Details for: DUSP1

Gene ID: 1843

Symbol: DUSP1

Ensembl ID: ENSG00000120129

Description: dual specificity phosphatase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 761.3220
    Cell Significance Index: -118.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 442.4913
    Cell Significance Index: -112.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 292.6146
    Cell Significance Index: -138.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 274.4490
    Cell Significance Index: -141.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 205.4180
    Cell Significance Index: -137.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 102.8545
    Cell Significance Index: -126.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 38.8969
    Cell Significance Index: -119.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 34.4813
    Cell Significance Index: -136.0700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 32.1303
    Cell Significance Index: -70.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.6764
    Cell Significance Index: -76.8200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 16.6263
    Cell Significance Index: 44.5400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 12.9803
    Cell Significance Index: 239.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 10.3404
    Cell Significance Index: 296.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.5794
    Cell Significance Index: 58.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.8029
    Cell Significance Index: 102.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.7620
    Cell Significance Index: 738.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0797
    Cell Significance Index: 138.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.5397
    Cell Significance Index: 292.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.4330
    Cell Significance Index: 1959.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.9789
    Cell Significance Index: 546.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.4841
    Cell Significance Index: 163.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.4089
    Cell Significance Index: 241.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4040
    Cell Significance Index: 158.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.6386
    Cell Significance Index: 60.9600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.5157
    Cell Significance Index: 14.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1463
    Cell Significance Index: 1172.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1093
    Cell Significance Index: 55.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7521
    Cell Significance Index: 226.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6239
    Cell Significance Index: 85.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4850
    Cell Significance Index: 182.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3416
    Cell Significance Index: 158.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2714
    Cell Significance Index: 229.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.2204
    Cell Significance Index: 25.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0473
    Cell Significance Index: 945.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0100
    Cell Significance Index: 99.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8952
    Cell Significance Index: 66.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8910
    Cell Significance Index: 169.5600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8406
    Cell Significance Index: 9.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.8218
    Cell Significance Index: 521.9000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.5778
    Cell Significance Index: 12.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5773
    Cell Significance Index: 20.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5559
    Cell Significance Index: 14.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4043
    Cell Significance Index: 69.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2519
    Cell Significance Index: 190.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2133
    Cell Significance Index: 34.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1703
    Cell Significance Index: 320.6700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1639
    Cell Significance Index: 2.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1597
    Cell Significance Index: 18.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1235
    Cell Significance Index: 12.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0538
    Cell Significance Index: 82.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0502
    Cell Significance Index: 1.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0005
    Cell Significance Index: -0.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0314
    Cell Significance Index: -57.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0623
    Cell Significance Index: -3.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0802
    Cell Significance Index: -58.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0880
    Cell Significance Index: -65.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0996
    Cell Significance Index: -62.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1398
    Cell Significance Index: -63.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1479
    Cell Significance Index: -4.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1685
    Cell Significance Index: -95.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1746
    Cell Significance Index: -120.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2142
    Cell Significance Index: -3.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2809
    Cell Significance Index: -55.7500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2903
    Cell Significance Index: -4.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3210
    Cell Significance Index: -34.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3259
    Cell Significance Index: -116.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3768
    Cell Significance Index: -79.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3869
    Cell Significance Index: -77.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4155
    Cell Significance Index: -119.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4279
    Cell Significance Index: -49.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4616
    Cell Significance Index: -16.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4818
    Cell Significance Index: -70.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6129
    Cell Significance Index: -30.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6613
    Cell Significance Index: -50.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7000
    Cell Significance Index: -28.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7466
    Cell Significance Index: -33.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8106
    Cell Significance Index: -94.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8205
    Cell Significance Index: -11.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1642
    Cell Significance Index: -69.8900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1759
    Cell Significance Index: -30.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2832
    Cell Significance Index: -133.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6461
    Cell Significance Index: -130.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6907
    Cell Significance Index: -54.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7210
    Cell Significance Index: -108.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.8039
    Cell Significance Index: -27.0300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.8208
    Cell Significance Index: -26.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8849
    Cell Significance Index: -115.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.9344
    Cell Significance Index: -130.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9410
    Cell Significance Index: -52.0100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.9828
    Cell Significance Index: -11.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.0638
    Cell Significance Index: -50.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.1700
    Cell Significance Index: -133.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.2164
    Cell Significance Index: -61.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.2215
    Cell Significance Index: -124.6600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -2.5035
    Cell Significance Index: -35.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.7811
    Cell Significance Index: -69.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.0304
    Cell Significance Index: -134.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.0523
    Cell Significance Index: -36.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.0754
    Cell Significance Index: -112.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.1676
    Cell Significance Index: -93.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual-Specificity Phosphatase Activity**: DUSP1 possesses the unique ability to dephosphorylate both tyrosine and threonine residues on MAPKs, making it a key regulator of MAPK signaling pathways. 2. **Negative Regulation of MAPK Signaling**: By dephosphorylating MAPKs, DUSP1 exerts negative regulation on these pathways, which can prevent excessive cell proliferation, differentiation, and survival. 3. **Tissue-Specific Expression**: DUSP1 is significantly expressed in various cell types, including immune cells, endothelial cells, and fibroblasts, suggesting its involvement in different physiological and pathological processes. 4. **MAPK Pathway Involvement**: DUSP1 is involved in several MAPK pathways, including the JNK, p38, and ERK pathways, which are crucial for regulating cell growth, differentiation, and survival. **Pathways and Functions:** DUSP1 plays a critical role in various MAPK signaling pathways, including: 1. **Mitogen-Activated Protein Kinase (MAPK) Pathway**: DUSP1 negatively regulates the MAPK pathway, which is involved in cell proliferation, differentiation, and survival. 2. **JNK (c-Jun N-terminal kinase) Pathway**: DUSP1 regulates the JNK pathway, which is involved in stress response, apoptosis, and cell growth. 3. **p38 MAPK Pathway**: DUSP1 negatively regulates the p38 MAPK pathway, which is involved in cell differentiation, survival, and inflammation. 4. **ERK (Extracellular Signal-Regulated Kinase) Pathway**: DUSP1 regulates the ERK pathway, which is involved in cell proliferation, differentiation, and survival. **Clinical Significance:** DUSP1 has significant implications in various diseases and disorders, including: 1. **Cancer**: DUSP1 is involved in the regulation of cell growth and proliferation, making it a potential target for cancer therapy. 2. **Inflammatory Diseases**: DUSP1 regulates the p38 MAPK pathway, which is involved in inflammation and immune responses, making it a potential target for inflammatory diseases. 3. **Neurological Disorders**: DUSP1 is involved in the regulation of JNK and ERK pathways, which are involved in neuronal survival and apoptosis, making it a potential target for neurological disorders. 4. **Cardiovascular Diseases**: DUSP1 regulates the p38 MAPK pathway, which is involved in vascular smooth muscle cell proliferation and migration, making it a potential target for cardiovascular diseases. In conclusion, DUSP1 is a critical gene involved in the regulation of MAPK signaling pathways, and its dysregulation has significant implications in various diseases and disorders. Further research is needed to fully understand the functional significance of DUSP1 and its potential as a therapeutic target.

Genular Protein ID: 634285571

Symbol: DUS1_HUMAN

Name: Mitogen-activated protein kinase phosphatase 1

UniProtKB Accession Codes:

P28562 D3DQL9 Q2V508

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 5 Ensembl 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 9 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1406996

Title: Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase.

PubMed ID: 1406996

DOI: 10.1038/359644a0

PubMed ID: 8106404

Title: Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene.

PubMed ID: 8106404

DOI: 10.1016/s0021-9258(17)41905-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 29052270

Title: Crystal structure of the human dual specificity phosphatase 1 catalytic domain.

PubMed ID: 29052270

DOI: 10.1002/pro.3328

Sequence Information:

  • Length: 367
  • Mass: 39298
  • Checksum: 11BD1D39A9FCD51F
  • Sequence:
    • MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM 
GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF 
LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF 
LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA 
IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS 
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP 
ITTSPSC

Genular Protein ID: 2926051622

Symbol: B4DU40_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DU40

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 8 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 8 Gene3D 2 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PIRSR 1 PRINTS 2 PROSITE 7 PeptideAtlas 1 Pfam 2 RefSeq 1 Rhea 6 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 340
  • Mass: 36511
  • Checksum: F5AE560F36DCAC9D
  • Sequence:
    • MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRTKGAM 
GLEHIVPNAK RDGTLVLAAG ALCREARAAQ VFFLKGGYEA FSASCPELCS KQSTPMGLSL 
PLSTSVPDSA ESGCSSCSTP LYDQGGPVEI LPFLYLGSAH HASRKDMLDA LGITALINVS 
ANCPNHFEGH YQYKSIPVED NHKADISSWF NEAIDFIDSI KNAGGRVFVH CQAGISRSAT 
ICLAYLMRTN RVKLDEAFEF VKQRRSIISP NFSFMGQLLQ FESQVLAPHC SAEAGSPAMA 
VLDRGTSTTT VFNFPVSIPV HSTNSALSYL QSPITTSPSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.