Details for: DOCK3

Gene ID: 1795

Symbol: DOCK3

Ensembl ID: ENSG00000088538

Description: dedicator of cytokinesis 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 465.0821
    Cell Significance Index: -117.9700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 223.7007
    Cell Significance Index: -90.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2662
    Cell Significance Index: -35.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.8407
    Cell Significance Index: 2094.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.6478
    Cell Significance Index: 312.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.4436
    Cell Significance Index: 196.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.3477
    Cell Significance Index: 164.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.0641
    Cell Significance Index: 2810.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 4.0476
    Cell Significance Index: 248.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.5528
    Cell Significance Index: 712.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.4884
    Cell Significance Index: 83.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1169
    Cell Significance Index: 239.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.6220
    Cell Significance Index: 83.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.3594
    Cell Significance Index: 67.3300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.2303
    Cell Significance Index: 15.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9929
    Cell Significance Index: 21.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9450
    Cell Significance Index: 53.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.8216
    Cell Significance Index: 521.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6810
    Cell Significance Index: 1282.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6583
    Cell Significance Index: 29.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.6290
    Cell Significance Index: 10.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4620
    Cell Significance Index: 209.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4412
    Cell Significance Index: 599.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3504
    Cell Significance Index: 539.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3044
    Cell Significance Index: 561.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0326
    Cell Significance Index: 5.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0025
    Cell Significance Index: -0.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0372
    Cell Significance Index: -6.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0742
    Cell Significance Index: -46.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0915
    Cell Significance Index: -67.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1112
    Cell Significance Index: -21.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1329
    Cell Significance Index: -74.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1359
    Cell Significance Index: -99.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1849
    Cell Significance Index: -139.9800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2047
    Cell Significance Index: -2.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.2091
    Cell Significance Index: -114.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.2627
    Cell Significance Index: -116.1500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2799
    Cell Significance Index: -3.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3834
    Cell Significance Index: -39.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4078
    Cell Significance Index: -117.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4352
    Cell Significance Index: -86.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4371
    Cell Significance Index: -5.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4838
    Cell Significance Index: -101.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.5398
    Cell Significance Index: -66.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.5846
    Cell Significance Index: -99.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.5977
    Cell Significance Index: -59.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7004
    Cell Significance Index: -13.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.7577
    Cell Significance Index: -82.4200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7792
    Cell Significance Index: -9.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.8830
    Cell Significance Index: -121.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.9043
    Cell Significance Index: -116.8400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.9487
    Cell Significance Index: -12.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9833
    Cell Significance Index: -100.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.9891
    Cell Significance Index: -116.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0191
    Cell Significance Index: -28.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0253
    Cell Significance Index: -12.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.0742
    Cell Significance Index: -16.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0854
    Cell Significance Index: -126.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.1263
    Cell Significance Index: -144.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1483
    Cell Significance Index: -68.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1511
    Cell Significance Index: -24.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.1522
    Cell Significance Index: -10.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1553
    Cell Significance Index: -24.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1951
    Cell Significance Index: -136.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.1977
    Cell Significance Index: -136.7200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.2211
    Cell Significance Index: -12.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2753
    Cell Significance Index: -101.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2847
    Cell Significance Index: -42.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.3187
    Cell Significance Index: -18.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3897
    Cell Significance Index: -27.9000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.4086
    Cell Significance Index: -97.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.4361
    Cell Significance Index: -29.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4368
    Cell Significance Index: -45.7600
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.5518
    Cell Significance Index: -14.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.5716
    Cell Significance Index: -117.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.7206
    Cell Significance Index: -49.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.7321
    Cell Significance Index: -90.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.8091
    Cell Significance Index: -116.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -1.8409
    Cell Significance Index: -23.2300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.8878
    Cell Significance Index: -27.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.9927
    Cell Significance Index: -104.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0502
    Cell Significance Index: -129.2200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.0638
    Cell Significance Index: -44.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.1160
    Cell Significance Index: -98.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.1595
    Cell Significance Index: -75.6500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -2.1872
    Cell Significance Index: -20.8100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -2.2155
    Cell Significance Index: -30.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -2.2949
    Cell Significance Index: -107.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.3369
    Cell Significance Index: -60.0700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.4917
    Cell Significance Index: -62.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.5170
    Cell Significance Index: -43.5200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -2.5681
    Cell Significance Index: -32.9300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.6830
    Cell Significance Index: -32.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.7110
    Cell Significance Index: -56.5800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.7501
    Cell Significance Index: -86.9800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -2.8288
    Cell Significance Index: -30.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.9443
    Cell Significance Index: -152.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -2.9868
    Cell Significance Index: -45.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.0081
    Cell Significance Index: -104.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.0498
    Cell Significance Index: -107.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DOCK3 is a GEF that belongs to the DOCK family of proteins, which are known to regulate the activity of small GTPases, such as Rac1, Rac2, and RhoG. DOCK3 is specifically involved in the activation of Rac1 and Rac2, which are crucial for various cellular processes, including cell migration, proliferation, and survival. Additionally, DOCK3 has been shown to interact with other signaling proteins, such as NTRK2 (also known as TRKB), and modulate their activity. **Pathways and Functions:** DOCK3 is involved in several signaling pathways, including: 1. **Neurotrophin TRK Receptor Signaling Pathway:** DOCK3 interacts with NTRK2 (TRKB) and modulates its activity, which is essential for neuronal development and survival. 2. **Rho GTPase Cycle:** DOCK3 regulates the activity of RhoGTPases, which are involved in cell migration, cytoskeleton reorganization, and cell survival. 3. **Rac GTPase Cycle:** DOCK3 activates Rac1 and Rac2, which are crucial for cell migration, proliferation, and survival. 4. **GTPase Activator Activity:** DOCK3 acts as a GEF for small GTPases, activating their GTPase activity and regulating their downstream signaling pathways. 5. **Hemostasis:** DOCK3 is involved in the regulation of platelet production and function, which is essential for maintaining hemostasis. **Clinical Significance:** Dysregulation of DOCK3 has been implicated in various diseases, including: 1. **Neurological Disorders:** Mutations in DOCK3 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** DOCK3 is overexpressed in certain types of cancer, including breast cancer and ovarian cancer, and is associated with poor prognosis. 3. **Immune Disorders:** DOCK3 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, DOCK3 is a multifunctional protein that plays a crucial role in regulating various signaling pathways, including those involved in cell migration, proliferation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying DOCK3 function.

Genular Protein ID: 3464766755

Symbol: DOCK3_HUMAN

Name: Dedicator of cytokinesis protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10854253

Title: Isolation and characterization of novel presenilin binding protein.

PubMed ID: 10854253

DOI: 10.1046/j.1471-4159.2000.0750109.x

PubMed ID: 14569117

Title: Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.

PubMed ID: 14569117

DOI: 10.1136/jmg.40.10.733

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 11696419

Title: Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation.

PubMed ID: 11696419

DOI: 10.1016/s0002-9440(10)63005-2

PubMed ID: 12432077

Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

PubMed ID: 12432077

DOI: 10.1242/jcs.00219

PubMed ID: 28195318

Title: Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability.

PubMed ID: 28195318

DOI: 10.1111/cge.12995

PubMed ID: 29130632

Title: DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.

PubMed ID: 29130632

DOI: 10.1002/ajmg.a.38517

PubMed ID: 30976111

Title: Variants in DOCK3 cause developmental delay and hypotonia.

PubMed ID: 30976111

DOI: 10.1038/s41431-019-0397-2

Sequence Information:

  • Length: 2030
  • Mass: 233103
  • Checksum: FF87E874B926C1C7
  • Sequence:
  • MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK PNVKGIFPAN 
    YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW KQLYVKHKVD LFYKLRHVMN 
    ELIDLRRQLL SGHLTQDQVR EVKRHITVRL DWGNEHLGLD LVPRKDFEVV DSDQISVSDL 
    YKMHLSSRQS VQQSTSQVDT MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY 
    DMREGKQISE RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML 
    LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE SEWSQIHENI 
    IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN RGLAITRKLG FPDVIMPGDI 
    RNDLYLTLEK GDFERGGKSV QKNIEVTMYV LYADGEILKD CISLGSGEPN RSSYHSFVLY 
    HSNSPRWGEI IKLPIPIDRF RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD 
    DIHELYVYKC DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS 
    TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV ILDDNTEKYG 
    LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY KELIRCLKWY MDCSAELIRQ 
    DHIQEAMRAL EYLFKFIVQS RILYSRATCG MEEEQFRSSI QELFQSIRFV LSLDSRNSET 
    LLFTQAALLN SFPTIFDELL QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART 
    VDSRLFSFSE SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV 
    EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS LLRQMCDTHF 
    QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM RLLTSNIIVT TVQYLSSALH 
    KNFTETDFDF KVWNSYFSLA VLFINQPSLQ LEIITSAKRK KILDKYGDMR VMMAYELFSM 
    WQNLGEHKIH FIPGMIGPFL GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI 
    DKLDSMVSEG KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL 
    LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ AENYTEAAFT 
    LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY FNKGKSWEFG IPLCRELACQ 
    YESLYDYQSL SWIRKMEASY YDNIMEQQRL EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY 
    ERLEAFQQRM LSEFPQAVAM QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD 
    RVKSFYRVNN VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE 
    LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA AVNGGIARYQ 
    EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH EKFVHPEMRP LHKKLIDQFQ 
    MMRASLYHEF PGLDKLSPAC SGTSTPRGNV LASHSPMSPE SIKMTHRHSP MNLMGTGRHS 
    SSSLSSHASS EAGNMVMLGD GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP 
    SSSSLSSTHS APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL 
    ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT PPALPARTLR 
    KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN FGHSSEAPPR TDTMDSMPSQ 
    AWNADEDLEP PYLPVHYSLS ESAVLDSIKA QPCRSHSAPG CVIPQDPMDP PALPPKPYHP 
    RLPALEHDEG VLLREETERP RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.