Details for: ROBO2
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 53.55rCSI 63.96%PRS 92.37
-
CSI 49.26rCSI 63.5%PRS 92.95
-
CSI 47.82rCSI 59.49%PRS 91.06
-
CSI 38.3rCSI 71.74%PRS 93.49
-
CSI 35.51rCSI 62.72%PRS 92.36
-
CSI 34.15rCSI 54.92%PRS 92.64
-
CSI 33.13rCSI 76.49%PRS 93.26
-
CSI 32.87rCSI 55.18%PRS 92.6
-
CSI 28.42rCSI 61.66%PRS 90.59
-
CSI 24.15rCSI 57.77%PRS 91.9
-
CSI 23.43rCSI 47.54%PRS 88.1
-
CSI 22.35rCSI 25.81%PRS 93.81
-
CSI 21.51rCSI 57.28%PRS 89.88
-
CSI 21.45rCSI 27.53%PRS 95.99
-
CSI 21.4rCSI 52.01%PRS 90.97
-
CSI 20.67rCSI 50.47%PRS 94
-
CSI 19.93rCSI 34.46%PRS 95.47
-
CSI 19.9rCSI 51.84%PRS 93.44
-
CSI 19.61rCSI 27.16%PRS 96.15
-
CSI 19.39rCSI 60.58%PRS 92.91
-
CSI 19.12rCSI 62.85%PRS 91
-
CSI 17.98rCSI 36.1%PRS 95.24
-
CSI 17.45rCSI 22.41%PRS 93.75
-
CSI 17.42rCSI 16.21%PRS 98.37
-
CSI 17.11rCSI 30.74%PRS 94.85
-
CSI 16.74rCSI 22.8%PRS 94.69
-
CSI 16.49rCSI 14.64%PRS 96.38
-
CSI 16.42rCSI 15.51%PRS 96.37
-
CSI 15.65rCSI 56.3%PRS 91.14
-
CSI 15.6rCSI 27.34%PRS 95.87
-
CSI 15.33rCSI 12.45%PRS 97.6
-
CSI 15.24rCSI 24.96%PRS 94.74
-
CSI 15.12rCSI 47.3%PRS 93.67
-
CSI 14.84rCSI 50.83%PRS 90.37
-
CSI 14.66rCSI 16.05%PRS 98.31
-
CSI 14.56rCSI 29.91%PRS 90.54
-
CSI 14.18rCSI 53.59%PRS 92.16
-
CSI 13.99rCSI 22.1%PRS 98.17
-
CSI 13.91rCSI 46.61%PRS 90.04
-
CSI 13.84rCSI 38.14%PRS 96.93
-
CSI 13.8rCSI 36.89%PRS 95.67
-
CSI 13.45rCSI 29.72%PRS 92.44
-
CSI 12.86rCSI 26.69%PRS 96.76
-
CSI 12.69rCSI 50.27%PRS 93.57
-
CSI 12.66rCSI 56.57%PRS 88.46
-
CSI 12.54rCSI 17.42%PRS 97.1
-
CSI 12.33rCSI 9.75%PRS 95.45
-
CSI 12.27rCSI 19.58%PRS 93.97
-
CSI 12.26rCSI 45.94%PRS 96.28
-
CSI 12.03rCSI 39.01%PRS 97.24
-
CSI 11.9rCSI 48.48%PRS 92.88
-
CSI 11.81rCSI 59.46%PRS 95.45
-
CSI 11.38rCSI 24.21%PRS 94.02
-
CSI 11.29rCSI 32.73%PRS 93.29
-
CSI 11.16rCSI 65.92%PRS 91.69
-
CSI 11.16rCSI 15.27%PRS 93.8
-
CSI 10.99rCSI 32.44%PRS 97.13
-
CSI 10.94rCSI 24.97%PRS 94.61
-
CSI 10.81rCSI 40.79%PRS 89.88
-
CSI 10.59rCSI 55.7%PRS 91.15
-
CSI 10.36rCSI 26.64%PRS 95.33
-
CSI 10.35rCSI 58.47%PRS 91.76
-
CSI 10.33rCSI 15.19%PRS 94.83
-
CSI 9.53rCSI 56.09%PRS 92.43
-
CSI 9.42rCSI 18.71%PRS 95.68
-
CSI 9.21rCSI 13.22%PRS 93.17
-
CSI 9.15rCSI 45.47%PRS 93.95
-
CSI 9rCSI 12.03%PRS 96.08
-
CSI 8.69rCSI 19.48%PRS 92.74
-
CSI 8.2rCSI 14.46%PRS 98.24
-
CSI 8.13rCSI 24%PRS 97.55
-
CSI 7.96rCSI 20.2%PRS 96.23
-
CSI 7.81rCSI 20.73%PRS 97.06
-
CSI 7.78rCSI 20.28%PRS 98.38
-
CSI 7.77rCSI 57.13%PRS 93.72
-
CSI 7.53rCSI 32.02%PRS 94.41
-
CSI 7.4rCSI 18.77%PRS 95.24
-
CSI 7.14rCSI 11.35%PRS 95.53
-
CSI 7.03rCSI 7.36%PRS 97.78
-
CSI 6.81rCSI 10.38%PRS 95.77
-
CSI 6.77rCSI 58.34%PRS 93.3
-
CSI 6.63rCSI 29.46%PRS 97.47
-
CSI 6.61rCSI 11.72%PRS 78.26
-
CSI 6.24rCSI 46.88%PRS 90.5
-
CSI 6.23rCSI 9.52%PRS 96.66
-
CSI 5.92rCSI 24.12%PRS 98.61
-
CSI 5.8rCSI 40.99%PRS 93.88
-
CSI 5.77rCSI 30.68%PRS 94.64
-
CSI 5.71rCSI 6.85%PRS 97.88
-
CSI 5.65rCSI 64.76%PRS 88.09
-
CSI 5.4rCSI 15.19%PRS 96.18
-
CSI 5.38rCSI 5.19%PRS 96.34
-
CSI 5.26rCSI 16.92%PRS 94.97
-
CSI 5.06rCSI 6.89%PRS 79.36
-
CSI 4.71rCSI 25.76%PRS 95.25
-
CSI 4.69rCSI 40.53%PRS 94.32
-
CSI 4.62rCSI 38.86%PRS 88.85
-
CSI 4.32rCSI 61.37%PRS 92.88
-
CSI 4.26rCSI 6.86%PRS 93.43
-
CSI 4.26rCSI 7.74%PRS 94.31
-
CSI 0.8rCSI 6.9%PRS 97.1%
-
CSI 1.3rCSI 14.0%PRS 95.3%
-
CSI 1.4rCSI 15.3%PRS 98.3%
-
CSI 1.4rCSI 9.5%PRS 92.1%
-
CSI 2.0rCSI 8.8%PRS 94.7%
-
CSI 2.0rCSI 4.5%PRS 97.2%
-
CSI 2.2rCSI 6.3%PRS 97.4%
-
CSI 2.3rCSI 2.4%PRS 96.3%
-
CSI 2.3rCSI 21.4%PRS 94.2%
-
CSI 2.4rCSI 57.4%PRS 90.0%
-
CSI 2.4rCSI 57.6%PRS 90.2%
-
CSI 2.6rCSI 20.3%PRS 97.2%
-
CSI 2.7rCSI 10.1%PRS 94.1%
-
CSI 2.7rCSI 6.0%PRS 97.8%
-
CSI 2.9rCSI 58.5%PRS 92.7%
-
CSI 2.9rCSI 58.9%PRS 92.6%
-
CSI 2.9rCSI 18.2%PRS 85.6%
-
CSI 2.9rCSI 5.2%PRS 95.0%
-
CSI 2.9rCSI 46.4%PRS 96.8%
-
CSI 3.0rCSI 13.2%PRS 91.0%
-
CSI 3.1rCSI 11.8%PRS 97.5%
-
CSI 3.1rCSI 17.2%PRS 98.2%
-
CSI 3.2rCSI 19.6%PRS 96.6%
-
CSI 3.3rCSI 5.4%PRS 79.9%
-
CSI 3.4rCSI 8.2%PRS 98.4%
-
CSI 3.6rCSI 5.3%PRS 96.2%
-
CSI 3.6rCSI 17.2%PRS 90.6%
-
CSI 3.7rCSI 23.6%PRS 93.3%
-
CSI 3.7rCSI 38.6%PRS 93.4%
-
CSI 3.8rCSI 10.5%PRS 98.4%
-
CSI 3.9rCSI 33.9%PRS 90.1%
-
CSI 3.9rCSI 12.6%PRS 97.4%
-
CSI 4.1rCSI 3.0%PRS 96.1%
-
CSI 4.3rCSI 7.7%PRS 94.3%
-
CSI 4.3rCSI 6.9%PRS 93.4%
-
CSI 4.3rCSI 61.4%PRS 92.9%
-
CSI 4.6rCSI 38.9%PRS 88.9%
-
CSI 4.7rCSI 40.5%PRS 94.3%
-
CSI 4.7rCSI 25.8%PRS 95.3%
-
CSI 5.1rCSI 6.9%PRS 79.4%
-
CSI 5.3rCSI 16.9%PRS 95.0%
-
CSI 5.4rCSI 5.2%PRS 96.3%
-
CSI 5.4rCSI 15.2%PRS 96.2%
-
CSI 5.7rCSI 64.8%PRS 88.1%
-
CSI 5.7rCSI 6.9%PRS 97.9%
-
CSI 5.8rCSI 30.7%PRS 94.6%
-
CSI 5.8rCSI 41.0%PRS 93.9%
-
CSI 5.9rCSI 24.1%PRS 98.6%
-
CSI 6.2rCSI 9.5%PRS 96.7%
-
CSI 6.2rCSI 46.9%PRS 90.5%
-
CSI 6.6rCSI 11.7%PRS 78.3%
-
CSI 6.6rCSI 29.5%PRS 97.5%
-
CSI 6.8rCSI 58.3%PRS 93.3%
-
CSI 6.8rCSI 10.4%PRS 95.8%
-
CSI 7.0rCSI 7.4%PRS 97.8%
-
CSI 7.1rCSI 11.4%PRS 95.5%
-
CSI 7.4rCSI 18.8%PRS 95.2%
-
CSI 7.5rCSI 32.0%PRS 94.4%
-
CSI 7.8rCSI 57.1%PRS 93.7%
-
CSI 7.8rCSI 20.3%PRS 98.4%
-
CSI 7.8rCSI 20.7%PRS 97.1%
-
CSI 8.0rCSI 20.2%PRS 96.2%
-
CSI 8.1rCSI 24.0%PRS 97.6%
-
CSI 8.2rCSI 14.5%PRS 98.2%
-
CSI 8.7rCSI 19.5%PRS 92.7%
-
CSI 9.0rCSI 12.0%PRS 96.1%
-
CSI 9.2rCSI 45.5%PRS 94.0%
-
CSI 9.2rCSI 13.2%PRS 93.2%
-
CSI 9.4rCSI 18.7%PRS 95.7%
-
CSI 9.5rCSI 56.1%PRS 92.4%
-
CSI 10.3rCSI 15.2%PRS 94.8%
-
CSI 10.4rCSI 58.5%PRS 91.8%
-
CSI 10.4rCSI 26.6%PRS 95.3%
-
CSI 10.6rCSI 55.7%PRS 91.2%
-
CSI 10.8rCSI 40.8%PRS 89.9%
-
CSI 10.9rCSI 25.0%PRS 94.6%
-
CSI 11.0rCSI 32.4%PRS 97.1%
-
CSI 11.2rCSI 15.3%PRS 93.8%
-
CSI 11.2rCSI 65.9%PRS 91.7%
-
CSI 11.3rCSI 32.7%PRS 93.3%
-
CSI 11.4rCSI 24.2%PRS 94.0%
-
CSI 11.8rCSI 59.5%PRS 95.5%
-
CSI 11.9rCSI 48.5%PRS 92.9%
-
CSI 12.0rCSI 39.0%PRS 97.2%
-
CSI 12.3rCSI 45.9%PRS 96.3%
-
CSI 12.3rCSI 19.6%PRS 94.0%
-
CSI 12.3rCSI 9.8%PRS 95.5%
-
CSI 12.5rCSI 17.4%PRS 97.1%
-
CSI 12.7rCSI 56.6%PRS 88.5%
-
CSI 12.7rCSI 50.3%PRS 93.6%
-
CSI 12.9rCSI 26.7%PRS 96.8%
-
CSI 13.5rCSI 29.7%PRS 92.4%
-
CSI 13.8rCSI 36.9%PRS 95.7%
-
CSI 13.8rCSI 38.1%PRS 96.9%
-
CSI 13.9rCSI 46.6%PRS 90.0%
-
CSI 14.0rCSI 22.1%PRS 98.2%
-
CSI 14.2rCSI 53.6%PRS 92.2%
-
CSI 14.6rCSI 29.9%PRS 90.5%
-
CSI 14.7rCSI 16.1%PRS 98.3%
-
CSI 14.8rCSI 50.8%PRS 90.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3926584561
Symbol: ROBO2_HUMAN
Name: Roundabout homolog 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16829019
Title: Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.
PubMed ID: 16829019
PubMed ID: 10997877
Title: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10997877
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9458045
Title: Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.
PubMed ID: 9458045
PubMed ID: 10102268
Title: Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.
PubMed ID: 10102268
PubMed ID: 11404413
Title: Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.
PubMed ID: 11404413
PubMed ID: 17357069
Title: Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.
PubMed ID: 17357069
DOI: 10.1086/512735
Sequence Information:
- Length: 1378
- Mass: 151200
- Checksum: 60F7CE3E53622B50
- Sequence:
MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG KMEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE GSQNLLFPNQ PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII LQGPANQTLA VDGTALLKCK ATGDPLPVIS WLKEGFTFPG RDPRATIQEQ GTLQIKNLRI SDTGTYTCVA TSSSGETSWS AVLDVTESGA TISKNYDLSD LPGPPSKPQV TDVTKNSVTL SWQPGTPGTL PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP QGLSDPSPMS DPVRTQDISP PAQGVDHRQV QKELGDVLVR LHNPVVLTPT TVQVTWTVDR QPQFIQGYRV MYRQTSGLQA TSSWQNLDAK VPTERSAVLV NLKKGVTYEI KVRPYFNEFQ GMDSESKTVR TTEEAPSAPP QSVTVLTVGS YNSTSISVSW DPPPPDHQNG IIQEYKIWCL GNETRFHINK TVDAAIRSVI IGGLFPGIQY RVEVAASTSA GVGVKSEPQP IIIGRRNEVV ITENNNSITE QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL SNYAVTFQRG DGGLMSNGSR PGLLNAGDPS YPWLADSWPA TSLPVNNSNS GPNEIGNFGR GDVLPPVPGQ GDKTATMLSD GAIYSSIDFT TKTSYNSSSQ ITQATPYATT QILHSNSIHE LAVDLPDPQW KSSIQQKTDL MGFGYSLPDQ NKGNNGGKGG KKKKNKNSSK PQKNNGSTWA NVPLPPPPVQ PLPGTELEHY AVEQQENGYD SDSWCPPLPV QTYLHQGLED ELEEDDDRVP TPPVRGVASS PAISFGQQST ATLTPSPREE MQPMLQAHLD ELTRAYQFDI AKQTWHIQSN NQPPQPPVPP LGYVSGALIS DLETDVADDD ADDEEEALEI PRPLRALDQT PGSSMDNLDS SVTGKAFTSS QRPRPTSPFS TDSNTSAALS QSQRPRPTKK HKGGRMDQQP ALPHRREGMT DEEALVPYSK PSFPSPGGHS SSGTASSKGS TGPRKTEVLR AGHQRNASDL LDIGYMGSNS QGQFTGEL
Genular Protein ID: 1556530623
Symbol: F8W703_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
Sequence Information:
- Length: 1443
- Mass: 157778
- Checksum: 0ACB7BB7E42D4234
- Sequence:
MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG KMEASATLTV RARPVAPPQF VVRPRDQIVA QGRTVTFPCE TKGNPQPAVF WQKEGSQNLL FPNQPQQPNS RCSVSPTGDL TITNIQRSDA GYYICQALTV AGSILAKAQL EVTDVLTDRP PPIILQGPAN QTLAVDGTAL LKCKATGDPL PVISWLKEGF TFPGRDPRAT IQEQGTLQIK NLRISDTGTY TCVATSSSGE TSWSAVLDVT ESGATISKNY DLSDLPGPPS KPQVTDVTKN SVTLSWQPGT PGTLPASAYI IEAFSQSVSN SWQTVANHVK TTLYTVRGLR PNTIYLFMVR AINPQGLSDP SPMSDPVRTQ DISPPAQGVD HRQVQKELGD VLVRLHNPVV LTPTTVQVTW TVDRQPQFIQ GYRVMYRQTS GLQATSSWQN LDAKVPTERS AVLVNLKKGV TYEIKVRPYF NEFQGMDSES KTVRTTEEAP SAPPQSVTVL TVGSYNSTSI SVSWDPPPPD HQNGIIQEYK IWCLGNETRF HINKTVDAAI RSVIIGGLFP GIQYRVEVAA STSAGVGVKS EPQPIIIGRR NEVVITENNN SITEQITDVV KQPAFIAGIG GACWVILMGF SIWLYWRRKK RKGLSNYAVT FQRGDGGLMS NGSRPGLLNA GDPSYPWLAD SWPATSLPVN NSNSGPNEIG NFGRGDVLPP VPGQGDKTAT MLSDGAIYSS IDFTTKTSYN SSSQITQATP YATTQILHSN SIHELAVDLP DPQWKSSIQQ KTDLMGFGYS LPDQNKGNNG GKGGKKKKNK NSSKPQKNNG STWANVPLPP PPVQPLPGTE LEHYAVEQQE NGYDSDSWCP PLPVQTYLHQ GLEDELEEDD DRVPTPPVRG VASSPAISFG QQSTATLTPS PREEMQPMLQ AHLDELTRAY QFDIAKQTWH IQSNNQPPQP PVPPLGYVSG ALISDLETDV ADDDADDEEE ALEIPRPLRA LDQTPGSSMD NLDSSVTGSM VNGWGSASDE DRNFSSHRSS VGSSSDGSIF ASGSFAQALV AAADKAGFRL DGTSLTRTGK AFTSSQRPRP TSPFSTDSNT SAALSQSQRP RPTKKHKGGR MDQQPALPHR REGMTDEEAL VPYSKPSFPS PGGHSSSGTA SSKGSTGPRK TEVLRAGHQR NASDLLDIGY MGSNSQGQFT GEL