Details for: GADD45B

Gene ID: 4616

Symbol: GADD45B

Ensembl ID: ENSG00000099860

Description: growth arrest and DNA damage inducible beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 586.9675
    Cell Significance Index: -91.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 352.1480
    Cell Significance Index: -89.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 189.4244
    Cell Significance Index: -76.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.8627
    Cell Significance Index: -87.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 172.9637
    Cell Significance Index: -88.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 131.5232
    Cell Significance Index: -88.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 83.5303
    Cell Significance Index: -79.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 73.8915
    Cell Significance Index: -91.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.4277
    Cell Significance Index: -78.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.3398
    Cell Significance Index: -92.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9815
    Cell Significance Index: -48.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 16.3517
    Cell Significance Index: 288.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 8.7837
    Cell Significance Index: 251.7900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 8.7625
    Cell Significance Index: 51.4800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.3748
    Cell Significance Index: 51.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 6.7999
    Cell Significance Index: 871.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.0093
    Cell Significance Index: 298.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.8442
    Cell Significance Index: 200.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.7047
    Cell Significance Index: 100.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2875
    Cell Significance Index: 154.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8764
    Cell Significance Index: 49.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.8221
    Cell Significance Index: 38.1400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8141
    Cell Significance Index: 33.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8132
    Cell Significance Index: 84.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7475
    Cell Significance Index: 225.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4195
    Cell Significance Index: 775.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3477
    Cell Significance Index: 86.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1912
    Cell Significance Index: 34.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1385
    Cell Significance Index: 503.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1287
    Cell Significance Index: 155.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9989
    Cell Significance Index: 117.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8118
    Cell Significance Index: 12.5600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7483
    Cell Significance Index: 92.0100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6669
    Cell Significance Index: 602.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6646
    Cell Significance Index: 108.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5281
    Cell Significance Index: 15.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3868
    Cell Significance Index: 8.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3696
    Cell Significance Index: 70.3400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2975
    Cell Significance Index: 3.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2960
    Cell Significance Index: 7.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2766
    Cell Significance Index: 14.5200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2589
    Cell Significance Index: 29.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2210
    Cell Significance Index: 7.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2004
    Cell Significance Index: 36.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1639
    Cell Significance Index: 308.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1419
    Cell Significance Index: 218.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0911
    Cell Significance Index: 4.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0883
    Cell Significance Index: 9.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0789
    Cell Significance Index: 5.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0684
    Cell Significance Index: 50.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0523
    Cell Significance Index: 33.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0523
    Cell Significance Index: 39.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0511
    Cell Significance Index: 0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0427
    Cell Significance Index: 78.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0358
    Cell Significance Index: 3.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0257
    Cell Significance Index: -4.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0288
    Cell Significance Index: -5.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0515
    Cell Significance Index: -70.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0622
    Cell Significance Index: -46.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0683
    Cell Significance Index: -42.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0786
    Cell Significance Index: -8.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0808
    Cell Significance Index: -36.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1051
    Cell Significance Index: -5.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1138
    Cell Significance Index: -64.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1664
    Cell Significance Index: -6.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2110
    Cell Significance Index: -42.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2237
    Cell Significance Index: -25.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2288
    Cell Significance Index: -6.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2335
    Cell Significance Index: -83.7400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.2508
    Cell Significance Index: -5.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2662
    Cell Significance Index: -9.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2711
    Cell Significance Index: -78.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2920
    Cell Significance Index: -13.2400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2976
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3388
    Cell Significance Index: -71.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3777
    Cell Significance Index: -54.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3947
    Cell Significance Index: -10.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4032
    Cell Significance Index: -27.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4499
    Cell Significance Index: -52.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4509
    Cell Significance Index: -27.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5001
    Cell Significance Index: -8.4300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.6477
    Cell Significance Index: -2.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6770
    Cell Significance Index: -11.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7149
    Cell Significance Index: -74.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7534
    Cell Significance Index: -6.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8406
    Cell Significance Index: -64.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8482
    Cell Significance Index: -67.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9196
    Cell Significance Index: -25.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0813
    Cell Significance Index: -15.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1265
    Cell Significance Index: -69.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3895
    Cell Significance Index: -93.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.4309
    Cell Significance Index: -87.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5505
    Cell Significance Index: -49.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.5803
    Cell Significance Index: -99.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6740
    Cell Significance Index: -22.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.6985
    Cell Significance Index: -39.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.7883
    Cell Significance Index: -100.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7927
    Cell Significance Index: -65.8100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.1072
    Cell Significance Index: -31.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.1746
    Cell Significance Index: -64.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GADD45B is a member of the GADD45 family of proteins, which are induced in response to DNA damage, oxidative stress, and other cellular stresses. This protein is characterized by its ability to regulate multiple signaling pathways, including the JNK and p38 MAPK cascades, which are involved in cell differentiation, apoptosis, and stress responses. GADD45B also interacts with various proteins, including transcription factors and kinases, to modulate its downstream effects. Its expression is tightly regulated, with a significant increase observed in response to DNA damage, oxidative stress, and other cellular stresses. **Pathways and Functions:** GADD45B is involved in several key cellular processes, including: 1. **Apoptosis:** GADD45B regulates the apoptotic process by modulating the activity of pro-apoptotic and anti-apoptotic proteins. 2. **Cell Cycle Regulation:** GADD45B inhibits cell cycle progression by inducing the expression of cyclin-dependent kinase inhibitors and promoting the activation of the p53 tumor suppressor. 3. **Differentiation:** GADD45B regulates cell differentiation by modulating the activity of transcription factors and signaling pathways involved in cell fate determination. 4. **Stress Response:** GADD45B is induced in response to various cellular stresses, including DNA damage, oxidative stress, and heat shock, and regulates the expression of genes involved in stress response. **Clinical Significance:** GADD45B has been implicated in various diseases, including: 1. **Cancer:** Overexpression of GADD45B has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor. 2. **Neurodegenerative Diseases:** GADD45B has been shown to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer's and Parkinson's disease. 3. ** Autoimmune Diseases:** GADD45B has been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and lupus, suggesting its potential role in regulating immune responses. 4. **Infectious Diseases:** GADD45B has been shown to be involved in the regulation of immune responses to infections, including viral and bacterial infections. In conclusion, GADD45B is a multifaceted protein that plays a critical role in maintaining cellular homeostasis and regulating various cellular processes, including apoptosis, cell cycle, and differentiation. Its clinical significance is evident in its involvement in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 3479569628

Symbol: GA45B_HUMAN

Name: Growth arrest and DNA damage-inducible protein GADD45 beta

UniProtKB Accession Codes:

O75293 A8KAM2 O75960 Q17R46

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9827804

Title: A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.

PubMed ID: 9827804

DOI: 10.1016/s0092-8674(00)81619-0

PubMed ID: 10773677

Title: Assignment of human GADD45G to chromosome 9q22.1-->q22.3 by radiation hybrid mapping.

PubMed ID: 10773677

DOI: 10.1159/000015496

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12716909

Title: CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.

PubMed ID: 12716909

DOI: 10.1074/jbc.m212835200

Sequence Information:

  • Length: 160
  • Mass: 17818
  • Checksum: 52712E307B322D46
  • Sequence:
    • MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA 
IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL 
LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.