Details for: DOCK3

Gene ID: 1795

Symbol: DOCK3

Ensembl ID: ENSG00000088538

Description: dedicator of cytokinesis 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.83
    Marker Score: 31,330
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 5.43
    Marker Score: 2,436
  • Cell Name: granule cell (CL0000120)
    Fold Change: 5.39
    Marker Score: 40,627
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.27
    Marker Score: 177,876
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.02
    Marker Score: 11,546
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.53
    Marker Score: 20,953
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.18
    Marker Score: 21,939
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.97
    Marker Score: 13,313
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.49
    Marker Score: 2,028
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.43
    Marker Score: 8,219
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.2
    Marker Score: 7,015
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.19
    Marker Score: 13,345
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.14
    Marker Score: 995
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.03
    Marker Score: 67,812
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.99
    Marker Score: 63,796
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.98
    Marker Score: 8,515
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.96
    Marker Score: 10,541
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.93
    Marker Score: 4,916
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57,865
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,057
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42,699
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.84
    Marker Score: 830
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.83
    Marker Score: 1,861
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.8
    Marker Score: 3,765
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.79
    Marker Score: 3,374
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.78
    Marker Score: 3,905
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.74
    Marker Score: 103,868
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.72
    Marker Score: 925
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.65
    Marker Score: 1,549
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.63
    Marker Score: 1,264
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,868
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.62
    Marker Score: 1,006
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.55
    Marker Score: 1,069
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.53
    Marker Score: 798
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,611
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.38
    Marker Score: 2,626
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9,149
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.32
    Marker Score: 2,898
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.3
    Marker Score: 1,291
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,687
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,969
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.05
    Marker Score: 1,542
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,351
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.93
    Marker Score: 1,124
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.91
    Marker Score: 521
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,177
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.8
    Marker Score: 545
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,563
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6
    Marker Score: 1,597
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.57
    Marker Score: 3,186
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.55
    Marker Score: 3,888
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.53
    Marker Score: 1,326
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.48
    Marker Score: 6,178
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,100
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.43
    Marker Score: 473
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.39
    Marker Score: 5,668
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.38
    Marker Score: 1,587
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.37
    Marker Score: 822
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.3
    Marker Score: 1,613
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.29
    Marker Score: 20,232
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.2
    Marker Score: 716
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.17
    Marker Score: 1,015
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,665
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.09
    Marker Score: 6,552
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.05
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 797
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.03
    Marker Score: 18,339
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,335
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.93
    Marker Score: 472
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.91
    Marker Score: 276
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.91
    Marker Score: 3,799
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.89
    Marker Score: 818
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.89
    Marker Score: 482
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.88
    Marker Score: 224
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,287
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.86
    Marker Score: 3,612
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.86
    Marker Score: 317
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.85
    Marker Score: 921
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 402
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.81
    Marker Score: 273
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.81
    Marker Score: 327
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.79
    Marker Score: 1,863
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.76
    Marker Score: 7,740
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.76
    Marker Score: 377
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.74
    Marker Score: 567

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DOCK3 is a GEF that belongs to the DOCK family of proteins, which are known to regulate the activity of small GTPases, such as Rac1, Rac2, and RhoG. DOCK3 is specifically involved in the activation of Rac1 and Rac2, which are crucial for various cellular processes, including cell migration, proliferation, and survival. Additionally, DOCK3 has been shown to interact with other signaling proteins, such as NTRK2 (also known as TRKB), and modulate their activity. **Pathways and Functions:** DOCK3 is involved in several signaling pathways, including: 1. **Neurotrophin TRK Receptor Signaling Pathway:** DOCK3 interacts with NTRK2 (TRKB) and modulates its activity, which is essential for neuronal development and survival. 2. **Rho GTPase Cycle:** DOCK3 regulates the activity of RhoGTPases, which are involved in cell migration, cytoskeleton reorganization, and cell survival. 3. **Rac GTPase Cycle:** DOCK3 activates Rac1 and Rac2, which are crucial for cell migration, proliferation, and survival. 4. **GTPase Activator Activity:** DOCK3 acts as a GEF for small GTPases, activating their GTPase activity and regulating their downstream signaling pathways. 5. **Hemostasis:** DOCK3 is involved in the regulation of platelet production and function, which is essential for maintaining hemostasis. **Clinical Significance:** Dysregulation of DOCK3 has been implicated in various diseases, including: 1. **Neurological Disorders:** Mutations in DOCK3 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** DOCK3 is overexpressed in certain types of cancer, including breast cancer and ovarian cancer, and is associated with poor prognosis. 3. **Immune Disorders:** DOCK3 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, DOCK3 is a multifunctional protein that plays a crucial role in regulating various signaling pathways, including those involved in cell migration, proliferation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying DOCK3 function.

Genular Protein ID: 3464766755

Symbol: DOCK3_HUMAN

Name: Dedicator of cytokinesis protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10854253

Title: Isolation and characterization of novel presenilin binding protein.

PubMed ID: 10854253

DOI: 10.1046/j.1471-4159.2000.0750109.x

PubMed ID: 14569117

Title: Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype.

PubMed ID: 14569117

DOI: 10.1136/jmg.40.10.733

PubMed ID: 9205841

Title: Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9205841

DOI: 10.1093/dnares/4.2.141

PubMed ID: 11696419

Title: Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation.

PubMed ID: 11696419

DOI: 10.1016/s0002-9440(10)63005-2

PubMed ID: 12432077

Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

PubMed ID: 12432077

DOI: 10.1242/jcs.00219

PubMed ID: 28195318

Title: Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability.

PubMed ID: 28195318

DOI: 10.1111/cge.12995

PubMed ID: 29130632

Title: DOCK3-related neurodevelopmental syndrome: Biallelic intragenic deletion of DOCK3 in a boy with developmental delay and hypotonia.

PubMed ID: 29130632

DOI: 10.1002/ajmg.a.38517

PubMed ID: 30976111

Title: Variants in DOCK3 cause developmental delay and hypotonia.

PubMed ID: 30976111

DOI: 10.1038/s41431-019-0397-2

Sequence Information:

  • Length: 2030
  • Mass: 233103
  • Checksum: FF87E874B926C1C7
  • Sequence:
  • MWTPTEEEKY GVVICSFRGS VPQGLVLEIG ETVQILEKCE GWYRGVSTKK PNVKGIFPAN 
    YIHLKKAIVS NRGQYETVVP LEDSIVTEVT ATLQEWASLW KQLYVKHKVD LFYKLRHVMN 
    ELIDLRRQLL SGHLTQDQVR EVKRHITVRL DWGNEHLGLD LVPRKDFEVV DSDQISVSDL 
    YKMHLSSRQS VQQSTSQVDT MRPRHGETCR MPVPHHFFLS LKSFTYNTIG EDTDVFFSLY 
    DMREGKQISE RFLVRLNKNG GPRNPEKIER MCALFTDLSS KDMKRDLYIV AHVIRIGRML 
    LNDSKKGPPH LHYRRPYGCA VLSILDVLQS LTEVKEEKDF VLKVYTCNNE SEWSQIHENI 
    IRKSSAKYSA PSASHGLIIS LQLLRGDMEQ IRRENPMIFN RGLAITRKLG FPDVIMPGDI 
    RNDLYLTLEK GDFERGGKSV QKNIEVTMYV LYADGEILKD CISLGSGEPN RSSYHSFVLY 
    HSNSPRWGEI IKLPIPIDRF RGSHLRFEFR HCSTKDKGEK KLFGFAFSTL MRDDGTTLSD 
    DIHELYVYKC DENSTFNNHA LYLGLPCCKE DYNGCPNIPS SLIFQRSTKE SFFISTQLSS 
    TKLTQNVDLL ALLKWKAFPD RIMDVLGRLR HVSGEEIVKF LQDILDTLFV ILDDNTEKYG 
    LLVFQSLVFI INLLRDIKYF HFRPVMDTYI QKHFAGALAY KELIRCLKWY MDCSAELIRQ 
    DHIQEAMRAL EYLFKFIVQS RILYSRATCG MEEEQFRSSI QELFQSIRFV LSLDSRNSET 
    LLFTQAALLN SFPTIFDELL QMFTVQEVAE FVRGTLGSMP STVHIGQSMD VVKLQSIART 
    VDSRLFSFSE SRRILLPVVL HHIHLHLRQQ KELLICSGIL GSIFSIVKTS SLEADVMEEV 
    EMMVESLLDV LLQTLLTIMS KSHAQEAVRG QRCPQCTAEI TGEYVSCLLS LLRQMCDTHF 
    QHLLDNFQSK DELKEFLLKI FCVFRNLMKM SVFPRDWMVM RLLTSNIIVT TVQYLSSALH 
    KNFTETDFDF KVWNSYFSLA VLFINQPSLQ LEIITSAKRK KILDKYGDMR VMMAYELFSM 
    WQNLGEHKIH FIPGMIGPFL GVTLVPQPEV RNIMIPIFHD MMDWEQRKNG NFKQVEAELI 
    DKLDSMVSEG KGDESYRELF SLLTQLFGPY PSLLEKVEQE TWRETGISFV TSVTRLMERL 
    LDYRDCMKGE ETENKKIGCT VNLMNFYKSE INKEEMYIRY IHKLCDMHLQ AENYTEAAFT 
    LLLYCELLQW EDRPLREFLH YPSQTEWQRK EGLCRKIIHY FNKGKSWEFG IPLCRELACQ 
    YESLYDYQSL SWIRKMEASY YDNIMEQQRL EPEFFRVGFY GRKFPFFLRN KEYVCRGHDY 
    ERLEAFQQRM LSEFPQAVAM QHPNHPDDAI LQCDAQYLQI YAVTPIPDYV DVLQMDRVPD 
    RVKSFYRVNN VRKFRYDRPF HKGPKDKENE FKSLWIERTT LTLTHSLPGI SRWFEVERRE 
    LVEVSPLENA IQVVENKNQE LRSLISQYQH KQVHGNINLL SMCLNGVIDA AVNGGIARYQ 
    EAFFDKDYIN KHPGDAEKIT QLKELMQEQV HVLGVGLAVH EKFVHPEMRP LHKKLIDQFQ 
    MMRASLYHEF PGLDKLSPAC SGTSTPRGNV LASHSPMSPE SIKMTHRHSP MNLMGTGRHS 
    SSSLSSHASS EAGNMVMLGD GSMGDAPEDL YHHMQLAYPN PRYQGSVTNV SVLSSSQASP 
    SSSSLSSTHS APSQMITSAP SSARGSPSLP DKYRHAREMM LLLPTYRDRP SSAMYPAAIL 
    ENGQPPNFQR ALFQQVVGAC KPCSDPNLSV AEKGHYSLHF DAFHHPLGDT PPALPARTLR 
    KSPLHPIPAS PTSPQSGLDG SNSTLSGSAS SGVSSLSESN FGHSSEAPPR TDTMDSMPSQ 
    AWNADEDLEP PYLPVHYSLS ESAVLDSIKA QPCRSHSAPG CVIPQDPMDP PALPPKPYHP 
    RLPALEHDEG VLLREETERP RGLHRKAPLP PGSAKEEQAR MAWEHGRGEQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.