTIDANK QQRQLIAELE NKNREILQEI 
QRLRLEHEQA SQPTPEKAQQ NPTLLAELRL LRQRKDELEQ RMSALQESRR ELMVQLEGLM 
KLLKTQGAGS PRSSPSHTIS RPIPMPIRSA SACSTPTHTP QDSLTGVGGD VQEAFAQSSR 
RNLRNDLLVA ADSITNTMSS LVKELNSEVG SETESNVDSE FARTQFEDLV PSPTSEKAFL 
AQIHARKPGY IHSGATTSTM RGDMVTEDAD PYVQPEDENY ENDSVRQLEN ELQMEEYLKQ 
KLQDEAYQVS LQG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.