Details for: DOCK3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: stellate neuron (CL0000122)
Fold Change: 5.83
Marker Score: 31,330 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 5.43
Marker Score: 2,436 - Cell Name: granule cell (CL0000120)
Fold Change: 5.39
Marker Score: 40,627 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.27
Marker Score: 177,876 - Cell Name: macroglial cell (CL0000126)
Fold Change: 5.02
Marker Score: 11,546 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 4.53
Marker Score: 20,953 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.18
Marker Score: 21,939 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.97
Marker Score: 13,313 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 3.49
Marker Score: 2,028 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.43
Marker Score: 8,219 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.2
Marker Score: 7,015 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.19
Marker Score: 13,345 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 3.14
Marker Score: 995 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.03
Marker Score: 67,812 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.99
Marker Score: 63,796 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.98
Marker Score: 8,515 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.96
Marker Score: 10,541 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.93
Marker Score: 4,916 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.91
Marker Score: 57,865 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.88
Marker Score: 22,057 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.86
Marker Score: 42,699 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.84
Marker Score: 830 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 2.83
Marker Score: 1,861 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.8
Marker Score: 3,765 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.79
Marker Score: 3,374 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.78
Marker Score: 3,905 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.74
Marker Score: 103,868 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 2.72
Marker Score: 925 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.65
Marker Score: 1,549 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.63
Marker Score: 1,264 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.62
Marker Score: 10,868 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.62
Marker Score: 1,006 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.55
Marker Score: 1,069 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.53
Marker Score: 798 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.46
Marker Score: 90,611 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.38
Marker Score: 2,626 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.37
Marker Score: 9,149 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.32
Marker Score: 2,898 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.3
Marker Score: 1,291 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.2
Marker Score: 20,687 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.08
Marker Score: 127,969 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 2.05
Marker Score: 1,542 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,351 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.93
Marker Score: 1,124 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.91
Marker Score: 521 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,177 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.8
Marker Score: 545 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.66
Marker Score: 2,563 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,170 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.6
Marker Score: 1,597 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.57
Marker Score: 3,186 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.55
Marker Score: 3,888 - Cell Name: astrocyte (CL0000127)
Fold Change: 1.53
Marker Score: 1,326 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.48
Marker Score: 6,178 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,100 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.43
Marker Score: 473 - Cell Name: neuron (CL0000540)
Fold Change: 1.39
Marker Score: 5,668 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.38
Marker Score: 1,587 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 871 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.37
Marker Score: 822 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.3
Marker Score: 1,613 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.29
Marker Score: 20,232 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 856 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.2
Marker Score: 716 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.17
Marker Score: 1,015 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7,665 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 503 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 1.09
Marker Score: 6,552 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.05
Marker Score: 380 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 797 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.03
Marker Score: 18,339 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,335 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.93
Marker Score: 472 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.93
Marker Score: 481 - Cell Name: fast muscle cell (CL0000190)
Fold Change: 0.91
Marker Score: 276 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,740 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.91
Marker Score: 3,799 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.89
Marker Score: 818 - Cell Name: contractile cell (CL0000183)
Fold Change: 0.89
Marker Score: 482 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.88
Marker Score: 224 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.86
Marker Score: 3,612 - Cell Name: podocyte (CL0000653)
Fold Change: 0.86
Marker Score: 317 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.85
Marker Score: 921 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.84
Marker Score: 402 - Cell Name: bipolar neuron (CL0000103)
Fold Change: 0.81
Marker Score: 273 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.81
Marker Score: 327 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.79
Marker Score: 1,863 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 704 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.76
Marker Score: 7,740 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.76
Marker Score: 377 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.74
Marker Score: 567
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3464766755
Symbol: DOCK3_HUMAN
Name: Dedicator of cytokinesis protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10854253
Title: Isolation and characterization of novel presenilin binding protein.
PubMed ID: 10854253
PubMed ID: 14569117
Title: Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.
PubMed ID: 14569117
PubMed ID: 9205841
Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9205841
PubMed ID: 11696419
Title: Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation.
PubMed ID: 11696419
PubMed ID: 12432077
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
PubMed ID: 12432077
DOI: 10.1242/jcs.00219
PubMed ID: 28195318
Title: Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability.
PubMed ID: 28195318
DOI: 10.1111/cge.12995
PubMed ID: 29130632
Title: DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.
PubMed ID: 29130632
DOI: 10.1002/ajmg.a.38517
PubMed ID: 30976111
Title: Variants in DOCK3 cause developmental delay and hypotonia.
PubMed ID: 30976111
Sequence Information:
- Length: 2030
- Mass: 233103
- Checksum: FF87E874B926C1C7
- Sequence:
MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK PNVKGIFPAN YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW KQLYVKHKVD LFYKLRHVMN ELIDLRRQLL SGHLTQDQVR EVKRHITVRL DWGNEHLGLD LVPRKDFEVV DSDQISVSDL YKMHLSSRQS VQQSTSQVDT MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY DMREGKQISE RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE SEWSQIHENI IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN RGLAITRKLG FPDVIMPGDI RNDLYLTLEK GDFERGGKSV QKNIEVTMYV LYADGEILKD CISLGSGEPN RSSYHSFVLY HSNSPRWGEI IKLPIPIDRF RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD DIHELYVYKC DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV ILDDNTEKYG LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY KELIRCLKWY MDCSAELIRQ DHIQEAMRAL EYLFKFIVQS RILYSRATCG MEEEQFRSSI QELFQSIRFV LSLDSRNSET LLFTQAALLN SFPTIFDELL QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART VDSRLFSFSE SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS LLRQMCDTHF QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM RLLTSNIIVT TVQYLSSALH KNFTETDFDF KVWNSYFSLA VLFINQPSLQ LEIITSAKRK KILDKYGDMR VMMAYELFSM WQNLGEHKIH FIPGMIGPFL GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI DKLDSMVSEG KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ AENYTEAAFT LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY FNKGKSWEFG IPLCRELACQ YESLYDYQSL SWIRKMEASY YDNIMEQQRL EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY ERLEAFQQRM LSEFPQAVAM QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD RVKSFYRVNN VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA AVNGGIARYQ EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH EKFVHPEMRP LHKKLIDQFQ MMRASLYHEF PGLDKLSPAC SGTSTPRGNV LASHSPMSPE SIKMTHRHSP MNLMGTGRHS SSSLSSHASS EAGNMVMLGD GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP SSSSLSSTHS APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT PPALPARTLR KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN FGHSSEAPPR TDTMDSMPSQ AWNADEDLEP PYLPVHYSLS ESAVLDSIKA QPCRSHSAPG CVIPQDPMDP PALPPKPYHP RLPALEHDEG VLLREETERP RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.