Details for: DUSP1
Gene ID: 1843
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DUSP1
Ensembl ID: ENSG00000120129
Description: dual specificity phosphatase 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 120.11rCSI 92.54%PRS 4.65
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CSI 92.73rCSI 70.15%PRS 7.24
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CSI 73.94rCSI 65.02%PRS 3.72
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CSI 71.09rCSI 47.38%PRS 14.43
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CSI 67.13rCSI 50.44%PRS 5.31
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CSI 65.68rCSI 60.3%PRS 5.86
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CSI 65.35rCSI 49%PRS 15.55
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CSI 60.99rCSI 45.32%PRS 7.71
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CSI 60.84rCSI 48.31%PRS 9.2
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CSI 57.43rCSI 75.25%PRS 7.22
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CSI 53.23rCSI 45.66%PRS 13.36
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CSI 52.61rCSI 59.22%PRS 8.62
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CSI 50.78rCSI 43.78%PRS 8.54
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CSI 48.98rCSI 41.05%PRS 6.2
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CSI 48.86rCSI 39.7%PRS 5.48
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CSI 47.03rCSI 64%PRS 7.92
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CSI 47.03rCSI 45.27%PRS 5.34
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CSI 46.8rCSI 43.18%PRS 5.21
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CSI 45.88rCSI 55.59%PRS 7.71
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CSI 45.77rCSI 45.2%PRS 22.43
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CSI 43.65rCSI 78.79%PRS 15.62
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CSI 43.19rCSI 73.88%PRS 11.23
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CSI 42.95rCSI 35.86%PRS 16.77
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CSI 42.7rCSI 63.31%PRS 49.49
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CSI 42.7rCSI 64.43%PRS 5.06
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CSI 42.23rCSI 52.6%PRS 7.48
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CSI 41.26rCSI 33.33%PRS 11.87
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CSI 39.78rCSI 61.1%PRS 5.98
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CSI 39.69rCSI 41.45%PRS 16.53
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CSI 39.32rCSI 30.58%PRS 7.42
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CSI 38.9rCSI 35.96%PRS 9.51
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CSI 38.79rCSI 22.91%PRS 7.22
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CSI 38.15rCSI 61.15%PRS 17.12
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CSI 37.18rCSI 35.75%PRS 11.24
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CSI 37.07rCSI 38.68%PRS 5.27
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CSI 37.05rCSI 44.75%PRS 6.04
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CSI 36.21rCSI 57.18%PRS 5.16
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CSI 35.54rCSI 67.1%PRS 6.41
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CSI 35.49rCSI 27.51%PRS 4.88
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CSI 35.2rCSI 47.04%PRS 9.89
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CSI 33.69rCSI 34.49%PRS 9.78
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CSI 33.31rCSI 47.54%PRS 5.87
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CSI 33.2rCSI 24.79%PRS 8.72
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CSI 32.54rCSI 41.73%PRS 5.95
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CSI 32.27rCSI 33.43%PRS 6.05
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CSI 31.21rCSI 45.22%PRS 7.59
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CSI 31.06rCSI 47.44%PRS 5.16
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CSI 30.01rCSI 26.64%PRS 5.16
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CSI 28.4rCSI 31.11%PRS 5.96
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CSI 28.08rCSI 54.62%PRS 5.26
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CSI 27.94rCSI 32.4%PRS 7.71
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CSI 25.77rCSI 37.76%PRS 30.6
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CSI 25.69rCSI 46.43%PRS 14.79
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CSI 25.67rCSI 70.53%PRS 8.62
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CSI 24.17rCSI 21.18%PRS 6.95
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CSI 24.15rCSI 28.37%PRS 45.87
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CSI 23.98rCSI 63.12%PRS 10.1
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CSI 23.7rCSI 56.87%PRS 9.8
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CSI 23.46rCSI 42.67%PRS 24.68
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CSI 23.44rCSI 21.81%PRS 5.18
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CSI 23.23rCSI 38.27%PRS 6.04
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CSI 23.19rCSI 22.8%PRS 15.48
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CSI 23.19rCSI 55.75%PRS 8.04
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CSI 23.1rCSI 16.23%PRS 15.33
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CSI 22.99rCSI 21.72%PRS 5.38
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CSI 22.09rCSI 27.22%PRS 17.38
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CSI 21.99rCSI 48.41%PRS 5.64
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CSI 21.9rCSI 33.65%PRS 7.45
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CSI 21.86rCSI 21.08%PRS 2.88
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CSI 21.76rCSI 39.88%PRS 32.64
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CSI 21.69rCSI 31.78%PRS 6.1
-
CSI 21.65rCSI 22.68%PRS 4.81
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CSI 21.48rCSI 19.39%PRS 4.54
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CSI 21.34rCSI 17.95%PRS 8.65
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CSI 21.31rCSI 17.65%PRS 5.15
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CSI 21.31rCSI 33.05%PRS 8.25
-
CSI 20.73rCSI 43.02%PRS 5.12
-
CSI 20.58rCSI 39.64%PRS 11.88
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CSI 20.42rCSI 25.68%PRS 7.93
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CSI 20.38rCSI 16.89%PRS 4.88
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CSI 20.37rCSI 26.06%PRS 23.69
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CSI 19.99rCSI 26.57%PRS 5.64
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CSI 19.94rCSI 14.92%PRS 8.48
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CSI 19.86rCSI 34.02%PRS 6.9
-
CSI 19.83rCSI 28.6%PRS 7.17
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CSI 19.71rCSI 13.28%PRS 6.26
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CSI 19.67rCSI 37.51%PRS 8.27
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CSI 19.46rCSI 81.8%PRS 14.24
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CSI 19.17rCSI 68.05%PRS 8.5
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CSI 18.84rCSI 22.5%PRS 9.03
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CSI 18.75rCSI 42.79%PRS 4.79
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CSI 18.13rCSI 19.43%PRS 4.76
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CSI 17.91rCSI 23.47%PRS 27.61
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CSI 17.54rCSI 13.34%PRS 6.84
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CSI 17.45rCSI 12.52%PRS 7.06
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CSI 17.25rCSI 15%PRS 6.35
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CSI 17.14rCSI 23.35%PRS 13.02
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CSI 17.12rCSI 23.71%PRS 7.43
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CSI 16.54rCSI 22.12%PRS 28.85
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CSI 16.53rCSI 15.06%PRS 8.11
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CSI -15.8rCSI -31.6%PRS 3.9%
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CSI -14.3rCSI -19.9%PRS 5.4%
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CSI -13.2rCSI -18.9%PRS 4.3%
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CSI -11.8rCSI -18.8%PRS 4.5%
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CSI -9.8rCSI -46.9%PRS 3.1%
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CSI -9.1rCSI -15.9%PRS 4.0%
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CSI -7.4rCSI -27.7%PRS 4.5%
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CSI -6.6rCSI -31.3%PRS 8.3%
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CSI -6.4rCSI -26.5%PRS 14.8%
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CSI -6.2rCSI -40.1%PRS 13.7%
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CSI -5.2rCSI -6.4%PRS 2.8%
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CSI -3.9rCSI -7.0%PRS 4.4%
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CSI -3.6rCSI -22.6%PRS 4.3%
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CSI -3.6rCSI -4.1%PRS 4.7%
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CSI -2.8rCSI -26.1%PRS 19.6%
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CSI -2.8rCSI -9.7%PRS 23.0%
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CSI -2.7rCSI -2.2%PRS 9.6%
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CSI -2.6rCSI -12.9%PRS 26.1%
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CSI -2.4rCSI -3.5%PRS 5.2%
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CSI -2.1rCSI -6.4%PRS 3.6%
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CSI -1.9rCSI -6.8%PRS 2.8%
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CSI -1.8rCSI -2.8%PRS 13.3%
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CSI -1.7rCSI -6.6%PRS 19.8%
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CSI -1.6rCSI -3.8%PRS 6.7%
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CSI -1.5rCSI -16.4%PRS 34.1%
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CSI -1.3rCSI -11.8%PRS 43.8%
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CSI -1.0rCSI -12.4%PRS 29.6%
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CSI -0.8rCSI -1.3%PRS 6.6%
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CSI -0.5rCSI -14.3%PRS 68.9%
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CSI -0.4rCSI -5.5%PRS 42.3%
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CSI 0.0rCSI 0.1%PRS 3.3%
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CSI 0.1rCSI 2.1%PRS 14.6%
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CSI 0.2rCSI 2.1%PRS 18.2%
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CSI 0.2rCSI 3.5%PRS 41.6%
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CSI 0.3rCSI 1.4%PRS 13.0%
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CSI 0.4rCSI 1.1%PRS 18.0%
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CSI 0.4rCSI 9.2%PRS 71.6%
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CSI 0.4rCSI 1.7%PRS 8.6%
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CSI 0.5rCSI 4.0%PRS 30.4%
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CSI 0.5rCSI 8.7%PRS 47.7%
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CSI 0.6rCSI 14.4%PRS 28.0%
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CSI 0.6rCSI 2.9%PRS 24.0%
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CSI 0.6rCSI 1.2%PRS 5.7%
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CSI 0.6rCSI 6.1%PRS 23.2%
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CSI 0.7rCSI 0.8%PRS 3.3%
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CSI 0.7rCSI 9.0%PRS 47.2%
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CSI 0.7rCSI 1.9%PRS 6.5%
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CSI 0.7rCSI 2.2%PRS 6.5%
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CSI 0.7rCSI 4.4%PRS 10.4%
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CSI 0.9rCSI 5.1%PRS 27.1%
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CSI 0.9rCSI 9.2%PRS 21.0%
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CSI 0.9rCSI 2.7%PRS 4.5%
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CSI 1.0rCSI 6.7%PRS 38.1%
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CSI 1.0rCSI 5.5%PRS 17.3%
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CSI 1.1rCSI 1.5%PRS 7.6%
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CSI 1.1rCSI 8.0%PRS 17.9%
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CSI 1.1rCSI 2.9%PRS 8.9%
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CSI 1.2rCSI 1.9%PRS 4.0%
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CSI 1.3rCSI 13.4%PRS 44.5%
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CSI 1.4rCSI 13.4%PRS 50.7%
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CSI 1.4rCSI 11.8%PRS 12.6%
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CSI 1.4rCSI 28.4%PRS 73.1%
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CSI 1.5rCSI 8.5%PRS 8.1%
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CSI 1.5rCSI 8.3%PRS 23.1%
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CSI 1.5rCSI 4.1%PRS 6.7%
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CSI 1.5rCSI 8.8%PRS 8.0%
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CSI 1.7rCSI 12.3%PRS 16.8%
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CSI 1.8rCSI 8.4%PRS 14.4%
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CSI 1.8rCSI 43.6%PRS 19.5%
-
CSI 1.9rCSI 33.8%PRS 13.2%
-
CSI 1.9rCSI 2.5%PRS 9.1%
-
CSI 1.9rCSI 7.2%PRS 11.2%
-
CSI 1.9rCSI 11.1%PRS 28.2%
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CSI 1.9rCSI 20.2%PRS 8.5%
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CSI 2.0rCSI 50.2%PRS 30.0%
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CSI 2.0rCSI 21.3%PRS 9.6%
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CSI 2.0rCSI 3.2%PRS 4.0%
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CSI 2.0rCSI 47.6%PRS 34.7%
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CSI 2.2rCSI 15.6%PRS 49.4%
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CSI 2.2rCSI 3.1%PRS 4.9%
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CSI 2.3rCSI 12.2%PRS 10.2%
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CSI 2.3rCSI 5.1%PRS 4.8%
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CSI 2.4rCSI 3.1%PRS 5.1%
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CSI 2.4rCSI 6.4%PRS 8.8%
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CSI 2.5rCSI 53.2%PRS 32.3%
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CSI 2.6rCSI 8.3%PRS 6.2%
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CSI 2.6rCSI 7.1%PRS 5.8%
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CSI 2.6rCSI 6.4%PRS 5.3%
-
CSI 2.6rCSI 25.9%PRS 15.8%
-
CSI 2.6rCSI 7.6%PRS 10.5%
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CSI 2.7rCSI 7.4%PRS 24.9%
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CSI 2.7rCSI 85.0%PRS 58.2%
-
CSI 2.8rCSI 17.1%PRS 25.6%
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CSI 2.8rCSI 69.9%PRS 18.4%
-
CSI 2.8rCSI 10.1%PRS 9.0%
-
CSI 2.9rCSI 11.6%PRS 21.0%
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CSI 2.9rCSI 32.5%PRS 17.6%
-
CSI 2.9rCSI 5.8%PRS 15.0%
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CSI 2.9rCSI 23.7%PRS 5.5%
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CSI 3.0rCSI 5.3%PRS 3.1%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 634285571
Symbol: DUS1_HUMAN
Name: Mitogen-activated protein kinase phosphatase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1406996
Title: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase.
PubMed ID: 1406996
DOI: 10.1038/359644a0
PubMed ID: 8106404
Title: Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.
PubMed ID: 8106404
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 29052270
Title: Crystal structure of the human dual specificity phosphatase 1 catalytic domain.
PubMed ID: 29052270
DOI: 10.1002/pro.3328
Sequence Information:
- Length: 367
- Mass: 39298
- Checksum: 11BD1D39A9FCD51F
- Sequence:
MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP ITTSPSC
Genular Protein ID: 2926051622
Symbol: B4DU40_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 340
- Mass: 36511
- Checksum: F5AE560F36DCAC9D
- Sequence:
MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRTKGAM GLEHIVPNAK RDGTLVLAAG ALCREARAAQ VFFLKGGYEA FSASCPELCS KQSTPMGLSL PLSTSVPDSA ESGCSSCSTP LYDQGGPVEI LPFLYLGSAH HASRKDMLDA LGITALINVS ANCPNHFEGH YQYKSIPVED NHKADISSWF NEAIDFIDSI KNAGGRVFVH CQAGISRSAT ICLAYLMRTN RVKLDEAFEF VKQRRSIISP NFSFMGQLLQ FESQVLAPHC SAEAGSPAMA VLDRGTSTTT VFNFPVSIPV HSTNSALSYL QSPITTSPSC