Details for: KTN1

Gene ID: 3895

Symbol: KTN1

Ensembl ID: ENSG00000126777

Description: kinectin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.57
    Cell Significance Index: 3
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.56
    Cell Significance Index: 2
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.46
    Cell Significance Index: 2
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.35
    Cell Significance Index: 2
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.35
    Cell Significance Index: 1
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.27
    Cell Significance Index: 1
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.25
    Cell Significance Index: 1
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.25
    Cell Significance Index: 2
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.11
    Cell Significance Index: 1
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.97
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.97
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KTN1, also known as kinectin 1, is a gene that encodes a protein essential for various cellular functions. It belongs to the kinectin family, which plays a crucial role in maintaining the structural integrity of cellular membranes. KTN1 is specifically expressed in numerous cell types, including GABAergic neurons, cortical cells of the adrenal gland, regular ventricular cardiac myocytes, skeletal muscle satellite stem cells, and lens epithelial cells, among others. This widespread expression suggests that KTN1 is a ubiquitous gene involved in maintaining cellular homeostasis. **Pathways and Functions:** KTN1 is involved in various signaling pathways, including: 1. **Cadherin binding:** KTN1 interacts with cadherins, which are essential for cell-cell adhesion and maintaining tissue structure. 2. **Cdc42 gtpase cycle:** KTN1 regulates the activity of Cdc42, a small GTPase involved in cell migration and cytoskeletal dynamics. 3. **Endoplasmic reticulum (ER) and ER lumen:** KTN1 is involved in regulating protein transport and modification within the ER, ensuring proper protein folding and secretion. 4. **Kinesin binding:** KTN1 interacts with kinesins, motor proteins responsible for transporting cargo along microtubules. 5. **Microtubule-based movement:** KTN1 regulates microtubule dynamics, which is crucial for cell movement, division, and intracellular transport. 6. **Post-translational protein modification and phosphorylation:** KTN1 is involved in regulating post-translational modifications, including phosphorylation, which is essential for protein function and signaling. 7. **Rho gtpase cycle:** KTN1 regulates the activity of Rho GTPases, which are involved in cell signaling, cytoskeleton reorganization, and cell migration. **Clinical Significance:** KTN1's involvement in various cellular processes makes it a gene of interest in different diseases and disorders. For instance: 1. **Insulin-like growth factor (IGF) transport and uptake:** KTN1 regulates the transport and uptake of IGFs, which are essential for growth and development. Dysregulation of KTN1 may contribute to IGF-related disorders, such as diabetes and cancer. 2. **Cancer:** KTN1's role in regulating cell signaling and cytoskeleton dynamics makes it a potential target for cancer therapy. 3. **Neurological disorders:** KTN1's expression in GABAergic neurons and other neural cells suggests that it may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular diseases:** KTN1's involvement in cardiac myocyte function and regulation of microtubule dynamics makes it a potential target for cardiovascular disease treatment. In conclusion, KTN1 is a complex gene with multiple roles in various cellular processes. Its involvement in signaling pathways, protein transport, and microtubule dynamics makes it a crucial gene in maintaining cellular homeostasis. Further research is necessary to fully understand the clinical significance of KTN1 and its potential applications in disease treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.