Details for: DUSP1

Gene ID: 1843

Symbol: DUSP1

Ensembl ID: ENSG00000120129

Description: dual specificity phosphatase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.02
    Marker Score: 12765
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.75
    Marker Score: 6182
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.67
    Marker Score: 3739
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.39
    Marker Score: 149366
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 4.37
    Marker Score: 2876
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.25
    Marker Score: 237840
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.02
    Marker Score: 5816
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.99
    Marker Score: 17116
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.97
    Marker Score: 11126
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.89
    Marker Score: 3349
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.67
    Marker Score: 3921
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.67
    Marker Score: 10134
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.65
    Marker Score: 11528
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.65
    Marker Score: 1576
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.65
    Marker Score: 4392
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.63
    Marker Score: 35993
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.61
    Marker Score: 4135
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.58
    Marker Score: 2713
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.54
    Marker Score: 7417
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.5
    Marker Score: 5150
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.47
    Marker Score: 8386
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.31
    Marker Score: 9665
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.27
    Marker Score: 4749
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.24
    Marker Score: 4473
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.24
    Marker Score: 1538
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.23
    Marker Score: 3178
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.21
    Marker Score: 6259
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.21
    Marker Score: 2864
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.2
    Marker Score: 8369
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.15
    Marker Score: 2224
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.12
    Marker Score: 16404
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.11
    Marker Score: 7080
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.1
    Marker Score: 24241
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 3.09
    Marker Score: 1128
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.05
    Marker Score: 1569
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.04
    Marker Score: 1961
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3
    Marker Score: 2195
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.98
    Marker Score: 2138
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.98
    Marker Score: 5954
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.97
    Marker Score: 2531
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.96
    Marker Score: 1736
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.96
    Marker Score: 2960
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.94
    Marker Score: 1655
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.93
    Marker Score: 1717
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.92
    Marker Score: 2455
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.92
    Marker Score: 731
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.91
    Marker Score: 1454
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.9
    Marker Score: 1251
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.87
    Marker Score: 2085
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.87
    Marker Score: 685
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.87
    Marker Score: 12364
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.87
    Marker Score: 2244
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.86
    Marker Score: 1190
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.85
    Marker Score: 18592
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.85
    Marker Score: 965
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.85
    Marker Score: 1225.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.85
    Marker Score: 662
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.83
    Marker Score: 1033
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.83
    Marker Score: 1723
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 2.83
    Marker Score: 1739
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.82
    Marker Score: 2653
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.81
    Marker Score: 71944
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.79
    Marker Score: 1749
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.79
    Marker Score: 864
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.78
    Marker Score: 5233
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.78
    Marker Score: 2496
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.78
    Marker Score: 3351.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.77
    Marker Score: 1822.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.75
    Marker Score: 145515
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.75
    Marker Score: 2249
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.74
    Marker Score: 31880
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.74
    Marker Score: 13454
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 2.74
    Marker Score: 1177
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.74
    Marker Score: 2581.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.73
    Marker Score: 2634
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.73
    Marker Score: 4470.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.72
    Marker Score: 4323
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.72
    Marker Score: 4596
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.71
    Marker Score: 1848
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.71
    Marker Score: 1797
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.69
    Marker Score: 787
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.69
    Marker Score: 2927
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.69
    Marker Score: 2893
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.68
    Marker Score: 2573
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.68
    Marker Score: 1220
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.68
    Marker Score: 3717.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.67
    Marker Score: 27038
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.65
    Marker Score: 1004
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.65
    Marker Score: 3417
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.61
    Marker Score: 629
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.6
    Marker Score: 3211
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.59
    Marker Score: 3023
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 2.58
    Marker Score: 678
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.58
    Marker Score: 1766
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.57
    Marker Score: 2185
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.56
    Marker Score: 648
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.55
    Marker Score: 2689
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.55
    Marker Score: 15469.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.54
    Marker Score: 628
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 2.54
    Marker Score: 512

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Other Information

**Key characteristics:** - DUSP1 is a serine/threonine phosphatase that is highly expressed in endothelial cells. - It is also expressed in other cell types, including myocytes, fibroblasts, and tumor cells. - DUSP1 is a key regulator of cell cycle progression, as it is involved in the regulation of cell cycle checkpoints and the initiation of DNA replication. - It is also involved in the regulation of epithelial-mesenchymal transition, as it is a key regulator of the switch between epithelial and mesenchymal cell types. - DUSP1 is a key regulator of angiogenesis, as it is involved in the regulation of blood vessel formation. - It is also involved in the regulation of inflammation, as it is a key regulator of the production of inflammatory cytokines. **Pathways and functions:** - DUSP1 is involved in a wide range of cellular processes, including cell cycle regulation, epithelial-mesenchymal transition, and immune responses. - In cell cycle regulation, DUSP1 is involved in the regulation of cell cycle checkpoints and the initiation of DNA replication. - It is also involved in the regulation of epithelial-mesenchymal transition, as it is a key regulator of the switch between epithelial and mesenchymal cell types. - DUSP1 is a key regulator of angiogenesis, as it is involved in the regulation of blood vessel formation. - It is also involved in the regulation of inflammation, as it is a key regulator of the production of inflammatory cytokines. **Clinical significance:** - DUSP1 is an important target for cancer therapy, as it is frequently overexpressed in cancer cells and is involved in the regulation of cancer cell growth, migration, and survival. - Targeting DUSP1 can inhibit cancer cell growth and metastasis, and is therefore being investigated as a potential therapeutic strategy for cancer.

Genular Protein ID: 634285571

Symbol: DUS1_HUMAN

Name: Mitogen-activated protein kinase phosphatase 1

UniProtKB Accession Codes:

P28562 D3DQL9 Q2V508

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 EPD 1 Ensembl 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 9 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1406996

Title: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase.

PubMed ID: 1406996

DOI: 10.1038/359644a0

PubMed ID: 8106404

Title: Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.

PubMed ID: 8106404

DOI: 10.1016/s0021-9258(17)41905-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29052270

Title: Crystal structure of the human dual specificity phosphatase 1 catalytic domain.

PubMed ID: 29052270

DOI: 10.1002/pro.3328

Sequence Information:

  • Length: 367
  • Mass: 39298
  • Checksum: 11BD1D39A9FCD51F
  • Sequence:
    • MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM 
GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF 
LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF 
LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA 
IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS 
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP 
ITTSPSC

Genular Protein ID: 2926051622

Symbol: B4DU40_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DU40

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 DNASU 1 EC 2 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 2 PROSITE 7 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 340
  • Mass: 36511
  • Checksum: F5AE560F36DCAC9D
  • Sequence:
    • MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRTKGAM 
GLEHIVPNAK RDGTLVLAAG ALCREARAAQ VFFLKGGYEA FSASCPELCS KQSTPMGLSL 
PLSTSVPDSA ESGCSSCSTP LYDQGGPVEI LPFLYLGSAH HASRKDMLDA LGITALINVS 
ANCPNHFEGH YQYKSIPVED NHKADISSWF NEAIDFIDSI KNAGGRVFVH CQAGISRSAT 
ICLAYLMRTN RVKLDEAFEF VKQRRSIISP NFSFMGQLLQ FESQVLAPHC SAEAGSPAMA 
VLDRGTSTTT VFNFPVSIPV HSTNSALSYL QSPITTSPSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.