Details for: DOCK3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 465.0821
Cell Significance Index: -117.9700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 223.7007
Cell Significance Index: -90.8800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.2662
Cell Significance Index: -35.6000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 5.8407
Cell Significance Index: 2094.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 4.6478
Cell Significance Index: 312.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 4.4436
Cell Significance Index: 196.5500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.3477
Cell Significance Index: 164.6400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 4.0641
Cell Significance Index: 2810.8500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 4.0476
Cell Significance Index: 248.7900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.5528
Cell Significance Index: 712.6900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.4884
Cell Significance Index: 83.6600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.1169
Cell Significance Index: 239.1900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.6220
Cell Significance Index: 83.9800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.3594
Cell Significance Index: 67.3300 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.2303
Cell Significance Index: 15.2600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.9929
Cell Significance Index: 21.7400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9450
Cell Significance Index: 53.0300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.8216
Cell Significance Index: 521.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.6810
Cell Significance Index: 1282.2900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6583
Cell Significance Index: 29.8400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.6290
Cell Significance Index: 10.7800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4620
Cell Significance Index: 209.7000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.4412
Cell Significance Index: 599.8900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.3504
Cell Significance Index: 539.3700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3044
Cell Significance Index: 561.4600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0326
Cell Significance Index: 5.3000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0025
Cell Significance Index: -0.3700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0372
Cell Significance Index: -6.7000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0742
Cell Significance Index: -46.3600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0915
Cell Significance Index: -67.7800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.1112
Cell Significance Index: -21.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1329
Cell Significance Index: -74.9400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1359
Cell Significance Index: -99.6400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1849
Cell Significance Index: -139.9800 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2047
Cell Significance Index: -2.2300 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.2091
Cell Significance Index: -114.1800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.2627
Cell Significance Index: -116.1500 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.2799
Cell Significance Index: -3.6300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3834
Cell Significance Index: -39.9200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4078
Cell Significance Index: -117.3300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.4352
Cell Significance Index: -86.3700 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4371
Cell Significance Index: -5.4500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4838
Cell Significance Index: -101.9000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.5398
Cell Significance Index: -66.3700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.5846
Cell Significance Index: -99.8300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.5977
Cell Significance Index: -59.1300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7004
Cell Significance Index: -13.8500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.7577
Cell Significance Index: -82.4200 - Cell Name: neural cell (CL0002319)
Fold Change: -0.7792
Cell Significance Index: -9.0900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.8830
Cell Significance Index: -121.2600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.9043
Cell Significance Index: -116.8400 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.9487
Cell Significance Index: -12.6600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.9833
Cell Significance Index: -100.4400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.9891
Cell Significance Index: -116.6500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0191
Cell Significance Index: -28.4800 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -1.0253
Cell Significance Index: -12.9400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -1.0742
Cell Significance Index: -16.3200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.0854
Cell Significance Index: -126.4900 - Cell Name: odontoblast (CL0000060)
Fold Change: -1.1263
Cell Significance Index: -144.3900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.1483
Cell Significance Index: -68.9400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1511
Cell Significance Index: -24.4300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -1.1522
Cell Significance Index: -10.6100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.1553
Cell Significance Index: -24.7000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.1951
Cell Significance Index: -136.9200 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.1977
Cell Significance Index: -136.7200 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.2211
Cell Significance Index: -12.7200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2753
Cell Significance Index: -101.0000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.2847
Cell Significance Index: -42.0600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.3187
Cell Significance Index: -18.8900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.3897
Cell Significance Index: -27.9000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.4086
Cell Significance Index: -97.4200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.4361
Cell Significance Index: -29.7900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4368
Cell Significance Index: -45.7600 - Cell Name: neuron (CL0000540)
Fold Change: -1.5518
Cell Significance Index: -14.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.5716
Cell Significance Index: -117.1300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.7206
Cell Significance Index: -49.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.7321
Cell Significance Index: -90.2200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.8091
Cell Significance Index: -116.7200 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -1.8409
Cell Significance Index: -23.2300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.8878
Cell Significance Index: -27.8700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.9927
Cell Significance Index: -104.6300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.0502
Cell Significance Index: -129.2200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -2.0638
Cell Significance Index: -44.5900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -2.1160
Cell Significance Index: -98.6600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.1595
Cell Significance Index: -75.6500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -2.1872
Cell Significance Index: -20.8100 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -2.2155
Cell Significance Index: -30.9800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -2.2949
Cell Significance Index: -107.8600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.3369
Cell Significance Index: -60.0700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -2.4917
Cell Significance Index: -62.1600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -2.5170
Cell Significance Index: -43.5200 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -2.5681
Cell Significance Index: -32.9300 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -2.6830
Cell Significance Index: -32.0900 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -2.7110
Cell Significance Index: -56.5800 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.7501
Cell Significance Index: -86.9800 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -2.8288
Cell Significance Index: -30.3300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -2.9443
Cell Significance Index: -152.9500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -2.9868
Cell Significance Index: -45.0100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -3.0081
Cell Significance Index: -104.5300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -3.0498
Cell Significance Index: -107.1700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3464766755
Symbol: DOCK3_HUMAN
Name: Dedicator of cytokinesis protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10854253
Title: Isolation and characterization of novel presenilin binding protein.
PubMed ID: 10854253
PubMed ID: 14569117
Title: Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.
PubMed ID: 14569117
PubMed ID: 9205841
Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9205841
PubMed ID: 11696419
Title: Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation.
PubMed ID: 11696419
PubMed ID: 12432077
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
PubMed ID: 12432077
DOI: 10.1242/jcs.00219
PubMed ID: 28195318
Title: Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability.
PubMed ID: 28195318
DOI: 10.1111/cge.12995
PubMed ID: 29130632
Title: DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.
PubMed ID: 29130632
DOI: 10.1002/ajmg.a.38517
PubMed ID: 30976111
Title: Variants in DOCK3 cause developmental delay and hypotonia.
PubMed ID: 30976111
Sequence Information:
- Length: 2030
- Mass: 233103
- Checksum: FF87E874B926C1C7
- Sequence:
MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK PNVKGIFPAN YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW KQLYVKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY DMREGKQISE RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE SEWSQIHENI IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD DIHELYVYKC DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGEHKIH FIPGMIGPFL GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ AENYTEAAFT LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY FNKGKSWEFG IPLCRELACQ YESLYDYQSL SWIRKMEASY YDNIMEQQRL EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY ERLEAFQQRM LSEFPQAVAM QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD RVKSFYRVNN VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA AVNGGIARYQ EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH EKFVHPEMRP LHKKLIDQFQ MMRASLYHEF PGLDKLSPAC SGTSTPRGNV LASHSPMSPE SIKMTHRHSP MNLMGTGRHS SSSLSSHASS EAGNMVMLGD GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP SSSSLSSTHS APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT PPALPARTLR KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN FGHSSEAPPR TDTMDSMPSQ AWNADEDLEP PYLPVHYSLS ESAVLDSIKA QPCRSHSAPG CVIPQDPMDP PALPPKPYHP RLPALEHDEG VLLREETERP RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.