Gene KTN1 - ENSG00000126777 | NCBI Gene ID: 3895

Details for: KTN1

Gene ID: 3895

Symbol: KTN1

Ensembl ID: ENSG00000126777

Description: kinectin 1

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Post-translational protein phosphorylation
(R-HSA-8957275)
Rac1 gtpase cycle
(R-HSA-9013149)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-HSA-381426)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhog gtpase cycle
(R-HSA-9013408)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate ktn1
(R-HSA-5625970)
Rnd2 gtpase cycle
(R-HSA-9696270)
Rnd3 gtpase cycle
(R-HSA-9696264)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Cadherin binding
(GO:0045296)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Kinesin binding
(GO:0019894)
Membrane
(GO:0016020)
Microtubule-based movement
(GO:0007018)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Rna binding
(GO:0003723)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: GABAergic neuron (CL0000617)
Fold Change: 4.35
Marker Score: 18139
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 4.13
Marker Score: 73294.5
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 4.02
Marker Score: 89898
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.51
Marker Score: 3743.5
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.34
Marker Score: 4041
Cell Name: anterior lens cell (CL0002223)
Fold Change: 3.28
Marker Score: 4416.5
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.13
Marker Score: 13101.5
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.11
Marker Score: 27009
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.05
Marker Score: 26755.5
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.04
Marker Score: 7429
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3
Marker Score: 11558.5
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.99
Marker Score: 1560
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.9
Marker Score: 2761
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.89
Marker Score: 690.5
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.88
Marker Score: 841
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.87
Marker Score: 9852
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.85
Marker Score: 97071
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.85
Marker Score: 6249
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.84
Marker Score: 2994
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 2.84
Marker Score: 21124
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.83
Marker Score: 97966
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.82
Marker Score: 4095
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.79
Marker Score: 7032
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.77
Marker Score: 8713
Cell Name: basal cell (CL0000646)
Fold Change: 2.76
Marker Score: 3566
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.75
Marker Score: 2348.5
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 2.73
Marker Score: 1823
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.72
Marker Score: 2933
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.7
Marker Score: 2423
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.7
Marker Score: 914
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.7
Marker Score: 13254
Cell Name: secretory cell (CL0000151)
Fold Change: 2.66
Marker Score: 4856
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.64
Marker Score: 15682
Cell Name: supporting cell (CL0000630)
Fold Change: 2.64
Marker Score: 4965
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.64
Marker Score: 7079
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.63
Marker Score: 5262
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.63
Marker Score: 2072
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.63
Marker Score: 844
Cell Name: ependymal cell (CL0000065)
Fold Change: 2.63
Marker Score: 917
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.61
Marker Score: 17024
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.59
Marker Score: 1057
Cell Name: melanocyte (CL0000148)
Fold Change: 2.59
Marker Score: 1050
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.53
Marker Score: 4478
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.52
Marker Score: 2714
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.51
Marker Score: 1461
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.51
Marker Score: 3026
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.46
Marker Score: 3626
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.46
Marker Score: 1434
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.46
Marker Score: 5603
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 2.44
Marker Score: 5849
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.44
Marker Score: 3386
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.44
Marker Score: 1734
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.43
Marker Score: 3335
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.42
Marker Score: 4593
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 2.41
Marker Score: 2215
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.41
Marker Score: 1410
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.4
Marker Score: 2896
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 2.4
Marker Score: 1195
Cell Name: podocyte (CL0000653)
Fold Change: 2.4
Marker Score: 888
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 2.4
Marker Score: 550.5
Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.4
Marker Score: 2069.5
Cell Name: Schwann cell (CL0002573)
Fold Change: 2.39
Marker Score: 828
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 2.38
Marker Score: 810
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 2.38
Marker Score: 700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.38
Marker Score: 751
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.37
Marker Score: 986.5
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.37
Marker Score: 8417
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.36
Marker Score: 1104
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.36
Marker Score: 6722
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.35
Marker Score: 2558.5
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.35
Marker Score: 1116
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.34
Marker Score: 3881
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.33
Marker Score: 905
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 2.33
Marker Score: 1130
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.33
Marker Score: 1388.5
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 2.32
Marker Score: 663
Cell Name: pericyte (CL0000669)
Fold Change: 2.32
Marker Score: 1357
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.32
Marker Score: 1159
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.32
Marker Score: 3278.5
Cell Name: lymphocyte (CL0000542)
Fold Change: 2.31
Marker Score: 1169
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 2.31
Marker Score: 2089
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 2.31
Marker Score: 502.5
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.31
Marker Score: 716
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 2.31
Marker Score: 574.5
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.31
Marker Score: 2656
Cell Name: erythroblast (CL0000765)
Fold Change: 2.31
Marker Score: 1440
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 2.3
Marker Score: 1569
Cell Name: hepatocyte (CL0000182)
Fold Change: 2.3
Marker Score: 1571
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2.3
Marker Score: 685
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.3
Marker Score: 3885.5
Cell Name: pro-B cell (CL0000826)
Fold Change: 2.29
Marker Score: 2213
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.29
Marker Score: 1208
Cell Name: memory B cell (CL0000787)
Fold Change: 2.29
Marker Score: 1735
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.29
Marker Score: 10597.5
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.29
Marker Score: 12038
Cell Name: stromal cell (CL0000499)
Fold Change: 2.28
Marker Score: 2674
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.28
Marker Score: 2414
Cell Name: tendon cell (CL0000388)
Fold Change: 2.27
Marker Score: 558.5
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 2.26
Marker Score: 504.5
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.26
Marker Score: 2290

Hover over a box to see details here...

**Key characteristics:** * KTN1 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. * It is a key component of the cadherin-based cell adhesion complex. * KTN1 is also a regulator of the Cdc42 gtpase cycle, a signaling pathway that is involved in cell cycle regulation, cell growth, and metabolism. * It is a substrate for the kinesin-1 protein, which is involved in cell motility and organelle transport. * KTN1 is also involved in the regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps). **Pathways and functions:** * KTN1 is involved in cell adhesion through its interaction with cadherins, a family of cell adhesion molecules. * It is also involved in the activation of the Cdc42 gtpase cycle, which is a signaling pathway that is involved in cell cycle regulation, cell growth, and metabolism. * KTN1 is a substrate for the kinesin-1 protein, which is involved in cell motility and organelle transport. * It is also involved in the regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps). * KTN1 is also involved in the regulation of Rho GTPases, a family of GTPases that are involved in cell signaling. **Clinical significance:** Mutations in the KTN1 gene have been linked to several neurological disorders, including autism, schizophrenia, and Alzheimer's disease. These mutations can disrupt the function of KTN1, leading to the formation of abnormal cell adhesions, cell cycle abnormalities, and abnormal migration. Overall, KTN1 is a key protein that plays a critical role in cell adhesion, cell signaling, and migration. Mutations in the KTN1 gene have been linked to several neurological disorders, highlighting the importance of this protein in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Kinectin

Genular Protein ID: 2023961058

Symbol: KTN1_HUMAN

Name: Kinectin

UniProtKB Accession Codes:

Q86UP2 B4DZ88 Q13999 Q14707 Q15387 Q17RZ5 Q5GGW3 Q86W57

Database IDs:

Citations:

PubMed ID: 7787243

Title: Molecular cloning and characterization of human kinectin.

PubMed ID: 7787243

DOI: 10.1091/mbc.6.2.161

PubMed ID: 8039706

Title: Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats.

PubMed ID: 8039706

DOI: 10.1016/0378-1119(94)90381-6

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11973345

Title: Integrin clustering induces kinectin accumulation.

PubMed ID: 11973345

DOI: 10.1242/jcs.115.10.2031

PubMed ID: 8575822

Title: The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22.

PubMed ID: 8575822

DOI: 10.1007/bf00587304

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27932480

Title: MAGI2 mutations cause congenital nephrotic syndrome.

PubMed ID: 27932480

DOI: 10.1681/asn.2016040387

Sequence Information:

Length: 1357
Mass: 156275
Checksum: 971FCDF8AA8FC88E
Sequence:

MEFYESAYFI VLIPSIVITV IFLFFWLFMK ETLYDEVLAK QKREQKLIPT KTDKKKAEKK 
KNKKKEIQNG NLHESDSESV PRDFKLSDAL AVEDDQVAPV PLNVVETSSS VRERKKKEKK 
QKPVLEEQVI KESDASKIPG KKVEPVPVTK QPTPPSEAAA SKKKPGQKKS KNGSDDQDKK 
VETLMVPSKR QEALPLHQET KQESGSGKKK ASSKKQKTEN VFVDEPLIHA TTYIPLMDNA 
DSSPVVDKRE VIDLLKPDQV EGIQKSGTKK LKTETDKENA EVKFKDFLLS LKTMMFSEDE 
ALCVVDLLKE KSGVIQDALK KSSKGELTTL IHQLQEKDKL LAAVKEDAAA TKDRCKQLTQ 
EMMTEKERSN VVITRMKDRI GTLEKEHNVF QNKIHVSYQE TQQMQMKFQQ VREQMEAEIA 
HLKQENGILR DAVSNTTNQL ESKQSAELNK LRQDYARLVN ELTEKTGKLQ QEEVQKKNAE 
QAATQLKVQL QEAERRWEEV QSYIRKRTAE HEAAQQDLQS KFVAKENEVQ SLHSKLTDTL 
VSKQQLEQRL MQLMESEQKR VNKEESLQMQ VQDILEQNEA LKAQIQQFHS QIAAQTSASV 
LAEELHKVIA EKDKQIKQTE DSLASERDRL TSKEEELKDI QNMNFLLKAE VQKLQALANE 
QAAAAHELEK MQQSVYVKDD KIRLLEEQLQ HEISNKMEEF KILNDQNKAL KSEVQKLQTL 
VSEQPNKDVV EQMEKCIQEK DEKLKTVEEL LETGLIQVAT KEEELNAIRT ENSSLTKEVQ 
DLKAKQNDQV SFASLVEELK KVIHEKDGKI KSVEELLEAE LLKVANKEKT VQDLKQEIKA 
LKEEIGNVQL EKAQQLSITS KVQELQNLLK GKEEQMNTMK AVLEEKEKDL ANTGKWLQDL 
QEENESLKAH VQEVAQHNLK EASSASQFEE LEIVLKEKEN ELKRLEAMLK ERESDLSSKT 
QLLQDVQDEN KLFKSQIEQL KQQNYQQASS FPPHEELLKV ISEREKEISG LWNELDSLKD 
AVEHQRKKNN DLREKNWEAM EALASTEKML QDKVNKTSKE RQQQVEAVEL EAKEVLKKLF 
PKVSVPSNLS YGEWLHGFEK KAKECMAGTS GSEEVKVLEH KLKEADEMHT LLQLECEKYK 
SVLAETEGIL QKLQRSVEQE ENKWKVKVDE SHKTIKQMQS SFTSSEQELE RLRSENKDIE 
NLRREREHLE MELEKAEMER STYVTEVREL KDLLTELQKK LDDSYSEAVR QNEELNLLKA 
QLNETLTKLR TEQNERQKVA GDLHKAQQSL ELIQSKIVKA AGDTTVIENS DVSPETESSE 
KETMSVSLNQ TVTQLQQLLQ AVNQQLTKEK EHYQVLE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: KTN1

Associated with

Cells (max top 100)

Other Information

Molecular cloning and characterization of human kinectin. PubMed ID: 7787243

Cloning of a gene encoding a human leukocyte protein characterised by extensive heptad repeats. PubMed ID: 8039706

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. PubMed ID: 7584026

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Integrin clustering induces kinectin accumulation. PubMed ID: 11973345

The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22. PubMed ID: 8575822

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

A single kinase generates the majority of the secreted phosphoproteome. PubMed ID: 26091039

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

MAGI2 mutations cause congenital nephrotic syndrome. PubMed ID: 27932480