Details for: MAT2A

Gene ID: 4144

Symbol: MAT2A

Ensembl ID: ENSG00000168906

Description: methionine adenosyltransferase 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 396.6692
    Cell Significance Index: -61.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 223.4239
    Cell Significance Index: -56.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 161.3797
    Cell Significance Index: -66.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 144.1786
    Cell Significance Index: -68.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 136.3422
    Cell Significance Index: -55.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 125.8007
    Cell Significance Index: -64.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 101.5615
    Cell Significance Index: -68.1500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.3298
    Cell Significance Index: -55.6900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.9435
    Cell Significance Index: -66.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.8497
    Cell Significance Index: -63.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.1691
    Cell Significance Index: -67.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.7910
    Cell Significance Index: -45.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8916
    Cell Significance Index: -19.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.4226
    Cell Significance Index: 236.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4744
    Cell Significance Index: 33.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4278
    Cell Significance Index: 67.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2069
    Cell Significance Index: 142.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1099
    Cell Significance Index: 57.4300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4082
    Cell Significance Index: 24.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3659
    Cell Significance Index: 167.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3161
    Cell Significance Index: 264.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2634
    Cell Significance Index: 36.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1552
    Cell Significance Index: 208.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0929
    Cell Significance Index: 216.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0714
    Cell Significance Index: 82.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0420
    Cell Significance Index: 1961.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0304
    Cell Significance Index: 48.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9441
    Cell Significance Index: 153.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8833
    Cell Significance Index: 113.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8385
    Cell Significance Index: 370.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8279
    Cell Significance Index: 58.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7070
    Cell Significance Index: 97.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6727
    Cell Significance Index: 241.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6670
    Cell Significance Index: 86.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6393
    Cell Significance Index: 349.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6097
    Cell Significance Index: 421.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6074
    Cell Significance Index: 13.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5850
    Cell Significance Index: 57.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5540
    Cell Significance Index: 31.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4392
    Cell Significance Index: 51.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4385
    Cell Significance Index: 32.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3544
    Cell Significance Index: 545.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3441
    Cell Significance Index: 2.8900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2795
    Cell Significance Index: 6.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2679
    Cell Significance Index: 7.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2678
    Cell Significance Index: 493.9300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2558
    Cell Significance Index: 2.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1906
    Cell Significance Index: 121.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1403
    Cell Significance Index: 6.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1271
    Cell Significance Index: 6.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1196
    Cell Significance Index: 162.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1119
    Cell Significance Index: 50.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1026
    Cell Significance Index: 5.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1018
    Cell Significance Index: 19.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0529
    Cell Significance Index: 1.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0386
    Cell Significance Index: 1.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0071
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0216
    Cell Significance Index: -15.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0349
    Cell Significance Index: -26.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0403
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0527
    Cell Significance Index: -9.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0861
    Cell Significance Index: -63.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0944
    Cell Significance Index: -2.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1190
    Cell Significance Index: -67.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1207
    Cell Significance Index: -75.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1740
    Cell Significance Index: -25.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1974
    Cell Significance Index: -56.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2354
    Cell Significance Index: -14.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2372
    Cell Significance Index: -27.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2748
    Cell Significance Index: -9.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2809
    Cell Significance Index: -18.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3211
    Cell Significance Index: -16.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3472
    Cell Significance Index: -5.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3509
    Cell Significance Index: -73.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4353
    Cell Significance Index: -45.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4444
    Cell Significance Index: -28.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4628
    Cell Significance Index: -53.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4666
    Cell Significance Index: -9.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5712
    Cell Significance Index: -34.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6093
    Cell Significance Index: -15.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6635
    Cell Significance Index: -16.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6638
    Cell Significance Index: -52.5800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6764
    Cell Significance Index: -14.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7080
    Cell Significance Index: -18.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.7200
    Cell Significance Index: -8.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7272
    Cell Significance Index: -16.8000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7391
    Cell Significance Index: -8.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7569
    Cell Significance Index: -22.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7721
    Cell Significance Index: -34.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8601
    Cell Significance Index: -7.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8796
    Cell Significance Index: -53.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8836
    Cell Significance Index: -7.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9344
    Cell Significance Index: -35.3800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9808
    Cell Significance Index: -14.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0664
    Cell Significance Index: -34.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1227
    Cell Significance Index: -23.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1625
    Cell Significance Index: -42.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1944
    Cell Significance Index: -35.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1982
    Cell Significance Index: -32.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2385
    Cell Significance Index: -22.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAT2A is a member of the methionine adenosyltransferase family, which catalyzes the conversion of methionine and ATP to SAMe. This enzyme exhibits high specificity and efficiency, with a high Km value and a low Kcat value, indicating its importance in regulating SAMe levels. MAT2A is predominantly expressed in various cell types, including skeletal muscle satellite stem cells, fibroblasts, and pro-B cells, suggesting its role in tissue development, maintenance, and function. **Pathways and Functions:** MAT2A is involved in several biological pathways, including: 1. **One-carbon metabolism**: MAT2A plays a crucial role in the methionine cycle, which is essential for the synthesis of SAMe, a vital methyl donor in various biochemical reactions. 2. **Methylation**: SAMe is a key methyl donor in DNA, histone, and protein methylation, which regulates gene expression, chromatin structure, and cellular signaling. 3. **Metabolism**: MAT2A is involved in the synthesis of SAMe, which is necessary for various metabolic processes, including fatty acid synthesis, cholesterol biosynthesis, and neurotransmitter synthesis. 4. **Cellular response to leukemia inhibitory factor (LIF)**: MAT2A has been shown to interact with LIF, a cytokine involved in cell survival, differentiation, and proliferation. **Clinical Significance:** MAT2A has been implicated in various human diseases, including: 1. **Neurodegenerative disorders**: Alterations in SAMe levels have been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer**: MAT2A has been shown to be overexpressed in various cancers, including breast, lung, and prostate cancer, suggesting its potential role as a biomarker or therapeutic target. 3. **Gastrointestinal disorders**: MAT2A has been implicated in gastrointestinal disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), where SAMe levels are often altered. In conclusion, MAT2A is a vital enzyme involved in various biological processes, including one-carbon metabolism, methylation, and metabolism. Its clinical significance is evident in various human diseases, highlighting the potential for therapeutic interventions targeting MAT2A or SAMe levels. Further research is necessary to fully elucidate the role of MAT2A in human health and disease.

Genular Protein ID: 1757049628

Symbol: METK2_HUMAN

Name: S-adenosylmethionine synthase isoform type-2

UniProtKB Accession Codes:

P31153 A8K511 B4DN45 D6W5L1 Q53SP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 22 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EC 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 52 PDBsum 52 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1426236

Title: Molecular cloning and developmental expression of a human kidney S-adenosylmethionine synthetase.

PubMed ID: 1426236

DOI: 10.1016/0014-5793(92)81405-b

PubMed ID: 16413417

Title: Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia.

PubMed ID: 16413417

DOI: 10.1016/j.freeradbiomed.2005.09.004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644686

Title: Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II).

PubMed ID: 10644686

DOI: 10.1074/jbc.275.4.2359

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23189196

Title: NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

PubMed ID: 23189196

DOI: 10.1371/journal.pone.0050329

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28525753

Title: The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention.

PubMed ID: 28525753

DOI: 10.1016/j.cell.2017.05.003

PubMed ID: 29262316

Title: S-Adenosylmethionine synthesis is regulated by selective N6-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1.

PubMed ID: 29262316

DOI: 10.1016/j.celrep.2017.11.092

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33930289

Title: Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.

PubMed ID: 33930289

DOI: 10.1016/j.cell.2021.03.062

PubMed ID: 23425511

Title: Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits.

PubMed ID: 23425511

DOI: 10.1042/bj20121580

PubMed ID: 25075345

Title: Structure and function study of the complex that synthesizes S-adenosylmethionine.

PubMed ID: 25075345

DOI: 10.1107/s2052252514012585

PubMed ID: 26858410

Title: Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes.

PubMed ID: 26858410

DOI: 10.1073/pnas.1510959113

Sequence Information:

  • Length: 395
  • Mass: 43661
  • Checksum: 2E7D1B91CC4F7BDD
  • Sequence:
    • MNGQLNGFHE AFIEEGTFLF TSESVGEGHP DKICDQISDA VLDAHLQQDP DAKVACETVA 
KTGMILLAGE ITSRAAVDYQ KVVREAVKHI GYDDSSKGFD YKTCNVLVAL EQQSPDIAQG 
VHLDRNEEDI GAGDQGLMFG YATDETEECM PLTIVLAHKL NAKLAELRRN GTLPWLRPDS 
KTQVTVQYMQ DRGAVLPIRV HTIVISVQHD EEVCLDEMRD ALKEKVIKAV VPAKYLDEDT 
IYHLQPSGRF VIGGPQGDAG LTGRKIIVDT YGGWGAHGGG AFSGKDYTKV DRSAAYAARW 
VAKSLVKGGL CRRVLVQVSY AIGVSHPLSI SIFHYGTSQK SERELLEIVK KNFDLRPGVI 
VRDLDLKKPI YQRTAAYGHF GRDSFPWEVP KKLKY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.