Details for: ITGA7

Gene ID: 3679

Symbol: ITGA7

Ensembl ID: ENSG00000135424

Description: integrin subunit alpha 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.91
    Marker Score: 1429
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3
    Marker Score: 10668
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.68
    Marker Score: 1450
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.53
    Marker Score: 2411
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.5
    Marker Score: 55872
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.9
    Marker Score: 1063
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.9
    Marker Score: 1351
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.89
    Marker Score: 40386
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.81
    Marker Score: 1188
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.8
    Marker Score: 3956
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.55
    Marker Score: 1652
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.52
    Marker Score: 4348
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.36
    Marker Score: 428
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.27
    Marker Score: 19810
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.15
    Marker Score: 2868
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.14
    Marker Score: 300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1746
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.03
    Marker Score: 1933.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.02
    Marker Score: 884
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.98
    Marker Score: 904.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.91
    Marker Score: 1049
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.88
    Marker Score: 250
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.85
    Marker Score: 406
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.8
    Marker Score: 6101
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.79
    Marker Score: 444
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.79
    Marker Score: 1599
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.77
    Marker Score: 449
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.76
    Marker Score: 1440.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.74
    Marker Score: 188
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.74
    Marker Score: 233
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.73
    Marker Score: 1708
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.72
    Marker Score: 211
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2933.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.7
    Marker Score: 458
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.65
    Marker Score: 437
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.59
    Marker Score: 167
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 368
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.56
    Marker Score: 64789
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.55
    Marker Score: 2132
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.54
    Marker Score: 20492
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 312
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.52
    Marker Score: 2005
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.51
    Marker Score: 227
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.49
    Marker Score: 2591
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.49
    Marker Score: 127
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.48
    Marker Score: 369
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.46
    Marker Score: 1907
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 145
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.44
    Marker Score: 746
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.44
    Marker Score: 212
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.4
    Marker Score: 264
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 124
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.39
    Marker Score: 5869
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.38
    Marker Score: 174
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 142
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.36
    Marker Score: 2190
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.36
    Marker Score: 454
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.36
    Marker Score: 93
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.35
    Marker Score: 3022
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.35
    Marker Score: 3325
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.34
    Marker Score: 3479
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 146
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.33
    Marker Score: 568
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.31
    Marker Score: 131
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.31
    Marker Score: 587
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.3
    Marker Score: 68
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.3
    Marker Score: 210
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 201
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 298
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.29
    Marker Score: 3917.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.29
    Marker Score: 1215
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.28
    Marker Score: 273.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.27
    Marker Score: 105
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.27
    Marker Score: 110
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.26
    Marker Score: 76
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 83
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.26
    Marker Score: 351
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.26
    Marker Score: 283
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.25
    Marker Score: 430.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.25
    Marker Score: 125

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Other Information

**Key characteristics:** * ITGA7 is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a transmembrane protein that is expressed on the cell surface. * ITGA7 is a member of the integrin family of cell adhesion molecules. * It is involved in cell-cell adhesion, cell-matrix adhesion, and cell adhesion mediated by integrins. **Pathways and functions:** * ITGA7 is involved in cell-cell adhesion by binding to other integrins on neighboring cells. * It is also involved in cell-matrix adhesion by interacting with extracellular matrix proteins, such as laminin. * ITGA7 is a key molecule in the regulation of cell shape. * It is involved in leukocyte migration by binding to integrins on immune cells. * ITGA7 is also involved in the regulation of muscle organ development. **Clinical significance:** * Mutations in ITGA7 have been linked to several diseases, including cancer and cardiovascular disease. * ITGA7 is a potential target for therapeutic interventions in these diseases. * Inhibition of ITGA7 has been shown to inhibit cell adhesion and migration, suggesting that it may be a potential therapeutic for cancer and cardiovascular disease. **Conclusion:** ITGA7 is a key cell adhesion molecule that plays a crucial role in cell-cell and cell-matrix adhesion. Its dysfunction has been linked to several diseases, and it is a potential target for therapeutic interventions in these diseases.

Genular Protein ID: 3188033869

Symbol: ITA7_HUMAN

Name: Integrin alpha-7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9473524

Title: A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing.

PubMed ID: 9473524

DOI: 10.1006/bbrc.1998.8092

PubMed ID: 9590299

Title: Mutations in the integrin alpha7 gene cause congenital myopathy.

PubMed ID: 9590299

DOI: 10.1038/ng0598-94

PubMed ID: 10403775

Title: Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7).

PubMed ID: 10403775

DOI: 10.1006/bbrc.1999.0916

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8126096

Title: Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases.

PubMed ID: 8126096

DOI: 10.1242/jcs.106.4.1139

PubMed ID: 9352853

Title: Relation between integrin alpha7Bbeta1 expression in human intestinal cells and enterocytic differentiation.

PubMed ID: 9352853

DOI: 10.1053/gast.1997.v113.pm9352853

PubMed ID: 1839357

Title: Laminin-binding integrin alpha 7 beta 1: functional characterization and expression in normal and malignant melanocytes.

PubMed ID: 1839357

DOI: 10.1091/mbc.2.10.805

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9307969

Title: The laminin-binding activity of the alpha 7 integrin receptor is defined by developmentally regulated splicing in the extracellular domain.

PubMed ID: 9307969

DOI: 10.1091/mbc.8.9.1723

PubMed ID: 10694445

Title: The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins.

PubMed ID: 10694445

DOI: 10.1006/excr.2000.4806

PubMed ID: 8626012

Title: Synaptic integrins in developing, adult, and mutant muscle: selective association of alpha1, alpha7A, and alpha7B integrins with the neuromuscular junction.

PubMed ID: 8626012

DOI: 10.1006/dbio.1996.0057

PubMed ID: 17641293

Title: Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.

PubMed ID: 17641293

DOI: 10.1165/rcmb.2007-0165oc

PubMed ID: 18940796

Title: Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.

PubMed ID: 18940796

DOI: 10.1074/jbc.m804661200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22779914

Title: Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.

PubMed ID: 22779914

DOI: 10.1139/o2012-021

Sequence Information:

  • Length: 1181
  • Mass: 128948
  • Checksum: 341C0C72CDB8CA57
  • Sequence:
  • MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR 
    QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE 
    NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE 
    WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH 
    LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD 
    LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL 
    TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS 
    PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI 
    KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA 
    GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ 
    ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP 
    ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL 
    FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL 
    CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS 
    ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL 
    GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL 
    EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW 
    GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV 
    PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT 
    GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A

Genular Protein ID: 4125268018

Symbol: Q4LE35_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1200
  • Mass: 130819
  • Checksum: 540E87C8095F8EC2
  • Sequence:
  • LAGAGAAGWR SGGRAGGLAG RTSGRRLKDQ RDFGDQRRAW GDLGLGACEI SLAFAGSSRR 
    DRPMAGARSR DPWGASGICY LFGSLLVELL FSRAVAFNLD VMGALRKEGE PGSLFGFSVA 
    LHRQLQPRPQ SWLLVGAPQA LALPGQQANR TGGLFACPLS LEETDCYRVD IDQGADMQKE 
    SKENQWLGVS VRSQGPGGKI VTCAHRYEAR QRVDQILETR DMIGRCFVLS QDLAIRDELD 
    GGEWKFCEGR PQGHEQFGFC QQGTAAAFSP DSHYLLFGAP GTYNWKGLLF VTNIDSSDPD 
    QLVYKTLDPA DRLPGPAGDL ALNSYLGFSI DSGKGLVRAE ELSFVAGAPR ANHKGAVVIL 
    RKDSASRLVP EVMLSGERLT SGFGYSLAVA DLNSDGWPDL IVGAPYFFER QEELGGAVYV 
    YLNQGGHWAG ISPLRLCGSP DSMFGISLAV LGDLNQDGFP DIAVGAPFDG DGKVFIYHGS 
    SLGVVAKPSQ VLEGEAVGIK SFGYSLSGSL DMDGNQYPDL LVGSLADTAV LFRARPILHV 
    SHEVSIAPRS IDLEQPNCAG GHSVCVDLRV CFSYIAVPSS YSPTVALDYV LDADTDRRLR 
    GQVPRVTFLS RNLEEPKHQA SGTVWLKHQH DRVCGDAMFQ LQENVKDKLR AIVVTLSYSL 
    QTPRLRRQAP GQGLPPVAPI LNAHQPSTQR AEIHFLKQGC GEDKICQSNL QLVRARFCTR 
    VSDTEFQPLP MDVDGTTALF ALSGQPVIGL ELMVTNLPSD PAQPQADGDD AHEAQLLVML 
    PDSLHYSGVR ALDPAEKPLC LSNENASHVE CELGNPMKRG AQVTFYLILS TSGISIETTE 
    LEVELLLATI SEQELHPVSA RARVFIELPL SIAGMAIPQQ LFFSGVVRGE RAMQSERDVG 
    SKVKYEVTVS NQGQSLRTLG SAFLNIMWPH EIANGKWLLY PMQVELEGGQ GPGQKGLCSP 
    RPNILHLDVD SRDRRRRELE PPEQQEPGER QEPSMSWWPV SSAEKKKNIT LDCARGTANC 
    VVFSCPLYSF DRAAVLHVWG RLWNSTFLEE YSAVKSLEVI VRANITVKSS IKNLMLRDAS 
    TVIPVMVYLD PMAVVAEGVP WWVILLAVLA GLLVLALLVL LLWKMGFFKR AKHPEATVPQ 
    YHAVKIPRED RQQFKEEKTG TILRNNWGSP RREGPDAHPI LAADGHPELG PDGHPGPGTA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.