Gene YWHAE - ENSG00000108953 | NCBI Gene ID: 7531

Details for: YWHAE

Gene ID: 7531

Symbol: YWHAE

Ensembl ID: ENSG00000108953

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Apoptosis
(R-HSA-109581)
Aurka activation by tpx2
(R-HSA-8854518)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cell death signalling via nrage, nrif and nade
(R-HSA-204998)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to heat stress
(R-HSA-3371556)
Centrosome maturation
(R-HSA-380287)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Cilium assembly
(R-HSA-5617833)
Death receptor signaling
(R-HSA-73887)
Defective intrinsic pathway for apoptosis
(R-HSA-9734009)
Deregulated cdk5 triggers multiple neurodegenerative pathways in alzheimer's disease models
(R-HSA-8862803)
Disease
(R-HSA-1643685)
Diseases of programmed cell death
(R-HSA-9645723)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
G2/m transition
(R-HSA-69275)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hsf1 activation
(R-HSA-3371511)
Infectious disease
(R-HSA-5663205)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Membrane trafficking
(R-HSA-199991)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nade modulates death signalling
(R-HSA-205025)
Neurodegenerative diseases
(R-HSA-8863678)
Organelle biogenesis and maintenance
(R-HSA-1852241)
P75 ntr receptor-mediated signalling
(R-HSA-193704)
Programmed cell death
(R-HSA-5357801)
Rab gefs exchange gtp for gdp on rabs
(R-HSA-8876198)
Rab regulation of trafficking
(R-HSA-9007101)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of hsf1-mediated heat shock response
(R-HSA-3371453)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by hippo
(R-HSA-2028269)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Calcium channel regulator activity
(GO:0005246)
Cellular response to heat
(GO:0034605)
Cerebral cortex development
(GO:0021987)
Cytoplasmic pattern recognition receptor signaling pathway
(GO:0002753)
Enzyme binding
(GO:0019899)
Hippocampus development
(GO:0021766)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Mapk cascade
(GO:0000165)
Mhc class ii protein complex binding
(GO:0023026)
Neuron migration
(GO:0001764)
Phosphoprotein binding
(GO:0051219)
Phosphoserine residue binding
(GO:0050815)
Positive regulation of protein export from nucleus
(GO:0046827)
Potassium channel regulator activity
(GO:0015459)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein localization to nucleus
(GO:0034504)
Protein phosphatase binding
(GO:0019903)
Protein sequestering activity
(GO:0140311)
Protein targeting
(GO:0006605)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of heart rate by hormone
(GO:0003064)
Regulation of membrane repolarization
(GO:0060306)
Regulation of mitotic cell cycle
(GO:0007346)
Rna binding
(GO:0003723)
Scaffold protein binding
(GO:0097110)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Substantia nigra development
(GO:0021762)
Transmembrane transporter binding
(GO:0044325)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: chromaffin cell (CL0000166)
Fold Change: 4.36
Marker Score: 6136
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.2
Marker Score: 142976
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.81
Marker Score: 9296
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.71
Marker Score: 3961
Cell Name: radial glial cell (CL0000681)
Fold Change: 3.7
Marker Score: 1365
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.58
Marker Score: 47168
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.56
Marker Score: 63226
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.55
Marker Score: 4290
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.54
Marker Score: 8936
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.44
Marker Score: 14336
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.4
Marker Score: 3212
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.37
Marker Score: 3515
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.34
Marker Score: 8946
Cell Name: stromal cell (CL0000499)
Fold Change: 3.33
Marker Score: 3906
Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.3
Marker Score: 2847
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.26
Marker Score: 11567.5
Cell Name: endocrine cell (CL0000163)
Fold Change: 3.22
Marker Score: 1667.5
Cell Name: cell in vitro (CL0001034)
Fold Change: 3.2
Marker Score: 110862
Cell Name: acinar cell (CL0000622)
Fold Change: 3.18
Marker Score: 2246
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.13
Marker Score: 4826
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.13
Marker Score: 5186
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.06
Marker Score: 2396
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 3.05
Marker Score: 14979.5
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.04
Marker Score: 19800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.04
Marker Score: 11715
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.02
Marker Score: 15819
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.98
Marker Score: 2346
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.97
Marker Score: 1679
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.96
Marker Score: 3140
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 2.95
Marker Score: 25631
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 2.94
Marker Score: 1846
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.92
Marker Score: 22785
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.9
Marker Score: 5903
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.9
Marker Score: 1688
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.89
Marker Score: 4591
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.88
Marker Score: 4720.5
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.88
Marker Score: 5744
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.87
Marker Score: 18732
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.87
Marker Score: 3735.5
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.86
Marker Score: 919
Cell Name: supporting cell (CL0000630)
Fold Change: 2.84
Marker Score: 5345
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.82
Marker Score: 18015
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.81
Marker Score: 5866
Cell Name: theca cell (CL0000503)
Fold Change: 2.79
Marker Score: 1999.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.78
Marker Score: 3124
Cell Name: motor neuron (CL0000100)
Fold Change: 2.78
Marker Score: 1648
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.77
Marker Score: 3341
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.76
Marker Score: 660.5
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.76
Marker Score: 7872
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.75
Marker Score: 6250.5
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.75
Marker Score: 949
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.75
Marker Score: 904
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.73
Marker Score: 3952
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.72
Marker Score: 30605
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.72
Marker Score: 23401
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.69
Marker Score: 2296.5
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.69
Marker Score: 6136.5
Cell Name: decidual cell (CL2000002)
Fold Change: 2.68
Marker Score: 11561
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.68
Marker Score: 2719
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.68
Marker Score: 1114.5
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.68
Marker Score: 4302
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.68
Marker Score: 15874.5
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.67
Marker Score: 2877
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.67
Marker Score: 2508.5
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.67
Marker Score: 1200
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.66
Marker Score: 3770
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.66
Marker Score: 4525
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.66
Marker Score: 3860
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.65
Marker Score: 2836
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.65
Marker Score: 26650.5
Cell Name: erythroblast (CL0000765)
Fold Change: 2.64
Marker Score: 1650
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.64
Marker Score: 6706
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.63
Marker Score: 1243
Cell Name: club cell (CL0000158)
Fold Change: 2.63
Marker Score: 3067
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.61
Marker Score: 885
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.61
Marker Score: 7111.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 2.61
Marker Score: 3745
Cell Name: basal cell (CL0000646)
Fold Change: 2.6
Marker Score: 3362
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.6
Marker Score: 1341
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.6
Marker Score: 1348
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.59
Marker Score: 8142
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.59
Marker Score: 2319
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.58
Marker Score: 10565.5
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.58
Marker Score: 3180
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.58
Marker Score: 2456
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.57
Marker Score: 2709
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.57
Marker Score: 2766
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.56
Marker Score: 4337
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.54
Marker Score: 5974
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.53
Marker Score: 1442
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.53
Marker Score: 881
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.52
Marker Score: 4474
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.52
Marker Score: 8674
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 2.51
Marker Score: 1024
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.5
Marker Score: 18595.5
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.49
Marker Score: 790
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.49
Marker Score: 836
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.47
Marker Score: 735
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.46
Marker Score: 932.5
Cell Name: podocyte (CL0000653)
Fold Change: 2.46
Marker Score: 908.5

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**Key Characteristics:** 1. **Structure:** YWHAE belongs to the 14-3-3 family of proteins, which are characterized by their conserved structure consisting of three subdomains (I, II, and III). 2. **Function:** YWHAE plays a multifaceted role in cellular processes, including signal transduction, apoptosis, and cell cycle regulation. 3. **Subcellular localization:** YWHAE is primarily localized to the cytoplasm and nucleus, where it interacts with various partners to regulate cellular processes. 4. **Interactions:** YWHAE interacts with numerous partners, including kinases, phosphatases, and other proteins, to regulate signaling pathways. **Pathways and Functions:** 1. **Apoptosis:** YWHAE plays a role in regulating apoptosis by interacting with pro-apoptotic and anti-apoptotic proteins. 2. **Cell cycle regulation:** YWHAE influences cell cycle progression by interacting with cyclin-dependent kinases and other cell cycle regulators. 3. **Signaling pathways:** YWHAE is involved in various signaling pathways, including those involved in cell death, proliferation, and differentiation. 4. **Mitochondrial function:** YWHAE interacts with mitochondrial proteins to regulate mitochondrial function and biogenesis. 5. **Stress response:** YWHAE is activated in response to cellular stress, such as heat shock, and regulates the stress response by interacting with heat shock transcription factors. **Clinical Significance:** 1. **Cancer:** YWHAE is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurodegenerative diseases:** YWHAE is involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Infectious diseases:** YWHAE is involved in the regulation of immune responses to viral infections, such as SARS-CoV-2. 4. **Cardiovascular disease:** YWHAE is involved in the regulation of cardiac function and is associated with cardiovascular disease. **Conclusion:** In conclusion, YWHAE is a multifaceted protein that plays a critical role in various cellular processes, including signal transduction, apoptosis, and cell cycle regulation. Its involvement in various diseases, including cancer, neurodegenerative diseases, and infectious diseases, highlights its importance in human health and disease. Further research is needed to fully understand the mechanisms by which YWHAE regulates cellular processes and to explore its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

14-3-3 protein epsilon

Genular Protein ID: 3210498557

Symbol: 1433E_HUMAN

Name: 14-3-3 protein epsilon

UniProtKB Accession Codes:

P62258 B3KY71 D3DTH5 P29360 P42655 Q4VJB6 Q53XZ5 Q63631 Q7M4R4

Database IDs:

Citations:

PubMed ID: 7644510

Title: 14-3-3 proteins associate with cdc25 phosphatases.

PubMed ID: 7644510

DOI: 10.1073/pnas.92.17.7892

PubMed ID: 8858348

Title: 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region.

PubMed ID: 8858348

DOI: 10.1101/gr.6.8.735

PubMed ID: 8684458

Title: Function of 14-3-3 proteins.

PubMed ID: 8684458

DOI: 10.1038/382308a0

PubMed ID: 20417184

Title: Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis.

PubMed ID: 20417184

DOI: 10.1016/j.bbrc.2010.04.104

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 2026444

Title: Isolation and partial characterization of the structures of fibroblast activating factor-related proteins from U937 cells.

PubMed ID: 2026444

PubMed ID: 10644344

Title: Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1.

PubMed ID: 10644344

DOI: 10.1128/jvi.74.4.1736-1741.2000

PubMed ID: 11427721

Title: Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

PubMed ID: 11427721

DOI: 10.1073/pnas.141118798

PubMed ID: 12042314

Title: Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.

PubMed ID: 12042314

DOI: 10.1074/jbc.m203668200

PubMed ID: 12917326

Title: Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.

PubMed ID: 12917326

DOI: 10.1128/mcb.23.17.6013-6026.2003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15722337

Title: Phosphorylation of grb10 regulates its interaction with 14-3-3.

PubMed ID: 15722337

DOI: 10.1074/jbc.m501477200

PubMed ID: 15696159

Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

PubMed ID: 15696159

DOI: 10.1038/ncb1228

PubMed ID: 16376338

Title: Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon.

PubMed ID: 16376338

DOI: 10.1016/j.febslet.2005.12.024

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18029012

Title: Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump.

PubMed ID: 18029012

DOI: 10.1016/j.ceca.2007.09.003

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22607805

Title: The mitochondrial targeting chaperone 14-3-3epsilon regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

PubMed ID: 22607805

DOI: 10.1016/j.chom.2012.04.006

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 26055712

Title: Phosphorylation-dependent regulation of Connecdenn/DENND1 guanine nucleotide exchange factors.

PubMed ID: 26055712

DOI: 10.1074/jbc.m115.636712

PubMed ID: 25588844

Title: Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.

PubMed ID: 25588844

DOI: 10.1242/jcs.161497

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27030597

Title: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

PubMed ID: 27030597

DOI: 10.1126/scitranslmed.aaf1471

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 29769719

Title: KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.

PubMed ID: 29769719

DOI: 10.1038/s41586-018-0128-9

PubMed ID: 37555661

Title: Cleavage of 14-3-3epsilon by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling.

PubMed ID: 37555661

DOI: 10.1128/jvi.00604-23

PubMed ID: 37599448

Title: Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy.

PubMed ID: 37599448

DOI: 10.1080/15384047.2023.2246203

PubMed ID: 17085597

Title: Structural basis for protein-protein interactions in the 14-3-3 protein family.

PubMed ID: 17085597

DOI: 10.1073/pnas.0605779103

Sequence Information:

Length: 255
Mass: 29174
Checksum: 07817CCBD1F75B26
Sequence:

MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW 
RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF 
YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF 
YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE 
EQNKEALQDV EDENQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: YWHAE

Associated with

Cells (max top 100)

Other Information

14-3-3 proteins associate with cdc25 phosphatases. PubMed ID: 7644510

14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region. PubMed ID: 8858348

Function of 14-3-3 proteins. PubMed ID: 8684458

Functional identification of a novel 14-3-3 epsilon splicing variant suggests dimerization is not necessary for 14-3-3 epsilon to inhibit UV-induced apoptosis. PubMed ID: 20417184

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. PubMed ID: 23572552

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. PubMed ID: 10409742

Isolation and partial characterization of the structures of fibroblast activating factor-related proteins from U937 cells. PubMed ID: 2026444

Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. PubMed ID: 10644344

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. PubMed ID: 11427721

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. PubMed ID: 12042314

Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. PubMed ID: 12917326

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Phosphorylation of grb10 regulates its interaction with 14-3-3. PubMed ID: 15722337

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. PubMed ID: 15696159

Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. PubMed ID: 16376338

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Inhibitory interaction of the 14-3-3 proteins with ubiquitous (PMCA1) and tissue-specific (PMCA3) isoforms of the plasma membrane Ca2+ pump. PubMed ID: 18029012

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. PubMed ID: 19640509

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. PubMed ID: 19592491

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

The mitochondrial targeting chaperone 14-3-3epsilon regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. PubMed ID: 22607805

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703

Phosphorylation-dependent regulation of Connecdenn/DENND1 guanine nucleotide exchange factors. PubMed ID: 26055712

Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. PubMed ID: 25588844

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. PubMed ID: 27030597

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. PubMed ID: 29769719

Cleavage of 14-3-3epsilon by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling. PubMed ID: 37555661

Nucleo-cytoplasmic shuttling of 14-3-3 epsilon carrying hnRNP C promotes autophagy. PubMed ID: 37599448

Structural basis for protein-protein interactions in the 14-3-3 protein family. PubMed ID: 17085597